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Structure of Clofarabine
CAS No.: 123318-82-1
*Storage: {[sel_prStorage]}
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Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.
Synonyms: Clolar; Evoltra; C1-F-Ara-A
4.5
*For Research Use Only !
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Search for reports by entering the product batch number.
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CAS No. : | 123318-82-1 |
Formula : | C10H11ClFN5O3 |
M.W : | 303.68 |
SMILES Code : | NC1=C2N=CN([C@H]3[C@@H](F)[C@@H]([C@@H](CO)O3)O)C2=NC(Cl)=N1 |
Synonyms : |
Clolar; Evoltra; C1-F-Ara-A
|
MDL No. : | MFCD00871077 |
InChI Key : | WDDPHFBMKLOVOX-AYQXTPAHSA-N |
Pubchem ID : | 119182 |
GHS Pictogram: |
![]() |
Signal Word: | Danger |
Hazard Statements: | H300 |
Precautionary Statements: | P264-P301+P310 |
Class: | 6.1 |
UN#: | 2811 |
Packing Group: | Ⅲ |
Target |
|
In Vitro:
Cell Line
|
Concentration | Treated Time | Description | References |
A375 | 30 nM | 24 hours | Induced G2/M phase cell cycle arrest | PMC11804206 |
A549 | 1 μM | 24 hours | Induced G2/M phase cell cycle arrest | PMC11804206 |
TC-71 | 10 μM | 48 h | To evaluate the cytotoxicity of Clofarabine on TC-71 cells, results showed that Clofarabine significantly inhibited cell proliferation. | PMC9936921 |
RDES | 10 μM | 48 h | To evaluate the cytotoxicity of Clofarabine on RDES cells, results showed that Clofarabine significantly inhibited cell proliferation. | PMC9936921 |
B16F10 | 1.5 μM | 48 hours | Induced apoptosis | PMC11804206 |
A4573 | 3 μM | 6 h | To evaluate the cytotoxicity of Clofarabine on A4573 cells, results showed that Clofarabine significantly inhibited cell proliferation. | PMC9936921 |
K562 cells | 8 nM | 72 hours | To evaluate the therapeutic effects of Clofarabine in combination with RSV or ATRA on CML cells, the results showed significant inhibition of cell growth and induction of caspase-3-dependent apoptosis. | PMC6755200 |
In Vivo:
Species
|
Animal Model
|
Administration | Dosage | Frequency | Description | References |
SCID/beige mice | TC-71 xenograft model | Oral | 30 mg/kg | Once daily for 14 days | To evaluate the antitumor activity of Clofarabine in the TC-71 xenograft model, results showed that Clofarabine significantly inhibited tumor growth and prolonged event-free survival. | PMC9936921 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT02425904 | Langerhans Cell Histiocytosis | PHASE2 | ACTIVE_NOT_RECRUITING | 2025-01-25 | Phoenix Children's Hospital, P... More >>hoenix, Arizona, 85016, United States|Arkansas Children's Hospital, Little Rock, Arkansas, 72202, United States|Children's Hospital of Los Angeles, Los Angeles, California, 90027, United States|University of California San Francisco Medical Center, San Francisco, California, 94143, United States|Children's National Medical Center, Washington, District of Columbia, 20010, United States|Massachusetts General Hospital, Boston, Massachusetts, 02114, United States|Boston Children's Hospital, Boston, Massachusetts, 02115, United States|Dana-Farber Cancer Institute, Boston, Massachusetts, 02115, United States|Dana-Farber Cancer Institute, Boston, Massachusetts, 02215, United States|Mount Sinai Medical Center, New York, New York, 10029, United States|Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229, United States|The Children's Hospital of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States|St. Jude Children's Research Hospital, Memphis, Tennessee, 38105, United States|Texas Children's Hospital, Houston, Texas, 77030, United States|The Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada Less << |
NCT00338494 | B-Cell Lymphoma | PHASE1 | COMPLETED | 2025-04-11 | Yale Comprehensive Cancer Cent... More >>er at Yale University School of Medicine, New Haven, Connecticut, 06520, United States Less << |
