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Chemical Structure| 196597-26-9 Chemical Structure| 196597-26-9

Structure of Ramelteon
CAS No.: 196597-26-9

Chemical Structure| 196597-26-9

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CAS No.: 196597-26-9

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Ramelteon is a synthetic melatonin analogue working by binding to and activating melatonin receptors 1 and 2.

Synonyms: TAK-375

4.5 *For Research Use Only !

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Product Details of Ramelteon

CAS No. :196597-26-9
Formula : C16H21NO2
M.W : 259.34
SMILES Code : O=C(NCC[C@H]1C2=C(C=CC3=C2CCO3)CC1)CC
Synonyms :
TAK-375
MDL No. :MFCD08067736

Safety of Ramelteon

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00642694 - Terminated(Enrollment disconti... More >>nued based on mutually agreed upon decision by PI and funding sponsor) Less << - -
NCT02969343 Central Line-Associated Bloods... More >>tream Infection (CLABSI) Venous Thromboembolism Patient Fall Catheter-Associated Infection Severe Hypoglycemia Opioid-Related Severe Adverse Drug Event Hospital Acquired Pressure Ulcer Adverse Drug Event Severe Hospital Acquired Delerium Rapid Response Related to Arrhythmia Less << Not Applicable Recruiting September 2018 United States, Massachusetts ... More >> Brigham and Women's Hospital Recruiting Boston, Massachusetts, United States, 02115 Contact: Alexandra C Businger ?? 617-732-7063 ?? abusinger@partners.org ?? Contact: Patricia Dykes, RN PhD ?? 617-732-8925 ?? pdykes@partners.org ?? Principal Investigator: David W Bates, MD MSc Less <<
NCT00893269 Marijuana Dependence Phase 1 Completed - United States, Maryland ... More >> Johns Hopkins University Baltimore, Maryland, United States, 21224 Less <<
NCT03461042 Chronic Insomnia Phase 4 Recruiting January 31, 2019 Japan ... More >> Yoyogi Sleep Disorder Clinic, Foundation of Sleep and Health Science Recruiting Shibuya-ku, Tokyo, Japan, 151-0053 Contact: Akira Usui, MD Less <<
NCT00337272 Chronic Insomnia Phase 4 Terminated(Lack of enrollment.... More >>) Less << - United States, Arkansas ... More >> Genesis Cancer Center Hot Springs, Arkansas, United States, 71913 United States, California Wilshire Oncology Medical Group, Inc. La Verne, California, United States, 91750 United States, Connecticut Eastern Connecticut Hematology and Oncology Associates Norwich, Connecticut, United States, 06360 United States, Georgia Augusta Oncology Associates, PC Augusta, Georgia, United States, 30901 United States, Idaho North Idaho Cancer Center Coeur d'Alene, Idaho, United States, 83814 United States, Montana Hematology Oncology Centers of the Northern Rockies Billings, Montana, United States, 59101 United States, Ohio Tri-County Hematology & Oncology Associates Canton, Ohio, United States, 44718 United States, Pennsylvania Pottsville Cancer Center Pottsville, Pennsylvania, United States, 17901 United States, Tennessee The West Clinic Memphis, Tennessee, United States, 38120 United States, Virginia Cancer Specialists of Tidewater, Ltd. Chesapeake, Virginia, United States, 23320 Less <<
NCT00688025 - Completed - United States, Michigan ... More >> Henry Ford Hospital Sleep Disorders & Research Center Detroit, Michigan, United States, 48202 Less <<
NCT00576927 Sleep Deprivation Phase 4 Completed - -
NCT00337272 - Terminated(Lack of enrollment.... More >>) Less << - -
NCT03432091 - Enrolling by invitation July 31, 2019 -
NCT02156271 - Completed - -
NCT00755508 Sleep Initiation and Maintenan... More >>ce Disorders Less << Phase 2 Completed - -
NCT00576927 - Completed - -
NCT00739024 - Terminated(Recruitment slow an... More >>d administrative reasons) Less << - -
NCT00319215 Insomnia Phase 1 Completed - Netherlands ... More >> Utrecht Institute for Pharmaceutical Sciences Utrecht, Netherlands, 3584CA Less <<
