Structure of Plerixafor
CAS No.: 110078-46-1
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Plerixafor is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.
Synonyms: AMD 3100; JM3100; JKL 169
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CAS No. : | 110078-46-1 |
Formula : | C28H54N8 |
M.W : | 502.78 |
SMILES Code : | N1(CC2=CC=C(CN3CCNCCCNCCNCCC3)C=C2)CCNCCCNCCNCCC1 |
Synonyms : |
AMD 3100; JM3100; JKL 169
|
MDL No. : | MFCD05662218 |
InChI Key : | YIQPUIGJQJDJOS-UHFFFAOYSA-N |
Pubchem ID : | 65015 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Target |
|
In Vitro:
Concentration | Treated Time | Description | References |
KU812F cells | 50 μM | 3 h | Reduced adhesion of CML cells to BM microenvironment components | PMC4124489 |
KU812F cells | 50 μM | 3 h | Reduced drug resistance of CML cells to nilotinib | PMC4124489 |
EJ cells | 50 μM | 24 h | Inhibited the proliferation and migration capacity of EJ cells by blocking CXCR4 downstream signaling | PMC9977173 |
MDA-MB-231 cells | 10 μg/mL | 1 h | To study the uptake of Plerixafor-modified nanocarriers in CXCR4-expressing MDA-MB-231 cells, results showed that Plerixafor-modified nanocarriers had a higher uptake rate in CXCR4-expressing cells compared to unmodified carriers. | PMC5474759 |
In Vivo:
Administration | Dosage | Frequency | Description | References |
Mice | Radiation-induced wound healing deficit model | Subcutaneous injection | 5 mg/kg | Single injection | Plerixafor combined with G-CSF enhanced the efficacy of MSC-FMB in correcting radiation-induced wound healing deficits | PMC3519961 |
Mice | Spinal cord injury model | Subcutaneous injection | 5 mg/kg | Once daily for 3 days | Plerixafor treatment increased the number of HSPCs released into the blood by more than 6-fold, with a corresponding increase in the number of HSPCs found in the spleen, and reversed the post-SCI leukopenia. | PMC7382469 |
Mice | BCR-ABL-positive leukemia mouse model | Subcutaneous injection | 5 mg/kg | Once daily for 10 days | Reduced leukemia burden and prolonged survival | PMC4124489 |
Nude mice | EJ xenograft model | Intravenous injection | 100 μM, 100 μl | Once every 2 days for a total of five times | Plerixafor significantly inhibited tumor growth, with a mean tumor volume of 647±147 mm3, compared to 1086±257 mm3 in the saline group | PMC9977173 |
Rhesus macaque | Rhesus gene therapy model | Intravenous injection | 1 mg/kg | Single dose, after 5 days of G-CSF administration | Mobilization of CD34+ cells for gene therapy model | PMC10570335 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT01164475 | - | Completed | - | - | |
NCT01711073 | End Stage Liver DIsease | Phase 1 | Unknown | September 2013 | United States, New Jersey ... More >> University of Medicine and Dentistry of New Jersey Recruiting Newark, New Jersey, United States, 07101 Contact: Baburao Koneru, MD ?? ?? koneruba@umdnj.edu Less << |
NCT01123499 | - | Recruiting | - | United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting Bethesda, Maryland, United States, 20892 Contact: Sandra Maxwell, B.S.N. ?? 301-402-1773 ?? maxwells@niaid.nih.gov Less << | |
NCT03055247 | Chronic Granulomatous Disease ... More >>X-linked (X-CGD) Less << | Phase 2 | Recruiting | August 2018 | Italy ... More >> Ospedale Pediatrico Bambino Gesù Recruiting Rome, Lazio, Italy, 00165 Contact: Franco Locatelli, MD, PhD ?? ?? ?? Sub-Investigator: Andrea Finocchi, MD ?? ?? ?? Ospedale San Raffaele Recruiting Milan, Lombardia, Italy, 20132 Contact: Fabio Ciceri, MD, PhD ?? ?? ?? Sub-Investigator: Alessandro Aiuti, MD, PhD ?? ?? ?? Sub-Investigator: Bernhard Gentner, MD, PhD ?? ?? ?? Sub-Investigator: Maddalena Migliavacca, MD ?? ?? ?? Sub-Investigator: Laura Bellio, MD Less << |
