成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 120-72-9 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 120-72-9
Chemical Structure| 120-72-9
Structure of 120-72-9 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 120-72-9 ]

Related Doc. of [ 120-72-9 ]

Alternatived Products of [ 120-72-9 ]
Product Citations

Product Citations      Expand+

Anushree Mondal ; Pronay Roy ; Jaclyn Carrannatto , et al. DOI: PubMed ID:

Abstract: The prenylated-flavin mononucleotide-dependent decarboxylases (also known as UbiD-like enzymes) are the most recently discovered family of decarboxylases. The modified flavin facilitates the decarboxylation of unsaturated carboxylic acids through a novel mechanism involving 1,3-dipolar cyclo-addition chemistry. UbiD-like enzymes have attracted considerable interest for biocatalysis applications due to their ability to catalyse (de)carboxylation reactions on a broad range of aromatic substrates at otherwise unreactive carbon centres. There are now ～35[thin space (1/6-em)]000 protein sequences annotated as hypothetical UbiD-like enzymes. Sequence similarity network analyses of the UbiD protein family suggests that there are likely dozens of distinct decarboxylase enzymes represented within this family. Furthermore, many of the enzymes so far characterized can decarboxylate a broad range of substrates. Here we describe a strategy to identify potential substrates of UbiD-like enzymes based on detecting enzyme-catalysed solvent deuterium exchange into potential substrates. Using ferulic acid decarboxylase (FDC) as a model system, we tested a diverse range of aromatic and heterocyclic molecules for their ability to undergo enzyme-catalysed H/D exchange in deuterated buffer. We found that FDC catalyses H/D exchange, albeit at generally very low levels, into a wide range of small, aromatic molecules that have little resemblance to its physiological substrate. In contrast, the sub-set of aromatic carboxylic acids that are substrates for FDC-catalysed decarboxylation is much smaller. We discuss the implications of these findings for screening uncharacterized UbiD-like enzymes for novel (de)carboxylase activity.

Purchased from AmBeed: ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;

Janssens, Liesl K ; Ametovski, Adam ; Sparkes, Eric , et al. DOI: PubMed ID:

Abstract: Over 200 synthetic cannabinoid receptor agonists (SCRAs) have been identified as newpsychoactive substances. EffectivemonitoringandcharacterizationofSCRAsarehindered by the rapid pace of structural evolution. Ahead of possible appearanceontheillicitdrugmarket,newSCRAsweresynthesized tocompletea systematic libraryof cumyl-indole-(e.g.,CUMYL CPrMICA,CUMYL-CPMICA)andcumyl-indazole-carboxamides (e.g.,CUMYL-CPrMINACA,CUMYL-CPMINACA), encompass ing butyl, pentyl, cyclopropylmethyl, cyclobutylmethyl, cyclo pentylmethyl, andcyclohexylmethyl tails.Comprehensivepharma cologicalcharacterizationwasperformedwiththreeassayformats, monitoring the recruitment of either wild-type or C-terminally truncated(βarr2d366)β-arrestin2totheactivatedcannabinoid1 receptor(CB1)ormonitoringGβγ-mediatedmembranehyperpolarization.Alteredcompoundcharacterizationwasobservedwhen comparingderivedpotency(EC50)andefficacy(Emax)values frombothassaysmonitoringthesameoradifferentsignalingevent, whereasrangesandrankingordersweresimilar.Structure?activityrelationships(SAR)wereassessedinthreefold, resultinginthe identificationof thependant tailasacriticalpharmacophore,withtheoptimalchainlengthforCB1activationapproximatingann pentyl (e.g., cyclopentylmethyl or cyclohexylmethyl tail). The activityof the SCRAs encompassing cyclic tails decreasedwith decreasingnumberofcarbonsformingthecyclicmoiety,withCUMYL-CPrMICAshowingtheleastCB1activityinallassayformats. The SARs were rationalized viamolecular docking, demonstrating the importance of the optimal steric contributionof the hydrophobictail.WhileSARconclusionsremainedlargelyunchanged, thedifferential compoundcharacterizationbybothsimilar anddifferentassaydesignsemphasizestheimportanceofdetailingspecificassaycharacteristicstoallowadequateinterpretationof potenciesandefficacies.