NCT00739024 Migraine Migr... More >>aine With Aura Migraine Without Aura Less << Phase 2 Terminated(Recruitment slow an... More >>d administrative reasons) Less << - United States, Washington ... More >> Swedish Pain and Headache Center Seattle, Washington, United States, 98104 Less <<
NCT00671190 Sleep Disorder Phase 2 Completed - United States, Arkansas ... More >> Hot Springs, Arkansas, United States United States, California Los Angeles, California, United States San Diego, California, United States United States, Florida Miami, Florida, United States United States, Georgia Atlanta, Georgia, United States Macon, Georgia, United States United States, Indiana Danville, Indiana, United States United States, Kansas Overland Park, Kansas, United States United States, Louisiana Metairie, Louisiana, United States United States, Maryland Chevy Chase, Maryland, United States United States, Nevada Las Vegas, Nevada, United States United States, Ohio Dublin, Ohio, United States United States, South Carolina Columbia, South Carolina, United States Less <<
NCT01207050 Insomnia Brai... More >>n Injury Less << Phase 4 Unknown December 2014 United States, New Jersey ... More >> Kessler Foundation Research Center West Orange, New Jersey, United States, 07052 Less <<
NCT02156271 Insomnia Phase 4 Completed - -
NCT00552760 - Completed - -
NCT01180855 Insomnia Phase 4 Unknown September 2010 United States, Arizona ... More >> University of Arizona Sleep Research Laboratory Tucson, Arizona, United States, 85721 Less <<
NCT00552760 Bipolar Disorder Phase 4 Completed - United States, Pennsylvania ... More >> Lehigh Valley Hospital, Department of Psychiatry Allentown, Pennsylvania, United States, 18103 Less <<
NCT00507546 Insomnia Spin... More >>al Cord Injury Tetraplegia Sleep Disorders Less << Phase 4 Completed - United States, California ... More >> VA Palo Alto Health Care System Palo Alto, California, United States, 94304-1290 Less <<
NCT00502320 - Completed - -
NCT00507546 - Completed - -
NCT00502320 Seasonal Affective Disorder Phase 4 Completed - United States, Pennsylvania ... More >> Lehigh Valley Hospital, Department of Psychiatry Allentown, Pennsylvania, United States, 18103 Less <<
NCT03075657 Schizophrenia Phase 4 Completed - India ... More >> All India Institute of Medical Sciences (AIIMS) Bhubaneswar, Odisha, India, 751019 Less <<
NCT00593736 Sleep Disorders, Circadian Rhy... More >>thm Less << Phase 2 Completed - -
NCT02560324 Tobacco Use Disorder Phase 2 Completed - United States, Pennsylvania ... More >> Center for Interdisciplinary Research on Nicotine Addiction, School of Medicine, University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Less <<
NCT00237497 Balance Phase 3 Completed - United Kingdom ... More >> London, United Kingdom Less <<
NCT00745030 REM Behavior Disorder ... More >> Parkinsonism Less << Not Applicable Terminated(Low subject recruit... More >>ment and enrollment.) Less << - United States, Illinois ... More >> Northwestern University Chicago, Illinois, United States, 60611 Less <<
NCT00745030 - Terminated(Low subject recruit... More >>ment and enrollment.) Less << - -
NCT00593736 - Completed - -
NCT00492011 Circadian Dysregulation Phase 4 Completed - United States, Florida ... More >> Miami, Florida, United States Pembroke Pines, Florida, United States United States, Hawaii Honolulu, Hawaii, United States United States, New York New York, New York, United States Less <<
NCT00492232 Chronic Insomnia Phase 4 Completed - -
NCT00492232 - Completed - -
NCT00671125 Chronic Insomnia Phase 3 Completed - -
NCT00755495 Sleep Initiation and Maintenan... More >>ce Disorders Less << Phase 2 Completed - -
NCT00811746 Obstructive Sleep Apnea Not Applicable Completed - United States, California ... More >> VA Long Beach Healthcare System Long Beach, California, United States, 90822-5201 Less <<
