成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 13574-13-5 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 13574-13-5
Chemical Structure| 13574-13-5
Structure of 13574-13-5 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 13574-13-5 ]

Related Doc. of [ 13574-13-5 ]

Alternatived Products of [ 13574-13-5 ]
Product Citations

Product Citations

Kim, Jaejeong ; Kang, Changyu ; Yoo, Jin-Wook , et al. DOI: PubMed ID:

Abstract: In our previous study, riluzole azo-linked to salicylic acid (RAS) was prepared as a colon-targeted prodrug of riluzole (RLZ) to facilitate the repositioning of RLZ as an anticolitic drug. RAS is more effective against rat colitis than RLZ and sulfasalazine, currently used as an anti-inflammatory bowel disease drug. The aim of this study is to further improve colon specificity, anticolitic potency, and safety of RAS. N-succinylaspart-1-ylRLZ (SAR) and N-succinylglutam-1-ylRLZ (SGR) were synthesized and evaluated as a ""me-better"" colon-targeted prodrug of RLZ against rat colitis. SAR but not SGR was converted to RLZ in the cecal contents, whereas both conjugates remained intact in the small intestine. When comparing the colon specificity of SAR with that of RAS, the distribution coefficient and cell permeability of SAR were lower than those of RAS. In parallel, oral SAR delivered a greater amount of RLZ to the cecum of rats than oral RAS. In a DNBS-induced rat model of colitis, oral SAR mitigated colonic damage and inflammation and was more potent than oral RAS. Moreover, upon oral administration, SAR had a greater ability to limit the systemic absorption of RLZ than RAS, indicating a reduced risk of systemic side effects of SAR. Taken together, SAR may be a "me-better" colon-targeted prodrug of RLZ to improve the safety and anticolitic potency of RAS, an azo-type colon-targeted prodrug of RLZ.

Keywords: riluzole ; colon-targeted drug delivery ; colitis ; prodrug ; N-succinylated acidic amino acids

Purchased from AmBeed: ; ; ;

Product Details of [ 13574-13-5 ]

CAS No. :13574-13-5 MDL No. :MFCD00065569
Formula : C17H23NO6 Boiling Point : No data available
Linear Structure Formula :- InChI Key :AJDUMMXHVCMISJ-ZDUSSCGKSA-N
M.W : 337.37 Pubchem ID :83589
Synonyms :

Calculated chemistry of [ 13574-13-5 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 24
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.47
Num. rotatable bonds : 11
Num. H-bond acceptors : 6.0
Num. H-bond donors : 2.0
Molar Refractivity : 87.05
TPSA : 101.93 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : No
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : Yes
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.77 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.91
Log Po/w (XLOGP3) : 2.23
Log Po/w (WLOGP) : 2.34
Log Po/w (MLOGP) : 1.83
Log Po/w (SILICOS-IT) : 1.99
Consensus Log Po/w : 2.06

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 1.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.56

Water Solubility

Log S (ESOL) : -2.8
Solubility : 0.54 mg/ml ; 0.0016 mol/l
Class : Soluble
Log S (Ali) : -4.01
Solubility : 0.0333 mg/ml ; 0.0000987 mol/l
Class : Moderately soluble
Log S (SILICOS-IT) : -3.64
Solubility : 0.0768 mg/ml ; 0.000228 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 3.3

Safety of [ 13574-13-5 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P305+P351+P338 UN#:
Hazard Statements:H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 13574-13-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 13574-13-5 ]

