[ CAS No. 1142-20-7 ] {[proInfo.proName]}

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2D 3D

Structure of 1142-20-7 * Storage: {[proInfo.prStorage]}

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Quality Control of [ 1142-20-7 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 1142-20-7 ]

SDS Specification

Alternatived Products of [ 1142-20-7 ]

Product Details of [ 1142-20-7 ]

CAS No. :	1142-20-7	MDL No. :	MFCD00002640
Formula :	C₁₁H₁₃NO₄	Boiling Point :	-
Linear Structure Formula :	HO₂CCH(NHCOOCH₂C₆H₅)CH₃	InChI Key :	TYRGLVWXHJRKMT-QMMMGPOBSA-N
M.W :	223.23	Pubchem ID :	736104
Synonyms :	(S)-2-(Benzyloxycarbonylamino)propanoic acid;L-Alanine, N-carboxy-, N-benzyl ester (6CI,7CI);N-[(Benzyloxy)carbonyl]-L-alanine	Chemical Name :	((Benzyloxy)carbonyl)-L-alanine

Safety of [ 1142-20-7 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 1142-20-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 1142-20-7 ]

[ 1142-20-7 ] Synthesis Path-Downstream 1~13

1
[ 1142-20-7 ]
[ 2011-66-7 ]
[ 58662-82-1 ]

Yield	Reaction Conditions	Operation in experiment
	With thionyl chloride; sodium hydrogencarbonate; In tetrahydrofuran; Petroleum ether;	(a) 53.6 g of carbobenzoxy-L-alanine are dissolved in 400 ml of dry tetrahydrofuran, the solution is treated dropwise with 30 g of thionyl chloride while cooling with ice and the mixture is stirred for 1 hour in the cold. A solution of 54 g (0.2 mol) of <strong>[2011-66-7]2-amino-5-nitro-2'-chlorobenzophenone</strong> in 150 ml of dry tetrahydrofuran is subsequently added dropwise thereto rapidly, whereupon the mixture is stirred at room temperature for 24 hours. The solution obtained is concentrated, the residue is treated with ice and 10 percent sodium bicarbonate solution and extracted with methylene chloride. The organic solution is dried over sodium sulphate and evaporated. The residue is treated with dry ether, left to crystallize for 1 hour and then filtered while rinsing with ether/petroleum ether (1:1). After drying, there is obtained (S)-benzyl-[1-[[2-(o-chlorobenzoyl)-4-nitrophenyl]carbamoyl]ethyl]carbamate of melting point 143-145; [alpha]25 D =18 (1 percent solution in methylene chloride).

Reference： [1]Patent: US4474777,1984,A

2
[ 1142-20-7 ]
[ 2338-18-3 ]
phenylmethyl [2-[(2,3-dihydro-1H-inden-2-yl)amino]-1R-methyl-2-oxoethyl]carbamate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		Example 20 phenylmethyl [2-[(2,3-dihydro-1H-inden-2-yl)amino]-1R-methyl-2-oxoethyl]carbamate STR29 (Z-(D)Ala-NH-2Indane) The title compound was prepared from Z-(D)Alanine (10 g, 44.8 mmol) and 2-amino indane hydrochloride (7.6 g, 44.8 mmol) by the method of Example 8. After workup, the crude solid was washed liberally with Et2 O to give 12.35 g of the white solid title material.

Reference： [1]Patent: US4822775,1989,A

3
[ 1142-20-7 ]
[ 2011-66-7 ]
[ 80080-94-0 ]

Yield	Reaction Conditions	Operation in experiment
	With phosphorus pentachloride; In tetrahydrofuran; toluene;	82 g of carbobenzoxy-L-alanine are dissolved in 100 ml of absolute tetrahydrofuran, the solution is cooled to -40 C and treated with 80 g of phosphorus pentachloride. The mixture is stirred at -30 C for 20 minutes and subsequently added to a shaken solution of 80 g of <strong>[2011-66-7]2-amino-5-nitro-2'-chlorobenzophenone</strong> in 100 ml of absolute tetrahydrofuran. The solution is concentrated on a rotary evaporator at 50-60 C, treated twice with toluene and evaporated each time. By crystallisation of the residue from ether, there is obtained (-)-benzyl-[1-[{2-(o-chlorobenzoyl)4-nitrophenyl}carbamoyl]-ethyl]carbamate which melts at 147 C and exhibits a rotation of [alpha]25D =-18.2 (in methylene chloride, 1%).

Reference： [1]Patent: US4031078,1977,A

4
[ 1142-20-7 ]
[ 73101-74-3 ]
[ 1254122-50-3 ]

Reference： [1]Tetrahedron,2010,vol. 66,p. 8189 - 8195

5
[ 1142-20-7 ]
[ 78603-91-5 ]

Reference： [1]Applied Organometallic Chemistry,2015,vol. 29,p. 661 - 667

6
[ 1142-20-7 ]
[ 68858-20-8 ]
[ 35661-60-0 ]
[ 35661-39-3 ]
N-(9-fluorenylmethoxycarbonyl)-(L)-5-hydroxy-norvaline-1-allyl ester [ No CAS ]
[ 73731-37-0 ]
[ 77128-73-5 ]
C₄₉H₇₂N₈O₁₂ [ No CAS ]