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Chemical Structure| 13241-33-3 Chemical Structure| 13241-33-3

Structure of Neohesperidin
CAS No.: 13241-33-3

Chemical Structure| 13241-33-3

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CAS No.: 13241-33-3

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Neohesperidin is a natural flavanone glycoside isolated from the peel of Citrus aurantium L. with antioxidant and neuroprotective properties.

Synonyms: Hesperetin 7-O-neohesperidoside; NSC 31048; Hesperetin 7-neohesperidoside

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Product Details of Neohesperidin

CAS No. :13241-33-3
Formula : C28H34O15
M.W : 610.56
SMILES Code : O=C1C[C@@H](C2=CC=C(OC)C(O)=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O[C@@]5([H])[C@@H]([C@@H]([C@H]([C@H](C)O5)O)O)O)=CC(O)=C13
Synonyms :
Hesperetin 7-O-neohesperidoside; NSC 31048; Hesperetin 7-neohesperidoside
MDL No. :MFCD16661259

Safety of Neohesperidin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
RBL-2H3 cells 60 and 90 μg/mL 2.5 hours Inhibited antigen-induced degranulation and MAPK phosphorylation PMC11678185
3T3-L1 adipocytes 500 μM 10 days NNMT inhibition increases oxygen consumption PMC8233977
HepG2 cells 100 μM 16 hours Evaluate the effect of SR9009 on BMAL1 mRNA expression PMC7406515
3T3-L1 cells 30, 50, 100 μM 8 days Inhibited adipogenesis in 3T3-L1 cells PMC8912486
HepG2 cells 50 μM 24 hours Evaluate the effect of SR9009 on BMAL1 mRNA expression PMC11904961
RAW 264.7 murine macrophages 100 or 500 μM 24 hours Evaluate the regulatory effects of NHDC and its metabolite DHCA on inflammatory responses. DHCA significantly down-regulated the secretion of pro-inflammatory cytokines IL-6 and TNF-α, while NHDC had limited effects. PMC8233977
Bone marrow mesenchymal stem cells (BMSCs) 12.5 μmol/L, 25 μmol/L, 50 μmol/L 1-3 days Promoted proliferation and osteogenic differentiation of BMSCs, with 10 μM Morusin showing the strongest effect PMC7733036
Bone marrow mesenchymal stem cells (BMSCs) 50 μmol/L Promoted proliferation and osteogenic differentiation of BMSCs, with 10 μM Morusin showing the strongest effect PMC7733036
Vascular smooth muscle cells 20 μM 24 hours To evaluate the inhibitory effect of Neohesperidin on angiotensin II-induced migration of vascular smooth muscle cells. Results showed that Neohesperidin significantly inhibited angiotensin II-induced migration of vascular smooth muscle cells. PMC9168427
Human umbilical vein endothelial cells 20 μM 24 hours FN stabilizes NRF2 levels in HUVECs, protecting cells from oxaliplatin-induced damage. PMC9168427

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Ob/ob mice Hyperlipidemia model Oral 100 mg/kg Once daily for 21 days To evaluate the effect of Neohesperidin on improving hyperlipidemia. The results showed that Neohesperidin significantly reduced plasma TG, TC, and LDL-C levels and improved intestinal barrier function. PMC11904961
Mice Non-alcoholic fatty liver disease (NAFLD) model Drinking water 0.1 mg/ml 11 weeks To evaluate the effect of Neohesperidin on non-alcoholic fatty liver disease (NAFLD). Results showed that Neohesperidin consumption did not cause significant liver inflammation or lipid accumulation. PMC8573958
BABL/c mice OVA-induced allergic asthma model Intragastric gavage 10, 50, and 100 mg/kg Once daily for 11 days Alleviated allergic asthma symptoms, reduced serum IgE and IL-13 levels, and inhibited lung inflammation PMC11678185
C57BL/6 male mice High-fat diet-induced obesity model Oral 0.1% or 1% NHDC 11 weeks Evaluate the effects of NHDC on high-fat diet-induced obesity and inflammation. NHDC dose-dependently suppressed body weight gain and increased the secretion of anti-inflammatory cytokine IL-10. PMC8233977
C57BL/6 mice High-fat diet-induced hepatic steatosis model Oral gavage 50 mg/kg Once daily for 12 weeks To investigate the effect of neohesperidin on high-fat diet-induced hepatic steatosis in mice, results showed that neohesperidin increased mitochondrial biogenesis and fatty acid oxidation by promoting PGC-1α expression, thereby improving hepatic steatosis and systemic insulin resistance. PMC7406515
C57BLKS/J db/db mice Obesity and diabetes model Oral gavage 100 mg/kg body weight 5 days per week for 4 weeks To evaluate the effects of NHDC and GNHDC on body weight, adipose tissue weight, lipid profile, and cytokines in db/db mice. Results showed that NHDC and GNHDC significantly reduced subcutaneous adipose tissue weight and total adipose tissue weight, and improved lipid profile. PMC8912486
C57BL/6J mice Steroid-induced osteonecrosis of the femoral head (SONFH) model Intragastric administration 22.5 g/d/kg body weight Once daily for 6 weeks NH ameliorated histopathological changes in the model mice and decreased the expression of HOT AIR. PMC7733036
C57BL/6 mice Angiotensin II-induced hypertension model Caudal vein injection 50 mg/kg/day Once daily for 16 days To evaluate the protective effect of Neohesperidin on angiotensin II-induced hypertension and vascular remodeling. Results showed that Neohesperidin significantly inhibited angiotensin II-induced hypertension, vascular hypertrophy, fibrosis, inflammation, and oxidative stress. PMC9168427

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.64mL

0.33mL

0.16mL

8.19mL

1.64mL

0.82mL

16.38mL

3.28mL

1.64mL

References

 

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