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CAS No. : | 173140-90-4 | MDL No. : | MFCD17018704 |
Formula : | C18H15NO3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | IHJYYLJZVBVLEK-INIZCTEOSA-N |
M.W : | 293.32 | Pubchem ID : | 11437812 |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium carbonate; In water; acetone; for 2.5h;Heating / reflux;Product distribution / selectivity; | Example 7Preparation of 8-benzyloxy-5-(R)-oxiranylcarbostyril (compound (I); Ri = benzyl)A 5 liter flask equipped with a mechanical stirrer, thermometer, and refluxing condenser was charged with 8-benzyloxy-5-[(R)-(2-bromo-1-hydroxyethyl)]-carbostyril (70gms/0.187 moles), potassium carbonate (74 gms/ 0.536 moles), acetone (3.5 liters) and water (35 ml). The resulting slurry was heated to reflux and maintained for 21/? hours. After completion of reaction, the hot mass was filtered on hylo bed to remove inorganics. The residue was slurried in dichloromethane (200 ml) and filtered on hyflo bed. The filtrates <n="42"/>were combined together and concentrated under vacuum completely. The residue was dissolved in dichloromethane (500ml) and filtered on hyflo bed to remove traces of insolubles and washed with dichloromethane(100 ml). The clear filtrate was distilled completely to obtain residue. The residue was charged with methanol (70 ml), stirred and 5 heated to 500C for 30 minutes. The slurry obtained was cooled to 25-300C, chilled to 0- 5C, stirred for 1 hour. The resulting solid was isolated by filtration, washed with methanol (30ml), followed by diisopropylether (100ml) and dried under vacuum at 60-65 0C for 10-12 hours to yield 40-41 gms of 8-benzyloxy- 5-( R )-oxiranylcarbostyril. |
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