成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 15450-69-8 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 15450-69-8
Chemical Structure| 15450-69-8
Structure of 15450-69-8 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 15450-69-8 ]

Related Doc. of [ 15450-69-8 ]

Alternatived Products of [ 15450-69-8 ]
Product Citations

Product Details of [ 15450-69-8 ]

CAS No. :15450-69-8 MDL No. :MFCD00766821
Formula : C9H9NO2 Boiling Point : No data available
Linear Structure Formula :- InChI Key :AUMQUQJTKCJMPA-UHFFFAOYSA-N
M.W : 163.17 Pubchem ID :267450
Synonyms :

Safety of [ 15450-69-8 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P305+P351+P338 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 15450-69-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 15450-69-8 ]

[ 15450-69-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 15450-69-8 ]
  • [ 92-55-7 ]
  • [ 57311-49-6 ]
  • 2
  • [ 15450-69-8 ]
  • [ 124467-36-3 ]
YieldReaction ConditionsOperation in experiment
96% With trichlorophosphate; In acetonitrile; at 75℃; for 1.25h;Inert atmosphere; Example 3A 2-Chloro-7,8-dihydroquinolin-5(6H)-one Under nitrogen, 21.02 g (0.13 mol) of 7,8-dihydroquinoline-2,5(1H,6H)-dione were suspended in 100 ml of acetonitrile (anhydrous, <30 ppm H2O), and 135.28 ml (density 1.46 g/ml, 1.29 mol) of phosphorus oxychloride were added. The yellowish suspension was then heated to 75 C. and stirred at this temperature for 1.25 hours. The yellow clear solution was then cooled to room temperature, and 150 ml of toluene were added. The solution was then concentrated on a rotary evaporator to about 100 ml, and another 150 ml of toluene were added. The solution was then concentrated to dryness on a rotary evaporator. 300 ml of ethyl acetate were then added to the orange oil obtained. Subsequently, the solution was carefully (evolution of gas) added to 500 ml of saturated aqueous sodium bicarbonate solution and stirred for 15 min. The phases were separated and the aqueous phase was extracted with 200 ml of ethyl acetate. The combined organic phases were washed twice with 250 ml of water and once with 100 ml of saturated sodium chloride solution, dried over sodium sulphate, filtered and concentrated to dryness under reduced pressure. This gave 22.58 g (0.12 mmol, 96% of theory) of the target compound as a slightly yellowish solid. 1H-NMR (400 MHz, DMSO-d6, delta/ppm): 2.06-2.17 (m, 2H), 2.61-2.70 (m, 2H), 3.05 (t, 2H), 7.51 (d, 1H), 8.18 (d, 1H).
90.9% With trichlorophosphate; In acetonitrile; for 2h;Reflux; To a solution of 7,8-dihydroquinoline-2,5(1H,6H)-dione (5 g, 27.6 mmol ) in acetonitrile(50 mL) was added POC13 (12.6 g, 82.5 mmol) dropwise at 0 C. The cooling bath was removedand the reaction mixture was refluxed for 2h. The reaction mixture was cooled to room temperature and the volatiles were evaporated under reduced pressure to get the residue, which was neutralized with ammonium hydroxide and extracted with ethyl acetate. The organic layer was dried over sodium sulfate, filtered and concentrated to get the title compound (5 g, 90.9%).LC-MS: 181.9 [M+H].
74% 3.2 2-Chloro-7,8-dihydroquinolin-5(6H)-oneTo a suspension of 7,8-dihydroquinoline-2,5(1H,6H)-dione (1.5 g, 9.19 mmol) in acetonitrile (22 mL) was added dropwise phosphorous oxychloride (1.714 mL, 18.39 mmol). The resulting solution was heated to 100 C. and stirred for 2 h. The reaction was cooled to RT and poured into ice-cold water. After basifying the mixture with 2 M sodium hydroxide solution it was extracted with ethyl acetate (3×). After each extraction the pH of the aqueous phase was checked and if necessary adjusted by adding 1 M sodium hydroxide solution. The combined organic layers were dried over sodium sulfate, filtered, and evaporated to dryness. The crude was purified by flash chromatography (silica gel, cyclohexane/ethyl acetate) yielding a colourless solid. Amount 1.23 g. Yield 74%.1H-NMR (DMSO-d6, 400 MHz) delta 2.13 (m, 2H), 2.68 (m, 2H), 3.08 (t, 2H), 7.53 (d, 1H), 8.20 (d, 1H)MS (ES-API) m/z 182.0 (M+H+, 100%).
