* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
With hydrogenchloride In aqueous sodium hypochlorite
EXAMPLE 1 A 306 mg. (0.002 mole) sample of 2-methoxynicotinic acid (the product of Preparation A) was added in one portion to 20 ml. of well-stirred 5.25percent aqueous sodium hypochlorite solution (Clorox). The resulting mixture (now a solution) was then allowed to stir at room temperature (~20° C.) for a period of approximately 18 hours (i.e., overnight). Upon completion of this step, the reaction mixture was acidified with 10 ml. of 1N hydrochloric acid and the resulting precipitate was subsequently extracted with chloroform. The organic extracts were then combined, dried over anhydrous magnesium sulfate and filtered, and the resulting filtrate was subsequently concentrated in vacuo to afford 195 mg. (52percent) of pure 5-chloro-2-methoxynicotinic acid, m.p. 139°-141° C. (literature m.p. 149°-150° C., according to D. E. Kuhla et al. in U.S. Pat. No. 3,879,403). The pure product was further characterized by means of nuclear magnetic resonance data and mass spectroscopy.
Reference：
[1] Journal of Medicinal Chemistry, 1990, vol. 33, # 7, p. 1859 - 1865
[2] Synthetic Communications, 1989, vol. 19, # 9-10, p. 1505 - 1508
[3] Patent: US4980357, 1990, A,
[4] Patent: US4716231, 1987, A,
[5] Patent: EP306251, , A2, [5] Patent: , 1989, ,
Chemistry
Pharmaceutical Intermediates
Inhibitors/Agonists
Material Science
For Research Only
120K+ Compounds
Competitive Price
1-2 Day Shipping
