Structure of Ramelteon
CAS No.: 196597-26-9
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Ramelteon is a synthetic melatonin analogue working by binding to and activating melatonin receptors 1 and 2.
Synonyms: TAK-375
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Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
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CAS No. : | 196597-26-9 |
Formula : | C16H21NO2 |
M.W : | 259.34 |
SMILES Code : | O=C(NCC[C@H]1C2=C(C=CC3=C2CCO3)CC1)CC |
Synonyms : |
TAK-375
|
MDL No. : | MFCD08067736 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302 |
Precautionary Statements: | P280-P305+P351+P338 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT00642694 | - | Terminated(Enrollment disconti... More >>nued based on mutually agreed upon decision by PI and funding sponsor) Less << | - | - | |
NCT02969343 | Central Line-Associated Bloods... More >>tream Infection (CLABSI) Venous Thromboembolism Patient Fall Catheter-Associated Infection Severe Hypoglycemia Opioid-Related Severe Adverse Drug Event Hospital Acquired Pressure Ulcer Adverse Drug Event Severe Hospital Acquired Delerium Rapid Response Related to Arrhythmia Less << | Not Applicable | Recruiting | September 2018 | United States, Massachusetts ... More >> Brigham and Women's Hospital Recruiting Boston, Massachusetts, United States, 02115 Contact: Alexandra C Businger ?? 617-732-7063 ?? abusinger@partners.org ?? Contact: Patricia Dykes, RN PhD ?? 617-732-8925 ?? pdykes@partners.org ?? Principal Investigator: David W Bates, MD MSc Less << |
NCT00893269 | Marijuana Dependence | Phase 1 | Completed | - | United States, Maryland ... More >> Johns Hopkins University Baltimore, Maryland, United States, 21224 Less << |
NCT03461042 | Chronic Insomnia | Phase 4 | Recruiting | January 31, 2019 | Japan ... More >> Yoyogi Sleep Disorder Clinic, Foundation of Sleep and Health Science Recruiting Shibuya-ku, Tokyo, Japan, 151-0053 Contact: Akira Usui, MD Less << |
NCT00337272 | Chronic Insomnia | Phase 4 | Terminated(Lack of enrollment.... More >>) Less << | - | United States, Arkansas ... More >> Genesis Cancer Center Hot Springs, Arkansas, United States, 71913 United States, California Wilshire Oncology Medical Group, Inc. La Verne, California, United States, 91750 United States, Connecticut Eastern Connecticut Hematology and Oncology Associates Norwich, Connecticut, United States, 06360 United States, Georgia Augusta Oncology Associates, PC Augusta, Georgia, United States, 30901 United States, Idaho North Idaho Cancer Center Coeur d'Alene, Idaho, United States, 83814 United States, Montana Hematology Oncology Centers of the Northern Rockies Billings, Montana, United States, 59101 United States, Ohio Tri-County Hematology & Oncology Associates Canton, Ohio, United States, 44718 United States, Pennsylvania Pottsville Cancer Center Pottsville, Pennsylvania, United States, 17901 United States, Tennessee The West Clinic Memphis, Tennessee, United States, 38120 United States, Virginia Cancer Specialists of Tidewater, Ltd. Chesapeake, Virginia, United States, 23320 Less << |
NCT00688025 | - | Completed | - | United States, Michigan ... More >> Henry Ford Hospital Sleep Disorders & Research Center Detroit, Michigan, United States, 48202 Less << | |
NCT00576927 | Sleep Deprivation | Phase 4 | Completed | - | - |
NCT00337272 | - | Terminated(Lack of enrollment.... More >>) Less << | - | - | |
NCT03432091 | - | Enrolling by invitation | July 31, 2019 | - | |
NCT02156271 | - | Completed | - | - | |
NCT00755508 | Sleep Initiation and Maintenan... More >>ce Disorders Less << | Phase 2 | Completed | - | - |
NCT00576927 | - | Completed | - | - | |
NCT00739024 | - | Terminated(Recruitment slow an... More >>d administrative reasons) Less << | - | - | |
NCT00319215 | Insomnia | Phase 1 | Completed | - | Netherlands ... More >> Utrecht Institute for Pharmaceutical Sciences Utrecht, Netherlands, 3584CA Less << |
NCT00739024 | Migraine Migr... More >>aine With Aura Migraine Without Aura Less << | Phase 2 | Terminated(Recruitment slow an... More >>d administrative reasons) Less << | - | United States, Washington ... More >> Swedish Pain and Headache Center Seattle, Washington, United States, 98104 Less << |
