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Chemical Structure| 198470-85-8 Chemical Structure| 198470-85-8
Chemical Structure| 198470-85-8

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CAS No.: 198470-85-8

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Parecoxib Sodium, a water-soluble and injectable prodrug of valdecoxib, is a COX2 inhibitor used for the short-term treatment of postoperative pain in adults.

Synonyms: SC 69124A; Parecoxib (sodium salt); SC-69124 Sodium

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Product Details of Parecoxib Sodium

CAS No. :198470-85-8
Formula : C19H17N2NaO4S
M.W : 392.40
SMILES Code : CCC([N-]S(=O)(C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C)=O)=O.[Na+]
Synonyms :
SC 69124A; Parecoxib (sodium salt); SC-69124 Sodium
MDL No. :MFCD04972608
InChI Key :HQPVVKXJNZEAFW-UHFFFAOYSA-M
Pubchem ID :15895902

Safety of Parecoxib Sodium

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H361
Precautionary Statements:P201-P202-P280-P308+P313-P405-P501

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02108171 Benign Neoplasm of Vocal Fold ... More >>- Glottis Less << Not Applicable Completed - China, Guangdong ... More >> Guangzhou First Municipal People's Hospital Guangzhou, Guangdong, China, 510180 China Guangzhou First Municipal People's Hospital Guangzhou, China, 510180 Less <<
NCT02576015 Pain Management ... More >> Sedation Peripheral Nerve Block Total Knee Arthroplasty Less << Not Applicable Unknown - China, Chongqing ... More >> The Department of Anesthesiology,the first Affiliated Hospital of Chongqing Medical University Not yet recruiting Chonqqing, Chongqing, China, 400016 Contact: Lihua Peng, MD ?? 86-23-89011061 ?? plhbest@163.com Less <<
NCT02108171 - Completed - -
NCT03421821 Postoperative Pain Not Applicable Recruiting June 30, 2018 China, Chongqing ... More >> First affiliated hospital of third military medical university Recruiting Chongqing, Chongqing, China, 400038 Contact: Wenquan He, master ?? 86-15902353219 ?? hewenquan3@163.com Less <<
NCT01782612 Anesthesia Hi... More >>p Osteoarthritis Less << Not Applicable Unknown March 2014 China, Beijing ... More >> Anesthesia and Operation Center, Chinese People's Liberation Army General Hospital Recruiting Beijing, Beijing, China, 100853 Contact: Zhang Hong, Director ?? 0086-10-66937462 ?? mazuimao301@yahoo.com.cn ?? Contact: Wang Xiaolin ?? ?? wangxiaol1025@yahoo.com ?? Sub-Investigator: Gong Maowei ?? ?? ?? Sub-Investigator: Zhao Ying Less <<
NCT01702389 Hyperalgesia Phase 4 Completed - Norway ... More >> Oslo University Hospital Oslo, Norway, 0424 Less <<
NCT01303809 Morbid Obesity Not Applicable Completed - New Zealand ... More >> Manukau Surgery Centre Auckland, New Zealand, 2025 Less <<
NCT02599623 Anesthesia In... More >>carcerated Inguinal Hernia Less << Not Applicable Recruiting December 2019 China ... More >> Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University Recruiting Shanghai, China Contact: Tao Chen, MD. Less <<
NCT00443404 Phantom Limb Pain Phase 2 Phase 3 Completed - Greece ... More >> Patras, Greece Less <<
NCT03135795 Epigenetics Phase 4 Recruiting May 31, 2017 China, Hubei ... More >> Department of Anaesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology Recruiting Wuhan, Hubei, China, 430030 Contact: Ai Ling ?? +8613667135571 ?? aileen911@126.com ?? Contact: Xu Hui ?? +8613971001596 Less <<
NCT01526525 Pain, Postoperative Phase 4 Completed - Greece ... More >> G.Gennimatas GENERAL HOSPITAL OF THESSALONIKI Thessaloniki, Greece, 54635 Less <<