NCT01182675 | Severe Combined Immunodeficien... More >>cy Less << | Phase 2 | Terminated(Insufficient eviden... More >>ce of efficacy) Less << | - | United States, California ... More >> UCSF Benioff Children's Hospital San Francisco, California, United States, 94143 Less << |
NCT01182675 | - | Terminated(Insufficient eviden... More >>ce of efficacy) Less << | - | - | |
NCT00914849 | - | Completed | - | - | |
NCT00291811 | - | - | - | - | |
NCT02231879 | Myelokathexis ... More >> WHIMS Neutropenia Warts Less << | Phase 3 | Active, not recruiting | May 31, 2021 | United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less << |
NCT00733824 | Lymphoma, Non-Hodgkin ... More >> Hodgkin Disease Less << | Phase 1 Phase 2 | Completed | - | United States, Missouri ... More >> Washington University School of Medicine St. Louis, Missouri, United States, 63110 Less << |
NCT00733824 | - | Completed | - | - | |
NCT02931071 | Fanconi Anemia | Phase 2 | Unknown | September 2018 | Spain ... More >> Hospital Universitari Vall d'Hebron Recruiting Barcelona, Spain, 08035 Contact: Cristina Díaz de Heredia, MD, PhD ?? +34934893093 ?? crdiaz@vhebron.net ?? Hospital Infantil Universitario Ni?o Jesus Recruiting Madrid, Spain, 28009 Contact: Julian Sevilla Navarro, MD, PhD ?? 0034 91 5035938 ?? jsevilla.hnjs@salud.madrid.org Less << |
NCT00914849 | Hematologic Neoplasms | Phase 2 | Completed | - | United States, Missouri ... More >> Washington University School of Medicine St. Louis, Missouri, United States, 63110 Less << |
NCT02098109 | - | Completed | - | - | |
NCT02098109 | Multiple Myeloma ... More >> Lymphoma, Non-Hodgkin Less << | Phase 2 | Completed | - | United States, Missouri ... More >> Washington University School of Medicine Saint Louis, Missouri, United States, 63110 Less << |
NCT00241358 | - | Completed | - | - | |
NCT01074060 | Refractory Multiple Myeloma ... More >> Stage I Multiple Myeloma Stage II Multiple Myeloma Stage III Multiple Myeloma Less << | Phase 1 | Completed | - | United States, California ... More >> City of Hope Duarte, California, United States, 91010 Less << |
NCT00241358 | Leukemia, Myeloid, Acute ... More >> Leukemia, Myelogenous, Chronic Leukemia, Lymphoblastic, Acute Lymphocytic Leukemia, Chronic Myelodysplastic Syndromes Multiple Myeloma Lymphoma, Non-Hodgkin Hodgkin Disease Less << | Phase 1 Phase 2 | Completed | - | United States, Missouri ... More >> Washington University School of Medicine Saint Louis, Missouri, United States, 63110 Less << |
NCT00720603 | Non-Hodgkin's Lymphoma|Hodgkin... More >>'s Disease|Multiple Myeloma Less << | NO_LONGER_AVAILABLE | - | - | |
NCT01288573 | Ewing's Sarcoma/Soft Tissue Sa... More >>rcoma Neuroblastoma Brain Tumors Less << | Phase 1 Phase 2 | Completed | - | - |
NCT01076270 | Accelerated Phase Chronic Myel... More >>ogenous Leukemia Adult Acute Lymphoblastic Leukemia in Remission Adult Acute Myeloid Leukemia in Remission Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) Adult Acute Myeloid Leukemia With t(15;17)(q22;q12) Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) Adult Acute Myeloid Leukemia With t(8;21)(q22;q22) Atypical Chronic Myeloid Leukemia, BCR-ABL Negative Blastic Phase Chronic Myelogenous Leukemia Chronic Phase Chronic Myelogenous Leukemia de Novo Myelodysplastic Syndromes Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable Nodal Marginal Zone B-cell Lymphoma Noncontiguous Stage II Adult Burkitt Lymphoma Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma Noncontiguous Stage II Adult Lymphoblastic Lymphoma Noncontiguous Stage II Grade 1 Follicular Lymphoma Noncontiguous Stage II Grade 2 Follicular Lymphoma Noncontiguous Stage II Grade 3 Follicular Lymphoma Noncontiguous Stage II Mantle Cell Lymphoma Noncontiguous Stage II Marginal Zone Lymphoma Noncontiguous Stage II Small Lymphocytic Lymphoma Previously Treated Myelodysplastic Syndromes