NCT00671190 | Sleep Disorder | Phase 2 | Completed | - | United States, Arkansas ... More >> Hot Springs, Arkansas, United States United States, California Los Angeles, California, United States San Diego, California, United States United States, Florida Miami, Florida, United States United States, Georgia Atlanta, Georgia, United States Macon, Georgia, United States United States, Indiana Danville, Indiana, United States United States, Kansas Overland Park, Kansas, United States United States, Louisiana Metairie, Louisiana, United States United States, Maryland Chevy Chase, Maryland, United States United States, Nevada Las Vegas, Nevada, United States United States, Ohio Dublin, Ohio, United States United States, South Carolina Columbia, South Carolina, United States Less << |
NCT01207050 | Insomnia Brai... More >>n Injury Less << | Phase 4 | Unknown | December 2014 | United States, New Jersey ... More >> Kessler Foundation Research Center West Orange, New Jersey, United States, 07052 Less << |
NCT02156271 | Insomnia | Phase 4 | Completed | - | - |
NCT00552760 | - | Completed | - | - | |
NCT01180855 | Insomnia | Phase 4 | Unknown | September 2010 | United States, Arizona ... More >> University of Arizona Sleep Research Laboratory Tucson, Arizona, United States, 85721 Less << |
NCT00552760 | Bipolar Disorder | Phase 4 | Completed | - | United States, Pennsylvania ... More >> Lehigh Valley Hospital, Department of Psychiatry Allentown, Pennsylvania, United States, 18103 Less << |
NCT00507546 | Insomnia Spin... More >>al Cord Injury Tetraplegia Sleep Disorders Less << | Phase 4 | Completed | - | United States, California ... More >> VA Palo Alto Health Care System Palo Alto, California, United States, 94304-1290 Less << |
NCT00502320 | - | Completed | - | - | |
NCT00507546 | - | Completed | - | - | |
NCT00502320 | Seasonal Affective Disorder | Phase 4 | Completed | - | United States, Pennsylvania ... More >> Lehigh Valley Hospital, Department of Psychiatry Allentown, Pennsylvania, United States, 18103 Less << |
NCT03075657 | Schizophrenia | Phase 4 | Completed | - | India ... More >> All India Institute of Medical Sciences (AIIMS) Bhubaneswar, Odisha, India, 751019 Less << |
NCT00593736 | Sleep Disorders, Circadian Rhy... More >>thm Less << | Phase 2 | Completed | - | - |
NCT02560324 | Tobacco Use Disorder | Phase 2 | Completed | - | United States, Pennsylvania ... More >> Center for Interdisciplinary Research on Nicotine Addiction, School of Medicine, University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Less << |
NCT00237497 | Balance | Phase 3 | Completed | - | United Kingdom ... More >> London, United Kingdom Less << |
NCT00745030 | REM Behavior Disorder ... More >> Parkinsonism Less << | Not Applicable | Terminated(Low subject recruit... More >>ment and enrollment.) Less << | - | United States, Illinois ... More >> Northwestern University Chicago, Illinois, United States, 60611 Less << |
NCT00745030 | - | Terminated(Low subject recruit... More >>ment and enrollment.) Less << | - | - | |
NCT00593736 | - | Completed | - | - | |
NCT00492011 | Circadian Dysregulation | Phase 4 | Completed | - | United States, Florida ... More >> Miami, Florida, United States Pembroke Pines, Florida, United States United States, Hawaii Honolulu, Hawaii, United States United States, New York New York, New York, United States Less << |
NCT00492232 | Chronic Insomnia | Phase 4 | Completed | - | - |
NCT00492232 | - | Completed | - | - | |
NCT00671125 | Chronic Insomnia | Phase 3 | Completed | - | - |
NCT00755495 | Sleep Initiation and Maintenan... More >>ce Disorders Less << | Phase 2 | Completed | - | - |
NCT00811746 | Obstructive Sleep Apnea | Not Applicable | Completed | - | United States, California ... More >> VA Long Beach Healthcare System Long Beach, California, United States, 90822-5201 Less << |
NCT00539110 | Sleep Burns | Phase 2 | Completed | - | United States, Ohio ... More >> Shriners Hospital for Children Cincinnati, Ohio, United States, 45229 Less << |
