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Chemical Structure| 1233339-22-4 Chemical Structure| 1233339-22-4

Structure of AZ20
CAS No.: 1233339-22-4

Chemical Structure| 1233339-22-4

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CAS No.: 1233339-22-4

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AZ 20 is a potent and selective inhibitor of ATR with an IC50 of 5 nM exhibiting 8-fold selectivity over mTOR (IC50=38 nM).

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Product Details of AZ20

CAS No. :1233339-22-4
Formula : C21H24N4O3S
M.W : 412.51
SMILES Code : O=S(C1(C2=CC(N3[C@H](C)COCC3)=NC(C4=CC=CC5=C4C=CN5)=N2)CC1)(C)=O
MDL No. :MFCD25976730
InChI Key :SCGCBAAYLFTIJU-CQSZACIVSA-N
Pubchem ID :46244454

Safety of AZ20

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Related Pathways of AZ20

DNA
PI3K-AKT

Isoform Comparison

Biological Activity

Target

  • ATR

    ATR, IC50:5 nM

In Vitro:

Cell Line
Concentration Treated Time Description References
MC3T3-E1 cells 5 nM AZ20 inhibited the ATM/ATR pathway, leading to reduced RAD51 expression, thereby inhibiting osteoblast differentiation and promoting osteoclastogenesis. PMC8974111
RAW264.7 cells 5 nM AZ20 inhibited the ATM/ATR pathway, leading to reduced RAD51 expression, thereby inhibiting osteoblast differentiation and promoting osteoclastogenesis. PMC8974111
AML cell lines 350 nM to 1.4 μM 72 hours AZ20 induced proliferation inhibition and apoptosis in AML cell lines PMC5296912
primary patient samples 800 nM to 27 μM 72 hours AZ20 induced proliferation inhibition and apoptosis in primary patient samples PMC5296912
SH-SY5Y APP695wt cells 10 μM 16 hours To investigate the effects of AZ20 on secreted Aβ peptides, results showed that AZ20 increased the relative levels of Aβ5-38 and Aβ5-40. PMC3273469
SH-SY5Y APP695swe cells 10 μM 16 hours To investigate the effects of AZ20 on secreted Aβ peptides, results showed that AZ20 increased the relative levels of Aβ5-38 and Aβ5-40. PMC3273469
7PA2 APP751 V717F cells 10 μM 16 hours To investigate the effects of AZ20 on secreted Aβ peptides, results showed that AZ20 increased the relative levels of Aβ5-33, Aβ5-38, Aβ5-40, and Aβ5-42. PMC3273469
AsPC-1 0.84 to 2.4 μM 72 hours AZ20 treatment resulted in growth inhibition but limited cell death, accompanied by decreased CHK1 phosphorylation, DNA damage, and S/G2/M cell cycle arrest PMC6918818
BxPC-3 0.84 to 2.4 μM 72 hours AZ20 treatment resulted in growth inhibition but limited cell death, accompanied by decreased CHK1 phosphorylation, DNA damage, and S/G2/M cell cycle arrest PMC6918818
CFPAC-1 0.84 to 2.4 μM 72 hours AZ20 treatment resulted in growth inhibition but limited cell death, accompanied by decreased CHK1 phosphorylation, DNA damage, and S/G2/M cell cycle arrest PMC6918818
HPAC 0.84 to 2.4 μM 72 hours AZ20 treatment resulted in growth inhibition but limited cell death, accompanied by decreased CHK1 phosphorylation, DNA damage, and S/G2/M cell cycle arrest PMC6918818
MIAPaCa-2 0.84 to 2.4 μM 72 hours AZ20 treatment resulted in growth inhibition but limited cell death, accompanied by decreased CHK1 phosphorylation, DNA damage, and S/G2/M cell cycle arrest PMC6918818
KM12 cells 10μM 8 hours To induce exogenous replication fork collapse and study the effect of AZ20 on replication forks PMC8916167

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Mouse TRF2 conditional knockout embryonic stem cells In vitro culture 600 ng/day Once daily for 4 weeks Inhibit ATR kinase activity to observe its effect on telomere fusion in TRF2-deficient embryonic stem cells PMC9161009

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.42mL

0.48mL

0.24mL

12.12mL

2.42mL

1.21mL

24.24mL

4.85mL

2.42mL
Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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