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Chemical Structure| 117570-53-3 Chemical Structure| 117570-53-3

Structure of Vadimezan
CAS No.: 117570-53-3

Chemical Structure| 117570-53-3

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CAS No.: 117570-53-3

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DMXAA is an apoptosis inducer with anti-vascular activity. It is mSTING agonist, selective for mouse STING over human STING. It Induces IFN-β and cytokine production from bone marrow-derived dendritic cells.

Synonyms: DMXAA; ASA-404; AS1404

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Product Details of Vadimezan

CAS No. :117570-53-3
Formula : C17H14O4
M.W : 282.29
SMILES Code : O=C(O)CC1=CC=CC(C2=O)=C1OC3=C2C=CC(C)=C3C
Synonyms :
DMXAA; ASA-404; AS1404
MDL No. :MFCD00870555
InChI Key :XGOYIMQSIKSOBS-UHFFFAOYSA-N
Pubchem ID :123964

Safety of Vadimezan

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Target
  • VDA

    DT-diaphorase, Ki:20 μM

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01031212 Tumors Phase 1 Withdrawn(The investigator has... More >> left the institution (UCSF) prior to study start-up) Less << June 2013 United States, California ... More >> UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, California, United States, 94115 Less <<
NCT00662597 Non-Small Cell Lung Cancer Phase 3 Terminated - -
NCT01057342 Lung Cancer Phase 2 Completed - Switzerland ... More >> Saint Claraspital AG Basel, Switzerland, CH-4016 Universitaetsspital-Basel Basel, Switzerland, CH-4031 Istituto Oncologico della Svizzera Italiana - Ospedale San Giovanni Bellinzona, Switzerland, CH-6500 Inselspital Bern Bern, Switzerland, CH-3010 Spitalzentrum Biel Biel, Switzerland, CH-2501 Centre Hospitalier Universitaire Vaudois Lausanne, Switzerland, CH-1011 Kantonsspital Olten Olten, Switzerland, CH-4600 Onkologie Schaffhausen Schaffhausen, Switzerland, CH-8200 Kantonsspital - St. Gallen St. Gallen, Switzerland, CH-9007 Regionalspital Thun, Switzerland, 3600 Kantonsspital Winterthur Winterthur, Switzerland, CH-8400 Klinik Hirslanden Zurich, Switzerland, CH-8032 Less <<
NCT00111618 Prostate Cancer Phase 2 Completed - -
NCT00003697 Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << Phase 1 Completed - United Kingdom ... More >> Mount Vernon Hospital Northwood, England, United Kingdom, HA6 2RN Less <<
NCT01240642 Metastatic Cancer With Impaire... More >>d Renal Function Metastatic Cancer With Normal Renal Function Less << Phase 1 Terminated - Belgium ... More >> Novartis Investigative Site Charleroi, Belgium Novartis Investigative Site Jette, Belgium Novartis Investigative Site Lambert, Belgium Novartis Investigative Site Wilrijk, Belgium Less <<
NCT01071928 Urothelial Carcinoma Phase 2 Withdrawn(Lack of efficacy of ... More >>experimental treatment) Less << - -
NCT00674102 Non-small Cell Lung Cancer Phase 1 Completed - Japan ... More >> Novartis Investigative Site Aichi, Japan Novartis Investigative Site Osaka, Japan Novartis Investigative Site Shizuoka, Japan Novartis Investigative Site Tokyo, Japan Less <<
NCT01278849 Histologically-proven and Radi... More >>ologically-confirmed Solid Tumors Less << Phase 1 Terminated - Italy ... More >> Novartis Investigative Site Ancona, AN, Italy, 60126 Novartis Investigative Site Milano, Italy, 2104 New Zealand Novarts Investigative Site Auckland, New Zealand Novartis Investigative Site Wellington, New Zealand Less <<
NCT01285453 Advanced or Recurrent Solid Tu... More >>mors Less << Phase 1 Completed - Japan ... More >> Novartis Investigative Site Aichi, Japan Novartis Investigative Site Osaka, Japan Less <<
NCT01299701 Advanced Solid Tumors Phase 1 Terminated - New Zealand ... More >> Novartis Investigative Site Grafton, Auckland, New Zealand Less <<
NCT01290380 Solid Tumor Malignancies Phase 1 Terminated - United States, Texas ... More >> The University of Texas Science Center at Houston Houston, Texas, United States, 77030 United States, Wisconsin University of Wisconsin & Paul P. Carbone Comprehensive Cancer Center Madison, Wisconsin, United States, 53792 Less <<
NCT01299415 Solid Tumors Phase 1 Terminated - United States, Indiana ... More >> Univ. of Indiana School of Medicine/Simon Cancer Center Indianapolis, Indiana, United States, 46202 United States, Minnesota Masonic Cancer Center/ Clinical Trials Office Minneapolis, Minnesota, United States, 55455 United States, Missouri Washington University School of Medicine/Siteman Cancer Center St. Louis, Missouri, United States, 63110 United States, Texas Cancer Therapy & Research Center San Antonio, Texas, United States, 78229 Less <<
NCT00856336 Refractory Tumors PHASE1 COMPLETED 2025-01-04 -
NCT00832494 Non-Small Cell Lung Cancer Phase 1 Phase 2 Completed - -
NCT01278758 Metastatic Cancer Phase 1 Terminated - United States, Indiana ... More >> Indiana University Melvin and Bren Simon Cancer Center, Hematology/Oncology Dept. Indiannapolis, Indiana, United States, 46202 United States, Maryland Hematology /Oncology Associates Rockville, Maryland, United States, 20850 United States, Michigan Joseph Ford Cancer Center/Clinical Trials Office, Henry Ford Health System Detroit, Michigan, United States, 48202 United States, Washington Seattle Cancer Care Alliance Seattle, Washington, United States, 98109-1023 Less <<
NCT00863733 Solid Tumors PHASE1 COMPLETED 2000-03-01 -
NCT00738387 Non-Small Cell Lung Cancer Phase 3 Terminated - -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.54mL

0.71mL

0.35mL

17.71mL

3.54mL

1.77mL

35.42mL

7.08mL

3.54mL

References

 

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