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Chemical Structure| 14678-93-4 Chemical Structure| 14678-93-4
Chemical Structure| 14678-93-4

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CAS No.: 14678-93-4

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Product Details of [ 14678-93-4 ]

CAS No. :14678-93-4
Formula : C11H11N3O2
M.W : 217.22
SMILES Code : O=C(C1=C(N)N(C2=CC=C(C)C=C2)N=C1)O
MDL No. :MFCD00973937
InChI Key :APMQYFHSZSHAOC-UHFFFAOYSA-N
Pubchem ID :4559194

Safety of [ 14678-93-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H317
Precautionary Statements:P280

Application In Synthesis of [ 14678-93-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 14678-93-4 ]

[ 14678-93-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 15001-11-3 ]
  • [ 14678-93-4 ]
YieldReaction ConditionsOperation in experiment
With water; In ethanol;Reflux; General procedure: Intermediates 13 6 was synthesized according to the literature by ML Bender [28]. Intermediates 5 was dissolved in a solution of 15 ethanol and 16 potassium hydroxide and refluxed for 2h. After cooling, the pH of the mixture was adjusted to 5-6by the dropwise addition of 10% 17 HCl solution to give an intermediate 13 6, which was filtered under vacuum and recrystallized from ethanol to give the pure products.
  • 2
  • [ 25365-71-3 ]
  • [ 14678-93-4 ]
  • (E)-5-(((2-phenyl-1H-indol-3-yl)methylene)amino)-1-(p-tolyl)-1H-pyrazole-4-carboxylic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; In ethanol; water; at 80℃; General procedure: Intermediate 4 (1mmol) and the intermediate 7 (1mmol) were dissolved in ethanol to the glass flask, then HCl solution was added as a catalyst refluxed at 80C for 15-18h. After the TLC monitoring reaction was completed, the mixture was vacuum filtered and concentrated. Finally, the above crude product can be isolated and purified by column chromatography (Hexane/EtOAc=8:1) to obtain target compounds.
 

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