66% With trichlorophosphate; at 90℃; for 0.666667h; Example 7 (+-)-[2-(2,6-Diethyl-phenyl)-5,6,7,8-tetrahydro-quinolin-5-yl]-ethyl-naphthlen-1-yl-amine (Compound #109) 7,8-Dihydro-1H,6H-quinoline-2,5-dione (101 mg, 0.621 mmol, 1 equiv) was treated with POCl3 (1.0 mL, 10.9 mmol, 18 equiv) and the resulting suspension was heated in a 90 C. oil bath for 40 minutes. The resulting mixture was concentrated and the residue was poured into ice (5 mL). The resulting suspension was neutralized to pH 7 by addition of solid Na2CO3 and was extracted with CH2Cl2 (3*5 mL). The organic phase was washed with water (15 mL), then was dried (Na2SO4), filtered, and concentrated. The residue was purified by flash column chromatography (SiO2, 0-20% EtOAc in hexanes) to yield 2-chloro-7,8-dihydro-6H-quinolin-5-one as a white solid (74.3 mg, 66%). 1H NMR (300 MHz, CDCl3) delta 8.23 (d, 1H), 7.31 (d, 1H), 3.14 (t, 2H), 2.69 (t, 2H), 2.20 (quint, 2H); MS m/z (MH+) 182.1.
To 200 mg (1.23 mmol) of 7,8-dihydroquinoline-2,5(1H,6H)-dione in acetonitrile (6.1 mL) was added 1.14 mL (12.3 mmol) of phosphorous oxychloride and the mixture was heated at 65 C. for 3 hours. The reaction was cooled to room temperature and the excess phosphorous oxychloride was removed via rotary evaporation. The residue was partitioned between EtOAc (400 mL) and water (200 mL) and the organic phase was washed sequentially with saturated NaHCO3 (200 mL) and brine (200 mL). The organic phase was dried over MgSO4 and concentrated to afford N-1 as a beige solid. Data for N-1: LC/MS: rt=1.64 min; m/z (M+H)=182.1 found; 182.0 required.
630 mg With trichlorophosphate; In acetonitrile; at 100℃; for 3h; Step 2: 2-Chloro-7,8-dihydro-6H-quinolin-5-one. 7,8-Dihydro-1 H,6H-quinoline-2,5-dione (1 .1 g, 6.74 mmol) is dissolved in acetonitrile (25 ml), phosphorus oxychloride (1 .26 ml, 13.5 mmol) is added dropwise and the mixture is stirred at 100C for 3 hours. The mixture is cooled to 0C and poured into cold water, NaOH 2M aq. solution is added until pH >7 is reached, then the mixture is extracted with dichloromethane (3 x 30 ml), the combined organic layers are dried over sodium sulphate, filtered and concentrated. The residue is purified by flash chromatography (0 - 20% ethyl acetate in cyclohexane) to give the title compound (Yield 630 mg). LC (Method 1 ): tR = 2.61 min; Mass spectrum (ES+): m/z = 182 [M+H]+.
13 g With trichlorophosphate; In acetonitrile;Reflux; S8. 20 g of compound P16015-2 was added to 200 mL+, and 98 g of phosphorus oxychloride was added dropwise to the reaction solution through a constant pressure dropping funnel; after the dropwise addition was completed, the temperature was raised to reflux, and the reaction was stirred overnight. After completion of the reaction, the mixture was concentrated under reduced vacuo.S9. The organic phase is washed with a saturated aqueous solution of sodium carbonate to a weak basic. The organic phase was washed three times with a saturated aqueous solution of sodium chloride and then evaporated.S10. The crude solid was recrystallized using EA/PE = 1:2 solvent system to give a solid. Solid product using vacuum dried soil Yellow product 13g

Recommend Products
Same Skeleton Products

Technical Information

Historical Records
; ;