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Chemical Structure| 144494-65-5 Chemical Structure| 144494-65-5
Chemical Structure| 144494-65-5

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CAS No.: 144494-65-5

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Tirofiban is a non-peptide reversible antagonist of the platelet integrin glycoprotein (GP) IIb/IIIa receptor used as an antiplatelet drug.

Synonyms: L700462; MK383

4.5 *For Research Use Only !

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Product Details of Tirofiban

CAS No. :144494-65-5
Formula : C22H36N2O5S
M.W : 440.60
SMILES Code : O=C(O)[C@H](CC1=CC=C(C=C1)OCCCCC2CCNCC2)NS(=O)(CCCC)=O
Synonyms :
L700462; MK383
MDL No. :MFCD05237246
InChI Key :COKMIXFXJJXBQG-NRFANRHFSA-N
Pubchem ID :60947

Safety of Tirofiban

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Related Pathways of Tirofiban

cytoskeleton

Isoform Comparison

Biological Activity

Target
  • Integrin

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01087723 - Completed - -
NCT01087723 Acute Coronary Syndrome Phase 3 Completed - -
NCT01103440 Stable Angina Phase 2 Completed - United States, New York ... More >> Mount Sinai Medical Center New York, New York, United States, 10029 Less <<
NCT03691675 Drug-coated Balloon Not Applicable Not yet recruiting April 2019 -
NCT01863134 Non ST Elevation Myocardial In... More >>farction Less << Phase 4 Completed - United States, New York ... More >> Albert Einstein College of Medicine New York, New York, United States Poland First Department of Cardiac Surgery, Medical University of Silesia Katowice, Slaskie, Poland, 40-635 Center for Cardiovascular Research and Development, American Heart of Poland Katowice, Poland Department of Internal Medicine and Clinical Pharmacology Katowice, Poland First Department of Cardiology, Medical University of Silesia Katowice, Poland Division of Molecular Biology and Clinical Genetics, Jagiellonian University Medical College Krakow, Poland Less <<
NCT01717573 ST-Elevation Myocardial Infarc... More >>tion Less << Not Applicable Completed - United Kingdom ... More >> Golden Jubilee National Hospital Clydebank, Glasgow, United Kingdom, G81 4DY Less <<
NCT03146858 Primary Percutaneous Coronary ... More >>Intervention Less << Phase 4 Completed - United Kingdom ... More >> Sheffield Teaching Hospitals NHS Foundation Trust Sheffield, South Yorkshire, United Kingdom, S5 7AU Less <<
NCT01863134 - Completed - -
NCT01598337 Coronary Artery Disease Phase 3 Unknown - Saudi Arabia ... More >> Prince Sultan Cardiac Center Recruiting Riyadh, Saudi Arabia Contact: Hussein S Alamri, MD ?? ?? amriheart@hotmail.com ?? Principal Investigator: Antonio Calafiore ?? ?? ?? Principal Investigator: Hussein S Alamri, MD ?? ?? ?? Principal Investigator: Abdulrahman M almoghairi, MD Less <<
NCT01103440 - Completed - -
NCT02592720 Acute Coronary Syndromes Phase 4 Unknown October 2017 China, Shaanxi ... More >> Xijing hospital Recruiting Xi'an, Shaanxi, China, 710032 Contact: Dongdong Sun, M.D.,Ph.D ?? 86 18691569930 ?? wintersun3@gmail.com Less <<
NCT01433627 Acute Coronary Syndromes ... More >> STEMI NSTEMI Less << Phase 3 Unknown December 2015 -
NCT03078257 Coronary Artery Disease Phase 1 Recruiting December 2017 China, Jiangsu ... More >> First Affiliated Hospital of Nanjing Medical University Recruiting Nanjing, Jiangsu, China, 210029 Contact: Fuming Zhang, M.D. ?? +86-25-83718836 ext 6360 ?? jsphkj@163.com ?? Contact: Yi Chai, M.D. ?? +86-25-83718836 ext 6360 ?? jsphkj@163.com ?? Sub-Investigator: Dingguo Zhang, Ph.D Less <<
