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Chemical Structure| 22161-81-5 Chemical Structure| 22161-81-5

Structure of S-(+)-Ketoprofen
CAS No.: 22161-81-5

Chemical Structure| 22161-81-5

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CAS No.: 22161-81-5

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(S)-Ketoprofen is a potent inhibitor of COX with IC50 of 1.9 and 27 nM for COX1 and 2 respectively.

Synonyms: (S)-Ketoprofen; Dexketoprofen; (S)-2-(3-benzoylphenyl)Propionic Acid

4.5 *For Research Use Only !

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Product Details of S-(+)-Ketoprofen

CAS No. :22161-81-5
Formula : C16H14O3
M.W : 254.28
SMILES Code : C[C@@H](C1=CC=CC(C(C2=CC=CC=C2)=O)=C1)C(O)=O
Synonyms :
(S)-Ketoprofen; Dexketoprofen; (S)-2-(3-benzoylphenyl)Propionic Acid
MDL No. :MFCD00673316
InChI Key :DKYWVDODHFEZIM-NSHDSACASA-N
Pubchem ID :667550

Safety of S-(+)-Ketoprofen

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H315-H319-H335-H400
Precautionary Statements:P261-P273-P301+P310-P305+P351+P338
Class:6.1
UN#:2811
Packing Group:Ⅲ

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.93mL

0.79mL

0.39mL

19.66mL

3.93mL

1.97mL

39.33mL

7.87mL

3.93mL
Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

[1]Diaz-Reval MI, Ventura-Martinez R, et al. Evidence for a central mechanism of action of S-(+)-ketoprofen. Eur J Pharmacol. 2004 Jan 12;483(2-3):241-8.

[2]Ghezzi P, Melillo G, et al. Differential contribution of R and S isomers in ketoprofen anti-inflammatory activity: role of cytokine modulation. J Pharmacol Exp Ther. 1998 Dec;287(3):969-74.

[3]Thompson KA, Papich MG, Higgins B, Flanagan J, Christiansen EF, Harms CA. Ketoprofen pharmacokinetics of R- and S-isomers in juvenile loggerhead sea turtles (Caretta caretta) after single intravenous and single- and multidose intramuscular administration. J Vet Pharmacol Ther. 2018 Apr;41(2):340-348

[4]Kaya C, Atalay YO, Meydan BC, Ustun YB, Koksal E, Caliskan S. Avalia??o dos efeitos neurotóxicos da administra??o intratecal do (S)‐(+)‐cetoprofeno em medula espinhal de rato: estudo experimental rand?mico e controlado [Evaluation of the neurotoxic effects of intrathecal administration of (S)-(+)-Ketoprofen on rat spinal cords: randomized controlled experimental study]. Rev Bras Anestesiol. 2019 Jul-Aug;69(4):403-412. Portuguese

[5]Serrano-Rodríguez JM, Serrano JM, Rodríguez JM, Machuca MM, Gómez-Villamandos RJ, Navarrete-Calvo R. Pharmacokinetics of the individual enantiomer S-(+)-ketoprofen after intravenous and oral administration in dogs at two dose levels. Res Vet Sci. 2014 Jun;96(3):523-5

[6]Ossipov MH, Jerussi TP, Ren K, Sun H, Porreca F. Differential effects of spinal (R)-ketoprofen and (S)-ketoprofen against signs of neuropathic pain and tonic nociception: evidence for a novel mechanism of action of (R)-ketoprofen against tactile allodynia. Pain. 2000 Aug;87(2):193-9

 

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