NCT03236051 Gastric Cancer Not Applicable Recruiting August 30, 2018 China, Jiangsu ... More >> Jinling Hospital, Medical School of Nanjing University Recruiting Nanjing, Jiangsu, China, 210002 Contact: Zhi-Wei JIANG, Ph.D. ?? 8602580860034 ?? surgery34@163.com ?? Contact: Jian ZHAO, Ph.D. ?? 8602580860034 ?? zhaojiangogo@163.com ?? Principal Investigator: Zhi-Wei JIANG, Ph.D. ?? ?? ?? Sub-Investigator: Jian ZHAO, Ph.D. ?? ?? ?? Sub-Investigator: Gang WANG, Ph.D. ?? ?? ?? Sub-Investigator: Jiang LIU, M.D. ?? ?? ?? The Second Affiliated Hospital of Nanjing Medical University Not yet recruiting Nanjing, Jiangsu, China, 210011 Contact: Qinghong ZHAO, Ph.D. ?? ?? njzhqh@sina.com ?? Principal Investigator: Baolin WANG, Ph.D. ?? ?? ?? Principal Investigator: Qinghong ZHAO, Ph.D. Less <<
NCT01361789 Rupture of Anterior Cruciate L... More >>igament Less << Phase 4 Completed - Norway ... More >> Baerum Hospital Rud, Norway, 1309 Less <<
NCT01541137 Postoperative Pain Not Applicable Completed - Finland ... More >> Helsinki University Central Hospital Helsinki, Finland Less <<
NCT00419549 ERCP Pancreat... More >>itis Less << Phase 2 Phase 3 Terminated(Because one of the ... More >>drugs Valdecoxib was withdrawn due to safety concerns.) Less << - India ... More >> All India Institute of Medical Sciences New Delhi, India Less <<
NCT01930318 Gastrointestinal Cancer Phase 4 Unknown September 2015 China, Jiangsu ... More >> Jinling Hospital Recruiting Nanjing, Jiangsu, China, 200002 Contact: Wencheng Kong, MD ?? 15850722032 ?? wenchengkong@gmail.com ?? Contact: Yousheng Li, MD ?? ?? liys@medmail.com.cn ?? Principal Investigator: Wencheng Kong, MD ?? ?? ?? Sub-Investigator: Danhua Yao, MD ?? ?? ?? Sub-Investigator: lele Ren, PhD Less <<
NCT00763997 Platelet Aggregation Not Applicable Completed - Germany ... More >> BG University Hospital Bergmannsheil GmbH Bochum, Germany, 44789 Less <<
NCT01186159 Post-Operative Pain PHASE4 COMPLETED 2025-09-11 Department of Anesthesiology, ... More >>Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China Less <<
NCT00651300 Pain Phase 3 Terminated(See Detailed Descri... More >>ption field.) Less << - Australia, New South Wales ... More >> Pfizer Investigational Site Port Macquarie, New South Wales, Australia Pfizer Investigational Site Randwick, New South Wales, Australia, 2031 Pfizer Investigational Site Westmead, New South Wales, Australia, 2145 Australia, Queensland Pfizer Investigational Site Coopers Plain, Queensland, Australia, 4108 Pfizer Investigational Site Townsville, Queensland, Australia, 4814 Australia, Victoria Pfizer Investigational Site Heidelberg, Victoria, Australia, 3084 Pfizer Investigational Site Prahran, Victoria, Australia, 3181 Australia, Western Australia Pfizer Investigational Site Perth, Western Australia, Australia, 6847 Less <<
NCT00139646 Colic Phase 3 Terminated(See Detailed Descri... More >>ption) Less << - Italy ... More >> Pfizer Investigational Site Alessandria, Italy, 15100 Pfizer Investigational Site Grosseto, Italy, 58100 Pfizer Investigational Site Modena, Italy, 41100 Pfizer Investigational Site Pavia, Italy, 27100 Pfizer Investigational Site Siena, Italy, 53100 Less <<
NCT00139607 Colectomy Phase 3 Terminated(Please see detailed... More >> description for termination reason.) Less << - Italy ... More >> Pfizer Investigational Site Biella, Italy, 13051 Pfizer Investigational Site Milano, Italy, 20123 Pfizer Investigational Site Siena, Italy, 53100 Less <<
