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[ CAS No. 142-25-6 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
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Limited Quantity USD 15-60
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Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 142-25-6
Chemical Structure| 142-25-6
Structure of 142-25-6 * Storage: {[proInfo.prStorage]}

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Product Citations

Product Citations

Li, Bowen ; Manan, Rajith Singh ; Liang, Shun-Qing , et al. DOI: PubMed ID:

Abstract: The expanding applications of nonviral genomic medicines in the lung remain restricted by delivery challenges. Here, leveraging a high-throughput platform, we synthesize and screen a combinatorial library of biodegradable ionizable lipids to build inhalable delivery vehicles for mRNA and CRISPR-Cas9 gene editors. Lead lipid nanoparticles are amenable for repeated intratracheal dosing and could achieve efficient gene editing in lung epithelium, providing avenues for gene therapy of congenital lung diseases.

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Product Details of [ 142-25-6 ]

CAS No. :142-25-6 MDL No. :MFCD00014874
Formula : C5H14N2 Boiling Point : No data available
Linear Structure Formula :NH(CH3)(CH2)2N(CH3)2 InChI Key :HVOYZOQVDYHUPF-UHFFFAOYSA-N
M.W : 102.18 Pubchem ID :67338
Synonyms :

Calculated chemistry of [ 142-25-6 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 7
Num. arom. heavy atoms : 0
Fraction Csp3 : 1.0
Num. rotatable bonds : 3
Num. H-bond acceptors : 2.0
Num. H-bond donors : 1.0
Molar Refractivity : 31.85
TPSA : 15.27 ?2

Pharmacokinetics

GI absorption : Low
BBB permeant : No
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -7.07 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.92
Log Po/w (XLOGP3) : -0.2
Log Po/w (WLOGP) : -0.23
Log Po/w (MLOGP) : 0.23
Log Po/w (SILICOS-IT) : -0.42
Consensus Log Po/w : 0.26

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -0.15
Solubility : 72.4 mg/ml ; 0.709 mol/l
Class : Very soluble
Log S (Ali) : 0.34
Solubility : 221.0 mg/ml ; 2.17 mol/l
Class : Highly soluble
Log S (SILICOS-IT) : -1.16
Solubility : 7.0 mg/ml ; 0.0685 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.0

Safety of [ 142-25-6 ]

Signal Word:Danger Class:3,8
Precautionary Statements:P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338-P310-P403+P235-P405 UN#:2733
Hazard Statements:H314-H225 Packing Group:Ⅱ
GHS Pictogram:

Application In Synthesis of [ 142-25-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 142-25-6 ]
  • Downstream synthetic route of [ 142-25-6 ]

[ 142-25-6 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 142-25-6 ]
  • [ 1421372-66-8 ]
Reference： [1] Patent: CN108129342, 2018, A,
  • 2
  • [ 142-25-6 ]
  • [ 1421373-65-0 ]
Reference： [1] Patent: CN105601620, 2016, A,
[2] Patent: CN108129342, 2018, A,
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