Keywords: structure?activity relationship ; functional assays ; membrane potential ; βarrestin2 recruitment ; new psychoactive substances ; molecular docking

Purchased from AmBeed: ; ; ; ; ; ; ;

Shriver, James A. ; Kaller, Kaylie S. ; Kinsey, Ally L. , et al. DOI: PubMed ID:

Abstract: The spontaneous conversion of 3-indoxyl to indigo was a well-established process used to produce indigo dyes. It was recently shown that some indoles, when reacted with molybdenum hexacarbonyl and cumyl peroxide, proceed through an indoxyl intermediate to produce significant amounts of indirubin through a competing mechanism. Modulation of this system to lower temperatures allows for careful tuning, leading to selective production of indirubins in a general process. A systematic assay of indoles show that electron deficient indoles work well when substituted at the 5 and 7 positions. In contrast, 6-substituted electron rich indoles give the best results whereas halogeno indoles work well in all cases. This process shows broad functional group tolerance for generally reactive carbonyl-containing compounds such as aldehydes and carboxylic acids.

Purchased from AmBeed: ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;

Pike, Edward ; Grafinger, Katharina Elisabeth ; Cannaert, Annelies , et al. DOI: PubMed ID:

Abstract: Synthetic cannabinoid receptor agonists (SCRAs) are one of the largest and most structurally diverse classes of new psychoactive substances. In this first of a three-part series, author describe the synthesis, anal. characterization, and binding affinity of a proactively generated, systematic library of 30 indole, indazole, and 7-azaindole SCRAs related to MMB-4en-PICA, MDMB-4en-PINACA, ADB-4en-PINACA, and MMB-4CN-BUTINACA featuring a 4-pentenyl, Bu, or 4-cyanobutyl tail and a Me L-valinate (MMB), Me L-tert-leucinate (MDMB), Me L-phenylalaninate (MPP), L-valinamide (AB), L-tert-leucinamide (ADB), L-phenylalaninamide (APP), adamantyl (A), or cumyl head group. Competitive radioligand binding assays demonstrated that the indazole core conferred the highest CB1 binding affinity (Ki = 0.17-39 nM), followed by indole- (Ki = 0.95-160 nM) and then 7-azaindole-derived SCRAs (Ki = 5.4-271 nM). Variation of the head group had the greatest effect on binding, with tert-leucine amides and Me esters (Ki = 0.17-14 nM) generally showing the greatest affinities, followed by valine derivatives (Ki = 0.72-180 nM), and then phenylalanine derivatives (Ki = 2.5-271 nM). Adamantyl head groups (Ki = 8.8-59 nM) were suboptimal for binding, whereas the cumyl analogs consistently conferred high affinity (Ki = 0.62-36 nM). Finally, both Bu (Ki = 3.1-163 nM) and 4-cyanobutyl (Ki = 5.5-44 nM) tail groups were less favorable for CB1 binding than their corresponding 4-pentenyl counterparts (Ki = 0.72-25 nM).

Keywords: 4en ; ADB ; MDMB ; PINACA ; cannabinoid

Purchased from AmBeed: ; 120-72-9

Product Details of [ 120-72-9 ]

CAS No. :120-72-9 MDL No. :MFCD00005607
Formula : C8H7N Boiling Point : -
Linear Structure Formula :- InChI Key :SIKJAQJRHWYJAI-UHFFFAOYSA-N
M.W : 117.15 Pubchem ID :798
Synonyms :
Chemical Name :1H-Indole

Calculated chemistry of [ 120-72-9 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 9
Num. arom. heavy atoms : 9
Fraction Csp3 : 0.0
Num. rotatable bonds : 0
Num. H-bond acceptors : 0.0
Num. H-bond donors : 1.0
Molar Refractivity : 38.3
TPSA : 15.79 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -5.56 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.43
Log Po/w (XLOGP3) : 2.05
Log Po/w (WLOGP) : 2.17
Log Po/w (MLOGP) : 1.57
Log Po/w (SILICOS-IT) : 2.66
Consensus Log Po/w : 1.98