NCT00539110 Sleep Burns Phase 2 Completed - United States, Ohio ... More >> Shriners Hospital for Children Cincinnati, Ohio, United States, 45229 Less <<
NCT00642694 Major Depressive Disorder ... More >> Insomnia Less << Phase 3 Terminated(Enrollment disconti... More >>nued based on mutually agreed upon decision by PI and funding sponsor) Less << - United States, Texas ... More >> University of Texas Southwestern Medical Center at Dallas Dallas, Texas, United States, 752390-9119 Less <<
NCT00671255 Chronic Insomnia Phase 3 Completed - -
NCT00325728 Chronic Insomnia Phase 2 Completed - -
NCT00671567 Chronic Insomnia Phase 3 Completed - -
NCT02691013 Delirium Slee... More >>p Deprivation Less << Not Applicable Enrolling by invitation December 31, 2018 -
NCT00907595 Huntington's Disease ... More >> Parkinson's Disease Dementia With Lewy Bodies Sleep Disorders Circadian Dysregulation Less << Not Applicable Withdrawn(unable to recruit su... More >>bjects for study.Collaborator stopped funding for study as of 3/31/2010) Less << - United States, Massachusetts ... More >> Massachusetts General Hospital Boston, Massachusetts, United States, 02144 Less <<
NCT00671398 Transient Insomnia Phase 3 Completed - United States, California ... More >> Palm Springs, California, United States San Diego, California, United States United States, Florida Miami, Florida, United States Pembroke Pines, Florida, United States United States, Georgia Atlanta, Georgia, United States United States, Kansas Overland Park, Kansas, United States United States, New York New York, New York, United States Rochester, New York, United States United States, Ohio Cincinnati, Ohio, United States Dublin, Ohio, United States United States, South Carolina Columbia, South Carolina, United States United States, Texas Houston, Texas, United States Less <<
NCT01401413 REM Sleep Behavior Disorder Phase 4 Completed - United States, New York ... More >> Sleep Medicine Centers of WNY West Seneca, New York, United States, 14224 Less <<
NCT00539110 - Completed - -
NCT00622427 ADHD With Sleep Onset Insomnia Phase 4 Completed - United States, Alabama ... More >> University of Alabama at Birmingham Birmingham, Alabama, United States, 35205 Less <<
NCT00622427 - Completed - -
NCT00671294 Chronic Insomnia Phase 3 Completed - United States, Arkansas ... More >> Hot Springs,, Arkansas, United States United States, California Irvine, California, United States Palm Springs, California, United States San Diego, California, United States United States, Florida Brandon, Florida, United States Miami, Florida, United States Naples, Florida, United States Pembroke Pines, Florida, United States St. Petersburg, Florida, United States United States, Georgia Atlanta, Georgia, United States United States, Kansas Overland Park, Kansas, United States United States, Kentucky Crestview Hills, Kentucky, United States United States, Michigan Troy, Michigan, United States United States, Missouri St. Louis, Missouri, United States United States, North Carolina Winston-Salem, North Carolina, United States United States, Ohio Cincinnati, Ohio, United States Toledo, Ohio, United States United States, Texas Houston, Texas, United States Less <<
NCT00414102 Chronic Insomnia Phase 4 Completed - -
NCT00672724 Chronic Insomnia Phase 3 Terminated(Issues with data co... More >>llection tool) Less << - -
NCT00585208 Insomnia Bipo... More >>lar Disorder Less << Phase 3 Terminated(sponsor terminated ... More >>study) Less << - United States, Ohio ... More >> The Lindner Center of HOPE Mason, Ohio, United States, 45040 Less <<
NCT00656994 Insomnia Phase 3 Completed - -
NCT00756002 Sleep Initiation and Maintenan... More >>ce Disorders Less << Phase 3 Completed - -
NCT00756002 - Completed - -
