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Chemical Structure| 112-72-1 Chemical Structure| 112-72-1
Chemical Structure| 112-72-1

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CAS No.: 112-72-1

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1-Tetradecanol is a straight-chain saturated fatty alcohol isolated from Myristica fragrans, with antibacterial and anti-inflammatory properties.

Synonyms: Tetradecyl Alcohol

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Product Details of 1-Tetradecanol

CAS No. :112-72-1
Formula : C14H30O
M.W : 214.39
SMILES Code : CCCCCCCCCCCCCCO
Synonyms :
Tetradecyl Alcohol
MDL No. :MFCD00004757
InChI Key :HLZKNKRTKFSKGZ-UHFFFAOYSA-N
Pubchem ID :8209

Safety of 1-Tetradecanol

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 1-Tetradecanol

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 112-72-1 ]

[ 112-72-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 112-72-1 ]
  • [ 320-47-8 ]
  • [ 1132110-16-7 ]
  • 2
  • [ 112-72-1 ]
  • [ 3543-75-7 ]
  • [ 1609623-05-3 ]
YieldReaction ConditionsOperation in experiment
36.4% With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20℃; for 20h;Inert atmosphere; Preparation of 4-{5-[Bis-(chloroethyl)-amino]-l-methyl-lH-benzimidazol-2-yl}butyric acid tetradecyl ester (<strong>[3543-75-7]bendamustine</strong> C ester): Method A: A 500 mL three necked round bottom flask equipped with a stir bar, thermocouple and nitrogen in/outlet was charged with 10.0 g (25.3 mmol) of <strong>[3543-75-7]<strong>[3543-75-7]bendamustine</strong> hydrochloride</strong>, 6.5 g (30.4 mmol, 1.2 eq) of teradecyl alcohol, 6.3 g (30.4 mmol, 1.2 eq) of dicyclohexyl carbodiimide (DCC), 100 mL of dichloromethane and 0.62 g (5.1 mmol, 0.2 eq) of Nu,Nu-dimethylamino pyridine (DMAP). The reaction mixture was stirred at room temperature for 20 hours at which time an HPLC analysis indicated the reaction was complete. Solids were removed by vacuum filtration and the wetcake was washed with 50 mL of dichloromethane before concentrating the filtrate to dryness in vacuo. The resultant light orange oil was triturated with 50 mL of dichloromethane and the undesired solids were removed by vacuum filtration. The filtrate was once again concentrated to dryness in vacuo to yield 16.5 g of a semi-solid which was shown by XH NMR to contain tetradecanol and DMAP. The residue was chromatographed on 150 g of silica gel 60, 230-400 mesh eluting with 1500 mL of MDC, 1000 mL of 0.5% methanol/MDC and 2000 mL of 1% methanol/MDC collecting 100-150 mL fractions. Fractions containing the desired product were combined and concentrated to dryness in vacuo. The residue was again triturated with 30 mL of MDC and the undesired solids removed by filtration. The filtrate was concentrated in vacuo to yield 5.0 g (9.2 mmol, 36.4%) of the desired product as a light purple solid with a purity of 95.0A%.
 

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