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Chemical Structure| 138786-67-1 Chemical Structure| 138786-67-1

Structure of Pantoprazole sodium
CAS No.: 138786-67-1

Chemical Structure| 138786-67-1

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CAS No.: 138786-67-1

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Pantoprazole sodium is an inhibitor of proton pump that can suppress function of H+/K+ ATPase. It is used for the treatment of hyperacidity.

Synonyms: SKF96022 sodium; BY1023 sodium; SKF-96022

4.5 *For Research Use Only !

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Product Details of Pantoprazole sodium

CAS No. :138786-67-1
Formula : C16H14F2N3NaO4S
M.W : 405.35
SMILES Code : COC1=CC=NC(CS(C2=NC3=C([N-]2)C=CC(OC(F)F)=C3)=O)=C1OC.[Na+]
Synonyms :
SKF96022 sodium; BY1023 sodium; SKF-96022
MDL No. :MFCD01658543
InChI Key :YNWDKZIIWCEDEE-UHFFFAOYSA-N
Pubchem ID :15008962

Safety of Pantoprazole sodium

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Isoform Comparison

Biological Activity

Target
  • Proton Pump

In Vitro:

Cell Line
Concentration Treated Time Description References
U87 human GBM cells 100-900 μM 12 hours and 24 hours To evaluate the effect of PPZ on glioma cell growth, results showed that PPZ significantly inhibited cell viability in a dose- and time-dependent manner. PMC11469912
C6 rat glioma cells 100-900 μM 12 hours and 24 hours To evaluate the effect of PPZ on glioma cell growth, results showed that PPZ significantly inhibited cell viability in a dose- and time-dependent manner. PMC11469912
Klebsiella pneumoniae 2 mg/mL 30 minutes To evaluate the inhibitory effect of pantoprazole on the hydrolytic activity of metallo-β-lactamases. Results showed that pantoprazole significantly inhibited the hydrolytic activity of metallo-β-lactamases, with higher inhibition effects compared to captopril. PMC10963397
Human osteoclasts 0.1-10 μg/mL 7 days To evaluate the effects of pantoprazole on the viability and function of human osteoclasts. Results showed that pantoprazole significantly decreased osteoclast viability and TRAP activity. PMC4385676

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Wistar albino rats Renal ischemia/reperfusion injury model Intraperitoneal injection 160 mg/kg Single dose Pantoprazole attenuated renal IRI by suppressing apoptosis, attenuating pro-inflammatory cytokines levels, and inhibiting the intracellular signaling pathway MAPK (ERK1/2, JNK, p38)–NF-κB. PMC8508698
Wistar albino rats Renal ischemia/reperfusion injury model Oral administration 40 mg/kg Twice daily for ten days Pantoprazole attenuated renal IRI by suppressing apoptosis, attenuating pro-inflammatory cytokines levels, and inhibiting the intracellular signaling pathway MAPK (ERK1/2, JNK, p38)–NF-κB. PMC8508698
C57BL/6J mice Chronic proton pump inhibitor use model Gavage 150 mg/kg Three times a week for 60 days To investigate the effects of pantoprazole on gut microbiota, intestinal barrier integrity, TLR4 signaling, and liver fibrosis. Results showed that pantoprazole altered microbiota composition, increased circulating LPS levels, activated hepatic TLR4 signaling, and led to liver microvesicular steatosis and fibrosis. PMC9693486
Wistar albino rats Renal ischemia/reperfusion injury model Oral 40 mg/kg Twice daily for 10 days To evaluate the protective effect of Pantoprazole sodium in renal ischemia/reperfusion injury, results showed it significantly reduced serum creatinine, BUN, and MDA levels, and inhibited inflammatory cytokines and apoptosis signaling pathways PMC8879001
CD-1 mice Femur fracture model Intraperitoneal injection 100 mg/kg Daily for 2 weeks or 5 weeks To study the effect of pantoprazole on fracture healing in aged mice. Results showed that pantoprazole impairs fracture healing in aged mice by affecting angiogenic and osteogenic growth factor expression, osteoclast activity and bone formation. PMC7758334

