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Chemical Structure| 1360705-96-9 Chemical Structure| 1360705-96-9
Chemical Structure| 1360705-96-9

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CAS No.: 1360705-96-9

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ML210 is a GPX4 inhibitor which can kill mutant RAS-expressing cell lines with IC50 values of 71 and 272 nM for HRAS G12v mutant expressing cell lines BJeLR and BJeH-LT, respectively.

Synonyms: DPI10; CID 49766530; SML 0521

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Product Details of ML-210

CAS No. :1360705-96-9
Formula : C22H20Cl2N4O4
M.W : 475.32
SMILES Code : O=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)C4=NOC(C)=C4[N+]([O-])=O
Synonyms :
DPI10; CID 49766530; SML 0521
MDL No. :MFCD22666407
InChI Key :VIBHJPDPEVVDTB-UHFFFAOYSA-N
Pubchem ID :49766530

Safety of ML-210

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Related Pathways of ML-210

ferroptosis

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description Reference
LNCaP 2 μM ML210 significantly increased ROS levels in LNCaP cells and significantly inhibited the proliferation of LNCaP cells. PMC11297951
C4-2 2 μM ML210 significantly increased ROS levels in C4-2 cells and significantly inhibited the proliferation of C4-2 cells. PMC11297951
LOX-IMVI cells 10 μM 90 min To assess the effect of ML-210 on lipid peroxidation, results showed that ML-210 treatment led to the accumulation of lipid hydroperoxides. PMC7251976
HCC4006 cells 10 μM 1 h To assess the effect of ML-210 on GPX4 thermal stability using CETSA, results showed that ML-210 stabilized GPX4. PMC7251976
LOX-IMVI cells 10 μM 1 h To assess protein modification by ML-210 using fluorescent labeling, results showed that the ML-210-yne probe modified fewer proteins. PMC7251976
SH-SY5Y cells 8.33 μM 24 h Differentiated SH-SY5Y cells exhibited higher sensitivity to ML210-induced ferroptosis compared to parental cells. PMC8051864
SKOV3 1 μM 24 h ML-210 treatment increased intracellular ROS levels, indicating it may inhibit cancer cells by inducing oxidative stress. PMC7855035
OVCAR5 2 μM 24 h ML-210 treatment increased intracellular ROS levels, indicating it may inhibit cancer cells by inducing oxidative stress. PMC7855035
A549 ACLY/ACSS2-DKO cells 2 μM 48 h To evaluate the sensitivity of ACLY/ACSS2-DKO cells to ferroptosis induced by ML-210, results showed that ACLY/ACSS2-DKO cells were more sensitive to ML-210-induced ferroptosis. PMC10156121
OVCAR-8 1 μM 3.5 h To assess the effect of ML-210 on lipid peroxidation in OVCAR-8 cells, results showed that MMD KO cells had lower lipid peroxidation compared to control cells. PMC10591818
786-O 0.25 μM 3.5 h To assess the effect of ML-210 on lipid peroxidation in 786-O cells, results showed that MMD KO cells had lower lipid peroxidation compared to control cells. PMC10591818
786-O 0.01953–20 μM 48–72 h Validate GPX4 inhibition-induced cell death PMC6453886
769-P 0.01953–20 μM 48–72 h Validate GPX4 inhibition-induced cell death PMC6453886
OS-RC2 0.01953–20 μM 48–72 h Validate GPX4 inhibition-induced cell death PMC6453886
RCC10RGB 0.01953–20 μM 48–72 h Validate GPX4 inhibition-induced cell death PMC6453886

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description Reference
Male BALB/c nude mice A375 cell xenograft model Subcutaneous injection 50 mg/kg Every two days, for 20 days ML210 triggered lipid peroxidation in vivo and synergized with MβCD to inhibit tumor growth PMC10036943
SCID mice Prostate cancer xenograft model Intraperitoneal injection 5 mg/kg Daily for 33 days ML210 combined with enzalutamide significantly inhibited tumor growth and increased H2O2 levels in tumors. PMC11297951
SCID mice Not specified Oral 50 mg/kg Single dose, over 24 hours To assess the pharmacokinetic properties of JKE-1674, results showed that the plasma concentration of JKE-1674 varied over time. PMC7251976
nude mice 786-O xenograft model subcutaneous injection 20 mg/kg once daily for 10 days Validate the anti-tumor effect of GPX4 inhibition in vivo PMC6453886

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.10mL

0.42mL

0.21mL

10.52mL

2.10mL

1.05mL

21.04mL

4.21mL

2.10mL
Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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