NCT01523379 - - - -
NCT01393925 Anti-Inflammatory Agents, Non-... More >>Steroidal Pain, Postoperative Laparoscopy Less << Not Applicable Completed - China, Guangdong ... More >> Department of Anesthesiology,,The first affiliated hospital of Sun Yat-Sen university Guangzhou, Guangdong, China, 510080 Less <<
NCT00660855 Pain, Post Surgical Phase 4 Terminated(See Detailed Descri... More >>ption.) Less << - Argentina ... More >> Pfizer Investigational Site Buenos Aires, Argentina, C1230AAW Pfizer Investigational Site Buenos Aires, Argentina, C1280AEB Less <<
NCT02408146 Pain, Postoperative Not Applicable Unknown - China, Heilongjiang ... More >> harbin Medical University Recruiting Harbin, Heilongjiang, China, 150086 Contact: Jiabei Wang, PhD ?? 86-451-85555049 ?? inn_2001@126.com Less <<
NCT00636064 Pain Phase 3 Completed - -
NCT00553605 Pain Phase 4 Completed - Brazil ... More >> Pfizer Investigational Site Rio de Janeiro, RJ, Brazil, CEP 20551-030 Pfizer Investigational Site Porto Alegre, RS, Brazil, 90035-003 Pfizer Investigational Site Porto Alegre, RS, Brazil, 90610-000 Pfizer Investigational Site Ribeirao Preto, SP, Brazil, 14015-130 Pfizer Investigational Site Ribeirao Preto, SP, Brazil, 14048-900 Pfizer Investigational Site Sao Bernardo do Campo, SP, Brazil, 09715-090 Pfizer Investigational Site Sao Paulo, SP, Brazil, 04262-000 Pfizer Investigational Site S?o Paulo, SP, Brazil, 04321-120 Pfizer Investigational Site Vila Mariana - S?o Paulo, SP, Brazil, 04122-000 Chile Pfizer Investigational Site Providencia, Santiago, RM, Chile, 7500921 Costa Rica Pfizer Investigational Site Desamparados, San Jose, Costa Rica Pfizer Investigational Site San José, San Jose, Costa Rica Pfizer Investigational Site Alajuela, Costa Rica Ecuador Pfizer Investigational Site Quito, Pichincha, Ecuador Honduras Pfizer Investigational Site San Pedro Sula, Honduras Peru Pfizer Investigational Site Lima, Peru, L 31 Pfizer Investigational Site Lima, Peru, L27 Less <<
NCT00346268 Pain, Postoperative Phase 4 Terminated(See termination rea... More >>son in detailed description.) Less << - Germany ... More >> Pfizer Investigational Site Essen, Germany, 45136 Pfizer Investigational Site Heidelberg, Germany, 69121 Pfizer Investigational Site Koeln, Germany, 50924 Pfizer Investigational Site Reutlingen, Germany, 72764 Less <<
NCT00553605 - Completed - -
NCT00143169 Pain, Postoperative Phase 3 Completed - China, Guangdong ... More >> Pfizer Investigational Site Guangzhou, Guangdong, China, 510080 China, Liaoning Pfizer Investigational Site Shenyang, Liaoning, China, 110001 China, Shandong Pfizer Investigational Site Qingdao, Shandong, China, 266011 China Pfizer Investigational Site Beijing, China, 100020 Pfizer Investigational Site Beijing, China, 100034 Pfizer Investigational Site Beijing, China, 100083 Pfizer Investigational Site Shanghai, China, 200025 Pfizer Investigational Site Shanghai, China, 200032 Less <<
NCT02569905 Postoperative Shivering Phase 4 Completed - China, Guangxi ... More >> Anesthesia Department, Tumor Hospital of Guangxi Medical University Nanning, Guangxi, China, 530021 Less <<
NCT00346268 - Terminated(See termination rea... More >>son in detailed description.) Less << - -
NCT01843010 Postoperative Pain Management,... More >> Pain Threshold, Shoulder Pain, Laparoscopies Less << Phase 4 Completed - China, Guangdong ... More >> Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University. Guangzhou, Guangdong, China, 510089 Less <<
