成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 147-94-4 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 147-94-4
Chemical Structure| 147-94-4
Structure of 147-94-4 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 147-94-4 ]

Related Doc. of [ 147-94-4 ]

Alternatived Products of [ 147-94-4 ]
Product Citations

Product Details of [ 147-94-4 ]

CAS No. :147-94-4 MDL No. :MFCD00066487
Formula : C9H13N3O5 Boiling Point : -
Linear Structure Formula :- InChI Key :UHDGCWIWMRVCDJ-CCXZUQQUSA-N
M.W : 243.21 Pubchem ID :6253
Synonyms :
Cytosine β-D-arabinofuranoside;Cytosine Arabinoside;U-19920A;NSC 287459;NSC 63878;1-β-D-Arabinofuranosylcytosine;Ara-C
Chemical Name :4-Amino-1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

Safety of [ 147-94-4 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335-H351-H361 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 147-94-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 147-94-4 ]

[ 147-94-4 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 10212-25-6 ]
  • [ 147-94-4 ]
YieldReaction ConditionsOperation in experiment
83% In ethanol; water; EXAMPLE 2 <strong>[10212-25-6]2,2'-O-<strong>[10212-25-6]cyclocytidine hydrochloride</strong></strong> (6.5 g) was dissolved in 35 mL water at 80 C. The solution was cooled to room temperature and t-butylarnine (2.8 g) was added and the mixture stirred for 2 hours. Thereafter, the solvent was evaporated under vacuum and ethanol (16 g) was added. The mixture was stirred at room temperature for 12 hours. Filtration of the resulting precipitation yielded 5 g of pure cytarabine after drying, which corresponds to a yield of 83%. The product was characterized by comparison of its melting point, and NMR and IR spectra with those previously reported for cytarabine.
  • 2
  • [ 147-94-4 ]
  • [ 7075-11-8 ]
  • 3
  • [ 147-94-4 ]
  • [ 69-74-9 ]
YieldReaction ConditionsOperation in experiment
96% With hydrogenchloride; In methanol; at 2 - 25℃; for 4h; An oven- dried 250 mL round bottom flask equipped with a magnetic stir bar was charged with 3.35 g of cytarabine-HCl and 6.0 mL of DMPU. Into this flask the reaction mixture from example 12 was filtered directly and the DABCO-HCl salt was washed quickly with acetonitrile (1×15 mL). Volatiles were removed on a rotary-evaporator under aspirator vacuum (bath temp <35 C.). The residual oil was briefly kept under high vacuum and stirred at room temperature for 48 h. The reaction mixture was treated with 100 mL of MeOH and stirred for 2 hours at room temperature. The pH of the reaction mixture was adjusted to 7.0 using 25 wt % NaOMe solution in methanol (approximately 13 mL were required). At this stage the reaction mixture was turbid. HPLC was run to insure integrity of the reaction profile. The reaction mixture was evaporated to dryness and the residue was stirred with 50 mL of dichloromethane for 30 minutes at room temperature. The precipitate was collected by filtration, washed with methylene chloride (1×20 mL) and transferred back to the flask, stirred again with 50 mL of dichloromethane for 15 minutes and filtered. The solid was stirred with 200 mL of ethanol for 1-2 hours, filtered and washed with ethanol (2×10 mL). The filtrate was evaporated to dryness to give 4.90 g of a white solid. This solid was dissolved in 10 mL of H2O and stirred at room temperature overnight to give a solid which was collected by filtration, washed with water (2×3 mL) and dried in a vacuum oven to give compound 9, 1.38 g, (26%).
With hydrogenchloride; In diethyl ether; A suspension of cytarabin hydrochloric salt (prepared from cytarabin and 1M HC1 in diethyl ether) (839 mg, 3.0 mmol) in DMA (10 ml) was added to the acid chloride of monomethyl azelaic acid (761 mg, 3.45 mmol) in DMA (2 ml) and the mixture stirred at room temperature overnight. NEt3 was added to the reaction mixture (303 mg, 3.0 mmol) and the mixture evaporated in vacuo. The residue was transferred to a flash column with silica gel and separated with (CH2C12/MEOH 10 : 1) as eluent system to leave the product as a white solid. Yield: 278 mg, (21.6 %). 1H-NMR (DMSO-D6, 300 MHz): 5 7.47 (d, 1 H), 7.10 (br d, 2 H), 6.09 (d, 1 H), 5.67 (d, 1 H), 5.60-5. 56 (m, 2 H), 4.33-3. 88 (m, 2 H), 3.98-3. 96 (m, 1 H), 3.94-3. 88 (m, 2 H), 3.57 (s, 3 H), 3.33 (br s, 1 H), 2.34-2. 25 (m, 4 H), 1.54-1. 47 (m, 4 H), 1.22 (br s, 6 H). 3C-NMR (DMSO-D6, 75 MHz) : 8 173.3, 172.8, 165.5, 155.0, 142.8, 92.5, 86.1, 81.7, 76.7, 74.2, 63.6, 51.1, 45.2, 33.5, 33.1, 28.2, 28.1, 24.3, 8.4.
  • 4
  • [ 23361-28-6 ]
  • [ 147-94-4 ]
  • [ 791111-70-1 ]
YieldReaction ConditionsOperation in experiment
21% With benzotriazol-1-ol; diisopropyl-carbodiimide; In DMF (N,N-dimethyl-formamide); at 20℃; A solution of <strong>[23361-28-6]Boc-Val-Pro-OH</strong> (94.5 mg, 0,30 mmmol) in DIMETHYLFORMAMIDE (1.5 mL), was successively treated, at room temperature, with 1-HYDROXIBENZOTRIAZOL (40.5 mg, 0.30 MMOL), N, N-DIISOPROPYLCARBODIIMIDE (46.7 ?L, 0.30 MMOL) and Ara-C (60.9 mg, 0.25 MMOL). The stirring was continued until complete disappearance of the starting material (overnight stirring). Then, the solvent was evaporated, the residue was dissolved in ethyl acetate and washed with citric acid (10%), NAHCO3 (10%) and brine. The organic layer was dried (NA2SO4) and evaporated to give a residue that was purified by CCTLC on the chromatotron with DICHLOROMETHANE : METANOL (20 : 1) to yield Ara-C-dipeptide (A) (21 % yield)
  • 5
  • [ 7075-11-8 ]
  • [ 147-94-4 ]
  • [ 18354-06-8 ]
  • 6
  • [ 133081-26-2 ]
  • [ 147-94-4 ]
  • [ 1187772-87-7 ]
Recommend Products
Same Skeleton Products
Historical Records
; ;