NCT00642694 | Major Depressive Disorder ... More >> Insomnia Less << | Phase 3 | Terminated(Enrollment disconti... More >>nued based on mutually agreed upon decision by PI and funding sponsor) Less << | - | United States, Texas ... More >> University of Texas Southwestern Medical Center at Dallas Dallas, Texas, United States, 752390-9119 Less << |
NCT00671255 | Chronic Insomnia | Phase 3 | Completed | - | - |
NCT00325728 | Chronic Insomnia | Phase 2 | Completed | - | - |
NCT00671567 | Chronic Insomnia | Phase 3 | Completed | - | - |
NCT02691013 | Delirium Slee... More >>p Deprivation Less << | Not Applicable | Enrolling by invitation | December 31, 2018 | - |
NCT00907595 | Huntington's Disease ... More >> Parkinson's Disease Dementia With Lewy Bodies Sleep Disorders Circadian Dysregulation Less << | Not Applicable | Withdrawn(unable to recruit su... More >>bjects for study.Collaborator stopped funding for study as of 3/31/2010) Less << | - | United States, Massachusetts ... More >> Massachusetts General Hospital Boston, Massachusetts, United States, 02144 Less << |
NCT00671398 | Transient Insomnia | Phase 3 | Completed | - | United States, California ... More >> Palm Springs, California, United States San Diego, California, United States United States, Florida Miami, Florida, United States Pembroke Pines, Florida, United States United States, Georgia Atlanta, Georgia, United States United States, Kansas Overland Park, Kansas, United States United States, New York New York, New York, United States Rochester, New York, United States United States, Ohio Cincinnati, Ohio, United States Dublin, Ohio, United States United States, South Carolina Columbia, South Carolina, United States United States, Texas Houston, Texas, United States Less << |
NCT01401413 | REM Sleep Behavior Disorder | Phase 4 | Completed | - | United States, New York ... More >> Sleep Medicine Centers of WNY West Seneca, New York, United States, 14224 Less << |
NCT00539110 | - | Completed | - | - | |
NCT00622427 | ADHD With Sleep Onset Insomnia | Phase 4 | Completed | - | United States, Alabama ... More >> University of Alabama at Birmingham Birmingham, Alabama, United States, 35205 Less << |
NCT00622427 | - | Completed | - | - | |
NCT00671294 | Chronic Insomnia | Phase 3 | Completed | - | United States, Arkansas ... More >> Hot Springs,, Arkansas, United States United States, California Irvine, California, United States Palm Springs, California, United States San Diego, California, United States United States, Florida Brandon, Florida, United States Miami, Florida, United States Naples, Florida, United States Pembroke Pines, Florida, United States St. Petersburg, Florida, United States United States, Georgia Atlanta, Georgia, United States United States, Kansas Overland Park, Kansas, United States United States, Kentucky Crestview Hills, Kentucky, United States United States, Michigan Troy, Michigan, United States United States, Missouri St. Louis, Missouri, United States United States, North Carolina Winston-Salem, North Carolina, United States United States, Ohio Cincinnati, Ohio, United States Toledo, Ohio, United States United States, Texas Houston, Texas, United States Less << |
NCT00414102 | Chronic Insomnia | Phase 4 | Completed | - | - |
NCT00672724 | Chronic Insomnia | Phase 3 | Terminated(Issues with data co... More >>llection tool) Less << | - | - |
NCT00585208 | Insomnia Bipo... More >>lar Disorder Less << | Phase 3 | Terminated(sponsor terminated ... More >>study) Less << | - | United States, Ohio ... More >> The Lindner Center of HOPE Mason, Ohio, United States, 45040 Less << |
NCT00656994 | Insomnia | Phase 3 | Completed | - | - |
NCT00756002 | Sleep Initiation and Maintenan... More >>ce Disorders Less << | Phase 3 | Completed | - | - |
NCT00756002 | - | Completed | - | - | |
NCT00672802 | Chronic Obstructive Pulmonary ... More >>Disease COPD Less << | Phase 2 | Completed | - | United States, Alabama ... More >> Birmingham, Alabama, United States United States, California Santa Monica, California, United States United States, Florida Miami Beach, Florida, United States Winter Park, Florida, United States United States, Kentucky Louisville, Kentucky, United States United States, Ohio Cincinnati, Ohio, United States Less << |
