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Chemical Structure| 138530-94-6 Chemical Structure| 138530-94-6
Chemical Structure| 138530-94-6

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CAS No.: 138530-94-6

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(R)-Lansoprazole, the dextrorotatory enantiomer of lansoprazole, can irreversibly inactivate the H+/K+-stimulated ATPase pump.

Synonyms: Dexlansoprazole; T-168390; TAK-390

4.5 *For Research Use Only !

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Product Details of (R)-Lansoprazole

CAS No. :138530-94-6
Formula : C16H14F3N3O2S
M.W : 369.36
SMILES Code : O=[S@@](C1=NC2=CC=CC=C2N1)CC3=NC=CC(OCC(F)(F)F)=C3C
Synonyms :
Dexlansoprazole; T-168390; TAK-390
MDL No. :MFCD13196699
InChI Key :MJIHNNLFOKEZEW-RUZDIDTESA-N
Pubchem ID :9578005

Safety of (R)-Lansoprazole

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Target
  • Proton Pump

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00274339 Laryngopharyngeal Reflux Not Applicable Unknown June 2008 United States, Kentucky ... More >> Commonwealth Ear, Nose & Throat Recruiting Louisville, Kentucky, United States, 40207 Contact: Marti Gardner, MSN ?? 502-893-0159 ext 1185 ?? mgardner@commonwealthent.com ?? Principal Investigator: Kenneth M Hodge, MD ?? ?? ?? Sub-Investigator: John R Morris, MD ?? ?? ?? Sub-Investigator: Donald V Welsh, MD ?? ?? ?? Sub-Investigator: Gorden T McMurry, MD ?? ?? ?? Sub-Investigator: Andrew R Gould, MD ?? ?? ?? Sub-Investigator: Keith D Forwith, PhD, MD ?? ?? ?? Sub-Investigator: Steven D Shotts, MD ?? ?? ?? Sub-Investigator: Tamalynn O'Daniel, MSN, ARNP ?? ?? ?? Sub-Investigator: Jolene H Boswell, PA-C ?? ?? ?? Sub-Investigator: Mary S McLaughlin, PA-C ?? ?? ?? Sub-Investigator: Martha L Gardner, MSN, ARNP ?? ?? ?? Sub-Investigator: Brian Walker, PA-C Less <<
NCT02297126 Adverse Drug Reaction Not Applicable Completed - United States, Indiana ... More >> Eskenazi Health System Indianapolis, Indiana, United States, 46250 Less <<
NCT00237679 Voice Disorders ... More >> Gastroesophageal Reflux Less << Not Applicable Terminated(Terminated due to f... More >>unding loss.) Less << - United States, Wisconsin ... More >> University of Wisconsin Madison, Wisconsin, United States, 53792 Less <<
NCT01922505 - Completed - Korea, Republic of ... More >> Seoul National University Bundang Hospital Bundang-gu, Seongnam, Gyeonggi-do, Korea, Republic of, 463-707 Less <<
NCT02442752 Pediatric Gastroesophageal Ref... More >>lux Disease Less << PHASE1 WITHDRAWN 2025-12-23 Children's Hospital Los Angele... More >>s, Los Angeles, California, 90027, United States|University of Louisville, Louisville, Kentucky, 40202, United States|Johns Hopkins University School Of Medicine, Baltimore, Maryland, 21218, United States|Michigan Pediatric GI Center, Flint, Michigan, 48532, United States|Promedica Toledo Children's Hospital, Toledo, Ohio, 43606, United States|Cook Children's Medical Center, Fort Worth, Texas, 76104, United States|Hadassah University Hospital - Ein Kerem, Jerusalem, 9112001, Israel|Schneider Children's Medical Center, Petach-Tikva, 4920235, Israel|Sheba Medical Center, Ramat Gan, 5262000, Israel|Assaf Harofeh M.C, Rishon Lezion, 75309, Israel|Azienda Ospedaliera Universitaria "Federico II", Napoli, 80131, Italy|Umberto I Pol. di Roma-Universita di Roma La Sapienza, Roma, 00161, Italy|Ospedale Pediatrico Bambino Gesu, Roma, 00165, Italy|Policlinico Universitario Agostino Gemelli, Roma, 00168, Italy|Centro de Investigacion Clinica Acelerada, S.C., Mexico, Distrito Federal, 07020, Mexico|Centro de Investigacion Clinica Chapultepec S.A. de C.V., Morelia, Michoacan, 58260, Mexico|Accelerium S. de R.L. de C.V., Monterrey, Nuevo Leon, 64000, Mexico|Szpital Uniwersytecki nr 2 im.dr J. Biziela, Bydgoszcz, 85-168, Poland|Uniwersytecki Szpital Dzieciecy w Krakowie, Krakow, 30-663, Poland|Uniwersytecki Szpital Dzieciecy w Lublinie, Lublin, 20-093, Poland|Szpital Wojewodzki nr 2 w Rzeszowie, Rzeszow, 35-301, Poland|Instytut "Pomnik - Centrum Zdrowia Dziecka", Warszawa, 04-730, Poland Less <<
