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Chemical Structure| 1452-77-3 Chemical Structure| 1452-77-3
Chemical Structure| 1452-77-3

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CAS No.: 1452-77-3

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Picolinamide is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.

Synonyms: 2-Picolinamide; 2-Pyridinecarboxamide; 2-Carbamoylpyridine

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Product Citations

Product Citations

Zang, Zhiyu ; Duncan, Olivia K ; Sabonis, Dziugas ; Shi, Yun ; Miraj, Gause ; Fedorova, Iana , et al.

Abstract: The rise of antibiotic resistance motivates a revived interest in phage therapy. However, bacteria possess dozens of anti-bacteriophage immune systems that confer resistance to therapeutic phages. Chemical inhibitors of these anti-phage immune systems could be employed as adjuvants to overcome resistance in phage-based therapies. Here, we report that anti-phage systems can be selectively inhibited by small molecules, thereby sensitizing phage-resistant bacteria to phages. We discovered a class of chemical inhibitors that inhibit the type II Thoeris anti-phage immune system. These inhibitors block the biosynthesis of a histidine-ADPR intracellular ‘a(chǎn)larm’ signal by ThsB and prevent ThsA from arresting phage replication. These inhibitors promiscuously inhibit type II Thoeris systems from diverse bacteria—including antibiotic-resistant pathogens. Chemical inhibition of the Thoeris defense improved the efficacy of a model phage therapy against a phage-resistant strain of P. aeruginosa in a mouse infection, suggesting a therapeutic potential. Furthermore, these inhibitors may be employed as chemical tools to dissect the importance of the Thoeris system for phage defense in natural microbial communities.

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Product Details of Picolinamide

CAS No. :1452-77-3
Formula : C6H6N2O
M.W : 122.12
SMILES Code : O=C(N)C1=NC=CC=C1
Synonyms :
2-Picolinamide; 2-Pyridinecarboxamide; 2-Carbamoylpyridine
MDL No. :MFCD00023483
InChI Key :IBBMAWULFFBRKK-UHFFFAOYSA-N
Pubchem ID :15070

Safety of Picolinamide

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Picolinamide

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1452-77-3 ]

[ 1452-77-3 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 1452-77-3 ]
  • [ 6283-81-4 ]
  • [ 1001915-34-9 ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide; water; In ethanol; at 20℃; for 15h; To a solution of pyridine-2-carboxamide (1.2 eq, 3.4 mmol, 0.41 g) in H2O (1.4 ml) and NaOH (1.5 eq, 4.3 mmol, 0.17 g), is added a solution of <strong>[6283-81-4]3-oxo-3-pyridin-3-yl-propionic acid ethyl ester</strong> (1eq, 2.85 mmol, 0.55 g) in EtOH (1.7 ml) at room temperature. The reaction is left to stir for 15 hours. The reaction solvent was removed under reduced pressure to give a solid residue. The crude product is purified by flash chromatography (DCM / MeOH 100:0 to 0:100) to afford 6-pyridin-3-yl-2-pyridin-2-yl-3H-pyrimidin-4-one as a white solid; MH+= 251
  • 2
  • [ 1452-77-3 ]
  • [ 26239-55-4 ]
  • [ 7722-84-1 ]
  • vanadia [ No CAS ]
  • [VO(O2)(picolinamide)2][VO(O2)(carbamoylmethyliminodiacetate)]*2H2O [ No CAS ]
  • 3
  • [ 1452-77-3 ]
  • [ 59-66-5 ]
  • C4H6N4O3S2*2C6H6N2O [ No CAS ]
  • 4
  • [ 1452-77-3 ]
  • europioum(III) chloride [ No CAS ]
  • [ 17217-57-1 ]
  • [Eu(pyridine-2-carboxamide)3(4,4'-dimethoxy-2,2'-bipyridine)].Cl3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
A mixture of 10 mL methanolic solution of pyridine-2-carboxamide (0.3663 g, 3 mmol) and 10 mL methanolic solution of 4,4'-dimethoxy-2,2'-bipyridine (0.2162 g, 1 mmol) was stirred at room temperature for half an hour. Solution of EuCl3 was prepared by dissolving 1 mmol (0.2583 g) of EuCl3 in 10 mL of methanol and this solution was added to the ligands solution drop by drop with continuous stirring. The pH of resulting solution was maintained between 6 and 7. The reaction mixture was refluxed at 70 °C for 4 h. After refluxing for 4 h, the solution was cooled to room temperature and left as such overnight. Complex C1 was obtained as white precipitate which was filtered off, washed with methanol nd then dried under vacuum. The synthesis of complexes C2-C4 were done by adopting the same method as given above. Complex C2 was obtained from 3 mmol PCAO (0.3663 g), 1 mmol DMBP (0.2162 g) and1 mmol EuCl3 (0.2583 g), complex C3 was obtained from 3 mmol PDCA(0.4473 g), 1 mmol DMBP (0.2162 g) and 1 mmol EuCl3 (0.2583 g) and complex C4 was obtained from 3 mmol PM (0.3 mL), 1 mmol DMBP(0.2162 g) and 1 mmol EuCl3 (0.2583 g).
 

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