Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | ||||||
{[ item.p_purity ]} | {[ item.pr_size ]} | Inquiry |
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price) ]} |
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price) ]} | {[ item.pr_usastock ]} | in stock Inquiry - | {[ item.pr_chinastock ]} | {[ item.pr_remark ]} in stock Inquiry - | Login | Inquiry |
Please Login or Create an Account to: See VIP prices and availability
CAS No. : | 139911-29-8 | MDL No. : | MFCD17214439 |
Formula : | C7H8BFO2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | IQMLIVUHMSIOQP-UHFFFAOYSA-N |
M.W : | 153.95 | Pubchem ID : | 2734665 |
Synonyms : |
|
Chemical Name : | 2-Methyl-4-fluorophenylboronic acid |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
3.4 g (92%) | tetrakis(triphenylphosphine)palladium (0); In ethanol; toluene; | Ethyl 2-(2-Methyl-4-fluorophenyl)-5-fluorobenzoate Tetrakis(triphenylphosphine)palladium(0) (0.02 eq, 0.31 g) was added to a vigorously stirred solution of <strong>[139911-28-7]ethyl 2-bromo-5-fluorobenzoate</strong> (1.0 eq, 3.3 g, 0.013 mol) and 2-methyl-4-fluorophenylboronic acid (1.2 eq, 0.016 mol, 2.4 g) in 45 mL of toluene, 22 mL of 2M aqueous sodium carbonate, and 11 mL of ethanol and the mixture was refluxed for 9 h. The cooled reaction mixture was poured into 50 mL each of water, ammonium hydroxide, and 2M aqueous sodium bicarbonate and then filtered through Celite. The filtrate was extracted with ethyl acetate and the organics were dried (MgSO4) and concentrated to yield 3.9 g of a yellow oil. Chromatography (silica gel, 20% ethyl acetate/hexane) gave 3.4 g (92%) of product as a light colored oil. 1 H NMR (CDCl3, 60 mHz) delta 7.7 (dd, 1 H), 7.5 (m, 1 H), 7.25- 6.75 (m, 4 H), 4.0 (q, 2 H), 2.0 (s, 3 H), 1.0 (t, 3 H); IR (CDCl3 solution) 3130, 2220, 1700, 1450, 1080 cm-1; MS m/z 276 (M+), 201 (base peak). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
3.4 g (92%) | In ethanol; toluene; | Ethyl 2-(2-Methyl-4-fluorophenyl)-5-fluorobenzoate Tetrakis(triphenylphosphine)palladium(O) (0.02 eq, 0.31 g) was added to a vigorously stirred solution of <strong>[139911-28-7]ethyl 2-bromo-5-fluorobenzoate</strong> (1.0 eq, 3.3 g, 0.013 mol) and 2-methyl-4-fluorophenylboronic acid (1.2 eq, 0.016 mol, 2.4 g) in 45 mL of toluene, 22 mL of 2M aqueous sodium carbonate, and 11 mL of ethanol and the mixture was refluxed for 9 h. The cooled reaction mixture was poured into 50 mLeach of water, ammonium hydroxide, and 2M aqueous sodium bicarbonate and then filtered through Celite. The filtrate was extracted with ethyl acetate an the organics were dried (MgSO4) and concentrated to yield 3.9 g of a yellow oil. Chromatography (silica gel, 20% ethyl acetate/hexane) gave 3.4 g (92%) of product as a light colored oil. 1 H NMR (CDCl3, 60 mHz) delta7.7 (dd, 1H), 7.5 (m, 1H), 7.25-6.75 (m, 4H), 4.0 (q, 2H), 2.0 (s, 3H), 1.0 (t, 3H); IR (CDCl3 solution) 3130, 2220, 1700, 1450, 1080 cm-1; MS m/z 276 (M+), 201 (base peak). |
[ 163517-62-2 ]
2-Methyl-5-fluorophenylboronic acid
Similarity: 0.98
[ 850593-06-5 ]
(3-Fluoro-5-methylphenyl)boronic acid
Similarity: 0.88
[ 1061223-45-7 ]
(4-Fluoro-2-(hydroxymethyl)phenyl)boronic acid
Similarity: 0.88
[ 170981-26-7 ]
(2-Fluoro-4-methylphenyl)boronic acid
Similarity: 0.87
[ 140369-67-1 ]
4-(4-Fluorophenyl)phenylboronic acid
Similarity: 0.87
[ 163517-62-2 ]
2-Methyl-5-fluorophenylboronic acid
Similarity: 0.98
[ 850593-06-5 ]
(3-Fluoro-5-methylphenyl)boronic acid
Similarity: 0.88
[ 1061223-45-7 ]
(4-Fluoro-2-(hydroxymethyl)phenyl)boronic acid
Similarity: 0.88
[ 170981-26-7 ]
(2-Fluoro-4-methylphenyl)boronic acid
Similarity: 0.87
[ 140369-67-1 ]
4-(4-Fluorophenyl)phenylboronic acid
Similarity: 0.87
[ 163517-62-2 ]
2-Methyl-5-fluorophenylboronic acid
Similarity: 0.98
[ 850593-06-5 ]
(3-Fluoro-5-methylphenyl)boronic acid
Similarity: 0.88
[ 1061223-45-7 ]
(4-Fluoro-2-(hydroxymethyl)phenyl)boronic acid
Similarity: 0.88
[ 170981-26-7 ]
(2-Fluoro-4-methylphenyl)boronic acid
Similarity: 0.87
[ 140369-67-1 ]
4-(4-Fluorophenyl)phenylboronic acid
Similarity: 0.87