成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 155075-23-3 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 155075-23-3
Chemical Structure| 155075-23-3
Structure of 155075-23-3 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 155075-23-3 ]

Related Doc. of [ 155075-23-3 ]

Alternatived Products of [ 155075-23-3 ]
Product Citations

Product Details of [ 155075-23-3 ]

CAS No. :155075-23-3 MDL No. :MFCD09954933
Formula : C14H17NO5 Boiling Point : -
Linear Structure Formula :- InChI Key :VVKAGQHUUDRPOI-VXGBXAGGSA-N
M.W : 279.29 Pubchem ID :688410
Synonyms :
Chemical Name :1-Benzyl 2-methyl (2R,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate

Calculated chemistry of [ 155075-23-3 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 20
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.43
Num. rotatable bonds : 6
Num. H-bond acceptors : 5.0
Num. H-bond donors : 1.0
Molar Refractivity : 73.87
TPSA : 76.07 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : No
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -7.23 cm/s

Lipophilicity

Log Po/w (iLOGP) : 2.37
Log Po/w (XLOGP3) : 1.09
Log Po/w (WLOGP) : 0.4
Log Po/w (MLOGP) : 0.76
Log Po/w (SILICOS-IT) : 0.66
Consensus Log Po/w : 1.06

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -2.08
Solubility : 2.3 mg/ml ; 0.00824 mol/l
Class : Soluble
Log S (Ali) : -2.28
Solubility : 1.47 mg/ml ; 0.00525 mol/l
Class : Soluble
Log S (SILICOS-IT) : -1.98
Solubility : 2.96 mg/ml ; 0.0106 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 0.0
Synthetic accessibility : 3.33

Safety of [ 155075-23-3 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 155075-23-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 155075-23-3 ]

[ 155075-23-3 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 501-53-1 ]
  • [ 114676-59-4 ]
  • [ 155075-23-3 ]
YieldReaction ConditionsOperation in experiment
98% With sodium hydrogencarbonate; In 1,4-dioxane; water; at 0℃; for 2.5h; A solution of (2S, 4R) -methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride (5.5 g, 30 mmol) in 1, 4-dioxane (17 mL) was cooled to 0 , and then a solution of sodium carbonate (3.5 g, 33 mmol) in H 2O (17 mL) was added in portions, after that, CbzCl (4.8 mL, 34 mmol) was added over 30 min. The obtaining reaction mixture was stirred at 0 for 2 hours. The mixture was concentrated in vacuo to remove 1, 4-dioxane, the residue was extracted with ethyl acetate (3 x 100 mL) . The combined organic phases were dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated in vacuo. The residue was purified by silica gel chromatograph (PE/EtOAc (V/V) = 1/1) to give the title compound as a colorless oil (6.7 g, 79%) .
98% With sodium hydrogencarbonate; In 1,4-dioxane; water; at 0℃; for 2.5h; <strong>[114676-59-4](2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid methyl ester hydrochloride</strong> (8 g, 44.0 mmol), 1,4-dioxane(80mL), water (80mL),Sodium bicarbonate (7.4 g, 88 mmol) andBenzyl chloroformate (8.0 mL, 53 mmol) was used as a raw material.According to the method of step 1 of embodiment 1,The title compound was obtained as a colorless oil (12.1 g, yield: 98%).(2S,4R)-4-Hydroxypyrrole-2-carboxylic acid methyl ester hydrochloride (5.5 g, 30 mmol) The 1,4-dioxane (17 mL) solution was cooled to 0 C. Then sodium carbonate (3.5 g, 33 mmol) was added in portions. H2O (17mL) solution, Then add CbzCl (4.8 mL, 34 mmol), After 30 minutes, the drop is completed. The resulting reaction solution was stirred at 0 C for 2 hours. The reaction mixture was concentrated to dryness The residue was purified with EtOAc EtOAc m. The title compound was obtained as a colorless oil ( 6.7 g, yield: 79%).
7.4 g With sodium carbonate; In tetrahydrofuran; water; at 0 - 20℃; for 2h; To a solution of D (17.94 g, 98.8 mmol) and Na2C03 (10.5 g, 98.8 mmol) in THF/H20 (150 mL/50 mL) was added CbzCI (20.2 g, 1 18.56 mmol) at 0 C and the mixture was stirred at room temperature for 2 h. The mixture was filtered through filter paper and the filtrate was concentrated. Water (200 mL) was added and the product was extracted with EtOAc (100 ml x 3). The combined organic layers were washed with brine, dried (MgS0 ), filtered, and concentrated. The residue was purified by column chromatography (silica gel, PetEther/EtOAc=5/1 -2/1) to get the desired product (7.4 g, 27%) as a light yellow oil. LC-MS : 279.9 ([M+1]+ ).
  • 2
  • [ 75315-63-8 ]
  • [ 114676-59-4 ]
  • [ 155075-23-3 ]
Recommend Products
Same Skeleton Products

Technical Information

Historical Records
; ;