NCT00435747 Pain, Postoperative Phase 4 Withdrawn - -
NCT00785863 Hyperalgesia, Secondary Phase 4 Completed - Norway ... More >> Ullevaal University Hospital Oslo, Norway, 0407 Less <<
NCT02552745 - Completed - -
NCT02198924 Pain Inflamma... More >>tion Less << Phase 4 Completed - China ... More >> Peking Union Medical College Hospital Beijing, China, 100730 Less <<
NCT02749409 Parecoxib Rib... More >> Fractures Less << Phase 3 Unknown July 2018 -
NCT03480165 Anesthesia; Functional ... More >> Anesthesia Less << Phase 3 Completed - Malaysia ... More >> Hospital Universiti Sains Malaysia (HUSM) Kubang Kerian, Kelantan, Malaysia, 15350 Less <<
NCT01859585 Postoperative Pain Phase 4 Completed - Thailand ... More >> Faculty of Medicine, Prince of Songkla University Hadyai, Sonkla, Thailand, 90110 Less <<
NCT01288924 Shoulder Pain ... More >> Post-operative Pain Less << Phase 2 Completed - Thailand ... More >> Department of Anesthesiology, Faculty of Medicine, Chiang Mai University Maung, Chiang Mai, Thailand, 50200 Department of Anesthesiology, Faculty of Medicine Maung, Chiang Mai, Thailand, 50200 Less <<
NCT01221025 Emergence Delirium ... More >> Postoperative Pain Less << Phase 4 Unknown June 2012 China, Guangdong ... More >> The First Affiliated Hospital of Sun Yat-sen University Recruiting Guangzhou, Guangdong, China, 510080 Contact: Haihua Shu, MD; Ph D ?? +86-20-87755766 ext 8273 ?? shuhaihua@gmail.com Less <<
NCT03059238 Liver Cancer ... More >>Pain Postoperative Less << Phase 3 Recruiting December 2019 China, Guangdong ... More >> Minimally Invasive Interventional Division, Department of Medical Imaging and Interventional Radiology, Sun Yat-sen University Cancer Center, Recruiting Guangzhou, Guangdong, China, 500060 Contact: Ming Zhao, MD ?? 86-20-87343272 ?? zhaoming@sysucc.org.cn Less <<
NCT02185924 POSTOPERATIVE ANALGESIA FOR TK... More >>A PARECOXIB/CFB Less << Phase 2 Phase 3 Completed - Greece ... More >> Department of Anaesthesia Asklepeion Voulas General Hospital Voula Athens, Greece, 16673 Less <<
NCT02729935 Postoperative Pain Phase 4 Completed - Tunisia ... More >> Ali JENDOUBI Tunis, Tunisia, 1006 Less <<
NCT03704623 Acute Renal Colic ... More >> Ureteric Stone Less << Not Applicable Not yet recruiting December 30, 2019 -
NCT02272660 Pain, Postoperative Phase 4 Completed - China, Beijing ... More >> The Peking Union Medical College Hospital Beijing, Beijing, China, 100005 Less <<
NCT01311804 Unilateral Primary Osteoarthri... More >>tis of Knee Less << Phase 3 Unknown October 2011 Malaysia ... More >> Hospital Tuanku Fauziah Not yet recruiting Kangar, Perlis, Malaysia, 01000 Contact: Yeap Ewe Juan ?? +604-976 3333 ?? ?? Principal Investigator: Yeap Ewe Juan Less <<
NCT00455117 Anaesthesia Phase 4 Completed - Australia, Victoria ... More >> Royal Melbourne Hospital Melbourne, Victoria, Australia, 3050 Less <<
NCT01566669 Benign Female Reproductive Sys... More >>tem Neoplasm Less << Not Applicable Completed - China, Guangdong ... More >> The First Affiliated Hospital of Sun Yat-sen University Guangzhou, Guangdong, China, 510080 Less <<
NCT02204878 Hepatic Hemangioma Located in ... More >>the Right Liver|Laparotomy Surgery Less << PHASE4 UNKNOWN - Peking union medical college h... More >>ospital, Beijing, Beijing, 100032, China Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.55mL

0.51mL

0.25mL

12.74mL

2.55mL

1.27mL

25.48mL

5.10mL

2.55mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

References

 

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