NCT00713557 - Terminated(devices applied in ... More >>the study were no more available in the market, and medical intervention section was completed.) Less << - China, Shanghai ... More >> Dept. of Cardiology, Ruijin Hospital Shanghai, Shanghai, China, 200025 Less <<
NCT00251576 Acute Coronary Syndrome Phase 3 Completed - -
NCT00445263 CORONARY DISEASE Phase 4 Terminated(Because of inclusio... More >>n delay) Less << - France ... More >> Samu 93 - Chu Avicenne Bobigny, Ile de France, France, 93000 Less <<
NCT03406819 ST Segment Elevation Myocardia... More >>l Infarction Primary Percutaneous Coronary Intervention Less << Not Applicable Recruiting December 31, 2019 China, Henan ... More >> Anyang District Hospital Recruiting Anyang, Henan, China, 455000 The 99th Central Hospital of the People's Liberation Army Recruiting Jiaozuo, Henan, China, 454000 The People's Hospital of Jiaozuo Recruiting Jiaozuo, Henan, China, 454002 The second people's Hospital of Jiyuan Recruiting Jiyuan, Henan, China, 454000 Huaihe Hospital of Henan University Recruiting Kaifeng, Henan, China, 475000 Kaifeng Central Hospital Recruiting Kaifeng, Henan, China, 475000 The First Affiliated Hospital of Henan University of Science and Technology Recruiting Luoyang, Henan, China, 471003 Lushan People's Hospital Recruiting Lushan, Henan, China, 467300 Nanyang City Center Hospital Recruiting Nanyang, Henan, China, 473000 Pingmei Shenma Medical Group General Hospital Recruiting Pingdingshan, Henan, China, 467000 The Second People's Hospital of Pingdingshan Recruiting Pingdingshan, Henan, China, 467000 Puyang Oilfield General Hospital Recruiting Puyang, Henan, China, 457000 Puyang People's Hospital Recruiting Puyang, Henan, China, 457099 Yellow River Sanmenxia hospital Recruiting Sanmenxia, Henan, China, 472000 The First People's Hospital of Shangqiu Recruiting Shangqiu, Henan, China, 476000 The First Affiliated Hospital of Xinxiang Medical University Recruiting Xinxiang, Henan, China, 453100 Xinyang Central Hospital Recruiting Xinyang, Henan, China, 464000 Yanshi People's Hospital Recruiting Yanshi, Henan, China, 471900 Zhengzhou First People's Hospital Recruiting Zhengzhou, Henan, China, 450004 Zhengzhou Cardiovascular Hospital Recruiting Zhengzhou, Henan, China, 450006 Zhengzhou Central Hospital Recruiting Zhengzhou, Henan, China, 450007 The First Affiliated Hospital of Zhengzhou University Recruiting Zhengzhou, Henan, China, 450052 Contact: Chunguang Qiu, Phd ?? ?? ?? People's Hospital of Zhengzhou Recruiting Zhengzhou, Henan, China, 450053 The First People's Hospital of Xinmi Recruiting Zhengzhou, Henan, China, 452370 Zhoukou Central Hospital Recruiting Zhoukou, Henan, China, 466000 The First People's Hospital of Zhumadian Recruiting Zhumadian, Henan, China, 463000 Zhumadian Central Hospital Recruiting Zhumadian, Henan, China, 463000 China, Shanxi Jincheng People's Hospital Recruiting Jincheng, Shanxi, China, 048026 Less <<
NCT00653601 - Unknown April 2011 United States, California ... More >> Cedars-Sinai Medical Center Recruiting Los Angeles, California, United States, 90048 Contact: Sanjay Kaul, MD ?? 310-423-4876 ?? sanjay.kaul@cshs.org ?? Contact: Suhail Dohad, MD ?? 310-278-3400 ?? dohad@cvmg.com ?? Principal Investigator: Sanjay Kaul, MD ?? ?? ?? Sub-Investigator: Amanda B Lamer, PharmD ?? ?? ?? Sub-Investigator: Hai Tran, PharmD ?? ?? ?? Sub-Investigator: Stanley Chou, MD ?? ?? ?? Sub-Investigator: Suhail Dohad, MD Less <<
