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CAS No. : | 1687-53-2 | MDL No. : | MFCD00010222 |
Formula : | C7H9NO2 | Boiling Point : | No data available |
Linear Structure Formula : | - | InChI Key : | BLQFHJKRTDIZLX-UHFFFAOYSA-N |
M.W : | 139.15 | Pubchem ID : | 74314 |
Synonyms : |
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Signal Word: | Warning | Class: | |
Precautionary Statements: | P261-P280-P305+P351+P338 | UN#: | |
Hazard Statements: | H302-H312-H315-H319-H332-H335 | Packing Group: | |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
261.6 mg (89.0%) | With pyridine hydrochloride; In 2-ethoxy-ethanol; | EXAMPLE 279 4-(3-Hydroxy-4-methoxy-phenylamino)-8-methoxy-quinoline-3-carbonitrile Using an analogous procedure to that described in Example 274. A reaction mixture of 200.0 mg (0.92 mmol) of <strong>[214476-78-5]4-chloro-8-methoxy-3-quinolinecarbonitrile</strong>, 105.7 mg (0.92 mmol) of pyridine hydrochloride and 140.6 mg (1.0 mmol) of 5-amino-2-methoxy-phenol in 10 mL of 2-ethoxyethanol was heated at 100 C. for 2 hr. The work up gave 261.6 mg (89.0%) of the product as a deep yellow solid, m.p. 138-140 C. (dec.), mass spectrum (electrospray, m/e): M+H 321.9. |
261.6 mg (89.0%) | With pyridine hydrochloride; In 2-ethoxy-ethanol; | EXAMPLE 279 4-(3-Hydroxy-4-methoxy-phenylamino)-8-methoxy-quinoline-3-carbonitrile Using an analogous procedure to that described in Example 274. A reaction mixture of 200.0 mg (0.92 mmol) of <strong>[214476-78-5]4-chloro-8-methoxy-3-quinolinecarbonitrile</strong>, 105.7 mg (0.92 mmol) of pyridine hydrochloride and 140.6 mg (1.0 mmol) of 5-amino-2-methoxyphenol in 10 mL of 2-ethoxyethanol was heated at 100 C. for 2 hr. The work up gave 261.6 mg (89.0%) of the product as a deep yellow solid, m.p. 138-140 C. (dec.), mass spectrum (electrospray, m/e): M+H 321.9. |
261.6 mg (89.0%) | With pyridine hydrochloride; In 2-ethoxy-ethanol; | Example 279 4-(3-Hydroxy-4-methoxy-phenylamino)-8-methoxy-quinoline-3-carbonitrile Using an analogous procedure to that described in Example 274. A reaction mixture of 200.0 mg (0.92 mmol) of <strong>[214476-78-5]4-chloro-8-methoxy-3-quinolinecarbonitrile</strong>, 105.7 mg (0.92 mmol) of pyridine hydrochloride and 140.6 mg (1.0 mmol) of 5-amino-2-methoxy--phenol in 10 mL of 2-ethoxyethanol was heated at 100 C for 2 hr. The work up gave 261.6 mg (89.0 %) of the product as a deep yellow solid, m.p. 138-140C (dec.), mass spectrum (electrospray, m/e): M+H 321.9. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In 2-ethoxy-ethanol; for 0.5h;Heating / reflux; | [0440] A solution of 3 -hydroxy -4-methoxyaniline (0.61 g, 4.4 mmol), 2-cyano-3,3- bis(methylthio)acrylamide (0.75 g, 4.0 mmol), and 8.0 ml of 2-ethoxyethanol is refluxed for 30 minutes and concentrated under vacuum. The residue is recrystallized from ethanol to provide the title compound as a white solid. Mp. 160-1640C, MS: m/e 280.2 (M+H)+1. |