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With pillar[5]arene; acetylcholinesterase; at 37℃; for 1.5h;
The hydrolysis percentageof G2 in the absence and presence ofWP5 by culturing with AChE at 37 °Cfor different times was monitored by 1H NMR experiments. Theconcentrations of G2, WP5 and AChE were 30 mM, 30 mM and 1 U/ml, respectively. The accuratehydrolysis percentage could be determined by calculating the peak area ratio ofthe protons on choline iodide (G1)and <strong>[2260-50-6]acetylcholine iodide</strong> (G2)
Add 3 mol of 3,5-dihydroxy-4-acetyltoluene and 5 mol of iodocholine to the reaction vessel to control the stirring speed.130rpm, raise the temperature to 65 ° C, maintain the temperature and continue to stir until completely dissolved, let stand for 120min, reduce the solution temperatureThe crystal was precipitated to 15 ° C, filtered, and the crystal was washed with a cyclohexane solution having a mass fraction of 85percent, and the mass fraction was 90percent.The toluene solution was washed, and the anhydrous potassium carbonate dehydrating agent was dehydrated to obtain 761.67 g of the finished iodoacetylcholine, and the yield was 93percent
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