NCT03406832 ST Segment Elevation Myocardia... More >>l Infarction Elective Percutaneous Coronary Intervention Less << Not Applicable Recruiting December 31, 2019 China, Henan ... More >> Anyang District Hospital Recruiting Anyang, Henan, China, 455000 The 99th Central Hospital of the People's Liberation Army Recruiting Jiaozuo, Henan, China, 454000 The People's Hospital of Jiaozuo Recruiting Jiaozuo, Henan, China, 454002 The second people's Hospital of Jiyuan Recruiting Jiyuan, Henan, China, 454000 Huaihe Hospital of Henan University Recruiting Kaifeng, Henan, China, 475000 Kaifeng Central Hospital Recruiting Kaifeng, Henan, China, 475000 The First Affiliated Hospital of Henan University of Science and Technology Recruiting Luoyang, Henan, China, 471003 Lushan People's Hospital Recruiting Lushan, Henan, China, 467300 Nanyang City Center Hospital Recruiting Nanyang, Henan, China, 473000 Pingmei Shenma Medical Group General Hospital Recruiting Pingdingshan, Henan, China, 467000 The Second People's Hospital of Pingdingshan Recruiting Pingdingshan, Henan, China, 467000 Puyang Oilfield General Hospital Recruiting Puyang, Henan, China, 457000 Puyang People's Hospital Recruiting Puyang, Henan, China, 457099 Yellow River Sanmenxia hospital Recruiting Sanmenxia, Henan, China, 472000 The First People's Hospital of Shangqiu Recruiting Shangqiu, Henan, China, 476000 The First Affiliated Hospital of Xinxiang Medical University Recruiting Xinxiang, Henan, China, 453100 Xinyang Central Hospital Recruiting Xinyang, Henan, China, 464000 Yanshi People's Hospital Recruiting Yanshi, Henan, China, 471900 Zhengzhou First People's Hospital Recruiting Zhengzhou, Henan, China, 450004 Zhengzhou Cardiovascular Hospital Recruiting Zhengzhou, Henan, China, 450006 Zhengzhou Central Hospital Recruiting Zhengzhou, Henan, China, 450007 The First Affiliated Hospital of Zhengzhou University Recruiting Zhengzhou, Henan, China, 450052 Contact: Chunguang Qiu, Phd ?? ?? ?? People's Hospital of Zhengzhou Recruiting Zhengzhou, Henan, China, 450053 The First People's Hospital of Xinmi Recruiting Zhengzhou, Henan, China, 452370 Zhoukou Central Hospital Recruiting Zhoukou, Henan, China, 466000 The First People's Hospital of Zhumadian Recruiting Zhumadian, Henan, China, 463000 Zhumadian Central Hospital Recruiting Zhumadian, Henan, China, 463000 China, Shanxi Jincheng People's Hospital Recruiting Jincheng, Shanxi, China, 048026 Less <<
NCT01696110 Acute Myocardial Infarction ... More >> Percutaneous Coronary Intervention Less << Phase 4 Completed - -
NCT00300833 Acute Myocardial Infarction PHASE4 UNKNOWN - Cardiovascular Division, The B... More >>aruch Padeh Medical Center, Poriya,, Tiberias, 15208, Israel|Magen David ,, Tiberias, Israel Less <<
NCT03691727 Subarachnoid Hemorrhage, Aneur... More >>ysmal Less << Phase 1 Phase 2 Not yet recruiting November 2022 -
NCT00611169 Acute Myocardial Infarction Phase 4 Completed - -
NCT00445263 - Terminated(Because of inclusio... More >>n delay) Less << - -
NCT00229515 Myocardial Infarction Phase 4 Unknown March 2012 Italy ... More >> Cattedra di Cardiologia, Azienda Ospedaliera Universitaria di Ferrara Ferrara, Italy, 44100 Less <<
NCT00538317 Acute Myocardial Infarction Phase 4 Completed - France ... More >> Hospices Civils de Lyon Lyon, France, 6900 Less <<
NCT00306228 Myocardial Infarction Phase 4 Completed - Spain ... More >> Instituto de Ciencias del Corazón (ICICOR). Hospital Clínico Universitario de Valladolid Valladolid, Spain, 47005 Less <<
NCT00790387 Acute Coronary Syndrome Phase 4 Completed - Australia, Queensland ... More >> The Prince Charles Hospital Brisbane, Queensland, Australia, 4032 Less <<
NCT02131220 Myocardial Infarction ... More >> Percutaneous Coronary Intervention Thrombolytic Therapy Less << Phase 4 Completed - China, Shanghai ... More >> Department of Cardiology, Zhongshan Hospital, Fudan University Shanghai, Shanghai, China, 200032 Less <<
