There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
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Excepted Quantity | USD 0.00 |
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CAS No. : | 12093-10-6 | MDL No. : | MFCD00001429 |
Formula : | C11H10FeO | Boiling Point : | No data available |
Linear Structure Formula : | (C5H5)Fe(C5H4C(O)H) | InChI Key : | - |
M.W : | 214.04 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Danger | Class: | 6.1 |
Precautionary Statements: | P264-P270-P301+P310-P330-P405-P501 | UN#: | 3467 |
Hazard Statements: | H301 | Packing Group: | Ⅱ |
GHS Pictogram: |
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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85% | With sodium tetrahydroborate; potassium carbonate; In chloroform; for 1.5h;Reflux; Inert atmosphere; Schlenk technique; | General procedure: Ferrocenecarboxaldehyde (856 mg, 4.0 mmol) and amino alcohol(4.2 mmol) were dissolved in previously dried chloroform(40 mL; dried over K2CO3) and the resulting solution was heated at reflux under argon for 90 min. Then, the solution was cooled to room temperature, the solvent was removed under reduced pressure and the red?brown residue immediately re-dissolved indry methanol (40 mL; distilled from a MeONa solution). The methanol\ic solution was cooled in an ice bath and treated slowly with solid NaBH4 (756 mg, 20 mmol over 30 min). After adding all the NaBH4, the mixture was stirred at 0°C for 1 h and at room temperature for further 90 min. Then, the cooled mixture was quenched with an aqueous solution of NaOH (10percent, 40 mL) and extracted withCH2Cl2 (2 40 mL). The combined organic layer was washed withbrine (2 40 mL), dried over anhydrous MgSO4, and evaporated,leaving the crude product as a yellow?brown solid. Subsequentpurification by column chromatography (silica gel, dichloromethane?methanol 10:1) led to the development of two bands: the first(minor) one containing mostly ferrocenyl methanol, followed by the major band of the amino alcohol. Careful evaporation of the second fraction afforded pure ferrocene based amino alcohol as an amber oil, which slowly solidifies to a brown solid. |
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