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Chemical Structure| 122306-01-8 Chemical Structure| 122306-01-8
Chemical Structure| 122306-01-8

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CAS No.: 122306-01-8

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Synonyms: 6-Bromo-3-pyridinemethanol

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Product Details of (6-Bromopyridin-3-yl)methanol

CAS No. :122306-01-8
Formula : C6H6BrNO
M.W : 188.02
SMILES Code : OCC1=CC=C(Br)N=C1
Synonyms :
6-Bromo-3-pyridinemethanol
MDL No. :MFCD04974508
InChI Key :QPPDKOIDAYZUHN-UHFFFAOYSA-N
Pubchem ID :6421249

Safety of (6-Bromopyridin-3-yl)methanol

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of (6-Bromopyridin-3-yl)methanol

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 122306-01-8 ]
  • Downstream synthetic route of [ 122306-01-8 ]

[ 122306-01-8 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 122306-01-8 ]
  • [ 168173-56-6 ]
YieldReaction ConditionsOperation in experiment
1.05 g With thionyl chloride In dichloromethane at 0 - 20℃; for 2 h; A solution of (6-bromopyridin-3-yl)methanol (1.000 g) in DCM (10 mL) was cooled to EtOAc. Ethylene was added dropwise thionylchloride (1.260 g) in remove the ice bath after the addition. Stir for 2 hours to allow the solution to naturally warm to room temperature. Direct concentration gave 1.050 g of 2-bromo-5-(chloromethyl)pyridine.
References: [1] Patent: WO2006/114213, 2006, A1, . Location in patent: Page/Page column 30.
[2] Patent: US5420270, 1995, A, .
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 7, p. 3201 - 3215.
[4] Inorganic Chemistry, 2016, vol. 55, # 16, p. 7944 - 7953.
[5] Journal of Biological Inorganic Chemistry, 2018, vol. 23, # 7, p. 1139 - 1151.
[6] Patent: TW2018/29406, 2018, A, . Location in patent: Page/Page column 31.
[7] Patent: WO2019/35008, 2019, A1, . Location in patent: Paragraph 731; 734; 735.
 

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