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Chemical Structure| 2163-48-6 Chemical Structure| 2163-48-6
Chemical Structure| 2163-48-6

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CAS No.: 2163-48-6

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Product Details of Diethyl propylmalonate

CAS No. :2163-48-6
Formula : C10H18O4
M.W : 202.25
SMILES Code : CCCC(C(=O)OCC)C(=O)OCC
MDL No. :MFCD00009168
InChI Key :GRRSDGHTSMJICM-UHFFFAOYSA-N
Pubchem ID :16552

Safety of Diethyl propylmalonate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Diethyl propylmalonate

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2163-48-6 ]

[ 2163-48-6 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 2163-48-6 ]
  • [ 2612-28-4 ]
YieldReaction ConditionsOperation in experiment
60% With diisobutylaluminium hydride; In dichloromethane; at -78 - 0℃; for 0.5h; Example E; Compound 5 ; {2-Methyl-4-[2-(4-trifluoromethyl-phenoxymethyl)-pentylsulfanyl]-phenoxy}-acetic acid; To a solution of 1.0 M diisobutylaluminum hydride (50 mL, 50 mmol) in CH2CI2 at-78C was added diethyl propylmalonate E1 (2.02 g, 10.0 mmol). The reaction mixture was allowed to gradually warm to 0C, stirred at 0C for 30 min, and quenched with MeOH. The precipitated solid was filtered through Celite and washed with MeOH/CH2CI2. The filtrate was concentrated and purified by column chromatography (EtOAc) to give 709 mg (60%) of E2; 1 H NMR (300 MHz, CDC . s) 8 3. 80 (dd, J = 10.7, 3.8 Hz, 2 H), 3.63 (dd, J = 10.7, 7.7 Hz, 2 H), 2.82 (s, 2 H), 1.84-1. 71 (m, 1 H), 1.42- 1.28 (m, 2 H), 1.24-1. 17 (m, 2 H), 0.91 (t, J = 7. 2 Hz, 3 H) ; MS (ES) m/z : 141 (M+Na+).
  • 2
  • [ 64-17-5 ]
  • [ 2163-48-6 ]
  • copper-chromium oxide [ No CAS ]
  • [ 2612-28-4 ]
  • 3
  • [ 64-17-5 ]
  • [ 2163-48-6 ]
  • sodium [ No CAS ]
  • [ 58175-57-8 ]
  • [ 71-41-0 ]
  • [ 2612-28-4 ]
  • [ 109-52-4 ]
  • 4
  • [ 2163-48-6 ]
  • [ 2217-08-5 ]
 

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