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Chemical Structure| 1619994-69-2 Chemical Structure| 1619994-69-2
Chemical Structure| 1619994-69-2

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CAS No.: 1619994-69-2

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Bromosporine inhibits various bromodomains including BRD2, BRD4, BRD9 and CECR2 with IC50s of 0.41 μM, 0.29 μM, 0.122 μM and 0.017 μM respectively.

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Product Details of Bromosporine

CAS No. :1619994-69-2
Formula : C17H20N6O4S
M.W : 404.44
SMILES Code : O=C(OCC)NC1=CC(C2=CC=C(C)C(NS(=O)(C)=O)=C2)=NN3C1=NN=C3C
MDL No. :MFCD26142669
InChI Key :UYBRROMMFMPJAN-UHFFFAOYSA-N
Pubchem ID :72943187

Safety of Bromosporine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Bromosporine

epigenetics

Isoform Comparison

Biological Activity

Target
  • bromodomain

    CECR2, IC50:17 nM

  • BET

    BRD9, IC50:0.122 μM

    BRD2, IC50:0.29 μM

In Vitro:

Cell Line
Concentration Treated Time Description Reference
BRAF-mutant melanoma cell lines 2-8μM To evaluate the cytotoxic effects of Bromosporine on BRAF-mutant melanoma cell lines, showing broad-based and dose-dependent cytotoxicity PMC9407673

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.47mL

0.49mL

0.25mL

12.36mL

2.47mL

1.24mL

24.73mL

4.95mL

2.47mL

References

 

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