成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 1192-80-9 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 1192-80-9
Chemical Structure| 1192-80-9
Structure of 1192-80-9 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 1192-80-9 ]

Related Doc. of [ 1192-80-9 ]

Alternatived Products of [ 1192-80-9 ]
Product Citations

Product Details of [ 1192-80-9 ]

CAS No. :1192-80-9 MDL No. :MFCD01809083
Formula : C4H5ClN2O Boiling Point : -
Linear Structure Formula :- InChI Key :ZFYVXZGJPJTIPQ-UHFFFAOYSA-N
M.W : 132.55 Pubchem ID :302157
Synonyms :

Calculated chemistry of [ 1192-80-9 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 8
Num. arom. heavy atoms : 5
Fraction Csp3 : 0.5
Num. rotatable bonds : 1
Num. H-bond acceptors : 3.0
Num. H-bond donors : 0.0
Molar Refractivity : 29.03
TPSA : 38.92 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.43 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.72
Log Po/w (XLOGP3) : 0.96
Log Po/w (WLOGP) : 0.96
Log Po/w (MLOGP) : -0.13
Log Po/w (SILICOS-IT) : 1.84
Consensus Log Po/w : 1.07

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 2.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -1.66
Solubility : 2.88 mg/ml ; 0.0217 mol/l
Class : Very soluble
Log S (Ali) : -1.36
Solubility : 5.72 mg/ml ; 0.0432 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -2.24
Solubility : 0.764 mg/ml ; 0.00577 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 2.33

Safety of [ 1192-80-9 ]

Signal Word:Danger Class:8
Precautionary Statements:P260-P264-P270-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P405-P501 UN#:3265
Hazard Statements:H302-H314 Packing Group:Ⅱ
GHS Pictogram:

Application In Synthesis of [ 1192-80-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1192-80-9 ]

[ 1192-80-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1192-80-9 ]
  • [ 208580-23-8 ]
  • [ 1258213-54-5 ]
YieldReaction ConditionsOperation in experiment
89.13% With potassium carbonate; In N,N-dimethyl-formamide; at 80℃; for 2h; Intermediate 51Ethyl 7-bromo-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]-4-oxo-1,4-dihydroquinoline-3-carboxylateTo a stirred solution of <strong>[208580-23-8]ethyl 7-bromo-4-oxo-1,4-dihydroquinoline-3-carboxylate</strong> (Intermediate 55, 3.5 g, 11.82 mmol) in dry dimethylformamide (40 mL), potassium carbonate (4.90 g, 85.47 mM) was added and stirred at room temperature. To the above reaction mixture 3-chloromethyl-5-methyl-1,2,4-oxadiazole (3.5 mL, 26.60 mmol) was added and the mixture was stirred at 80 C. for 2 h. After the completion of the reaction, the reaction mixture was filtered and the filtrate was concentrated to dryness. The residue was triturated with petroleum ether (40 mL) to obtain solid compound which was filtered and dried to afford 4.1 g (89.13%) of ethyl 7-bromo-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]-4-oxo-1,4-dihydroquinoline-3-carboxylate as pale brown solid.1H NMR (400 MHz, DMSO-d6): delta 1.29 (t, 3H), 2.50 (s, 3H), 4.22-4.27 (q, 2H), 5.89 (s, 2H), 7.63-7.65 (m, 1H), 7.97 (d, 1H), 8.12-8.14 (d, 1H), 8.85 (s, 1H).LC-MS: m/z 392.1 (M+H).
Recommend Products
Same Skeleton Products

Technical Information

Historical Records

Related Functional Groups of
[ 1192-80-9 ]

Chlorides

Chemical Structure| 51791-12-9

[ 51791-12-9 ]

3-(Chloromethyl)-1,2,4-oxadiazole

Similarity: 0.83

Related Parent Nucleus of
[ 1192-80-9 ]

Oxadiazoles

Chemical Structure| 51791-12-9

[ 51791-12-9 ]

3-(Chloromethyl)-1,2,4-oxadiazole

Similarity: 0.83

Chemical Structure| 1184986-84-2

[ 1184986-84-2 ]

(5-Methyl-1,2,4-oxadiazol-3-yl)methanamine hydrochloride

Similarity: 0.79

Chemical Structure| 40019-21-4

[ 40019-21-4 ]

Ethyl 3-methyl-1,2,4-oxadiazole-5-carboxylate

Similarity: 0.62

Chemical Structure| 1121057-52-0

[ 1121057-52-0 ]

3-Methyl-5-(pyrrolidin-3-yl)-1,2,4-oxadiazole hydrochloride

Similarity: 0.61

Chemical Structure| 40483-47-4

[ 40483-47-4 ]

5-Methyl-1,2,4-oxadiazol-3-amine

Similarity: 0.58

; ;