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Chemical Structure| 1123231-07-1 Chemical Structure| 1123231-07-1
Chemical Structure| 1123231-07-1

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CAS No.: 1123231-07-1

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WAY-262611 is an agonist of β-Catenin and can increase bone formation rate with EC50 of 0.63 μM.

Synonyms: BML-WN110; Dkk1 Inhibitor; WAY-262611 dihydrochloride WAY 262611 dihydrochloride

4.5 *For Research Use Only !

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Product Details of WAY-262611

CAS No. :1123231-07-1
Formula : C20H22N4
M.W : 318.42
SMILES Code : NCC1CCN(C2=NC=CC(C3=CC=C4C=CC=CC4=C3)=N2)CC1
Synonyms :
BML-WN110; Dkk1 Inhibitor; WAY-262611 dihydrochloride WAY 262611 dihydrochloride
MDL No. :MFCD20527803
InChI Key :QHLITPHIARVDJI-UHFFFAOYSA-N
Pubchem ID :25199517

Safety of WAY-262611

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.14mL

0.63mL

0.31mL

15.70mL

3.14mL

1.57mL

31.41mL

6.28mL

3.14mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

[1]Enochson L, Stenberg J, et al. GDF5 reduces MMP13 expression in human chondrocytes via DKK1 mediated canonical Wnt signaling inhibition. Osteoarthritis Cartilage. 2014 Apr;22(4):566-77.

[2]Pelletier JC, Lundquist JT 4th, et al. (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate. J Med Chem. 2009 Nov 26;52(22):6962-5.

[3]Ahn VE, Chu ML, Choi HJ, Tran D, Abo A, Weis WI. Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6. Dev Cell. 2011 Nov 15;21(5):862-73. doi: 10.1016/j.devcel.2011.09.003. Epub 2011 Oct 13. PMID: 22000856; PMCID: PMC3215855.

[4]Niehrs C. Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene. 2006 Dec 4;25(57):7469-81. doi: 10.1038/sj.onc.1210054. PMID: 17143291.

[5]Pelletier JC, Lundquist JT 4th, Gilbert AM, Alon N, Bex FJ, Bhat BM, Bursavich MG, Coleburn VE, Felix LA, Green DM, Green P, Hauze DB, Kharode YP, Lam HS, Lockhead SR, Magolda RL, Matteo JJ, Mehlmann JF, Milligan C, Murrills RJ, Pirrello J, Selim S, Sharp MC, Unwalla RJ, Vera MD, Wrobel JE, Yaworsky P, Bodine PV. (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate. J Med Chem. 2009 Nov 26;52(22):6962-5. doi: 10.1021/jm9014197. PMID: 19856966.

[6]Choe JY, Hun Kim J, Park KY, Choi CH, Kim SK. Activation of dickkopf-1 and focal adhesion kinase pathway by tumour necrosis factor α induces enhanced migration of fibroblast-like synoviocytes in rheumatoid arthritis. Rheumatology (Oxford). 2016 May;55(5):928-38. doi: 10.1093/rheumatology/kev422. Epub 2015 Dec 29. PMID: 26715774.

 

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