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Chemical Structure| 123663-49-0 Chemical Structure| 123663-49-0
Chemical Structure| 123663-49-0

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CAS No.: 123663-49-0

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Iguratimod is a selective inhibitor of COX2 (IC50 = 20 μM/7.7 μg/mL) and several inflammatory cytokines including interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor, it's an anti-inflammatory agent.

Synonyms: T614; IGU; N7methanesulfonamido4oxo6(phenoxy)chromen3ylformamide

4.5 *For Research Use Only !

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Product Details of Iguratimod

CAS No. :123663-49-0
Formula : C17H14N2O6S
M.W : 374.37
SMILES Code : O=CNC1=COC2=C(C=C(OC3=CC=CC=C3)C(NS(=O)(C)=O)=C2)C1=O
Synonyms :
T614; IGU; N7methanesulfonamido4oxo6(phenoxy)chromen3ylformamide
MDL No. :MFCD00882374
InChI Key :ANMATWQYLIFGOK-UHFFFAOYSA-N
Pubchem ID :124246

Safety of Iguratimod

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H361
Precautionary Statements:P501-P202-P201-P280-P308+P313-P405

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description Reference
CD19+ B cells 100 μg/ml 7 days IGU inhibits T cell-dependent antibody production PMC9199372
CD4+ T cells 100 μg/ml 24-72 hours Inhibited Th17 cell differentiation by modulating protein acetylation PMC9199372
CD34+ cells 100 μM 10 days To evaluate the effect of Iguratimod on megakaryocyte differentiation. Results showed that Iguratimod increased the expression of IL-35 receptor subunits IL-12Rβ2 and gp130, promoting megakaryocyte proliferation and differentiation. PMC10966519
Cardiac fibroblasts 5 μM 6 hours To evaluate the effect of iguratimod on hypoxia/reoxygenation-induced pyroptosis in cardiac fibroblasts, results showed iguratimod significantly reduced LDH release and improved cell viability PMC8573346

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description Reference
C57BL/6 mice Bleomycin-induced skin fibrosis model Oral 30 mg/kg/day Once daily for 3 weeks Iguratimod significantly decreased the dermis thickness, collagen deposition, hydroxyproline content, and α-SMA positive myofibroblast density PMC10439582
C57BL/6 NCr mice Acetaminophen (APAP)-induced hepatotoxicity model Intraperitoneal injection 20 mg/kg Administered 1 h pre- and 6 h post-APAP, then once daily for four days Evaluate the protective effect of T-614 in the APAP overdose model; results showed that prophylactic T-614 significantly improved survival PMC10976746
Mice Immune thrombocytopenia (ITP) mouse model Oral gavage 30 mg/kg/day Once daily for 10 days To evaluate the therapeutic effect of Iguratimod in ITP mice. Results showed that Iguratimod increased platelet counts and promoted megakaryocyte proliferation and differentiation. PMC10966519
C57BL/6 mice Myocardial ischemia/reperfusion injury model Intraperitoneal injection 5 mg/kg Single dose, 1 hour before ischemia To evaluate the protective effect of iguratimod on myocardial ischemia/reperfusion injury, results showed iguratimod significantly reduced myocardial infarct area and serum cTnI level PMC8573346

