成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 14733-73-4 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 14733-73-4
Chemical Structure| 14733-73-4
Structure of 14733-73-4 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 14733-73-4 ]

Related Doc. of [ 14733-73-4 ]

Alternatived Products of [ 14733-73-4 ]
Product Citations

Product Details of [ 14733-73-4 ]

CAS No. :14733-73-4 MDL No. :MFCD01664246
Formula : C7H4BrNO2 Boiling Point : -
Linear Structure Formula :- InChI Key :DMHTZWJRUUOALC-UHFFFAOYSA-N
M.W : 214.02 Pubchem ID :26853
Synonyms :

Calculated chemistry of [ 14733-73-4 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 11
Num. arom. heavy atoms : 9
Fraction Csp3 : 0.0
Num. rotatable bonds : 0
Num. H-bond acceptors : 2.0
Num. H-bond donors : 1.0
Molar Refractivity : 44.53
TPSA : 46.0 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.29 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.67
Log Po/w (XLOGP3) : 1.85
Log Po/w (WLOGP) : 1.88
Log Po/w (MLOGP) : 1.59
Log Po/w (SILICOS-IT) : 2.72
Consensus Log Po/w : 1.94

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -2.94
Solubility : 0.247 mg/ml ; 0.00115 mol/l
Class : Soluble
Log S (Ali) : -2.44
Solubility : 0.783 mg/ml ; 0.00366 mol/l
Class : Soluble
Log S (SILICOS-IT) : -3.68
Solubility : 0.0446 mg/ml ; 0.000208 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 2.43

Safety of [ 14733-73-4 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 14733-73-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 14733-73-4 ]

[ 14733-73-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 14733-73-4 ]
  • [ 489446-42-6 ]
  • [ 1448190-05-3 ]
YieldReaction ConditionsOperation in experiment
37% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In N,N-dimethyl-formamide; at 110℃; for 1h;Microwave irradiation; Inert atmosphere; Sealed tube; Under an atmosphere of nitrogen, a mixture of (4-(((tert- butoxycarbonyl)amino)methyl)phenyl)boronic acid (commercially available from for example Aldrich) (387 mg, 1.54 mmol), 5-bromobenzo[d]oxazol-2(3H)-one (commercially available from for example Aldrich) (300 mg, 1.40 mmol) and sodium carbonate (446 mg, 4.21 mmol) in DMF (4 mL) was treated with dicholoro[l,l'- bis(diphenylphosphino)ferrocene]palladium(II) (commercially available from for example Aldrich) (72 mg, 0.098 mmol) then sealed and heated in a Biotage "Initiator" microwave at 110 C for 1 hr. The cooled product mixture was treated with dichloromethane (50 mL) and water (10 mL). The mixture was separated and the organic fraction was evaporated to dryness. The product was subjected to purification by mass-directed automated preparative HPLC (formic acid modifier) to afford the title compound (178 mg, 0.52 mmol, 37 % yield). LCMS RT= 1.03 min, ES+ve m/z 341 [M+H]+.
37% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In dichloromethane; water; N,N-dimethyl-formamide; at 110℃; for 1h;Inert atmosphere; Microwave irradiation; Under an atmosphere of nitrogen, a mixture of <strong>[489446-42-6](4-(((tert-butoxycarbonyl)amino)methyl)phenyl)boronic acid</strong> (commercially available from for example Aldrich) (387 mg, 1.54 mmol), 5-bromobenzo[d]oxazol-2(3H)-one (commercially available from for example Aldrich) (300 mg, 1.40 mmol) and sodium carbonate (446 mg, 4.21 mmol) in DMF (4 mL) was treated with dicholoro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) (commercially available from for example Aldrich) (72 mg, 0.098 mmol) then sealed and heated in a Biotage "Initiator" microwave at 110 C. for 1 hr. The cooled product mixture was treated with dichloromethane (50 mL) and water (10 mL). The mixture was separated and the organic fraction was evaporated to dryness. The product was subjected to purification by mass-directed automated preparative HPLC (formic acid modifier) to afford the title compound (178 mg, 0.52 mmol, 37% yield). LCMS RT=1.03 min, ES+ve m/z 341 [M+H]+.
Recommend Products
Same Skeleton Products

