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Chemical Structure| 1184-16-3 Chemical Structure| 1184-16-3
Chemical Structure| 1184-16-3

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CAS No.: 1184-16-3

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NADP sodium is a coenzyme that is widely distributed in living matter which participates in oxidation-reduction reactions.

Synonyms: Sodium NADP

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Product Citations

Product Citations

Panse, N ; Gerk, PM ;

Abstract: Although exogenous ketogenic dietary supplements continue to grow in popularity, their pharmacokinetic properties have not been adequately studied, thus hindering their optimal use and benefts. Here, the metabolic characteristics of one such supplement (Veech ketone mono-ester ((R)-3-hydroxybutyl(R)-3-hydroxybutyrate) (KE)) were studied along with its metabolite- (R)-1,3-butanediol ((R)-1,3-BD), both of which are precursors and undergo metabolic conversion to (R)-beta-hydroxybutyrate (BHB). The metabolism of aldol (an aldehyde intermediate between the conversion of (R)-1,3-BD to (R)-BHB was also evaluated, as it is frequently not considered in any scientifc discussion. The metabolic parameters were calculated using pooled human (mixed gender) and pooled rat (male and female) liver fractions. These were later used to estimate the hepatic extraction ratio and the hepatic clearance of these molecules. KE showed rapid and non-saturable clearance in human and rat liver fractions, even at concentrations as high as 15,000 μM. In the case of (R)-1,3-BD, there was saturable metabolism in rats and humans with Km and Vmax values of 8,000 μM and 27.1 nmol/min/mg of protein (humans), 19,300 μM and 113.5 nmol/min/mg of protein (male rats), and 11,910 μM and 75.8 nmol/min/mg of protein (female rats). The metabolism of aldol showed rapid and non-saturable hepatic clearance in human liver fractions.

Keywords: beta-hydroxybutyrate ; clearance ; hepatic metabolism ; ketone bodies ; Veech ketone ester

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Product Details of NADP sodium salt

CAS No. :1184-16-3
Formula : C21H27N7NaO17P3
M.W : 765.39
SMILES Code : O=P(O)(O[C@H]1[C@@H](O[C@@H]([C@H]1O)COP(OP(OC[C@H]2O[C@H]([C@@H]([C@@H]2O)O)[N+]3=CC=CC(C(N)=O)=C3)([O-])=O)([O-])=O)N4C5=C(N=C4)C(N)=NC=N5)O.[Na+]
Synonyms :
Sodium NADP
MDL No. :MFCD00036973

Safety of NADP sodium salt

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H319
Precautionary Statements:P305+P351+P338

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01686204 Intestinal Barrier Function ... More >> Chronic Inflammation Less << Not Applicable Completed - United States, Wisconsin ... More >> Department of Food Science, Babcock Hall Madison, Wisconsin, United States, 53706 Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.31mL

0.26mL

0.13mL

6.53mL

1.31mL

0.65mL

13.07mL

2.61mL

1.31mL
Dissolving Methods
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

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