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02170896 Healthy Phase 1 Completed - -
NCT03545243 Dysbiosis Phase 4 Recruiting March 8, 2021 Belgium ... More >> UZ Leuven Recruiting Leuven, Belgium, 3000 Contact: Lucas Wauters, MD ?? 003216342538 ?? lucas.wauters@kuleuven.be Less <<
NCT00681005 GERD Not Applicable Completed - -
NCT03038009 Gastric Ulcer Induced by Antip... More >>latelet Agent Ulcer of the Gastrointestinal Tract Proton Pump Inhibitor Less << Phase 4 Not yet recruiting September 2020 China ... More >> Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Not yet recruiting Shanghai, China, 200025 Contact: Lifen Yu, MD, Ph.D ?? 0086-13641937166 ?? ylf10975@rjh.com.cn ?? Contact: Yunpeng Zhu, MD ?? 0086-13816819346 ?? zypB1014@rjh.com.cn ?? Principal Investigator: Lifen Yu, MD, Ph.D ?? ?? ?? Principal Investigator: Qiang Zhao, MD, Ph.D ?? ?? ?? Sub-Investigator: Yunpeng Zhu, MD Less <<
NCT01016717 Coronary Artery Disease Phase 4 Withdrawn(Since the published ... More >>data resolved the study goals we decided not to start it) Less << - Israel ... More >> Leviev Heart Center, Sheba Medical Center Tel Hashomer, Israel, 52621 Less <<
NCT02929563 Gastrointestinal Hemorrhage Phase 3 Recruiting December 2018 Canada, Alberta ... More >> Alberta Children's Hospital Recruiting Calgary, Alberta, Canada Contact: Elaine Gilfoyle, MD ?? ?? ?? Canada, Nova Scotia IWK Health Centre Recruiting Halifax, Nova Scotia, Canada Contact: Jennifer Foster, MD ?? ?? ?? Canada, Ontario McMaster Children's Hospital Recruiting Hamilton, Ontario, Canada, L8N 3Z5 Contact: Mark Duffett, PhD ?? ?? ?? Principal Investigator: Mark Duffett ?? ?? ?? Sub-Investigator: Karen Choong ?? ?? ?? Children's Hospital - London Health Science Centre Not yet recruiting London, Ontario, Canada, N6A 5W9 Contact: Janice A Tijssen, MD ?? ?? ?? Children's Hospital of Eastern Ontario Not yet recruiting Ottawa, Ontario, Canada, K1H 8L1 Contact: Kusum Menon, MD ?? ?? ?? Hospital for Sick Children Not yet recruiting Toronto, Ontario, Canada Contact: Alejandro Floh, MD ?? ?? ?? Canada, Quebec CHU Sainte-Justine Recruiting Montreal, Quebec, Canada Contact: Jacques Lacroix, MD ?? ?? ?? Montreal Children's Hospital Recruiting Montréal, Quebec, Canada Contact: Patricia Fontela, MD, PhD Less <<
NCT00304421 Gastroesophageal Reflux Diseas... More >>e Less << Phase 4 Completed - United States, California ... More >> VA Greater Los Angeles Healthcare System Los Angeles, California, United States, 90073 Less <<
NCT01703858 Healthy Phase 1 Completed - Germany ... More >> 1314.3.1 Boehringer Ingelheim Investigational Site Ingelheim, Germany Less <<
NCT01703858 - Completed - -
NCT02170623 Healthy Phase 1 Completed - -
NCT00768651 - Completed - -
NCT00768651 Type 1 Diabetes Phase 2 Completed - Canada, Alberta ... More >> University of Alberta - Clinical Islet Transplant Program Edmonton, Alberta, Canada, T6G2C8 Less <<
NCT00362609 Gastroesophageal Reflux Phase 3 Completed - -
NCT00362609 - Completed - -
NCT01801280 Bioavailability ... More >> Drug Interactions Less << Phase 4 Completed - Germany ... More >> Charité Hospital Campus Mitte Berlin, Germany, 10117 Less <<
NCT00868296 Gastroesophageal Reflux Phase 3 Completed - -
NCT01801280 - Completed - -
NCT00206050 Healthy Phase 4 Completed - United States, Oklahoma ... More >> Research Site Oklahoma City, Oklahoma, United States Less <<
NCT00950339 Coronary Heart Disease ... More >> GI Bleeding Less << Phase 4 Completed - Israel ... More >> Tel Aviv Medical Center Tel Aviv, Israel Less <<
NCT00410592 Gastroesophageal Reflux Diseas... More >>e Less << Phase 4 Completed - United States, California ... More >> Research Site Anaheim, California, United States Research Site Orange, California, United States Research Site San Diego, California, United States United States, Florida Research Site Miami, Florida, United States United States, Illinois Research Site Chicago, Illinois, United States United States, North Carolina Research SIte Chapel Hill, North Carolina, United States United States, Texas Research Site Houston, Texas, United States Puerto Rico Research Site San Juan, Puerto Rico Less <<