NCT00672061 | Sleep Apnea, Obstructive | Phase 2 | Completed | - | United States, Alabama ... More >> Birmingham, Alabama, United States United States, California Palm Springs, California, United States Santa Monica, California, United States United States, Florida Winter Park, Florida, United States United States, Ohio Cincinnati, Ohio, United States Less << |
NCT02324153 | Delirium Deli... More >>rium, Dementia, Amnestic, Cognitive Disorders Delayed Emergence From Anesthesia Cognitive Disorders Less << | Phase 2 | Recruiting | June 30, 2019 | United States, Maryland ... More >> Johns Hopkins Bayview Medical Center Recruiting Baltimore, Maryland, United States, 21224 Contact: Kori Kindbom, MA ?? 410-550-0197 ?? kindbom@jhmi.edu ?? Contact: Karin J Neufeld, MD MPH ?? 410-550-0197 ?? kneufel2@jhmi.edu Less << |
NCT00595075 | Healthy | Not Applicable | Completed | - | - |
NCT00671086 | Sleep Initiation and Maintenan... More >>ce Disorders Less << | Phase 3 | Completed | - | - |
NCT00869167 | Insomnia|Asthma | PHASE3 | TERMINATED | 2025-06-09 | Northwestern University, Chica... More >>go, Illinois, 60611, United States Less << |
NCT00247390 | Chronic Insomnia | Phase 3 | Completed | - | - |
NCT00316992 | Chronic Obstructive Pulmonary ... More >>Disease Less << | Phase 4 | Completed | - | United States, Alabama ... More >> Birmingham, Alabama, United States, 35213 United States, California Los Angeles, California, United States Santa Monica, California, United States, 90404 United States, Florida Naples, Florida, United States, 34110 St. Petersburg, Florida, United States, 33707 United States, Kentucky Louisville, Kentucky, United States, 40217 United States, Nebraska Lincoln, Nebraska, United States, 68510 United States, New York New York, New York, United States, 10025 Less << |
NCT00869167 | Insomnia|Asthma | PHASE3 | TERMINATED | 2025-06-09 | Northwestern University, Chica... More >>go, Illinois, 60611, United States Less << |
NCT00462254 | Parkinson's Disease | Phase 4 | Terminated(Study discontinued.... More >>) Less << | - | United States, California ... More >> VA Long Beach Healthcare System Long Beach, California, United States, 90822 Less << |
NCT00568789 | Insomnia | Phase 4 | Completed | - | United States, California ... More >> Costa Mesa, California, United States San Diego, California, United States United States, Florida Miami, Florida, United States Miramar, Florida, United States Orlando, Florida, United States United States, New York New York, New York, United States Less << |
NCT00595075 | - | Completed | - | - | |
NCT00746239 | - | Terminated(Funding for continu... More >>ation was not received.) Less << | - | - | |
NCT00595504 | Schizophrenia ... More >> Schizoaffective Disorder Schizophreniform Disorders Less << | Phase 4 | Completed | - | United States, Massachusetts ... More >> Freedom Trail Clinic Boston, Massachusetts, United States, 02114 Less << |
NCT00391755 | Migraine Headache | Phase 4 | Terminated(Failure to recruit ... More >>necessary number of patients.) Less << | - | United States, Virginia ... More >> Patricia Shipley, MD Charlottesville, Virginia, United States, 22902 Less << |
NCT00915135 | Chronic Insomnia | Phase 2 | Completed | - | - |
NCT00746239 | Panic Disorder ... More >> Insomnia Less << | Not Applicable | Terminated(Funding for continu... More >>ation was not received.) Less << | - | United States, Pennsylvania ... More >> Penn State Hershey Medical Center Hershey, Pennsylvania, United States, 17033 Less << |
NCT00671632 | Drug Abuse | Phase 2 | Completed | - | United States, Maryland ... More >> Baltimore, Maryland, United States Less << |
NCT00753623 | Neuropathic Pain | Not Applicable | Terminated(Recruitment did not... More >> accrue as expected.) Less << | - | United States, Massachusetts ... More >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Less << |
NCT01467713 | Bipolar Disorder | Phase 3 | Terminated(Business Decision; ... More >>No Safety Concerns.) Less << | - | - |
