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Chemical Structure| 194423-06-8 Chemical Structure| 194423-06-8

Structure of CL-387785
CAS No.: 194423-06-8

Chemical Structure| 194423-06-8

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CAS No.: 194423-06-8

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CL-387785 (EKI785; WAY-EKI 785) is an irreversible EGFR inhibitor with an IC50 of 370 pM.

Synonyms: EKI-785; WAY-EKI 785; EKB-785

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Product Details of CL-387785

CAS No. :194423-06-8
Formula : C18H13BrN4O
M.W : 381.23
SMILES Code : CC#CC(NC1=CC2=C(NC3=CC=CC(Br)=C3)N=CN=C2C=C1)=O
Synonyms :
EKI-785; WAY-EKI 785; EKB-785
MDL No. :MFCD02179194
InChI Key :BTYYWOYVBXILOJ-UHFFFAOYSA-N
Pubchem ID :2776

Safety of CL-387785

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of CL-387785

RTK
JAK-STAT

Isoform Comparison

Biological Activity

Target
  • EGFR/ErbB1

    EGFR, IC50:370 pM

In Vitro:

Cell Line
Concentration Treated Time Description References
RT4 cells 1 μM 2 hours CL-387785 inhibited the EGFR/PI3K/AKT pathway and attenuated the effects of PYCR1 overexpression on RT4 cells but had no effect on PYCR1 expression. PMC10552724
H1975 cells 0.5 μM 3 days CL-387785 synergized with blebbistatin to suppress H1975 cell proliferation and induce apoptosis PMC5528336
H1975 cells 0.1, 1, or 10 μM 2 hours CL-387785 effectively inhibited the phosphorylation of EGFR and its downstream targets ERK and AKT in H1975 cells, and at higher concentrations (10 μM) further disrupted the interactions of EGFR with MYH9 and β-actin PMC5528336

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.62mL

0.52mL

0.26mL

13.12mL

2.62mL

1.31mL

26.23mL

5.25mL

2.62mL

References

 

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