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Chemical Structure| 159624-15-4 Chemical Structure| 159624-15-4

Structure of 159624-15-4

Chemical Structure| 159624-15-4

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CAS No.: 159624-15-4

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Product Details of [ 159624-15-4 ]

CAS No. :159624-15-4
Formula : C17H26BNO4
M.W : 319.20
SMILES Code : CC(C)(C)OC(=O)NC1=C(C=CC=C1)B1OC(C)(C)C(C)(C)O1
MDL No. :MFCD03411943
InChI Key :LVHGGVGVAUJQBB-UHFFFAOYSA-N
Pubchem ID :2773231

Safety of [ 159624-15-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

Application In Synthesis of [ 159624-15-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 159624-15-4 ]

[ 159624-15-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 890315-72-7 ]
  • [ 159624-15-4 ]
  • [ 1237518-14-7 ]
YieldReaction ConditionsOperation in experiment
With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In 1,2-dimethoxyethane; water; for 2.5h;Reflux; Inert atmosphere; Reference Example 36a; Water (0.6 mL), sodium carbonate (0.16 g), tert-butyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate (0.19 g), and tetrakis(triphenylphosphine)palladium(0) (29 mg) were added to an ethylene glycol dimethyl ether (2.0 mL) solution of <strong>[890315-72-7]tert-butyl 4-bromo-2-nitrobenzoate</strong> (0.15 g), followed by heating to reflux under a nitrogen atmosphere for 2 hours and 30 minutes. The reaction mixture was cooled to room temperature, and then ethyl acetate and a 10% aqueous solution of citric acid were added thereto. The organic layer was separated, washed with a saturated aqueous solution of sodium chloride, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography [eluent: 91-80% hexane/ethyl acetate] to obtain 0.21 g of tert-butyl 4-(2-(tert-butoxycarbonylamino)phenyl)-2-nitrobenzoate as a yellow solid.1H-NMR (CDCl3) delta: 1.46 (9H, s), 1.60 (9H, s), 6.14-6.22 (1H, broad), 7.16-7.23 (2H, m), 7.38-7.45 (1H, m), 7.67 (1H, dd, J=8.1, 1.7 Hz), 7.84 (1H, d, J=8.1 Hz), 7.85 (1H, d, J=1.7 Hz), 7.96 (1H, d, J=8.5 Hz).
 

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