NCT03050359 Duodenal Ulcer Phase 3 Recruiting June 7, 2019 -
NCT01129713 Gastroesophageal Reflux Diseas... More >>e (GERD) Heartburn Indigestion Less << Phase 1 Phase 2 Unknown May 2015 United States, Arizona ... More >> Southern Arizona Veterans Health Care System Recruiting Tucson, Arizona, United States, 85723 Principal Investigator: Ronnie Fass, MD Less <<
NCT00738543 Healthy Volunteers Phase 3 Completed - Mexico ... More >> University of Guanajuato School of Medicine Leon, Guanajuato, Mexico, 37000 Less <<
NCT02615184 Erosive Esophagitis PHASE2 RECRUITING 2027-10-31 University of South Alabama, M... More >>obile, Alabama, 36604, United States|University of California San Francisco, San Francisco, California, 94158, United States|D&H National Research Centers, Miami, Florida, 33155, United States|Children's Center for Digestive Health Care, LLC, Atlanta, Georgia, 30342, United States|Gastrointestinal Associates, PA, Flowood, Mississippi, 39232, United States|University Hospitals Cleveland Medical Center, Cleveland, Ohio, 44106, United States|Measurable Outcome Research, Oklahoma City, Oklahoma, 73112, United States|GI for Kids, Knoxville, Tennessee, 37922, United States|Vanderbilt University Medical Center, Nashville, Tennessee, 37212, United States|Envision Clinical Research, LLC, Laredo, Texas, 78041, United States|The Children's Hospital of The King's Daughters, Norfolk, Virginia, 23507, United States|Women and Children's Health Research Institute, Edmonton, Alberta, T6G 1C9, Canada|London Health Sciences Centre (LHSC) - Children's Hospital, London, Ontario, N6A 5W9, Canada|Hospital Universitario San Ignacio, Bogota, 110231, Colombia|Fundacion Valle del Lili, Cali, 760032, Colombia|Centro Medico Imbanaco de Cali S.A, Cali, 760042, Colombia|Hospital of Lithuanian University of Health Sciences Kauno Klinikos, Kaunas, LT-50161, Lithuania|Children's Hospital, Affiliate of Vilnius University Hospital Santaros Klinikos, Public Institution, Vilnius, LT-08661, Lithuania|Boca Clinical Trials Mexico SC, Colonia Las Americas, Distrito Federal, 1120, Mexico|Clinical Research Institute S.C., Tlalnepantla, Estado De Mexico, 54055, Mexico|Inspirepharma S. de R.L. de C.V., Monterrey, Nuevo Leon, 64660, Mexico|El Cielo Medical Center, Puebla, 72160, Mexico|SMIQ S. de R.L. de C.V., Queretaro, 76070, Mexico|In Vivo Osrodek Badan Klinicznych, Bydgoszcz, Kuyavia, 85-048, Poland|Uniwersytecki Szpital Dzieciecy w Krakowie, Krakow, Malopolskie, 30-663, Poland|Instytut "Pomnik - Centrum Zdrowia Dziecka", Warszawa, Masovia, 04-730, Poland|Gabinet Lekarski Bartosz Korczowski, Rzeszow, Podkarpackie, 35-302, Poland Less <<
NCT00762359 Stomach Ulcer ... More >> Duodenal Ulcer Less << Phase 3 Terminated(AG-1749 superior to... More >> Gefarnate in ulcer prevention) Less << - -
NCT01321125 Infectious Diseases Phase 3 Completed - Mexico ... More >> University of Guanajuato School of Medicine Leon, Guanajuato, Mexico, 37000 Less <<
NCT00787254 Stomach Ulcer ... More >> Duodenal Ulcer Less << Phase 3 Completed - -
