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Chemical Structure| 20575-57-9 Chemical Structure| 20575-57-9
Chemical Structure| 20575-57-9

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CAS No.: 20575-57-9

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Calycosin, a phytoestrogen, is a partial agonist of ER and a calcium channel blocker. It also shows prevention of reperfusion injury. Calycosin can be isolated and purified from the herb of Astragalus membranaceus Bge. var. mongholicus with anti-oxidative activity.

Synonyms: Cyclosin; 3'-Hydroxyformononetin

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Product Details of Calycosin

CAS No. :20575-57-9
Formula : C16H12O5
M.W : 284.26
SMILES Code : O=C1C(C2=CC=C(OC)C(O)=C2)=COC3=C1C=CC(O)=C3
Synonyms :
Cyclosin; 3'-Hydroxyformononetin
MDL No. :MFCD00210598
InChI Key :ZZAJQOPSWWVMBI-UHFFFAOYSA-N
Pubchem ID :5280448

Safety of Calycosin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P280-P305+P351+P338

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.52mL

0.70mL

0.35mL

17.59mL

3.52mL

1.76mL

35.18mL

7.04mL

3.52mL
Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

[1]Chen J, Lin C, et al. Calycosin and genistein induce apoptosis by inactivation of HOTAIR/p-Akt signaling pathway in human breast cancer MCF-7 cells. Cell Physiol Biochem. 2015;35(2):722-8.

[2]Chen J, Liu L, et al. Calycosin promotes proliferation of estrogen receptor-positive cells via estrogen receptors and ERK1/2 activation in vitro and in vivo. Cancer Lett. 2011 Sep 28;308(2):144-51.

[3]Zhou Y, Liu QH, Liu CL, Lin L. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Tumour Biol. 2015 Jul;36(7):5333-9

[4]Tian J, Wang Y, Zhang X, Ren Q, Li R, Huang Y, Lu H, Chen J. Calycosin inhibits the in vitro and in vivo growth of breast cancer cells through WDR7-7-GPR30 Signaling. J Exp Clin Cancer Res. 2017 Nov 2;36(1):153

[5]Chen J, Lin C, Yong W, Ye Y, Huang Z. Calycosin and genistein induce apoptosis by inactivation of HOTAIR/p-Akt signaling pathway in human breast cancer MCF-7 cells. Cell Physiol Biochem. 2015;35(2):722-8

[6]Hu R, Wang MQ, Liu LY, You HY, Wu XH, Liu YY, Wang YJ, Lu L, Xiao W, Wei LB. Calycosin inhibited autophagy and oxidative stress in chronic kidney disease skeletal muscle atrophy by regulating AMPK/SKP2/CARM1 signalling pathway. J Cell Mol Med. 2020 Oct;24(19):11084-11099

[7]Zhang D, Sun G, Peng L, Tian J, Zhang H. Calycosin inhibits viability, induces apoptosis, and suppresses invasion of cervical cancer cells by upregulating tumor suppressor miR-375. Arch Biochem Biophys. 2020 Sep 30;691:108478

 

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