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With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; triphenylphosphine; In 1,2-dimethoxyethane; water; at 90℃; for 4h;
In a 200 mL glass reaction vessel,16 g (75.4 mmol) of tripotassium phosphate, 42 mL of distilled water, 42 mL of 1,2-dimethoxyethane (DME), 5.0 g (25.8 mmol) of 4-trimethylsilylphenylboronic acid,4.19 g (21.5 mmol) of 7-bromo-1 H-indene,420 mg (0.60 mmol) of dichlorobis (triphenylphosphine) palladium and 313 mg (1.19 mmol) of triphenylphosphine were sequentially added, followed by heating under reflux at 90 C. for 4 hours. After being released to room temperature, the reaction solution was poured into 50 mL of distilled water, transferred to a separating funnel, and extracted three times with hexane. The hexane solution was washed with saturated brine and steamAfter washing three times with distilled water, drying with sodium sulfate, sodium sulfate was filtered, the solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography (developing solvent, hexane / diisopropyl ether = 20: 1)To obtain 5.69 g (yield: 100%) of 4- (4-trimethylsilylphenyl) indene as a colorless oil.
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