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Chemical Structure| 213697-53-1 Chemical Structure| 213697-53-1
Chemical Structure| 213697-53-1

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CAS No.: 213697-53-1

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Gilbert, Robert ; Davis, Christopher W ; Bingham, Tanner W ; Sarlah, David ;

Abstract: A dearomative 1,4-hydroamination of nonactivated arenes has been developed, using a key arene-arenophile photocycloaddition strategy to disrupt aromaticity. Palladium catalysis with K-Selectride? as a hydride source uniquely enables selective reactivity and provides access to a range of substituted 1,4-cyclohexadienes from aromatic starting materials. We demonstrate a few synthetic applications of this scalable procedure by preparing highly-functionalized small molecules in three to four steps from naphthalene.

Keywords: Dearomatization ; Hydroamination ; Arenophiles ; Palladium ; Catalysis

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Product Details of DavePhos

CAS No. :213697-53-1
Formula : C26H36NP
M.W : 393.54
SMILES Code : CN(C1=CC=CC=C1C2=CC=CC=C2P(C3CCCCC3)C4CCCCC4)C
MDL No. :MFCD02183572
InChI Key :ZEMZPXWZVTUONV-UHFFFAOYSA-N
Pubchem ID :2734217

Safety of DavePhos

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338
 

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