Structure of 117-21-5
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CAS No. : | 117-21-5 |
Formula : | C8H3ClO3 |
M.W : | 182.56 |
SMILES Code : | O=C(C1=CC=CC(Cl)=C12)OC2=O |
MDL No. : | MFCD00023107 |
InChI Key : | UERPUZBSSSAZJE-UHFFFAOYSA-N |
Pubchem ID : | 67014 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In acetic acid; for 3h;Reflux; | SYNTHESIS EXAMPLE 105-1 An acetic acid (200 mL) solution of <strong>[117-21-5]3-chlorophthalic anhydride</strong> (36.5 g) and aniline (18.6 g) was heated to reflux for 3 hours. After cooling to room temperature, the reaction mixture was poured into iced water, and the precipitated crystal was collected by filtration, washed with water and 5% isopropanol aqueous solution, and then dried. The resulting crude crystal was washed with a t-butylmethylether/petroleum ether mixed solvent to obtain 3-chloro-N-phenylphthalimide (50.1 g). 1H-NMR (CDCl3, δ ppm): 7.38-7.55 (5H, m), 7.69-7.74 (2H, m), 7.85-7.91 (1H, m). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
83% | With aluminum (III) chloride; at 90℃; for 2h; | General procedure: A mixture of the corresponding phthalic anhydride (1 mol. equiv.), the appropriate halobenzene (8 mol. equiv.), and aluminium chloride (2.4 mol. equiv.) was heated at 90 oC for 2h, then cooled to room temperature. Ice was added followed by conc. HCl (5 mL) and the mixture was extracted into DCM (3 x 50 mL) and washed with 10% Na2CO3 solution (2 x 50 mL). The Na2CO3 washings were combined and acidified to pH3 with conc. HCl acid. The resulting precipitate was collected by filtration and dried in a vacuum oven. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
93% | With hydrazine hydrate; acetic acid; at 0 - 125℃; for 2h;Inert atmosphere; | 3-Chloro-phthalic anhydride (5a, purchased from TCI) (10 g, 54.95 mmol) was dissolved in glacial acetic acid (100 mL), and hydrazine hydrate (20 mL) was added dropwise at 0C, and then refluxed for two hours at 125C. When the reaction was completed, the solution was cooled down to room temperature, filtrated, and washed with water until the filtrate pH=6.0, and then dried to give 5-chloro-2,3-dihydrophthalazin-1,4-dione (5b), 10.08 g white solid (yield 93%). |
93% | With hydrazine hydrate; acetic acid; In acetic acid; at 0 - 125℃; for 2h; | 3-Chloro-phthalic anhydride (5a, purchased from TCI) (10 g, 54.95 mmol) was dissolved in glacial acetic acid (100 mL), and hydrazine hydrate (20 mL) was added dropwise at 0 C., and then refluxed for two hours at 125 C. When the reaction was completed, the solution was cooled down to room temperature, filtrated, and washed with water until the filtrate pH 6.0, and then dried to give 5-chloro-2,3-dihydrophthalazin-1,4-dione (5b), 10.08 g white solid (yield 93%). |
With hydrogenchloride; hydrazine hydrate; In quinoline; for 24h;Reflux; | General procedure: A stirred solution of phthalic anhydride (S1, 1.0 equiv), HCl (10 wt% aq), and N2H4*H2O (1.5 equiv) was refluxed in an oil bath for 24 hours under air. Then, the reaction mixture was cooled to room temperature and filtered through filter paper.The filter cake was washed with H2O and dried under reduced pressure to give 2,3-dihydrophthalazine-1,4-dione (S2). The crude material was used for the next step without further purification. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
96% | With acetic acid; at 100℃; for 3h; | Add <strong>[117-21-5]3-chlorophthalic anhydride</strong> (365 mg, 2.0 mmol) and aminopropionic acid (190 mg, 2.1 mmol) to glacial acetic acid(10 mL), heated to 100 C for 3 h. The reaction was quenched with water (10 mL), and the pH of the solution was adjusted to NaOH solution (0.1 mol/L).6-8. Filtered and dried to give a yellow solid 425mg, LC-MS and 1H-NMR confirmed the expected intermediate compound, yield 96.0%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
A 45.85 g sample of an oxidation mixture in acetic acid from the oxidation of 3- and 4-chloroxylene in the presence of a catalyst composition comprising cobalt and manganese was treated with 0.143 g. of oxalic acid dihydrate and brought to reflux for 30 minutes (this process removed about 90% of the cobalt and >50% of the manganese by precipitation as the oxalate salts). The solution was then passed through a glass frit under vacuum. The remainder of the solvent was removed by evaporation (down to 16.2 g.) and distillation (down to 14.0 g. residue). The remaining light yellow solid was combined with 60 ml. of water and 40 ml. of toluene, and mixed. There was some emulsion layer which was treated in a second wash with an additional 15 ml. each of water and toluene. The solvent was removed by evaporation of each fraction to leave 10.6 g. in the water fraction and 2.7 g. in the toluene fraction. The fractions were analyzed by GC. The analytical results are shown in Table 7. |