Technical Information

? Acyl Group Substitution ? Alkyl Halide Occurrence ? Baeyer-Villiger Oxidation ? Barbier Coupling Reaction ? Baylis-Hillman Reaction ? Benzylic Oxidation ? Birch Reduction ? Blanc Chloromethylation ? Bucherer-Bergs Reaction ? Chan-Lam Coupling Reaction ? Clemmensen Reduction ? Complex Metal Hydride Reductions ? Corey-Bakshi-Shibata (CBS) Reduction ? Corey-Chaykovsky Reaction ? Fischer Indole Synthesis ? Friedel-Crafts Reaction ? General Reactivity ? Grignard Reaction ? Henry Nitroaldol Reaction ? Hiyama Cross-Coupling Reaction ? Horner-Wadsworth-Emmons Reaction ? Hydride Reductions ? Hydrogenolysis of Benzyl Ether ? Kinetics of Alkyl Halides ? Kumada Cross-Coupling Reaction ? Lawesson's Reagent ? Leuckart-Wallach Reaction ? McMurry Coupling ? Meerwein-Ponndorf-Verley Reduction ? Passerini Reaction ? Paternò-Büchi Reaction ? Petasis Reaction ? Peterson Olefination ? Pictet-Spengler Tetrahydroisoquinoline Synthesis ? Preparation of Aldehydes and Ketones ? Preparation of Alkylbenzene ? Preparation of Amines ? Prins Reaction ? Reactions of Aldehydes and Ketones ? Reactions of Alkyl Halides with Reducing Metals ? Reactions of Amines ? Reactions of Benzene and Substituted Benzenes ? Reactions of Dihalides ? Reformatsky Reaction ? Robinson Annulation ? Schlosser Modification of the Wittig Reaction ? Schmidt Reaction ? Specialized Acylation Reagents-Carbodiimides and Related Reagents ? Specialized Acylation Reagents-Ketenes ? Stille Coupling ? Stobbe Condensation ? Substitution and Elimination Reactions of Alkyl Halides ? Suzuki Coupling ? Tebbe Olefination ? Ugi Reaction ? Vilsmeier-Haack Reaction ? Wittig Reaction ? Wolff-Kishner Reduction
Historical Records

Related Functional Groups of
[ 14733-73-4 ]

Bromides

Chemical Structure| 19932-85-5

[ 19932-85-5 ]

6-Bromobenzo[d]oxazol-2(3H)-one

Similarity: 1.00

Chemical Structure| 871367-14-5

[ 871367-14-5 ]

7-Bromobenzo[d]oxazol-2(3H)-one

Similarity: 0.85

Chemical Structure| 169303-80-4

[ 169303-80-4 ]

tert-Butyl (2-bromo-5-methoxyphenyl)carbamate

Similarity: 0.83

Chemical Structure| 67927-44-0

[ 67927-44-0 ]

6-Bromo-3-methylbenzo[d]oxazol-2(3H)-one

Similarity: 0.83

Chemical Structure| 401811-77-6

[ 401811-77-6 ]

tert-Butyl (5-bromobenzo[d][1,3]dioxol-4-yl)carbamate

Similarity: 0.78

Amides

Chemical Structure| 19932-85-5

[ 19932-85-5 ]

6-Bromobenzo[d]oxazol-2(3H)-one

Similarity: 1.00

Chemical Structure| 871367-14-5

[ 871367-14-5 ]

7-Bromobenzo[d]oxazol-2(3H)-one

Similarity: 0.85

Chemical Structure| 169303-80-4

[ 169303-80-4 ]

tert-Butyl (2-bromo-5-methoxyphenyl)carbamate

Similarity: 0.83

Chemical Structure| 67927-44-0

[ 67927-44-0 ]

6-Bromo-3-methylbenzo[d]oxazol-2(3H)-one

Similarity: 0.83

Chemical Structure| 81282-60-2

[ 81282-60-2 ]

7-Aminobenzo[d]oxazol-2(3H)-one

Similarity: 0.80

Related Parent Nucleus of
[ 14733-73-4 ]

Benzoxazoles

Chemical Structure| 19932-85-5

[ 19932-85-5 ]

6-Bromobenzo[d]oxazol-2(3H)-one

Similarity: 1.00

Chemical Structure| 871367-14-5

[ 871367-14-5 ]

7-Bromobenzo[d]oxazol-2(3H)-one

Similarity: 0.85

Chemical Structure| 67927-44-0

[ 67927-44-0 ]

6-Bromo-3-methylbenzo[d]oxazol-2(3H)-one

Similarity: 0.83

Chemical Structure| 81282-60-2

[ 81282-60-2 ]

7-Aminobenzo[d]oxazol-2(3H)-one

Similarity: 0.80

Chemical Structure| 5579-85-1

[ 5579-85-1 ]

6-Bromo-5-chlorobenzo[d]oxazol-2(3H)-one

Similarity: 0.74

; ;