NCT00195208 Gastroesophageal Reflux ... More >> Esophagitis Less << Phase 3 Completed - United States, California ... More >> Anaheim, California, United States, 92801 Los Angeles, California, United States, 90073 Orange, California, United States, 92869 San Diego, California, United States, 92103 United States, Florida Miami, Florida, United States, 33173 United States, Oklahoma Oklahoma City, Oklahoma, United States, 73104 Oklahoma City, Oklahoma, United States, 73112 United States, Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Philadelphia, Pennsylvania, United States, 19140 Less <<
NCT00868296 - Completed - -
NCT02084420 Peptic Ulcer Phase 3 Completed - Korea, Republic of ... More >> Soonchunhang University Hospital Bucheon-si, Gyeonggi-do, Korea, Republic of Inje Busan Paik Hospital Busan, Korea, Republic of Pusan National University Hospital Busan, Korea, Republic of Kyungpook National University Medical Center Daegu, Korea, Republic of Yeungnam University Medical Center Daegu, Korea, Republic of Konyang University Hospital Daejeon, Korea, Republic of Gachon University Gill Medical Center Incheon city, Korea, Republic of Wonkwang University of Medicine & Hospital Jeollabuk-do, Korea, Republic of Chung Ang University Hospital Seoul, Korea, Republic of Ewha Womens University Mokdong Hospital Seoul, Korea, Republic of Inje University Seoul Paik Hospital Seoul, Korea, Republic of Kangbuk Samsung Hospital Seoul, Korea, Republic of KyungHee University Medical center Seoul, Korea, Republic of Seoul Asan hoapital Seoul, Korea, Republic of Seoul National University Hospital Seoul, Korea, Republic of Severance Hospital Seoul, Korea, Republic of The Catholic University of Korea, Seoul Seoul, Korea, Republic of Wonju Severance Christian Hospital Wonju-si, Gangwon-do, Korea, Republic of Less <<
NCT01848457 Osteosarcoma ... More >>Nephrotoxicity Ototoxicity Less << Phase 2 Active, not recruiting January 2019 United States, Pennsylvania ... More >> Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 Less <<
NCT00040495 Peptic Ulcer Hemorrhage Phase 3 Completed - -
NCT00237367 Gastroesophageal Reflux Phase 4 Completed - -
NCT00325676 Gastroesophageal Reflux Diseas... More >>e Less << Phase 4 Completed - -
NCT01882296 Healthy Male Subjects Phase 1 Unknown - -
NCT02170805 Healthy Phase 1 Completed - -
NCT02209831 Healthy Phase 1 Completed - -
NCT00261339 Gastroesophageal Reflux ... More >> GERD GORD Less << Phase 4 Completed - United Kingdom ... More >> Altana Pharma/Nycomed Antrim, United Kingdom, BT41 3AE Altana Pharma/Nycomed Ashford, United Kingdom, TW15 3RN Altana Pharma/Nycomed Aston Clinton, Aylesbury, United Kingdom, HP22 5LB Altana Pharma/Nycomed Atherstone, Warwick, United Kingdom, CV9 1EU Altana Pharma/Nycomed Bangor, Northern Ireland, United Kingdom, BT19 1PP Altana Pharma/Nycomed Barry, Vale of Glamorgan, Cardiff, United Kingdom, CF63 4HP Altana Pharma/Nycomed Barry, United Kingdom, CS62 7EB Altana Pharma/Nycomed Bath, United Kingdom, BA1 2SR Altana Pharma/Nycomed Bath, United Kingdom, BA2 4BY Altana Pharma/Nycomed Belfast, United Kingdom, BT5 7BP Altana Pharma/Nycomed Belfast, United Kingdom, BT7 1DA Altana Pharma/Nycomed Bexhill-on-Sea, Easr Sussex, United Kingdom, TN40 1JJ Altana Pharma/Nycomed Blackpool, United Kingdom, FY3 7EN Altana Pharma/Nycomed Bradford on Avon, Wiltshire, United Kingdom, BA15 1DQ Altana Pharma/Nycomed Cardiff (Wales), United Kingdom, CF14 9BB Altana Pharma/Nycomed Chesterfield, United Kingdom, S40 1LE Altana Pharma/Nycomed Chesterfield, United Kingdom, S40 4TF Altana Pharma/Nycomed Chippenham, Wiltshire, United Kingdom, SN15 2SB Altana Pharma/Nycomed Chippenham, United Kingdom, SN15 1HP Altana Pharma/Nycomed Cookstown, United Kingdom, BT80 8BG Altana Pharma/Nycomed Crawley, West Sussex, United Kingdom, RH10 1LL Altana Pharma/Nycomed Crawley, United Kingdom, RH10 7DX Altana Pharma/Nycomed Downpatrick, Northern Ireland, United Kingdom, BT30 6HY Altana Pharma/Nycomed Dronfield, United Kingdom, S18 1RU Altana Pharma/Nycomed Ely, United Kingdom, CF5 4AE Altana Pharma/Nycomed Glasgow, United Kingdom, G45 9AW Altana Pharma/Nycomed Hull, United Kingdom, HU3 3BH Altana Pharma/Nycomed Kent, United Kingdom, CT5 1BZ Altana Pharma/Nycomed Keresely End, Coventry, United Kingdom, CV7 8LA Altana Pharma/Nycomed Leigh Lancs, United Kingdom, WN7 2RB Altana Pharma/Nycomed Leigh on Sea, Essex, United Kingdom, SS9 2SQ Altana Pharma/Nycomed Lisburn, United Kingdom, BT28 1LU Altana Pharma/Nycomed Middlesex, United Kingdom, HA6 2RN Altana Pharma/Nycomed New Street, Ledbury, United Kingdom, HR8 2DX Altana Pharma/Nycomed