成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart Sign in  
Chemical Structure| 138977-28-3 Chemical Structure| 138977-28-3

Structure of Capsazepine
CAS No.: 138977-28-3

Chemical Structure| 138977-28-3

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

{[proInfo.proName]}

CAS No.: 138977-28-3

,{[proInfo.pro_purity]}

Capsazepine, a synthetic analogue of the sensory neurone excitotoxin, acts as an antagonist of the TRPV1 receptor with an IC50 of 562 nM.

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of Capsazepine

CAS No. :138977-28-3
Formula : C19H21ClN2O2S
M.W : 376.90
SMILES Code : S=C(N1CC2=CC(O)=C(O)C=C2CCC1)NCCC3=CC=C(Cl)C=C3
MDL No. :MFCD00153778
InChI Key :DRCMAZOSEIMCHM-UHFFFAOYSA-N
Pubchem ID :2733484

Safety of Capsazepine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
HEK293 cells 100 μM Capsazepine elicited a response in HEK293 cells, indicating that it inhibits TRPM1 current. PMC3365217
HEM cells 100 μM Capsazepine reduced the standing current in HEM cells, indicating that it inhibits TRPM1 activity. PMC3365217

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Mice Chronic dry eye disease model Topical ocular instillation 2 mg/kg Every other day, for a total of five times To evaluate the effectiveness of Capsazepine in alleviating corneal pain syndrome in severe dry eye disease mice. Results showed that Capsazepine reduced corneal polymodal responsiveness to heat, cold, and acidic stimulation, inhibited the upregulation of genes involved in neuropathic and inflammatory pain, and reduced ocular pain and anxiety-like behaviors associated with severe DED. PMC8114509

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.65mL

0.53mL

0.27mL

13.27mL

2.65mL

1.33mL

26.53mL

5.31mL

2.65mL

References

 

Historical Records

Categories