NCT01336348 ST Segment Elevation Myocardia... More >>l Infarction Less << Phase 3 Completed - Italy ... More >> Cardiology Unit Ferrara, Italy, 44100 Less <<
NCT01660373 Non-ST Segment Elevation Acute... More >> Coronary Syndrome Less << Phase 3 Unknown August 2013 Korea, Republic of ... More >> Pusan National University Yangsan Hospital Recruiting Yangsan, Kyeongsangnamdo, Korea, Republic of, 626-770 Contact: June Hong Kim, MD, PhD ?? +82-10-8231-7171 ?? junehongk@gmail.com ?? Contact: Dongcheul Han, MD ?? +82-10-2992-6270 ?? usdoc12@gmail.com ?? Principal Investigator: June Hong Kim, MD,PhD ?? ?? ?? Sub-Investigator: Dongcheul Han, MD Less <<
NCT00383136 Acute Myocardial Infarction Phase 4 Completed - Italy ... More >> Divisione Di Cardiologia, Ospedale Maggiore Bologna, BO, Italy, 40100 Laboratorio Di Emodinamica, Istituto Di Cardiologia, Azienda Ospedaliera S.Orsola Malpighi Bologna, BO, Italy, 40138 Azienda Ospedaliera Universitaria Policlinico Modena, MO, Italy, 41100 Divisione Di Cardiologia, Ospedale S.Maria Nuova Reggio Emilia, RE, Italy, 42100 Divisione Di Cardiologia, Ospedale Per Gli Infermi Rimini, RN, Italy, 47900 Divisione Di Cardiologia Ii, Ospedale Policlinico Le Molinette Torino, TO, Italy, 10100 Less <<
NCT00398463 Angioplasty, Transluminal, Per... More >>cutaneous Coronary Less << Phase 4 Completed - Italy ... More >> Cattedra di Cardiologia, Azienda Ospedaliera Universitaria di Ferrara Ferrara, Fe, Italy, 44100 Less <<
NCT01522417 Myocardial Infarction ... More >> Acute Coronary Syndromes Unstable Angina Less << Phase 2 Recruiting July 2019 United States, Florida ... More >> Osceola Regional Medical Center Completed Kissimmee, Florida, United States, 34741 Northside Hospital Completed Saint Petersburg, Florida, United States, 33709 United States, Georgia Emory University Hospital Midtown Completed Atlanta, Georgia, United States, 30308 Emory University Hospital Completed Atlanta, Georgia, United States, 30322 North Georgia Heart Center Completed Gainesville, Georgia, United States, 30501 Redmond Regional Medical Center Recruiting Rome, Georgia, United States, 30165 Principal Investigator: Hector R Picon, MD ?? ?? ?? Archbold Medical Center Completed Thomasville, Georgia, United States, 31792 United States, New York Lenox Hill Hospital Completed New York, New York, United States, 10075 United States, Oklahoma University of Oklahoma Health Sciences Center Recruiting Oklahoma City, Oklahoma, United States, 73104 Principal Investigator: Mazen Abu-Fadel, MD ?? ?? ?? United States, Pennsylvania Doylestown Hospital Completed Doylestown, Pennsylvania, United States, 18901 Penn Presbyterian Medical Center Completed Philadelphia, Pennsylvania, United States, 19104 United States, Tennessee Centennial Heart Recruiting Nashville, Tennessee, United States, 37203 Principal Investigator: Brian K Jefferson, MD ?? ?? ?? United States, Virginia Chippenham Hospital Recruiting Richmond, Virginia, United States, 23225 Principal Investigator: Michael L Arcarese, MD Less <<
NCT01498003 Coronary Artery Disease Phase 4 Completed - China, Shanghai ... More >> Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai, Shanghai, China, 200025 Less <<
NCT01245725 Myocardial Infarction ... More >> Acute Coronary Syndromes Unstable Angina Percutaneous Coronary Intervention Less << Phase 3 Withdrawn(Study was not initia... More >>ted, change in clinical development) Less << - -