Sheffield, United Kingdom, S39DA Altana Pharma/Nycomed Sheffield, United Kingdom, S5 7QB Altana Pharma/Nycomed Slough, Berks, United Kingdom, SI2 1HD Altana Pharma/Nycomed Somerset, United Kingdom, BA111EZ Altana Pharma/Nycomed Southdown, Bath, United Kingdom, BA2 1NH Altana Pharma/Nycomed St George`s Way, Sunderland, United Kingdom, SR2 7BW Altana Pharma/Nycomed Sunbury on Thames, Middlesex, United Kingdom, TW16 6RH Altana Pharma/Nycomed Trowbridge, Wilts, United Kingdom, BA14 7EG Altana Pharma/Nycomed Trowbridge, United Kingdom, BA14 9AR Altana Pharma/Nycomed Warminster Wiltshire, United Kingdom, BA12 9AA Altana Pharma/Nycomed Watford, United Kingdom, WD25 0EA Less <<
NCT02264119 Healthy Phase 1 Completed - -
NCT00307944 Acid Reflux Disease ... More >> Obstructive Sleep Apnea Less << Phase 4 Completed - United States, Ohio ... More >> University Ear, Nose and Throat Specialists Cincinnati, Ohio, United States, 45267-0528 Less <<
NCT00037570 Peptic Ulcer Hemorrhage Phase 2 Completed - United States, California ... More >> Los Angeles, California, United States, 90073 San Diego, California, United States, 62103-8401 United States, Ohio Cincinnati, Ohio, United States, 45267-0595 United States, Pennsylvania Philadelphia, Pennsylvania, United States, 19140 United States, Texas Houston, Texas, United States, 77030-4211 United States, Virginia Norfolk, Virginia, United States, 23507 Less <<
NCT02264106 Healthy Phase 1 Completed - -
NCT02028234 Coronary Artery Disease Phase 4 Unknown April 2016 Italy ... More >> Sapienza Univeristy of Rome Not yet recruiting Rome, Italy, 00166 Contact: MD Marina Polacco ?? +393333347960 ?? dott.mpolacco@gmail.com ?? Principal Investigator: MD Marina Polacco Less <<
NCT02173730 Healthy Phase 1 Completed - -
NCT02170610 Healthy Phase 1 Completed - -
NCT00141817 Gastroesophageal Reflux Phase 3 Completed - -
NCT00625274 Heartburn Upp... More >>er Abdominal Pain Nausea Acid Regurgitation Less << Phase 4 Completed - -
NCT02551744 Peptic Ulcer Not Applicable Recruiting July 2018 Taiwan ... More >> Kaohsiung Veterans General Hospital Recruiting Kaohsiung, Taiwan, 813 Contact: Ping I Hsu, MD ?? 886-7346-8237 ?? williamhsup@yahoo.com.tw ?? Contact: Feng-Woei Chiae, Bachelor ?? +886-7-342-2121 ext 2074 ?? fwchiae@vghks.gov.tw ?? Sub-Investigator: Ping I Hsu, MD Less <<
NCT01608750 Nonulcer Dyspepsia Phase 4 Unknown June 2013 Turkey ... More >> Bezmialem medical faculty Not yet recruiting Istanbul, Turkey Contact: Birol Baysal ?? +905057758585 ?? babbaysal@gmail.com ?? Principal Investigator: Birol Baysal Less <<
NCT02274961 Non Erosive Reflux Disease Phase 3 Unknown - Korea, Republic of ... More >> Seoul National University Bundang Hospital Recruiting Sung-Nam, Gyeong-gi, Korea, Republic of Contact: Dong-Ho Lee, Professor ?? ?? ?? Soon Chun Hyang University Hospital Bucheon Recruiting Bucheon, GyeongGi-Do, Korea, Republic of Contact: Su-Jin Hong, Professor ?? ?? ?? Bundang CHA Medical Center Recruiting Sung-Nam, Gyeonggi-do, Korea, Republic of Contact: Gwang-Hyun Go, Professor ?? ?? ?? Yeungnam University Medical Center Recruiting Daegu, Korea, Republic of Contact: Si-Hyung Lee, Professor ?? ?? ?? Asan Medical Center Recruiting Seoul, Korea, Republic of Contact: Hun-Yong Jung, Professor ?? ?? ?? Gangnam Severance Hospital Recruiting Seoul, Korea, Republic of Contact: Hyo-Jin Park, Professor ?? ?? ?? Seoul Metropolitan Government Seoul National University Boramae Medical Center Recruiting Seoul, Korea, Republic of Contact: Ji-Won Kim, Professor ?? ?? ?? Seoul National University Hospital Recruiting Seoul, Korea, Republic of Contact: Sang-Gyun Kim, Professor ?? ?? ?? Seoul St. Mary's Hospital Recruiting Seoul, Korea, Republic of Contact: JINHYUNG KIM ?? 82-2-3289-4362 ?? jhkim04@ahn-gook.com ?? Severance Hospital Recruiting Seoul, Korea, Republic of Contact: Yong-Chan Lee, Professor Less <<
NCT00161096 Chronic Use of Acid Suppressiv... More >>e Medication GORD GERD Reflux Peptic Ulcer Less << Phase 3 Unknown - -
