成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 20781-06-0 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 20781-06-0
Chemical Structure| 20781-06-0
Structure of 20781-06-0 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 20781-06-0 ]

Related Doc. of [ 20781-06-0 ]

Alternatived Products of [ 20781-06-0 ]
Product Citations

Product Citations

Cifone, Matthew T. ; He, YongLe ; Basu, Rajeswari , et al. DOI: PubMed ID:

Abstract: The relationship between drug-target residence time and the post-antibiotic effect (PAE) provides insights into target vulnerability. To probe the vulnerability of bacterial acetyl-CoA carboxylase (ACC), a series of heterobivalent inhibitors were synthesized based on pyridopyrimidine 1 and moiramide B (3) which bind to the biotin carboxylase and carboxyltransferase ACC active sites, resp. The heterobivalent compound 17, which has a linker of 50 ?, was a tight binding inhibitor of Escherichia coli ACC (Kiapp 0.2 nM) and could be displaced from ACC by a combination of both 1 and 3 but not just by 1. In agreement with the prolonged occupancy of ACC resulting from forced proximity binding, the heterobivalent inhibitors produced a PAE in E. coli of 1-4 h in contrast to 1 and 3 in combination or alone, indicating that ACC is a vulnerable target and highlighting the utility of kinetic, time-dependent effects in the drug mechanism of action.

Purchased from AmBeed: ; ; ; ; ; ; ; ; ; ; ; ;

Product Details of [ 20781-06-0 ]

CAS No. :20781-06-0 MDL No. :MFCD04973412
Formula : C5H6N4O Boiling Point : -
Linear Structure Formula :- InChI Key :GPWNWKWQOLEVEQ-UHFFFAOYSA-N
M.W : 138.13 Pubchem ID :309176
Synonyms :

Calculated chemistry of [ 20781-06-0 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 10
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.0
Num. rotatable bonds : 1
Num. H-bond acceptors : 3.0
Num. H-bond donors : 2.0
Molar Refractivity : 36.23
TPSA : 94.89 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : No
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -7.48 cm/s

Lipophilicity

Log Po/w (iLOGP) : 0.45
Log Po/w (XLOGP3) : -0.48
Log Po/w (WLOGP) : -0.53
Log Po/w (MLOGP) : -1.41
Log Po/w (SILICOS-IT) : -0.34
Consensus Log Po/w : -0.46

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -0.77
Solubility : 23.4 mg/ml ; 0.169 mol/l
Class : Very soluble
Log S (Ali) : -1.05
Solubility : 12.4 mg/ml ; 0.09 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -0.85
Solubility : 19.3 mg/ml ; 0.14 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.65

Safety of [ 20781-06-0 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 20781-06-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 20781-06-0 ]

[ 20781-06-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 20781-06-0 ]
  • [ 67197-53-9 ]
  • [ 179343-23-8 ]
YieldReaction ConditionsOperation in experiment
In 2-ethoxy-ethanol; EXAMPLE 60 6-(2,6-Dibromo-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine To a solution of 0.23 g 60% sodium hydride suspension in 11.0 mL of 2-ethoxyethanol was added 4.18 g of <strong>[67197-53-9]2,6-dibromophenylacetonitrile</strong> and 2.00 g of 2,4-diaminopyrimidine-5-carboxaldehyde. The reaction was refluxed for 4 hours, cooled, and poured into ice water. The residue was washed well with acetonitrile then diethyl ether to give 3.62 g of 6-(2,6-dibromo-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine, CIMS (1% NH3 in CH4): 422=M+ +C2 H5, 396 (Base), 394=M+ +H, 393=M+; mp 284-289 C.
Recommend Products
Same Skeleton Products

Technical Information

Historical Records

Related Functional Groups of
[ 20781-06-0 ]

Aldehydes

Chemical Structure| 120747-84-4

[ 120747-84-4 ]

2-Aminopyrimidine-5-carbaldehyde

Similarity: 0.80

Chemical Structure| 1588441-19-3

[ 1588441-19-3 ]

2-Aminopyrimidine-5-carbaldehyde hydrate

Similarity: 0.80

Chemical Structure| 1393547-54-0

[ 1393547-54-0 ]

4-Amino-2-chloropyrimidine-5-carbaldehyde

Similarity: 0.75

Chemical Structure| 90905-33-2

[ 90905-33-2 ]

2-Methylpyrimidine-5-carbaldehyde

Similarity: 0.69

Chemical Structure| 10070-92-5

[ 10070-92-5 ]

Pyrimidine-5-carbaldehyde

Similarity: 0.69

Amines

Chemical Structure| 66131-74-6

[ 66131-74-6 ]

2,4-Diaminopyrimidine-5-carboxamide

Similarity: 0.92

Chemical Structure| 120747-84-4

[ 120747-84-4 ]

2-Aminopyrimidine-5-carbaldehyde

Similarity: 0.80

Chemical Structure| 1588441-19-3

[ 1588441-19-3 ]

2-Aminopyrimidine-5-carbaldehyde hydrate

Similarity: 0.80

Chemical Structure| 15400-54-1

[ 15400-54-1 ]

Ethyl 2,4-diaminopyrimidine-5-carboxylate

Similarity: 0.78

Chemical Structure| 16462-27-4

[ 16462-27-4 ]

2,4-Diaminopyrimidine-5-carbonitrile

Similarity: 0.75

Related Parent Nucleus of
[ 20781-06-0 ]

Pyrimidines

Chemical Structure| 66131-74-6

[ 66131-74-6 ]

2,4-Diaminopyrimidine-5-carboxamide

Similarity: 0.92

Chemical Structure| 120747-84-4

[ 120747-84-4 ]

2-Aminopyrimidine-5-carbaldehyde

Similarity: 0.80

Chemical Structure| 1588441-19-3

[ 1588441-19-3 ]

2-Aminopyrimidine-5-carbaldehyde hydrate

Similarity: 0.80

Chemical Structure| 15400-54-1

[ 15400-54-1 ]

Ethyl 2,4-diaminopyrimidine-5-carboxylate

Similarity: 0.78

Chemical Structure| 16462-27-4

[ 16462-27-4 ]

2,4-Diaminopyrimidine-5-carbonitrile

Similarity: 0.75

; ;