NCT00762359 - Terminated(AG-1749 superior to... More >> Gefarnate in ulcer prevention) Less << - -
NCT00738543 - Completed - -
NCT00787254 - Completed - -
NCT02099708 - Completed - -
NCT02099708 - Completed - -
NCT03050307 Gastric Ulcer ... More >> Peptic Ulcer Gastrointestinal Diseases Digestive System Diseases Lansoprazole Anti-Ulcer Agents Gastrointestinal Agents Proton Pump Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Less << Phase 3 Recruiting April 19, 2019 -
NCT02099682 - Completed - -
NCT02151786 - Completed - -
NCT01131026 Helicobacter Pylori Infection Phase 3 Completed - Turkey ... More >> Erciyes University School of Medicine Hospital, Department of Internal Medicine and Gastroenterology Kayseri, Turkey, 38039 Less <<
NCT02170207 - Completed - -
NCT02151786 - Completed - -
NCT02170207 - Completed - -
NCT01990339 - Completed - -
NCT02703896 Pulmonary Aspiration of Gastri... More >>c Contents Less << Phase 4 Completed - -
NCT02099682 - Completed - -
NCT03488173 Effect of Drugs ... More >> Safety Issues Less << Phase 1 Recruiting October 2018 China, Zhejiang ... More >> First affiliated hospital of Zhejiang University Recruiting Hangzhou, Zhejiang, China, 310003 Contact: Lihua Wu, Doctor ?? 86 571 87236560 ?? lihuawu73@163.com ?? Contact: Jian Liu, Master ?? 86 571 87236560 ?? lindaliu87@163.com ?? Principal Investigator: Lihua Wu ?? ?? ?? Principal Investigator: Jian Liu Less <<
NCT03043521 Healthy Phase 1 Completed - Korea, Republic of ... More >> Asan Medical Center Seoul, Korea, Republic of Less <<
NCT01990339 - Completed - -
NCT01762657 Type 1 Diabetes Phase 3 Withdrawn(Study stopped prior ... More >>to Patient Enrollment) Less << September 2015 -
NCT03079050 GERD Proton P... More >>ump Inhibitor Less << Phase 4 Completed - Lebanon ... More >> American University of Beirut - Medical Center Beirut, Lebanon Less <<
NCT03355170 GERD Cardiac ... More >>Event Safety Issues Less << Phase 4 Not yet recruiting January 1, 2019 Turkey ... More >> Ba?kent University Hospital Gastroenterology Dep. Not yet recruiting Adana, Turkey Contact: Birol ?zer, Prof Dr ?? ?? birolozer@yahoo.com ?? ?ukurova University Medical Faculty Cardiology Dep. Not yet recruiting Adana, Turkey Contact: Mesut Demir, Prof Dr ?? ?? mdemir46@hotmail.com ?? Ankara University Medical Faculty Gastroenterology Dep. Not yet recruiting Ankara, Turkey Contact: Mehmet Bekta?, Prof Dr ?? ?? Mehmet.Bektas@medicine.ankara.edu.tr ?? D??kap? Research and Training Hospital Gastroenterology Dep. Not yet recruiting Ankara, Turkey Contact: Elife Erarslan, Assoc Prof Dr ?? ?? elifeerarslan@gmail.com ?? Yüksek ?htisas Research and Training Hospital Gastroenterology Dep. Not yet recruiting Ankara, Turkey Contact: ?smail Hakk? Kalkan, Assoc Prof Dr ?? ?? drismailster@gmail.com ?? Antalya Research and Training Hospital Gastroenterology Dep. Not yet recruiting Antalya, Turkey Contact: Ayhan Hilmi ?ekin, Assoc Prof Dr ?? ?? ayhancekin@hotmail.com ?? Bal?kesir University Medical Faculty Gastroenterology Dep. Not yet recruiting Bal?kesir, Turkey Contact: Ayla Y?ld?z Sava? ?? ?? drmssa@gmail.com ?? Gaziantep ?ahinbey Research and Training Hospital Gastroenterology Dep. Not yet recruiting Gaziantep, Turkey Contact: Abdullah Emre Y?ld?r?m, Assoc Prof Dr ?? ?? draemreyildirim@gmail.com ?? Dr. Sadi Konuk Research and Training Hospital Gastroenterology Dep. Not yet recruiting Istanbul, Turkey Contact: Aliye Soylu, Prof Dr ?? ?? aliyesoylu@superonline.com ?? ümraniye Research and Training Hospital Gastroenterology Dep. Not yet recruiting Istanbul, Turkey Contact: Zuhal ?al??kan, Assoc Prof Dr ?? ?? caliskanzuhal@gmail.com ?? Ege University Medical Faculty Gastroenterology Dep. Not yet recruiting ?zmir, Turkey Contact: Serhat Bor, Prof Dr ?? ?? serhatbor@yahoo.com ?? Tepecik Research and Training Hospital Gastroenterology Dep. Not yet recruiting ?zmir, Turkey Contact: Betül Pak?z, MD ?? ?? betulpakoz@yahoo.com ?? Celal Bayar University Medical Faculty Gastroenterology Dep. Not yet recruiting Manisa, Turkey Contact: Elmas Kasap, Assoc Prof Dr ?? ?? elmaskasap@yahoo.com ?? S?tk? Ko?man University Medical Faculty Gastroenterology Dep. Not yet recruiting Mu?la, Turkey Contact: Burak ?z?eker, Assoc Prof Dr ?? ?? burakozseker@gmail.com ?? Recep Tayyip Erdo?an University Medical Faculty Gastroenterology Dep. Not yet recruiting Rize, Turkey Contact: Remzi Adnan Akdo?an, Assoc Prof Dr ?? ?? remziadnan@yahoo.com ?? Cumhuriyet University Medical Faculty Gastroenterology Dep. Not yet recruiting Sivas, Turkey Contact: ?zlem Y?nem, Prof Dr ?? ?? ozlemyonem@gmail.com Less <<
NCT03488186 Effect of Drugs ... More >> Safety Issues Less << Phase 1 Not yet recruiting December 2018 China, Zhejiang ... More >> First affiliated hospital of Zhejiang University Hangzhou, Zhejiang, China, 310003 Less <<
NCT02541786 Helicobacter Pylori Infection Phase 4 Completed - Taiwan ... More >> Kaohsiung Medical University Hospital Kaohsiung, Taiwan, 807 Kaohsiung Veterans General Hospital Kaohsiung, Taiwan, 813 Less <<
NCT01568944 Chronic Periodontitis Not Applicable Completed - United States, Georgia ... More >> GHSU-CDM Clinical Research Center Augusta, Georgia, United States, 30912 Less <<
NCT03316976 Healthy Volunteers PHASE1 COMPLETED 2018-02-08 Phase I Clinical Trial Departm... More >>ent, Beijing, Beijing, 100005, China Less <<
NCT01149395 Heartburn|Gastroesophageal Ref... More >>lux Disease Less << PHASE1 COMPLETED 2025-04-12 University of North Carolina a... More >>t Chapel Hill, Chapel Hill, North Carolina, 27599, United States Less <<
NCT02096458 Gastroesophageal Reflux Diseas... More >>e|Erosive Esophagitis|Heartburn Less << PHASE1 COMPLETED 2025-02-14 Woburn, Massachusetts, 01801, ... More >>United States Less <<
NCT02616302 Gastroesophageal Reflux Diseas... More >>e (GERD) Less << PHASE2 RECRUITING 2027-10-31 University of South Alabama, M... More >>obile, Alabama, 36604, United States|University of California San Francisco, San Francisco, California, 94158, United States|D&H National Research Centers, Miami, Florida, 33155, United States|Children's Center for Digestive Health Care, LLC, Atlanta, Georgia, 30342, United States|Gastrointestinal Associates, PA, Flowood, Mississippi, 39232, United States|University Hospitals Cleveland Medical Center, Cleveland, Ohio, 44106, United States|Measurable Outcome Research, Oklahoma City, Oklahoma, 73112, United States|GI for Kids, Knoxville, Tennessee, 37922, United States|Vanderbilt University Medical Center, Nashville, Tennessee, 37212, United States|Envision Clinical Research, LLC, Laredo, Texas, 78041, United States|The Children's Hospital of The King's Daughters, Norfolk, Virginia, 23507, United States|Women and Children's Health Research Institute, Edmonton, Alberta, T6G 1C9, Canada|London Health Sciences Centre (LHSC) - Children's Hospital, London, Ontario, N6A 5W9, Canada|Hospital Universitario San Ignacio, Bogota, 110231, Colombia|Fundacion Valle del Lili, Cali, 760032, Colombia|Centro Medico Imbanaco de Cali S.A, Cali, 760042, Colombia|Hospital of Lithuanian University of Health Sciences Kauno Klinikos, Kaunas, LT-50161, Lithuania|Children's