NCT00672802 Chronic Obstructive Pulmonary ... More >>Disease COPD Less << Phase 2 Completed - United States, Alabama ... More >> Birmingham, Alabama, United States United States, California Santa Monica, California, United States United States, Florida Miami Beach, Florida, United States Winter Park, Florida, United States United States, Kentucky Louisville, Kentucky, United States United States, Ohio Cincinnati, Ohio, United States Less <<
NCT00672061 Sleep Apnea, Obstructive Phase 2 Completed - United States, Alabama ... More >> Birmingham, Alabama, United States United States, California Palm Springs, California, United States Santa Monica, California, United States United States, Florida Winter Park, Florida, United States United States, Ohio Cincinnati, Ohio, United States Less <<
NCT02324153 Delirium Deli... More >>rium, Dementia, Amnestic, Cognitive Disorders Delayed Emergence From Anesthesia Cognitive Disorders Less << Phase 2 Recruiting June 30, 2019 United States, Maryland ... More >> Johns Hopkins Bayview Medical Center Recruiting Baltimore, Maryland, United States, 21224 Contact: Kori Kindbom, MA ?? 410-550-0197 ?? kindbom@jhmi.edu ?? Contact: Karin J Neufeld, MD MPH ?? 410-550-0197 ?? kneufel2@jhmi.edu Less <<
NCT00595075 Healthy Not Applicable Completed - -
NCT00671086 Sleep Initiation and Maintenan... More >>ce Disorders Less << Phase 3 Completed - -
NCT00869167 Insomnia|Asthma PHASE3 TERMINATED 2025-06-09 Northwestern University, Chica... More >>go, Illinois, 60611, United States Less <<
NCT00247390 Chronic Insomnia Phase 3 Completed - -
NCT00316992 Chronic Obstructive Pulmonary ... More >>Disease Less << Phase 4 Completed - United States, Alabama ... More >> Birmingham, Alabama, United States, 35213 United States, California Los Angeles, California, United States Santa Monica, California, United States, 90404 United States, Florida Naples, Florida, United States, 34110 St. Petersburg, Florida, United States, 33707 United States, Kentucky Louisville, Kentucky, United States, 40217 United States, Nebraska Lincoln, Nebraska, United States, 68510 United States, New York New York, New York, United States, 10025 Less <<
NCT00869167 Insomnia|Asthma PHASE3 TERMINATED 2025-06-09 Northwestern University, Chica... More >>go, Illinois, 60611, United States Less <<
NCT00462254 Parkinson's Disease Phase 4 Terminated(Study discontinued.... More >>) Less << - United States, California ... More >> VA Long Beach Healthcare System Long Beach, California, United States, 90822 Less <<
NCT00568789 Insomnia Phase 4 Completed - United States, California ... More >> Costa Mesa, California, United States San Diego, California, United States United States, Florida Miami, Florida, United States Miramar, Florida, United States Orlando, Florida, United States United States, New York New York, New York, United States Less <<
NCT00595075 - Completed - -
NCT00746239 - Terminated(Funding for continu... More >>ation was not received.) Less << - -
NCT00595504 Schizophrenia ... More >> Schizoaffective Disorder Schizophreniform Disorders Less << Phase 4 Completed - United States, Massachusetts ... More >> Freedom Trail Clinic Boston, Massachusetts, United States, 02114 Less <<
NCT00391755 Migraine Headache Phase 4 Terminated(Failure to recruit ... More >>necessary number of patients.) Less << - United States, Virginia ... More >> Patricia Shipley, MD Charlottesville, Virginia, United States, 22902 Less <<
NCT00915135 Chronic Insomnia Phase 2 Completed - -
NCT00746239 Panic Disorder ... More >> Insomnia Less << Not Applicable Terminated(Funding for continu... More >>ation was not received.) Less << - United States, Pennsylvania ... More >> Penn State Hershey Medical Center Hershey, Pennsylvania, United States, 17033 Less <<
NCT00671632 Drug Abuse Phase 2 Completed - United States, Maryland ... More >> Baltimore, Maryland, United States Less <<
NCT00753623 Neuropathic Pain Not Applicable Terminated(Recruitment did not... More >> accrue as expected.) Less << - United States, Massachusetts ... More >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Less <<