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT06244628 cGVHD PHASE3 RECRUITING 2025-12-31 Kailin Xu, Xuzhou, Jiangsu, 22... More >>1000, China Less <<
NCT01554917 Rheumatoid Arthritis PHASE4 COMPLETED 2025-08-15 Peking University People's Hos... More >>pital, Beijing, China Less <<
NCT03023592 Sjogren's Syndrome PHASE1|PHASE2 UNKNOWN 2025-04-18 Peking Union Medical College H... More >>ospital, Beijing, Beijing, 100730, China Less <<
NCT06146972 Rheumatoid Arthritis|Therapy PHASE4 RECRUITING 2024-05-31 Yanfeng Hou, Jinan, Shandong, ... More >>250000, China Less <<
NCT05302024 Immune Thrombocytopenia PHASE2 UNKNOWN 2023-12-12 Peking University Insititute o... More >>f Hematology, Peking University People's Hospital, Beijing, Beijing, 100010, China Less <<
NCT01850966 Rheumatoid Arthritis COMPLETED 2014-04-13 Aisai, Aichi, Japan|Ama, Aichi... More >>, Japan|Anjo, Aichi, Japan|Chita, Aichi, Japan|Gamagori, Aichi, Japan|Handa, Aichi, Japan|Hekinan, Aichi, Japan|Ichinomiya, Aichi, Japan|Kasugai, Aichi, Japan|Kitanagoya, Aichi, Japan|Nagakute, Aichi, Japan|Nagoya, Aichi, Japan|Okazaki, Aichi, Japan|Tokoname, Aichi, Japan|Toyohashi, Aichi, Japan|Toyokawa, Aichi, Japan|Toyota, Aichi, Japan|Tsushima, Aichi, Japan|Yatomi, Aichi, Japan|Minamiakita, Akita, Japan|Noshiro, Akita, Japan|Yurihonjo, Akita, Japan|Hachinohe, Aomori, Japan|Hirosaki, Aomori, Japan|Minamitsugaru, Aomori, Japan|Sannohe, Aomori, Japan|Abiko, Chiba, Japan|Awa, Chiba, Japan|Chosei, Chiba, Japan|Funabashi, Chiba, Japan|Ichihara, Chiba, Japan|Ichikawa, Chiba, Japan|Kashiwa, Chiba, Japan|Katori, Chiba, Japan|Kisarazu, Chiba, Japan|Matsudo, Chiba, Japan|Minamiboso, Chiba, Japan|Mobara, Chiba, Japan|Narashino, Chiba, Japan|Narita, Chiba, Japan|Sakura, Chiba, Japan|Sosa, Chiba, Japan|Tomisato, Chiba, Japan|Urayasu, Chiba, Japan|Yachiyo, Chiba, Japan|Yotsukaido, Chiba, Japan|Matsuyama, Ehime, Japan|Niihama, Ehime, Japan|Saijo, Ehime, Japan|Shikokuchuo, Ehime, Japan|Uwajima, Ehime, Japan|Mikatakaminaka, Fukui, Japan|Sabae, Fukui, Japan|Tsuruga, Fukui, Japan|Chikushi, Fukuoka, Japan|Fukutsu, Fukuoka, Japan|Itoshima, Fukuoka, Japan|Kasuga, Fukuoka, Japan|Kitakyushu, Fukuoka, Japan|Kurume, Fukuoka, Japan|Munakata, Fukuoka, Japan|Nakama, Fukuoka, Japan|Omuta, Fukuoka, Japan|Onga, Fukuoka, Japan|Yame, Fukuoka, Japan|Aizuwakamatsu, Fukushima, Japan|Iwaki, Fukushima, Japan|Koriyama, Fukushima, Japan|Shirakawa, Fukushima, Japan|Ibi, Gifu, Japan|Kakamigahara, Gifu, Japan|Kamo, Gifu, Japan|Motosu, Gifu, Japan|Nakatsugawa, Gifu, Japan|Ogaki, Gifu, Japan|Seki, Gifu, Japan|Yoro, Gifu, Japan|Agatsuma, Gumma, Japan|Annaka, Gumma, Japan|Fujioka, Gumma, Japan|Isesaki, Gumma, Japan|Kiryu, Gumma, Japan|Maebashi, Gumma, Japan|Ota, Gumma, Japan|Shibukawa, Gumma, Japan|Takasaki, Gumma, Japan|Akitakata, Hiroshima, Japan|Fukuyama, Hiroshima, Japan|Higashihiroshima, Hiroshima, Japan|Kure, Hiroshima, Japan|Onomichi, Hiroshima, Japan|Takehara, Hiroshima, Japan|Yamagata, Hiroshima, Japan|Abashiri, Hokkaido, Japan|Asahikawa, Hokkaido, Japan|Bibai, Hokkaido, Japan|Chitose, Hokkaido, Japan|Date, Hokkaido, Japan|Ebetsu, Hokkaido, Japan|Furano, Hokkaido, Japan|Hakodate, Hokkaido, Japan|Kitami, Hokkaido, Japan|Kushiro, Hokkaido, Japan|Matsumae, Hokkaido, Japan|Nayoro, Hokkaido, Japan|Obihiro, Hokkaido, Japan|Sapporo, Hokkaido, Japan|Shari, Hokkaido, Japan|Sorachi, Hokkaido, Japan|Takikawa, Hokkaido, Japan|Yoichi, Hokkaido, Japan|Ako, Hyogo, Japan|Amagasaki, Hyogo, Japan|Ashiya, Hyogo, Japan|Himeji, Hyogo, Japan|Kako, Hyogo, Japan|Kato, Hyogo, Japan|Kawanishi, Hyogo, Japan|Kobe, Hyogo, Japan|Miki, Hyogo, Japan|Minamiawaji, Hyogo, Japan|Nishinomiya, Hyogo, Japan|Ono, Hyogo, Japan|Sayo, Hyogo, Japan|Sumoto, Hyogo, Japan|Takarazuka, Hyogo, Japan|Takasago, Hyogo, Japan|Tamba, Hyogo, Japan|Tatsuno, Hyogo, Japan|Chikusei, Ibaraki, Japan|Higashiibaraki, Ibaraki, Japan|Hitachinaka, Ibaraki, Japan|Hitachi, Ibaraki, Japan|Inashiki, Ibaraki, Japan|Kasama, Ibaraki, Japan|Kashima, Ibaraki, Japan|Koga, Ibaraki, Japan|Mito, Ibaraki, Japan|Moriya, Ibaraki, Japan|Ryugasaki, Ibaraki, Japan|Toride, Ibaraki, Japan|Tsuchiura, Ibaraki, Japan|Tsukuba, Ibaraki, Japan|Yuki, Ibaraki, Japan|Hakui, Ishikawa, Japan|Kaga, Ishikawa, Japan|Kahoku, Ishikawa, Japan|Kanazawa, Ishikawa, Japan|Komatsu, Ishikawa, Japan|Hanamaki, Iwate, Japan|Ichinoseki, Iwate, Japan|Kitakami, Iwate, Japan|Morioka, Iwate, Japan|Ofunato, Iwate, Japan|Oshu, Iwate, Japan|Shimohei, Iwate, Japan|Ayauta, Kagawa, Japan|Kanonji, Kagawa, Japan|Marugame, Kagawa, Japan|Sakaide, Kagawa, Japan|Sanuki, Kagawa, Japan|Takamatsu, Kagawa, Japan|Akune, Kagoshima, Japan|Kanoya, Kagoshima, Japan|Oshima, Kagoshima, Japan|Soh, Kagoshima, Japan|Chigasaki, Kanagawa, Japan|Ebina, Kanagawa, Japan|Fujisawa, Kanagawa, Japan|Hiratsuka, Kanagawa, Japan|Isehara, Kanagawa, Japan|Kawasaki, Kanagawa, Japan|Sagamihara, Kanagawa, Japan|Yokohama, Kanagawa, Japan|Yokosuka, Kanagawa, Japan|Zushi, Kanagawa, Japan|Agawa, Kochi, Japan|Aki, Kochi, Japan|Kami, Kochi, Japan|Nankoku, Kochi, Japan|Shimanto, Kochi, Japan|Aso, Kumamoto, Japan|Hitoyoshi, Kumamoto, Japan|Kuma, Kumamoto, Japan|Minamata, Kumamoto, Japan|Tamana, Kumamoto, Japan|Yamaga, Kumamoto, Japan|Fukuchiyama, Kyoto, Japan|Joyo, Kyoto, Japan|Kameoka, Kyoto, Japan|Kizugawa, Kyoto, Japan|Kyotanabe, Kyoto, Japan|Maizuru, Kyoto, Japan|Nagaokakyo, Kyoto, Japan|Nantan, Kyoto, Japan|Soraku, Kyoto, Japan|Uji, Kyoto, Japan|Yawata, Kyoto, Japan|Kuwana, Mie, Japan|Matsusaka, Mie, Japan|Shima, Mie, Japan|Suzuka, Mie, Japan|Tsu, Mie, Japan|Yokkaichi, Mie, Japan|Higashimatsushima, Miyagi, Japan|Ishinomaki, Miyagi, Japan|Iwanuma, Miyagi, Japan|Kesennuma, Miyagi, Japan|Osaki, Miyagi, Japan|Sendai, Miyagi, Japan|Shibata, Miyagi, Japan|Hyuga, Miyazaki, Japan|Kobayashi, Miyazaki, Japan|Kushima, Miyazaki, Japan|Miyakonojo, Miyazaki, Japan|Saito, Miyazaki, Japan|Azumino, Nagano, Japan|Chiisagata, Nagano, Japan|Hanishina, Nagano, Japan|Iida, Nagano, Japan|Iiyama, Nagano, Japan|Ina, Nagano, Japan|Kamiminochi, Nagano, Japan|Komoro, Nagano, Japan|Matsumoto, Nagano, Japan|Okaya, Nagano, Japan|Saku, Nagano, Japan|Shimoina, Nagano, Japan|Shiojiri, Nagano, Japan|Suwa, Nagano, Japan|Ueda, Nagano, Japan|Omura, Nagasaki, Japan|Sasebo, Nagasaki, Japan|Kashiba, Nara, Japan|Kashihara, Nara, Japan|Kitakatsuragi, Nara, Japan|Shiki, Nara, Japan|Uda, Nara, Japan|Yamatokoriyama, Nara, Japan|Yamatotakada, Nara, Japan|Yoshino, Nara, Japan|Joetsu, Niigata, Japan|Kamo, Niigata, Japan|Sado, Niigata, Japan|Sanjo, Niigata, Japan|Shibata, Niigata, Japan|Beppu, Oita, Japan|Kunisaki, Oita, Japan|Nakatsu, Oita, Japan|Saiki, Oita, Japan|Yufu, Oita, Japan|Asakuchi, Okayama, Japan|Kurashiki, Okayama, Japan|Setouchi, Okayama, Japan|Tsukubo, Okayama, Japan|Naha, Okinawa, Japan|Tomigusuku, Okinawa, Japan|Urasoe, Okinawa, Japan|Daito, Osaka, Japan|Habikino, Osaka, Japan|Hannan, Osaka, Japan|Higashiosaka, Osaka, Japan|Hirakata, Osaka, Japan|Ibaraki, Osaka, Japan|Ikeda, Osaka, Japan|Izumiotsu, Osaka, Japan|Izumisano, Osaka, Japan|Kadoma, Osaka, Japan|Kaizuka, Osaka, Japan|Katano, Osaka, Japan|Kishiwada, Osaka, Japan|Mino, Osaka, Japan|Mishima, Osaka, Japan|Moriguchi, Osaka, Japan|Neyagawa, Osaka, Japan|Osakasayama, Osaka, Japan|Sakai, Osaka, Japan|Sennan, Osaka, Japan|Settsu, Osaka, Japan|Shijonawate, Osaka, Japan|Suita, Osaka, Japan|Takatsuki, Osaka, Japan|Toyonaka, Osaka, Japan|Ogi, Saga, Japan|Takeo, Saga, Japan|Taku, Saga, Japan|Tosu, Saga, Japan|Chichibu, Saitama, Japan|Fujimino, Saitama, Japan|Fujimi, Saitama, Japan|Fukaya, Saitama, Japan|Gyoda, Saitama, Japan|Hasuda, Saitama, Japan|Hidaka, Saitama, Japan|Higashimatsuyama, Saitama, Japan|Hiki, Saitama, Japan|Iruma, Saitama, Japan|Kasukabe, Saitama, Japan|Kawagoe, Saitama, Japan|Kawaguchi, Saitama, Japan|Kitakatsushika, Saitama, Japan|Kitamoto, Saitama, Japan|Koshigaya, Saitama, Japan|Kumagaya, Saitama, Japan|Minamisaitama, Saitama, Japan|Niiza, Saitama, Japan|Osato, Saitama, Japan|Satte, Saitama, Japan|Sayama, Saitama, Japan|Soka, Saitama, Japan|Tokorozawa, Saitama, Japan|Tsurugashima, Saitama, Japan|Wako, Saitama, Japan|Yashio, Saitama, Japan|Gamo, Shiga, Japan|Higashiomi, Shiga, Japan|Koka, Shiga, Japan|Kusatsu, Shiga, Japan|Moriyama, Shiga, Japan|Nagahama, Shiga, Japan|Otsu, Shiga, Japan|Izumo, Shimane, Japan|Matsue, Shimane, Japan|Oda, Shimane, Japan|Oki, Shimane, Japan|Yasugi, Shimane, Japan|Fujieda, Shizuoka, Japan|Fuji, Shizuoka, Japan|Gotemba, Shizuoka, Japan|Hamamatsu, Shizuoka, Japan|Izunokuni, Shizuoka, Japan|Kamo, Shizuoka, Japan|Mishima, Shizuoka, Japan|Numazu, Shizuoka, Japan|Syuchi, Shizuoka, Japan