NCT00449813 Gastroesophageal Reflux Diseas... More >>e Non-erosive Reflux Disease Less << Phase 4 Terminated(Inclusion-rate does... More >> not seem feasible anymore to obtain te required number of patients before the end of the trial.) Less << - Netherlands ... More >> Altana Pharma/Nycomed BT Oss, Netherlands, 5342 Altana Pharma/Nycomed Den Helder, Netherlands, 1782 GZ Altana Pharma/Nycomed EH Geldrop, Netherlands, 5664 Switzerland Altana Pharma/Nycomed Basel, Switzerland, 4001 Altana Pharma/Nycomed Basel, Switzerland, 4051 Altana Pharma/Nycomed Biel/Bienne, Switzerland, 2502 Altana Pharma/Nycomed Bülach, Switzerland, 8180 Altana Pharma/Nycomed Locarno, TI., Switzerland, 6600 Altana Pharma/Nycomed Luzern, Switzerland, 6003 Altana Pharma/Nycomed Luzern, Switzerland, 6004 Altana Pharma/Nycomed Reinach BL, Switzerland, 4153 Altana Pharma/Nycomed Sion, Switzerland, 1950 Altana Pharma/Nycomed Thun, Switzerland, 3600 Altana Pharma/Nycomed Winterthur, Switzerland, 8400 Altana Pharma/Nycomed Zürich, Switzerland, 8050 Less <<
NCT01499693 Gastric pH Control Phase 3 Withdrawn - Mexico ... More >> Hospital Espa?ol de Mexico Mexico City, Mexico, 11850 Less <<
NCT00141817 - Completed - -
NCT01821521 Healthy Male Subjects Phase 1 Unknown - Korea, Republic of ... More >> Asan Medical Center Not yet recruiting Seoul, Korea, Republic of Contact: Cheul-Hun Seong ?? +82-2-3289-4284 ?? ?? Principal Investigator: Kyun-Seop Bae, M.D., Ph.D. Less <<
NCT00365300 Gastroesophageal Reflux Phase 3 Completed - -
NCT00839488 Stomach Ulcer Phase 4 Terminated(the chief of GS lef... More >>t the hopsital and the successor did't want to keep on this study) Less << - Taiwan ... More >> Far Eastern Memorial Hospital Taipei, Taiwan, 22050 Less <<
NCT01710462 Gastroesophageal Reflux Diseas... More >>e Less << Phase 3 Withdrawn(Change of company's ... More >>strategy) Less << - Brazil ... More >> Goiania Goiania, Goias, Brazil Belo Horizonte Belo Horizonte, Minas Gerais, Brazil Curitiba Curitiba, Paraná, Brazil Porto Alegre Porto Alegre, Rio Grande do Sul, Brazil Campinas Campinas, S?o Paulo, Brazil Jaú Jaú, S?o Paulo, Brazil S?o José do Rio Preto S?o José do Rio Preto, S?o Paulo, Brazil Rio de Janeiro Rio de Janeiro, Brazil Less <<
NCT00365300 - Completed - -
NCT00163306 Gastroesophageal Reflux Phase 3 Completed - -
NCT02235311 Upper Gastrointestinal Bleed Not Applicable Terminated(Difficulty recruiti... More >>ng and consenting participants) Less << - United States, Missouri ... More >> University Hospital Columbia, Missouri, United States, 65112 Less <<
NCT00336219 GERD Phase 3 Completed - Australia ... More >> Altana Pharma/Nycomed Bondi Junction, Australia, NSW 2022 Altana Pharma/Nycomed Box Hill, Victoria, Australia, 3128 Altana Pharma/Nycomed New South Wales, Australia, 2138 Altana Pharma/Nycomed South Australia, Australia, 5000 Austria Altana Pharma/Nycomed Feldbach, Austria, 8330 Altana Pharma/Nycomed Graz, Austria, 8020 Altana Pharma/Nycomed Stockerau, Austria, 2000 Altana Pharma/Nycomed Wiener Neustadt, Austria, 2700 Altana Pharma/Nycomed Wien, Austria, 1140 Germany Altana Pharma/Nycomed Amberg, Germany, 92224 Altana Pharma/Nycomed Aschersleben, Germany, 6449 Altana Pharma/Nycomed Berlin, Germany, 10409 Altana Pharma/Nycomed Berlin, Germany, 12587 Altana Pharma/Nycomed Berlin, Germany, 13581 Altana Pharma/Nycomed Freising, Germany, 85356 Altana Pharma/Nycomed Germersheim, Germany, 76726 Altana Pharma/Nycomed Grünstadt, Germany, 67269 Altana Pharma/Nycomed Jülich, Germany, 52428 Altana Pharma/Nycomed K?ln, Germany, 50999 Altana Pharma/Nycomed K?ln, Germany, 51065 Altana Pharma/Nycomed K?then, Germany, 6366 Altana Pharma/Nycomed Künzing, Germany, 94550 Altana Pharma/Nycomed Landsberg, Germany, 6188 Altana Pharma/Nycomed Langen, Germany, 63225 Altana Pharma/Nycomed Leipzig, Germany, 4105 Altana Pharma/Nycomed Ludwigshafen, Germany, 67067 Altana Pharma/Nycomed Lüneburg, Germany, 21335 Altana Pharma/Nycomed M?nchengladbach, Germany, 41239 Altana Pharma/Nycomed München, Germany, 80639 Altana Pharma/Nycomed Potsdam-Babelsberg, Germany, 14482 Altana Pharma/Nycomed Reinfeld, Germany, 23858 Altana Pharma/Nycomed Saarbrücken, Germany, 66111 Hungary Altana Pharma/Nycomed Budapest, Hungary, 1125 Altana Pharma/Nycomed Gy?r, Hungary, 9024 Altana Pharma/Nycomed Hatvan, Hungary, 3000 Altana Pharma/Nycomed Kaposvár, Hungary, 7400 Altana Pharma/Nycomed Kistarcsa, Hungary, 2143 Altana Pharma/Nycomed Miskolc, Hungary, 3526 Altana Pharma/Nycomed Szentes, Hungary, 6600 Altana Pharma/Nycomed Vác, Hungary, 2601 Less <<
NCT01322633 - Completed - -
NCT01129427 Healthy Phase 1 Completed - United States, New Jersey ... More >> Sanofi-Aventis Administrative Office Bridgewater, New Jersey, United States, 08807 Less <<