[ 13574-13-5 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 13574-13-5 ]
  • [ 2886-33-1 ]
  • [ 99429-23-9 ]
  • 2
  • [ 15761-39-4 ]
  • [ 13734-41-3 ]
  • [ 13139-15-6 ]
  • [ 15761-38-3 ]
  • C16H28N3O5PolS [ No CAS ]
  • [ 7536-55-2 ]
  • [ 13726-85-7 ]
  • [ 13574-13-5 ]
  • [ 13836-37-8 ]
  • [ 23680-31-1 ]
  • [ 47355-10-2 ]
  • [ 83468-83-1 ]
  • Fmoc-Asp-Cys(Acm)-His-Leu-Gln-Ala-Val-Val-Leu-His-Leu-Ala-Arg-Arg-Ser-Val-Cys(Acm)-Val-His-Pro-Gln-Asn-Arg-Ser-Leu-Ala-Arg-Trp-Leu-Glu-Arg-Gln-Gly-S-CH2CH2CO-Leu-NH2 [ No CAS ]
  • 3
  • [ 13734-41-3 ]
  • [ 13139-16-7 ]
  • [ 15761-38-3 ]
  • [ 27144-18-9 ]
  • [ 13734-34-4 ]
  • [ 15260-10-3 ]
  • [ 13574-13-5 ]
  • [ 13836-37-8 ]
  • [ 65420-40-8 ]
  • [ 55260-24-7 ]
  • [ 35899-43-5 ]
  • H-LQIFVKTLTGKTITLEVEPSDTIENVK-SCH2CH2CONH2 [ No CAS ]
  • 4
  • [ 41654-04-0 ]
  • [ 13574-13-5 ]
  • C23H20N3O3Pol [ No CAS ]
  • [ 123639-61-2 ]
  • [ 204777-78-6 ]
  • C50H66N7O12Pol [ No CAS ]
  • 5
  • [ 883566-52-7 ]
  • [ 13734-41-3 ]
  • [ 13139-16-7 ]
  • [ 13139-15-6 ]
  • [ 15761-38-3 ]
  • [ 7536-58-5 ]
  • [ 13574-13-5 ]
  • [ 68262-71-5 ]
  • [ 54613-99-9 ]
  • [ 55260-24-7 ]
  • C154H254N40O52S [ No CAS ]
  • 6
  • [ 883566-52-7 ]
  • [ 13734-41-3 ]
  • [ 13139-15-6 ]
  • [ 15260-10-3 ]
  • [ 13574-13-5 ]
  • [ 23680-31-1 ]
  • Boc-Thr(PO<SUB>3</SUB>Me<SUB>2</SUB>)-OH [ No CAS ]
  • [ 47689-67-8 ]
  • [ 55260-24-7 ]
  • C60H90N11O24PS [ No CAS ]
  • 7
  • [ 15761-39-4 ]
  • [ 13734-41-3 ]
  • [ 13139-15-6 ]
  • [ 7536-55-2 ]
  • [ 7536-58-5 ]
  • [ 13726-85-7 ]
  • [ 13574-13-5 ]
  • [ 120267-95-0 ]
  • [ 18942-46-6 ]
  • C24H29N2O6Pol [ No CAS ]
  • [ 54613-99-9 ]
  • [ 47355-10-2 ]
  • [ 139952-87-7 ]
  • [ 141509-91-3 ]
  • C14H19(15)NO4 [ No CAS ]
  • C123H198N32(15)N4O36S [ No CAS ]
  • 8
  • [ 15761-39-4 ]
  • [ 13734-41-3 ]
  • [ 13139-15-6 ]
  • [ 15761-38-3 ]
  • [ 7536-55-2 ]
  • [ 7536-58-5 ]
  • [ 13726-85-7 ]
  • [ 13574-13-5 ]
  • [ 120267-95-0 ]
  • [ 18942-46-6 ]
  • C24H29N2O6Pol [ No CAS ]
  • [ 54613-99-9 ]
  • [ 47355-10-2 ]
  • C14H19(15)NO4 [ No CAS ]
  • C123H198N35(15)NO36S [ No CAS ]
  • 9
  • [ 4530-20-5 ]
  • [ 15761-39-4 ]
  • [ 13734-41-3 ]
  • [ 13139-15-6 ]
  • [ 15761-38-3 ]
  • [ 7536-58-5 ]
  • [ 13726-85-7 ]
  • [ 27144-18-9 ]
  • [ 13574-13-5 ]
  • [ 23680-31-1 ]
  • [ 54613-99-9 ]
  • [ 51077-16-8 ]
  • [ 47355-10-2 ]
  • [ 25024-53-7 ]
  • Boc-R(PG)-OH [ No CAS ]
  • C155H252N41O43PolS2 [ No CAS ]
  • 10
  • [ 4530-20-5 ]
  • [ 13734-41-3 ]
  • [ 13139-15-6 ]
  • [ 15761-38-3 ]
  • [ 2488-15-5 ]
  • [ 13726-85-7 ]
  • [ 27144-18-9 ]
  • [ 13574-13-5 ]
  • [ 54613-99-9 ]
  • [ 51077-16-8 ]
  • [ 47355-10-2 ]
  • Boc-R(PG)-OH [ No CAS ]
  • C99H150N27O26PolS3 [ No CAS ]
Recommend Products
Same Skeleton Products

Technical Information

Historical Records

Related Functional Groups of
[ 13574-13-5 ]

Amino Acid Derivatives

Chemical Structure| 3886-08-6

[ 3886-08-6 ]

(S)-2-(((Benzyloxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid

Similarity: 1.00

Chemical Structure| 51644-83-8

[ 51644-83-8 ]

Z-D-Glu(OtBu)-OH

Similarity: 1.00

Chemical Structure| 35793-73-8

[ 35793-73-8 ]

Boc-D-Glu(OBzl)-OH

Similarity: 1.00

Chemical Structure| 30924-93-7

[ 30924-93-7 ]

Boc-Glu-OBzl

Similarity: 0.99

Chemical Structure| 5891-45-2

[ 5891-45-2 ]

Z-Glu-OtBu

Similarity: 0.99

; ;