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 2.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -2.6
Solubility : 0.296 mg/ml ; 0.00252 mol/l
Class : Soluble
Log S (Ali) : -2.01
Solubility : 1.14 mg/ml ; 0.00977 mol/l
Class : Soluble
Log S (SILICOS-IT) : -3.23
Solubility : 0.069 mg/ml ; 0.000589 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.0

Safety of [ 120-72-9 ]

Signal Word:Danger Class:6.1
Precautionary Statements:P264-P270-P273-P280-P301+P312+P330-P302+P352+P312-P305+P351+P338-P337+P313-P391-P405-P501 UN#:2811
Hazard Statements:H302-H311-H319-H400 Packing Group:Ⅲ
GHS Pictogram:

Application In Synthesis of [ 120-72-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 120-72-9 ]
  • Downstream synthetic route of [ 120-72-9 ]

[ 120-72-9 ] Synthesis Path-Upstream   1~9

  • 1
  • [ 120-72-9 ]
  • [ 1670-85-5 ]
Reference： [1] Marine Drugs, 2016, vol. 14, # 12,
  • 2
  • [ 120-72-9 ]
  • [ 1670-85-5 ]
Reference： [1] Russian Journal of General Chemistry, 2017, vol. 87, # 12, p. 3006 - 3016
  • 3
  • [ 120-72-9 ]
  • [ 67-64-1 ]
  • [ 2770-92-5 ]
Reference： [1] Acta Chemica Scandinavica (1947-1973), 1954, vol. 8, p. 119,123
  • 4
  • [ 120-72-9 ]
  • [ 67-64-1 ]
  • [ 2770-92-5 ]
Reference： [1] Acta Chemica Scandinavica (1947-1973), 1954, vol. 8, p. 119,123
  • 5
  • [ 120-72-9 ]
  • [ 226883-79-0 ]
Reference： [1] ACS Chemical Neuroscience, 2017, vol. 8, # 10, p. 2159 - 2167
  • 6
  • [ 120-72-9 ]
  • [ 73183-34-3 ]
  • [ 25015-63-8 ]
  • [ 642494-37-9 ]
Reference： [1] European Journal of Organic Chemistry, 2017, vol. 2017, # 27, p. 4044 - 4053
  • 7
  • [ 120-72-9 ]
  • [ 642494-37-9 ]
Reference： [1] Organic Letters, 2016, vol. 18, # 7, p. 1554 - 1557
  • 8
  • [ 120-72-9 ]
  • [ 1421372-66-8 ]
Reference： [1] Patent: WO2013/14448, 2013, A1,
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 20, p. 8249 - 8267
[3] Patent: WO2017/117070, 2017, A1,
[4] European Journal of Medicinal Chemistry, 2019, p. 367 - 380
[5] Patent: CN109280048, 2019, A,
  • 9
  • [ 120-72-9 ]
  • [ 1421373-65-0 ]
Reference： [1] Patent: WO2013/14448, 2013, A1,
[2] Patent: WO2013/14448, 2013, A1,
[3] Patent: WO2013/14448, 2013, A1,
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 20, p. 8249 - 8267
Recommend Products
Same Skeleton Products
Historical Records

Similar Product of
[ 120-72-9 ]

Chemical Structure| 853409-50-4

A1446427[ 853409-50-4 ]

1H-Indole-3a,4,5,6,7,7a-13C6

Reason: Stable Isotope

Related Parent Nucleus of
[ 120-72-9 ]

Indoles

Chemical Structure| 3420-02-8

[ 3420-02-8 ]

6-Methyl-1H-indole

Similarity: 1.00

Chemical Structure| 5192-03-0

[ 5192-03-0 ]

1H-Indol-5-amine

Similarity: 1.00

Chemical Structure| 5649-36-5

[ 5649-36-5 ]

2,6-Dimethyl-1H-indole

Similarity: 0.97

Chemical Structure| 5318-27-4

[ 5318-27-4 ]

6-Aminoindole

Similarity: 0.97

Chemical Structure| 30877-30-6

[ 30877-30-6 ]

5,6-Dimethyl-1H-indole

Similarity: 0.97

; ;