NCT01467713 Bipolar Disorder Phase 3 Terminated(Business Decision; ... More >>No Safety Concerns.) Less << - -
NCT01467713 - Terminated(Business Decision; ... More >>No Safety Concerns.) Less << - -
NCT01685151 Bipolar Disorder Phase 3 Withdrawn(Business Decision (p... More >>lease see below)) Less << November 2015 -
NCT01048242 Insomnia Obst... More >>ructive Sleep Apnea Less << Phase 3 Completed - United States, Pennsylvania ... More >> University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Less <<
NCT00595504 - Completed - -
NCT00753623 - Terminated(Recruitment did not... More >> accrue as expected.) Less << - -
NCT01048242 - Completed - -
NCT00914862 Insomnia PHASE1 COMPLETED 2025-04-11 Overland Park, Kansas, United ... More >>States|Kalamazoo, Michigan, United States Less <<
NCT00914862 Insomnia PHASE1 COMPLETED 2025-04-11 Overland Park, Kansas, United ... More >>States|Kalamazoo, Michigan, United States Less <<
NCT02153086 Insomnia COMPLETED 2025-06-14 Osaka, Japan|Tokyo, Japan
NCT01467700 - Terminated(Business Decision; ... More >>No Safety Concerns) Less << - -
NCT02564939 Delirium Phase 4 Recruiting June 2019 United States, Connecticut ... More >> Hartford Hospital Recruiting Hartford, Connecticut, United States, 06102 Contact: Robert S Dicks, MD ?? 860-545-7043 ?? robert.dicks@hhchealth.org ?? Contact: Christine Waszynski, DNP ?? 860-545-7043 ?? christine.waszynski@hhchealth.org Less <<
NCT01467700 Acute Depressive Episode Phase 3 Terminated(Business Decision; ... More >>No Safety Concerns) Less << - -
NCT02058992 Insomnia COMPLETED 2025-04-13 -
NCT03265951 Insomnia Phase 4 Recruiting June 30, 2020 United States, New York ... More >> Veterans Affairs Medical Center in Buffalo Recruiting Buffalo, New York, United States, 14215 Contact: Ali El-Solh, MD, MPH ?? 716-862-8622 ?? solh@buffalo.edu Less <<
NCT02058992 Insomnia COMPLETED 2025-04-13 -
NCT02153086 Insomnia COMPLETED 2025-06-14 Osaka, Japan|Tokyo, Japan
NCT01677182 Bipolar Disorder Phase 3 Terminated(Business Decision; ... More >>Terminated due to futility, with no safety concerns (see below)) Less << - -
NCT01128582 Gastroesophageal Reflux Diseas... More >>e Chronic Insomnia Less << Phase 3 Unknown December 2011 United States, Arizona ... More >> Southern Arizona Veterans Health Care System Tucson, Arizona, United States, 85723 Less <<
NCT03165695 Delirium in Old Age Phase 4 Not yet recruiting December 31, 2018 United States, Massachusetts ... More >> Brigham and Women's Hospital Not yet recruiting Boston, Massachusetts, United States, 02115 Contact: Elizabeth B Klerman, M.D.,PhD ?? 617-331-4580 ?? ebklerman@research.bwh.harvard.edu Less <<
NCT01677182 - Terminated(Business Decision; ... More >>Terminated due to futility, with no safety concerns (see below)) Less << - -
NCT03091738 Cirrhosis Phase 4 Completed - United States, Virginia ... More >> Virginia Commonwealth University Richmond, Virginia, United States, 23298 Less <<
NCT02840591 Delirium Phase 4 Withdrawn(Stopped the study du... More >>e to feasibility issues, no enrollment has taken place.) Less << - United States, Texas ... More >> The University of Texas Southwestern Medical Center at Dallas Dallas, Texas, United States, 75390 Less <<
NCT02669082 Insomnia|Major Depressive Diso... More >>rder Less << PHASE4 COMPLETED 2018-01-31 You Ariyoshi Sleep Clinic, Kit... More >>akyushu, Fukuoka, Japan|Ishikawa Mental Clinic, Sapporo, Hokkaido, Japan|Minami 1jo Mental Clinic, Sapporo, Hokkaido, Japan|Senzoku Psychosomatic Clinic, Meguro, Tokyo, Japan|Sangenjaya Neurology and Psychosomatic Clinic, Setagaya, Tokyo, Japan|Himorogi Kokorono Clinic, Shinjuku, Tokyo, Japan|Seiwa Hospital, Shinjuku, Tokyo, Japan Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.86mL

0.77mL

0.39mL

19.28mL

3.86mL

1.93mL

38.56mL

7.71mL

3.86mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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