NCT02235311 - Terminated(Difficulty recruiti... More >>ng and consenting participants) Less << - -
NCT01322633 - Completed - -
NCT01281501 Dyspepsia Eme... More >>rgency Pain Less << Phase 4 Completed - Thailand ... More >> Emergency Medicine Unit, King Chulalongkorn Memorial Hospital Patumwan, Bangkok, Thailand, 11130 Less <<
NCT01281501 - Completed - -
NCT00383916 Healthy Subjects Phase 1 Completed - -
NCT00600041 Healthy Phase 1 Completed - Germany ... More >> Dept. of Cardiology and Pneumology; Herzzentrum Goettingen Goettingen, Germany, 37099 Less <<
NCT00938366 - Completed - -
NCT00246909 Gastroesophageal Reflux Phase 4 Completed - -
NCT00300755 Gastroesophageal Reflux Phase 3 Completed - -
NCT02788123 NSAID-induced Gastropathy Phase 4 Terminated(Internal reassessme... More >>nt of the medicinal product development strategy by Sponsor) Less << - Russian Federation ... More >> Site RU70001 Moscow, Russian Federation Site RU70008 Saint-Petersburg, Russian Federation Site RU70012 Saint-Petersburg, Russian Federation Site RU70006 Volgograd, Russian Federation Site RU70013 Volgograd, Russian Federation Less <<
NCT00300755 - Completed - -
NCT00881413 Peptic Ulcer Phase 4 Withdrawn(problems in funding) - -
NCT02733640 Antiplatelet Effect Not Applicable Completed - Korea, Republic of ... More >> Seoul National University Bundang Hospital Seongnam, Gyeonggi-do, Korea, Republic of, 463-707 Less <<
NCT01737840 Dyspepsia Phase 4 Completed - Turkey ... More >> Akdeniz University Antalya, Turkey, 07050 Less <<
NCT00261300 Gastroesophageal Reflux Diseas... More >>e (GERD) Peptic Ulcers Less << Phase 3 Completed - Germany ... More >> Altana Pharma/Nycomed Hannover, Germany, 30659 Less <<
NCT01737840 - Completed - -
NCT01847404 Ulcers, Duodenal and Gastric Phase 1 Completed - India ... More >> GSK Investigational Site Hyderabad, India, 500 013 Less <<
NCT00938366 Multiple Sclerosis Phase 1 Completed - -
NCT01735227 Acute Coronary Syndromes Phase 4 Unknown October 2013 China, Liaoning ... More >> OPEN trail Not yet recruiting Shenyang, Liaoning, China, 110016 Contact: Han Yaling, MD ?? +86-24-28897309 ?? lijing790126@sina.com ?? ShenyangNH Not yet recruiting Shenyang, Liaoning, China, 110016 Contact: Han Yaling MD ?? +86-24-23922184 ?? hanyaling@263.net Less <<
NCT00843063 Peptic Ulcer/Erosions Phase 4 Completed - China, Hong Kong ... More >> Ruttonjee Hospital Wan Chai, Hong Kong, China Less <<
NCT01847417 Ulcers, Duodenal and Gastric Phase 1 Completed - India ... More >> GSK Investigational Site Hyderabad, India, 500 013 Less <<
NCT00829738 - Completed - -
NCT01132638 GERD Phase 3 Completed - Brazil ... More >> Investigational site Belo Horizonte/MG, Brazil Investigational site Curitiba/PR, Brazil Investigational site Goiania/GO, Brazil Investigational site Porto Alegre/RS, Brazil Investigational site Ribeir?o Preto/SP, Brazil Investigational site Rio de Janeiro/RJ, Brazil Investigational site Salvador/BA, Brazil Investigational site Santo André/SP, Brazil Investigational site S?o Paulo/SP, Brazil Less <<
NCT01146483 Drug Interaction Potentiation Phase 1 Completed - Canada, Quebec ... More >> Centre hospitalier de l'Université de Montréal (CHUM) Montreal, Quebec, Canada, H2W1T7 Less <<
NCT00259012 Gastroesophageal Reflux Phase 3 Completed - -
NCT00829738 - Completed - -
NCT02108756 Bleeding Gastric Ulcer ... More >> Bleeding Duodenal Ulcer Less << Not Applicable Unknown June 2015 China, Shaanxi ... More >> The first affiliated hospital of the Fourth Military Medical University Recruiting Xi'an, Shaanxi, China, 710032 Contact: Han Ying, doctor ?? 13991963770 ?? hanying@fmmu.edu.cn ?? Principal Investigator: Fan Dai ming, doctor ?? ?? ?? Principal Investigator: Wu Kai chun, doctor ?? ?? ?? Sub-Investigator: Han Ying, doctor Less <<
NCT00668902 - Completed - -
NCT00668902 Healthy Not Applicable Completed - United States, Indiana ... More >> Indiana University Indianapolis, Indiana, United States, 46202 Less <<
NCT01418417 Healthy Phase 1 Completed - India ... More >> Lotus Labs Pvt. Ltd. Bangalore,, Karnataka,, India Less <<
NCT01418443 Healthy Phase 1 Completed - India ... More >> Lotus Labs Pvt. Ltd. Bangalore,, Karnataka,, India Less <<
NCT00259012 - Completed - -