NCT01467713 | - | Terminated(Business Decision; ... More >>No Safety Concerns.) Less << | - | - | |
NCT01685151 | Bipolar Disorder | Phase 3 | Withdrawn(Business Decision (p... More >>lease see below)) Less << | November 2015 | - |
NCT01048242 | Insomnia Obst... More >>ructive Sleep Apnea Less << | Phase 3 | Completed | - | United States, Pennsylvania ... More >> University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Less << |
NCT00595504 | - | Completed | - | - | |
NCT00753623 | - | Terminated(Recruitment did not... More >> accrue as expected.) Less << | - | - | |
NCT01048242 | - | Completed | - | - | |
NCT00914862 | Insomnia | PHASE1 | COMPLETED | 2025-04-11 | Overland Park, Kansas, United ... More >>States|Kalamazoo, Michigan, United States Less << |
NCT00914862 | Insomnia | PHASE1 | COMPLETED | 2025-04-11 | Overland Park, Kansas, United ... More >>States|Kalamazoo, Michigan, United States Less << |
NCT02153086 | Insomnia | COMPLETED | 2025-06-14 | Osaka, Japan|Tokyo, Japan | |
NCT01467700 | - | Terminated(Business Decision; ... More >>No Safety Concerns) Less << | - | - | |
NCT02564939 | Delirium | Phase 4 | Recruiting | June 2019 | United States, Connecticut ... More >> Hartford Hospital Recruiting Hartford, Connecticut, United States, 06102 Contact: Robert S Dicks, MD ?? 860-545-7043 ?? robert.dicks@hhchealth.org ?? Contact: Christine Waszynski, DNP ?? 860-545-7043 ?? christine.waszynski@hhchealth.org Less << |
NCT01467700 | Acute Depressive Episode | Phase 3 | Terminated(Business Decision; ... More >>No Safety Concerns) Less << | - | - |
NCT02058992 | Insomnia | COMPLETED | 2025-04-13 | - | |
NCT03265951 | Insomnia | Phase 4 | Recruiting | June 30, 2020 | United States, New York ... More >> Veterans Affairs Medical Center in Buffalo Recruiting Buffalo, New York, United States, 14215 Contact: Ali El-Solh, MD, MPH ?? 716-862-8622 ?? solh@buffalo.edu Less << |
NCT02058992 | Insomnia | COMPLETED | 2025-04-13 | - | |
NCT02153086 | Insomnia | COMPLETED | 2025-06-14 | Osaka, Japan|Tokyo, Japan | |
NCT01677182 | Bipolar Disorder | Phase 3 | Terminated(Business Decision; ... More >>Terminated due to futility, with no safety concerns (see below)) Less << | - | - |
NCT01128582 | Gastroesophageal Reflux Diseas... More >>e Chronic Insomnia Less << | Phase 3 | Unknown | December 2011 | United States, Arizona ... More >> Southern Arizona Veterans Health Care System Tucson, Arizona, United States, 85723 Less << |
NCT03165695 | Delirium in Old Age | Phase 4 | Not yet recruiting | December 31, 2018 | United States, Massachusetts ... More >> Brigham and Women's Hospital Not yet recruiting Boston, Massachusetts, United States, 02115 Contact: Elizabeth B Klerman, M.D.,PhD ?? 617-331-4580 ?? ebklerman@research.bwh.harvard.edu Less << |
NCT01677182 | - | Terminated(Business Decision; ... More >>Terminated due to futility, with no safety concerns (see below)) Less << | - | - | |
NCT03091738 | Cirrhosis | Phase 4 | Completed | - | United States, Virginia ... More >> Virginia Commonwealth University Richmond, Virginia, United States, 23298 Less << |
NCT02840591 | Delirium | Phase 4 | Withdrawn(Stopped the study du... More >>e to feasibility issues, no enrollment has taken place.) Less << | - | United States, Texas ... More >> The University of Texas Southwestern Medical Center at Dallas Dallas, Texas, United States, 75390 Less << |
NCT02669082 | Insomnia|Major Depressive Diso... More >>rder Less << | PHASE4 | COMPLETED | 2018-01-31 | You Ariyoshi Sleep Clinic, Kit... More >>akyushu, Fukuoka, Japan|Ishikawa Mental Clinic, Sapporo, Hokkaido, Japan|Minami 1jo Mental Clinic, Sapporo, Hokkaido, Japan|Senzoku Psychosomatic Clinic, Meguro, Tokyo, Japan|Sangenjaya Neurology and Psychosomatic Clinic, Setagaya, Tokyo, Japan|Himorogi Kokorono Clinic, Shinjuku, Tokyo, Japan|Seiwa Hospital, Shinjuku, Tokyo, Japan Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
3.86mL 0.77mL 0.39mL |
19.28mL 3.86mL 1.93mL |
38.56mL 7.71mL 3.86mL |
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Dissolving Methods |
in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:
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