NCT00727766 | Leukemia, Myeloid, Acute | PHASE1 | COMPLETED | 2025-11-14 | Washington University, St. Lou... More >>is, Missouri, 63110, United States Less << |
NCT00299156 | Myelodysplastic Syndrome|Chron... More >>ic Myelomonocytic Leukemia Less << | PHASE2 | COMPLETED | 2025-12-12 | U.T.M.D. Anderson Cancer Cente... More >>r, Houston, Texas, 77030, United States Less << |
NCT01796405 | Langerhans Cell Histiocytosis | PHASE2 | WITHDRAWN | - | - |
NCT01196013 | Acute Lymphoblastic Leukemia | PHASE1 | COMPLETED | 2025-05-11 | National Kyusyu Cancer Center,... More >> Fukuoka, Japan|Fukushima Medical University Hospital, Fukushima, Japan|Kagoshima University Medical and Dental Hospital, Kagoshima, Japan|Tokai University Hospital, Kanagawa, Japan|Niigata Cancer Center Hospital, Niigata, Japan|Osaka City General Hospital, Osaka, Japan|Saitama Chilidren's Medical Center, Saitama, Japan|Shizuoka Children's Hospital, Shizuoka, Japan|St. Luke's International Hospital, Tokyo, Japan Less << |
NCT00028418 | Hematologic Neoplasms|Lymphopr... More >>oliferative Disorders|Leukemia|Leukemia, Lymphocytic, Chronic Less << | PHASE1 | COMPLETED | 2025-03-04 | University of Texas M. D. Ande... More >>rson Cancer Center, Houston, Texas, 77030, United States Less << |
NCT01065545 | Acute Myeloid Leukemia | PHASE1 | WITHDRAWN | - | - |
NCT00081887 | Chronic Lymphocytic Leukemia|L... More >>eukemia Less << | PHASE1 | TERMINATED | 2025-06-07 | The University of Texas M.D. A... More >>nderson Cancer Center, Houston, Texas, 77030, United States Less << |
NCT00201669 | Non-Hodgkin's Lymphoma | PHASE2 | COMPLETED | 2025-06-06 | Ohio State University, Columbu... More >>s, Ohio, 43210, United States Less << |
NCT01169012 | Myelodysplastic Syndrome|Acute... More >> Myeloid Leukemia|Acute Lymphoblastic Leukemia|Chronic Myelomonocytic Leukemia Less << | PHASE1 | COMPLETED | 2025-01-13 | University of North Carolina a... More >>t Chapel Hill, Chapel Hill, North Carolina, 27599, United States Less << |
NCT01063257 | Myelodysplastic Syndrome | PHASE1|PHASE2 | COMPLETED | 2025-03-14 | H?pital Avicenne, Bobigny, 930... More >>09, France|Institut Paoli-Calmettes, Marseille, 13009, France|H?pital Saint-Louis, Paris, 75475, France|Hopital Cochin Service d'Hématologie, Paris, 75679, France|Centre Henri Becquerel, Rouen, 76038, France Less << |
NCT01279096 | Acute Lymphoid Leukemia Relaps... More >>e|Acute Lymphoid Leukemia Relapse After Bone Marrow Transplant Less << | PHASE1 | COMPLETED | 2025-06-13 | Besan?on University Hospital, ... More >>Besan?on, 25000, France|Lille University Hospital, Lille, 59037, France Less << |
NCT00724009 | Leukemia | PHASE2 | COMPLETED | 2025-09-12 | The University of Chicago hosp... More >>itals, Chicago, Illinois, 60637, United States Less << |
NCT00644189 | Follicular Lymphoma|Marginal Z... More >>one Lymphoma|Mantle Cell Lymphoma|Small Lymphocytic Lymphoma|Lymphoplasmacytic Lymphoma|Low Grade B-cell Lymphoma, Not Otherwise Specified|Diffuse Large B-cell Lymphoma|Peripheral T-cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Anaplastic Large-cell Lymphoma Less << | PHASE1|PHASE2 | COMPLETED | 2025-07-21 | Massachusetts General Hospital... More >>, Boston, Massachusetts, 02114, United States|Dana-Farber Cancer Institute, Boston, Massachusetts, 02115, United States Less << |
NCT00422032 | Myelodysplastic Syndrome|Leuke... More >>mia Less << | PHASE2 | COMPLETED | 2025-11-11 | UT MD Anderson Cancer Center, ... More >>Houston, Texas, 77030, United States Less << |
NCT01188174 | AML | PHASE2 | COMPLETED | 2025-12-14 | CHU de Bordeaux, Bordeaux, Fra... More >>nce|CHU Caen, Caen, France|CHRU lille, Lille, France|H?pital Edouard Herriot, Lyon, France|Institut Paoli Calmette, Marseille, France|Nantes University hospital, Nantes, 44200, France|Paris saint Louis, Paris, France|CHRU de Strasbourg, Strasbourg, France|CHU Toulouse, Toulouse, France Less << |