|Tagata, Shizuoka, Japan|Yaizu, Shizuoka, Japan|Ashikaga, Tochigi, Japan|Moka, Tochigi, Japan|Nasushiobara, Tochigi, Japan|Nikko, Tochigi, Japan|Oyama, Tochigi, Japan|Sano, Tochigi, Japan|Shimotsuke, Tochigi, Japan|Shioya, Tochigi, Japan|Utsunomiya, Tochigi, Japan|Anan, Tokushima, Japan|Itano, Tokushima, Japan|Miyoshi, Tokushima, Japan|Yoshinogawa, Tokushima, Japan|Adachi, Tokyo, Japan|Akiruno, Tokyo, Japan|Akishima, Tokyo, Japan|Arakawa, Tokyo, Japan|Bunkyo, Tokyo, Japan|Chiyoda, Tokyo, Japan|Chofu, Tokyo, Japan|Chuo, Tokyo, Japan|Edogawa, Tokyo, Japan|Fuchu, Tokyo, Japan|Hachioji, Tokyo, Japan|Higashikurume, Tokyo, Japan|Hino, Tokyo, Japan|Itabashi, Tokyo, Japan|Katsushika, Tokyo, Japan|Kita, Tokyo, Japan|Koganei, Tokyo, Japan|Kokubunji, Tokyo, Japan|Koto, Tokyo, Japan|Machida, Tokyo, Japan|Meguro, Tokyo, Japan|Minato, Tokyo, Japan|Mitaka, Tokyo, Japan|Musashimurayama, Tokyo, Japan|Musashino, Tokyo, Japan|Nakano, Tokyo, Japan|Nerima, Tokyo, Japan|Ome, Tokyo, Japan|Ota, Tokyo, Japan|Setagaya, Tokyo, Japan|Shibuya, Tokyo, Japan|Shinagawa, Tokyo, Japan|Shinjuku, Tokyo, Japan|Suginami, Tokyo, Japan|Sumida, Tokyo, Japan|Tachikawa, Tokyo, Japan|Taito, Tokyo, Japan|Tama, Tokyo, Japan|Toshima, Tokyo, Japan|Kurayoshi, Tottori, Japan|Sakaiminato, Tottori, Japan|Tohaku, Tottori, Japan|Yonago, Tottori, Japan|Himi, Toyama, Japan|Imizu, Toyama, Japan|Kurobe, Toyama, Japan|Nakaniikawa, Toyama, Japan|Nanto, Toyama, Japan|Oyabe, Toyama, Japan|Shimoniikawa, Toyama, Japan|Takaoka, Toyama, Japan|Tonami, Toyama, Japan|Arida, Wakayama, Japan|Nishimuro, Wakayama, Japan|Tanabe, Wakayama, Japan|Higashimurayama, Yamagata, Japan|Nishiokitama, Yamagata, Japan|Shinjo, Yamagata, Japan|Tendo, Yamagata, Japan|Tsuruoka, Yamagata, Japan|Yonezawa, Yamagata, Japan|Hofu, Yamaguchi, Japan|Nagato, Yamaguchi, Japan|Shimonoseki, Yamaguchi, Japan|Shunan, Yamaguchi, Japan|Ube, Yamaguchi, Japan|Chuo, Yamanashi, Japan|Fuefuki, Yamanashi, Japan|Kai, Yamanashi, Japan|Kofu, Yamanashi, Japan|Minamikoma, Yamanashi, Japan|Nirasaki, Yamanashi, Japan|Akita, Japan|Aomori, Japan|Chiba, Japan|Fukui, Japan|Fukuoka, Japan|Fukushima, Japan|Gifu, Japan|Hiroshima, Japan|Kagoshima, Japan|Kochi, Japan|Kumamoto, Japan|Kyoto, Japan|Miyagi, Japan|Miyazaki, Japan|Nagano, Japan|Nagasaki, Japan|Nara, Japan|Niigata, Japan|Oita, Japan|Okayama, Japan|Osaka, Japan|Saga, Japan|Saitama, Japan|Shizuoka, Japan|Tochigi, Japan|Tokushima, Japan|Tottori, Japan|Toyama, Japan|Wakayama, Japan|Yamagata, Japan|Yamaguchi, Japan Less <<
NCT03054545 Lupus Nephritis UNKNOWN 2019-04-30 RenJi Hospital, Shanghai, Shan... More >>ghai, 200001, China Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.67mL

0.53mL

0.27mL

13.36mL

2.67mL

1.34mL

26.71mL

5.34mL

2.67mL
Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

References

 

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