NCT02978040 Coronary Artery Disease ... More >> STEMI - ST Elevation Myocardial Infarction Less << Phase 4 Recruiting April 2019 France ... More >> Group Hospitalier Pitié-Salpetrière Not yet recruiting Paris, France, 75013 Contact: Jean-Philippe Collet, Prof ?? ?? jean-philippe.collet@aphp.fr ?? Italy University of Ferrara Not yet recruiting Ferrara, Italy, 44124 Contact: Gianluca Campo, Prof ?? ?? cmpglc@unife.it ?? University of Naples Federico II Recruiting Naples, Italy, 80131 Contact: Giovanni Esposito, Prof ?? ?? espogiov@unina.it ?? University of Sassari Not yet recruiting Sassari, Italy, 07100 Contact: Guido Parodi, Prof ?? ?? parodiguido@gmail.com ?? Principal Investigator: Pierfranco Terrosu, MD ?? ?? ?? Switzerland Bern University Hospital Recruiting Bern, Switzerland, 3010 Contact: Marco Valgimigli, Prof ?? +41 316329653 ?? marco.valgimigli@insel.ch ?? Contact: Giuseppe Gargiulo, MD ?? +41 316327205 ?? giuseppe.gargiulo@insel.ch Less <<
NCT00566891 Coronary Artery Disease Phase 4 Completed - Italy ... More >> S Anna Hospital Catanzaro, Italy, 88100 Less <<
NCT00407771 Coronary Artery Disease PHASE4 UNKNOWN 2025-12-08 Jordan Hospital, Amman, 11152,... More >> Jordan Less <<
NCT03357133 Ischemic Stroke Phase 2 Phase 3 Recruiting March 31, 2019 China, An Hui ... More >> Suzhou Municipal Hoapital Recruiting Suzhou, An Hui, China Contact: Zhengfei Ma, MD ?? ?? ?? China, Beijing Xuanwu Hospital, Capital Medical University Recruiting Beijing, Beijing, China, 100053 Contact: Xunming Ji ?? ?? ?? Principal Investigator: Xunming Ji ?? ?? ?? China, Henan The Central Hospital of Luohe City Recruiting Luohe, Henan, China Contact: Shengming Huang, MD ?? ?? hsm912@126.com ?? China, Sichuan Luzhou People's Hospital Recruiting Luzhou, Sichuan, China Contact: Li Zhou, MD ?? ?? ?? China Xiangtan Central Hospital Recruiting Xiangtan, China Contact: Yong Liang ?? ?? ?? The Fifth Affiliated Hospital of Zhengzhou University Recruiting Zhengzhou, China Contact: Lijun Wang ?? ?? ?? The First Affiliated Hospital of Zhengzhou University Recruiting Zhengzhou, China Contact: Yajun Lian Less <<
NCT01181388 Myocardial Infarction Not Applicable Unknown October 2012 China, Beijing ... More >> the 28th division, Beijing Anzhen Hospital Recruiting Beijing, Beijing, China, 100029 Contact: Shaoping Shaoping, MD. PhD ?? +861064456995 ?? wang_shaoping@hotmail.com ?? Contact: Yunpeng Chi, MD ?? +861064456541 ?? chiyunpeng0711@sohu.com Less <<
NCT01109134 Acute Myocardial Infarction Phase 3 Completed - -
NCT03048019 - Recruiting May 29, 2019 United States, Virginia ... More >> Inova Health Care System Recruiting Falls Church, Virginia, United States, 22042 Contact: Kevin Bliden, BS, MBA ?? 703-776-7702 ?? kevin.bliden@inova.org Less <<
NCT03114995 Non-ST Elevation Myocardial In... More >>farction Less << PHASE4 COMPLETED 2015-10-01 -
NCT02592694 ST-elevation Myocardial Infarc... More >>tion Less << Phase 4 Unknown October 2017 China, Shaanxi ... More >> Xijing hospital Recruiting Xi'an, Shaanxi, China, 710032 Contact: Dongdong Sun, M.D.,Ph.D ?? 86 18691569930 ?? wintersun3@gmail.com Less <<
NCT01766154 Renal Insufficiency PHASE1 COMPLETED 2025-03-13 Avail Clinical Research, LLC, ... More >>DeLand, Florida, 32720, United States Less <<
NCT02054000 No-Reflow Phenomenon Phase 4 Completed - Turkey ... More >> Erciyes University School of Medicine Kayseri, Turkey, 38039 Less <<
NCT03114995 Non-ST Elevation Myocardial In... More >>farction Less << PHASE4 COMPLETED 2015-10-01 -
NCT02294994 Coronary Artery Disease Phase 4 Unknown December 2016 China, Jilin ... More >> The sencond hospital of Jilin University Recruiting Changchun, Jilin, China, 130041 Contact: Liu Bin, M.D. ?? +86 13500810268 ?? liubin3333@vip.sina.com Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.27mL

0.45mL

0.23mL

11.35mL

2.27mL

1.13mL

22.70mL

4.54mL

2.27mL

References

 

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