NCT00531232 | Myelodysplastic Syndromes|Seco... More >>ndary Acute Myeloid Leukemia (AML) Less << | PHASE2 | COMPLETED | 2011-05-12 | The University of Chicago, Chi... More >>cago, Illinois, 60637, United States|Weill Medical College of Cornell University, New York, New York, 10065, United States|Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina, 27157, United States|Cleveland Clinic, Cleveland, Ohio, 44195, United States|Baylor University Medical Center Blood Marrow Transplantation Research, Dallas, Texas, 75246, United States|University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, United States Less << |
NCT00241371 | Multiple Myeloma | PHASE2 | TERMINATED | 2025-12-07 | Washington University School o... More >>f Medicine, St. Louis, Missouri, 63110, United States Less << |
NCT01295307 | Acute Myeloid Leukemia | PHASE2 | COMPLETED | 2025-12-13 | HELIOS Klinikum Bad Saarow, Ba... More >>d Saarow, Germany|Klinikum Chemnitz gGmbH, Chemnitz, Germany|University Hospital Carl Gustav Carus, Dresden, 01307, Germany|Universit?tsklinikum Erlangen, Erlangen, Germany|Klinikum der J. W. Goethe-Universit?t, Frankfurt am Main, Germany|Klinikum Mannheim GmbH, Mannheim, Germany|Universit?tsklinikum Münster, Münster, Germany|Klinikum Nürnberg Nord, Nürnberg, Germany|Universit?tsklinikum Tübingen, Tübingen, Germany|Universit?tsklinikum Würzburg, Würzburg, Germany Less << |
NCT02544789 | Acute Lymphoblastic Leukemia | PHASE2 | COMPLETED | 2025-05-12 | Department of Pediatrics, Peki... More >>ng University People's Hospital, Beijing, China|Department of Phase 1 Clinical Trial, Peking University People's Hospital, Beijing, China|Guangdong General Hospital, Guangdong Academy of Medical Science, Guangzhou, China|The First Affiliated Hospital, Zhejiang University, Hangzhou, China|The First Hospital of China Medical University, Shenyang, China|The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China Less << |
NCT00708721 | Cancer|Chronic Myelomonocytic ... More >>Leukemia Less << | PHASE1|PHASE2 | TERMINATED | 2025-11-14 | Huntsman Cancer Institute, Sal... More >>t Lake City, Utah, 84112, United States Less << |
NCT01003678 | Myelodysplastic Syndrome | PHASE1 | TERMINATED | 2025-10-13 | Roswell Park Cancer Institute,... More >> Buffalo, New York, 14263, United States Less << |
Tags: Clofarabine | Nucleoside Antimetabolite/Analog | Autophagy | Apoptosis | nucleoside analogue | ribonucleotide reductase | DNA synthesis inhibitor | ribonucleotide reductase inhibitor | 123318-82-1
Precautionary Statements-General | |
Code | Phrase |
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Code | Phrase |
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P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
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P243 | Take precautionary measures against static discharge. |
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P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
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P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
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P322 | |
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P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
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P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
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P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
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H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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