Hospital, Affiliate of Vilnius University Hospital Santaros Klinikos, Public Institution, Vilnius, LT-08661, Lithuania|Boca Clinical Trials Mexico SC, Colonia Las Americas, Distrito Federal, 1120, Mexico|Clinical Research Institute S.C., Tlalnepantla, Estado De Mexico, 54055, Mexico|Inspirepharma S. de R.L. de C.V., Monterrey, Nuevo Leon, 64660, Mexico|El Cielo Medical Center, Puebla, 72160, Mexico|SMIQ S. de R.L. de C.V., Queretaro, 76070, Mexico|In Vivo Osrodek Badan Klinicznych, Bydgoszcz, Kuyavia, 85-048, Poland|Uniwersytecki Szpital Dzieciecy w Krakowie, Krakow, Malopolskie, 30-663, Poland|Instytut "Pomnik - Centrum Zdrowia Dziecka", Warszawa, Masovia, 04-730, Poland|Gabinet Lekarski Bartosz Korczowski, Rzeszow, Podkarpackie, 35-302, Poland Less <<
NCT01642602 Gastroesophageal Reflux Diseas... More >>e Less << PHASE2 COMPLETED 2025-01-14 Huntsville, Alabama, United St... More >>ates|Mobile, Alabama, United States|Phoenix, Arizona, United States|Tucson, Arizona, United States|Anaheim, California, United States|Los Angeles, California, United States|San Francsco, California, United States|Centennial, Colorado, United States|Thornton, Colorado, United States|Miami, Florida, United States|Atlanta, Georgia, United States|Chicago, Illinois, United States|Park Ridge, Illinois, United States|Indianapolis, Indiana, United States|Louisville, Kentucky, United States|Boston, Massachusetts, United States|Flint, Michigan, United States|Plymouth, Minnesota, United States|Jackson, Mississippi, United States|Kansas City, Missouri, United States|Mays Landing, New Jersey, United States|Brooklyn, New York, United States|Huntsville, North Carolina, United States|Toledo, Ohio, United States|Youngstown, Ohio, United States|Greenville, South Carolina, United States|Kingsport, Tennessee, United States|Ft. Worth, Texas, United States|Houston, Texas, United States|Laredo, Texas, United States|San Antonio, Texas, United States|Ogden, Utah, United States|Salt Lake City, Utah, United States|Fairfax, Virginia, United States|Norfolk, Virginia, United States|Bruxelles, Belgium|Passo Fundo, Rio Grande do Sul, Brazil|Porto Alegre, Rio Grande do Sul, Brazil|Santo Andre, Sao Paulo, Brazil|Santo André, Sao Paulo, Brazil|S?o José do Rio Preto, Sao Paulo, Brazil|Debrecen, Hungary|Gy?r, Hungary|Miskolc, Hungary|Nyiregyhaza, Hungary|Pecs, Hungary|Veszprem, Hungary|Bari, Italy|Messina, Italy|Roma, Italy|Mexico, Distrito Federal, Mexico|Monterrey, Nuevo León, Mexico|Culiacan, Sinaloa, Mexico|Bydgoszcz, Poland|Krakow, Poland|Rzeszow, Poland|Szczecin, Poland|Torun, Poland|Warszawa, Poland|Wroclaw, Poland|Amadora, Portugal|Braga, Portugal|Coimbra, Portugal|Lisboa, Portugal|Porto, Portugal Less <<
NCT00928161 Head and Neck Cancer|Oropharyn... More >>geal Cancer|Gastroesophageal Reflux Disease Less << WITHDRAWN - -
NCT01328392 Laryngo-pharyngeal Reflux WITHDRAWN 2025-04-12 University of Washington, Seat... More >>tle, Washington, 98105, United States Less <<
NCT02351960 Gastroesophageal Reflux Diseas... More >>e Less << PHASE4 COMPLETED 2016-07-13 Shatin, New Territories, Hong ... More >>Kong|Gyeonggi-do, 463-707, Korea, Republic of|Gyeonggi-do, Korea, Republic of|Seoul, 137-701, Korea, Republic of|Seoul, Korea, Republic of|Kaoshiung, Taiwan|Taichung, Taiwan|Tainan, Taiwan|Taipei, Taiwan|Taoyuan, Taiwan Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.71mL

0.54mL

0.27mL

13.54mL

2.71mL

1.35mL

27.07mL

5.41mL

2.71mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

Historical Records

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