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Chemical Structure| 183610-70-0 Chemical Structure| 183610-70-0

Structure of 183610-70-0

Chemical Structure| 183610-70-0

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CAS No.: 183610-70-0

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Product Details of [ 183610-70-0 ]

CAS No. :183610-70-0
Formula : C6H5F3N2
M.W : 162.11
SMILES Code : NC1=NC=CC=C1C(F)(F)F
MDL No. :MFCD04972538
InChI Key :YWOWJQMFMXHLQD-UHFFFAOYSA-N
Pubchem ID :2760920

Safety of [ 183610-70-0 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H317-H319
Precautionary Statements:P280-P301+P310-P305+P351+P338
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 183610-70-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 183610-70-0 ]
  • Downstream synthetic route of [ 183610-70-0 ]

[ 183610-70-0 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 183610-70-0 ]
  • [ 1121056-94-7 ]
YieldReaction ConditionsOperation in experiment
75% With sulfuric acid; nitric acid In water at 0 - 50℃; for 3.25 h; To a solution of 2-amino-3-(trifluoromethyl)pyridine (2 g, 12.34 mmol) in cone <n="242"/>sulfuric acid (10 mL) at 0 0C was added dropwise fuming nitric acid (0.56 mL, 12.34 mmol). After 15 min, the reaction was allowed to stir at room temperature. After 1 hour, the mixture was heated to 50 0C. After 2 hours, the reaction was cooled to room temperature and slowly poured into ice-water (200 mL). The precipitate was filtered and dried under high vacuum to give 5-nitro-3-trifluoromethyl-pyridin-2-ylamine (1.92 g, 75percent). 1H NMR (d6-DMSO, 300 MHz) δ 8.02 (brs, 2H), 8.38 (d, IH, J = 2.6 Hz), 9.04 (d, IH, J = 2.6 Hz); MS (ESI) m/z = 208 (MH+).
References: [1] Patent: WO2009/23179, 2009, A2, . Location in patent: Page/Page column 240-241.
 

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