NCT02186652 Gastroesophageal Reflux Diseas... More >>e Less << Phase 1 Completed - United States, Arkansas ... More >> University of Arkansas Little Rock, Arkansas, United States, 72202 United States, Missouri Children's Mercy Hospital Kansas City, Missouri, United States, 64108 United States, North Carolina East Carolina University Greenville, North Carolina, United States, 27834 United States, Utah University of Utah Salt Lake City, Utah, United States, 84108 Less <<
NCT00367614 Gastroesophageal Reflux Phase 3 Completed - -
NCT00835393 Healthy Phase 1 Completed - United States, Missouri ... More >> Gateway Medical Research, Inc. St. Charles, Missouri, United States, 63301 United States, Texas Bioassay Laboratory, Inc. Houston, Texas, United States, 77099 Less <<
NCT00561730 - Completed - -
NCT00561730 - Completed - -
NCT01214408 Acid Peptic Disorder Phase 4 Completed - India ... More >> Site Reference ID/Investigator# 42043 Chennai, India, 600 096 Less <<
NCT01541735 Type 2 Diabetes Phase 2 Phase 3 Completed - Mexico ... More >> Instituto Mexicano del Seguro Social. Hospital de Especialidades. Guadalajara, Jalisco, Mexico, 44380 Less <<
NCT00562094 - Completed - -
NCT01541735 - Completed - -
NCT01179659 Healthy Phase 1 Completed - Canada, Quebec ... More >> MDS Pharma Services Saint-Laurent, Montreal, Quebec, Canada, H4R 2N6 Less <<
NCT00830115 - Completed - -
NCT02345239 Diabetes Mellitus Phase 3 Unknown - -
NCT00699361 Congestive Heart Failure Phase 3 Withdrawn(Study withdrawn for ... More >>financial issues) Less << - Germany ... More >> Johann Wolfgang Goethe University Hospitals, Department of Cardiology Frankfurt am Main, Germany, 60590 Less <<
NCT02401035 Gastroesophageal Reflux Diseas... More >>e Less << Phase 4 Recruiting August 30, 2022 United States, Michigan ... More >> Children's Hospital of Michigan Recruiting Detroit, Michigan, United States, 48201 Bronson Methodist Hospital Recruiting Kalamazoo, Michigan, United States, 49007 Western Michigan University Homer Stryker M.D. School of Medicine Center of Clinical Research Recruiting Kalamazoo, Michigan, United States, 49007 United States, New York Albany Medical Center Hospital Recruiting Albany, New York, United States, 12208 Columbia University Medical Center / New York Presbyterian Hospital Recruiting New York, New York, United States, 10032 NewYork-Presbyterian Morgan Stanley Children's Hospital Recruiting New York, New York, United States, 10032 United States, North Carolina East Carolina University, Pediatric Gastroenterology Recruiting Greenville, North Carolina, United States, 27834 Vidant Medical Center Recruiting Greenville, North Carolina, United States, 27834 United States, Texas Children's Health Specialty Center Dallas Campus Recruiting Dallas, Texas, United States, 75207 Children's Medical Center Dallas Recruiting Dallas, Texas, United States, 75235 United States, Utah Primary Children's Hospital Recruiting Salt Lake City, Utah, United States, 84113 Argentina Hospital General de Agudos Dr. Ignacio Pirovano Not yet recruiting Buenos Aires, Ciudad Autónoma DE Buenos Aires, Argentina, C1430BKC Germany Klinik für Kinder- und Jugendmedizin der Ruhr-Universit?t Bochum im St. Josef-Hospital Recruiting Bochum, Germany, 44791 Zentralapotheke St. Joseph Hospital Recruiting Bochum, Germany, 44791 Italy Azienda Ospedaliera Universitaria Federico II di Napoli Servizio di Endoscopia Recruiting Napoli, Italy, 80131 Farmacia - AOU Federico II di Napoli Recruiting Napoli, Italy, 80131 Centro Trials - Dipartimento Pediatrico Universitario Ospedaliero Padiglione Salviati Recruiting Roma, Italy, 00165 IRCCS Ospedale Pediatrico Bambino Gesù Recruiting Roma, Italy, 00165 IRCCS-Ospedale Pediatrico Bambino Gesù Farmacia Ospedaliera Recruiting Roma, Italy, 00165 Serbia Clinical Center Nis, Childrens Clinic of Internal Medicine Recruiting Nis, Serbia, 18000 Institute for Child and Youth Health Care of Vojvodina Recruiting Novi Sad, Serbia, 21000 Slovakia Detska fakultna nemocnica s poliklinikou Bratislava Recruiting Bratislava, Slovakia, 833 40 Univerzitna nemocnica Martin Recruiting Martin, Slovakia, 036 59 Spain Hospital Universitari Vall d′Hebron Recruiting Barcelona, Spain, 08035 Less <<
NCT02213887 Psychotic Disorders ... More >> Gastroesophageal Reflux Less << Phase 4 Active, not recruiting August 2018 Canada, British Columbia ... More >> UBC Hospital - Detwiller Pavilion Vancouver, British Columbia, Canada, V6T 2A1 Less <<
NCT00830115 - Completed - -
NCT00562094 - Completed - -
NCT01179646 Healthy Phase 1 Completed - United States, Nebraska ... More >> MDS Pharma Services Lincoln, Nebraska, United States, 68502 Less <<
NCT00326027 Gastroesophageal Reflux Phase 3 Completed - Germany ... More >> Nycomed Deutschland GmbH Augsburg, Germany, 86156 Nycomed Deutschland GmbH Berlin, Germany, 10117 Nycomed Deutschland GmbH Brandenburg, Germany, 14770 Nycomed Deutschland GmbH Erlangen, Germany, 91054 Nycomed Deutschland GmbH Frankfurt, Germany, 60488 Nycomed Deutschland GmbH Frankfurt, Germany, 60569 Nycomed Deutschland GmbH Gera, Germany, 07548 Nycomed Deutschland GmbH Greifswald, Germany, 17489 Nycomed Deutschland GmbH G?ttingen, Germany, 37075 Nycomed Deutschland GmbH Halle (Saale), Germany, 06110 Nycomed Deutschland GmbH Hamburg, Germany, 21075 Nycomed Deutschland GmbH Hamburg, Germany, 22457 Nycomed Deutschland GmbH Ingolstadt, Germany, 85049 Nycomed Deutschland GmbH Jena, Germany, 07747 Nycomed Deutschland GmbH Kassel, Germany, 34125 Nycomed Deutschland GmbH Kiel, Germany, 24105 Nycomed Deutschland GmbH K?ln, Germany, 51067 Nycomed Deutschland GmbH K?ln, Germany, 51109 Nycomed Deutschland GmbH Leipzig, Germany, 04103 Nycomed Deutschland GmbH Ludwigsburg, Germany, 71640 Nycomed Deutschland GmbH Ludwigshafen, Germany, 67063 Nycomed Deutschland GmbH Lübeck, Germany, 23538 Nycomed Deutschland GmbH Mainz, Germany, 55131 Nycomed Deutschland GmbH Marburg, Germany, 35043 Nycomed Deutschland GmbH Minden, Germany, 32427 Nycomed Deutschland GmbH München, Germany, 81377 Nycomed Deutschland GmbH Münster, Germany, 48149 Nycomed Deutschland GmbH Neubrandenburg, Germany, 17036 Nycomed Deutschland GmbH Offenbach, Germany, 63069 Nycomed Deutschland GmbH Oldenburg, Germany, 26133 Nycomed Deutschland GmbH Recklinghausen, Germany, 45655 Nycomed Deutschland GmbH Rostock, Germany, 18057 Nycomed Deutschland GmbH Stade, Germany, 21682 Nycomed Deutschland GmbH Weimar, Germany, 99425 Nycomed Deutschland GmbH Wiesbaden, Germany, 65189 Less <<
NCT01748500 Prostate Cancer Phase 2 Active, not recruiting December 2018 Canada, Ontario ... More >> Princess Margaret Cancer Centre Toronto, Ontario, Canada, M5G2M9 Less <<
NCT00744419 Gastroesophageal Reflux Phase 1 Completed - United States, Kentucky ... More >> University of Louisville Research Foundation, Inc/KCPCRU Louisville, Kentucky, United States, 40202 Less <<
NCT00674245 Gastroesophageal Reflux Diseas... More >>e Less << Phase 2 Phase 3 Completed - United States, Arizona ... More >> Southern Arizona VA Health Care System Tucson, Arizona, United States, 85723 Less <<
NCT00835588 Healthy Phase 1 Completed - United States, Missouri ... More >> Gateway Medical Research, Inc. St. Charles, Missouri, United States, 63301 United States, Texas Bioassay Laboratory, Inc. Houston, Texas, United States, 77099 Less <<
NCT00312806 Gastroesophageal Reflux Diseas... More >>e (GERD) Less << Phase 3 Completed - -
NCT01654718 Healthy Not Applicable Completed - India ... More >> Clinical Pharmacology Unit, Ranbaxy Laboratories Limited Noida, Uttar Pradesh, India Less <<
NCT00133770 Esophagitis Phase 4 Completed - United States, Georgia ... More >> Emory University School of Medicine Atlanta, Georgia, United States, 30322 Less <<
NCT01654705 Healthy Not Applicable Completed - India ... More >> Clinical Pharmacology Unit, Ranbaxy Laboratories Limited Noida, Uttar Pradesh, India, 201301 Less <<
NCT01887743 Obesity GERD Phase 1 Unknown July 2015 United States, Missouri ... More >> Children's Mercy Hospital and Clinics Not yet recruiting Kansas City, Missouri, United States, 64108 Principal Investigator: Gregory L Kearns, Pharm.D.,PhD ?? ?? ?? Children's Mercy Hospital and Clinics Recruiting Kansas CIty, Missouri, United States, 64108 Contact: Jaylene D Weigel, RN ?? 816-701-1338 ?? jweigel@cmh.edu ?? Contact: Valentina Shakhnovich, MD ?? 816-234-3016 ?? vshakhnovich@cmh.edu Less <<
NCT00835588 - Completed - -
NCT01283932 FED Phase 1 Completed - India ... More >> VimtaLabsLtd. Hyderabad, Andhrapradesh, India, 500 051 Less <<
NCT01163903 Advanced Solid Tumours Phase 1 Completed - Canada, Ontario ... More >> Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Less <<
NCT01283919 Fasting Phase 1 Completed - India ... More >> VimtaLabsLtd. Hyderabad, Andhrapradesh, India, 500 051 Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.47mL

0.49mL

0.25mL

12.34mL

2.47mL

1.23mL

24.67mL

4.93mL

2.47mL

References

 

Historical Records

Categories