Recurrent Adult Acute Lymphoblastic Leukemia Recurrent Adult Acute Myeloid Leukemia Recurrent Adult Burkitt Lymphoma Recurrent Adult Diffuse Large Cell Lymphoma Recurrent Adult Diffuse Mixed Cell Lymphoma Recurrent Adult Diffuse Small Cleaved Cell Lymphoma Recurrent Adult Hodgkin Lymphoma Recurrent Adult Immunoblastic Large Cell Lymphoma Recurrent Adult Lymphoblastic Lymphoma Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma Recurrent Grade 1 Follicular Lymphoma Recurrent Grade 2 Follicular Lymphoma Recurrent Grade 3 Follicular Lymphoma Recurrent Mantle Cell Lymphoma Recurrent Marginal Zone Lymphoma Recurrent Mycosis Fungoides/Sezary Syndrome Recurrent Small Lymphocytic Lymphoma Refractory Chronic Lymphocytic Leukemia Refractory Hairy Cell Leukemia Refractory Multiple Myeloma Relapsing Chronic Myelogenous Leukemia Secondary Acute Myeloid Leukemia Secondary Myelodysplastic Syndromes Splenic Marginal Zone Lymphoma Stage I Multiple Myeloma Stage II Multiple Myeloma Stage III Adult Burkitt Lymphoma Stage III Adult Diffuse Large Cell Lymphoma Stage III Adult Diffuse Mixed Cell Lymphoma Stage III Adult Diffuse Small Cleaved Cell Lymphoma Stage III Adult Hodgkin Lymphoma Stage III Adult Immunoblastic Large Cell Lymphoma Stage III Adult Lymphoblastic Lymphoma Stage III Chronic Lymphocytic Leukemia Stage III Grade 1 Follicular Lymphoma Stage III Grade 2 Follicular Lymphoma Stage III Grade 3 Follicular Lymphoma Stage III Mantle Cell Lymphoma Stage III Marginal Zone Lymphoma Stage III Multiple Myeloma Stage III Small Lymphocytic Lymphoma Stage IV Adult Burkitt Lymphoma Stage IV Adult Diffuse Large Cell Lymphoma Stage IV Adult Diffuse Mixed Cell Lymphoma Stage IV Adult Diffuse Small Cleaved Cell Lymphoma Stage IV Adult Hodgkin Lymphoma Stage IV Adult Immunoblastic Large Cell Lymphoma Stage IV Adult Lymphoblastic Lymphoma Stage IV Chronic Lymphocytic Leukemia Stage IV Grade 1 Follicular Lymphoma Stage IV Grade 2 Follicular Lymphoma Stage IV Grade 3 Follicular Lymphoma Stage IV Mantle Cell Lymphoma Stage IV Marginal Zone Lymphoma Stage IV Small Lymphocytic Lymphoma Less << | Not Applicable | Terminated(Funding withdrawal) | - | United States, Washington ... More >> Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium Seattle, Washington, United States, 98109 Less << |
NCT01076270 | - | Terminated(Funding withdrawal) | - | - | |
NCT01186224 | Multiple Myeloma ... More >> Plasma Cell Dyscrasia Lymphoma Lymphoproliferative Disorders Less << | Not Applicable | Unknown | May 2012 | United Kingdom ... More >> Dept of Haematology, University of Liverpool Recruiting Liverpool, Merseyside, United Kingdom, L7 8XP Principal Investigator: Richard E Clark, BA, MB, BS Less << |
NCT01027923 | Leukemia, Myeloid, Acute | Phase 1 | Terminated(Withdrawal of suppo... More >>rt from sponsor) Less << | - | United States, Missouri ... More >> Washington University School of Medicine St. Louis, Missouri, United States, 63110 Less << |
NCT01225419 | Children Cancer, Solid Tumor | Phase 2 | Completed | - | France ... More >> CHU Clermont-Ferrand Clermont-Ferrand, France, 63003 Less << |
NCT00444912 | Non-Hodgkin Lymphoma ... More >> Hodgkin Disease Less << | Phase 2 | Completed | - | United States, Georgia ... More >> Winship Cancer Institute Atlanta, Georgia, United States, 30322 Less << |
NCT01610999 | Chronic Lymphocytic Leukemia|L... More >>ymphoma|Multiple Myeloma Less << | PHASE1 | TERMINATED | 2025-12-15 | Tufts Medical Center, Boston, ... More >>Massachusetts, 02111, United States Less << |
NCT00444912 | - | Completed | - | - | |
NCT00103610 | Lymphoma, Non-Hodgkin | Phase 3 | Completed | - | - |
NCT00103662 | Multiple Myeloma | Phase 3 | Completed | - | - |
NCT00103610 | - | Completed | - | - | |
NCT00103662 | - | Completed | - | - | |
NCT00822770 | Stem Cell Transplantation ... More >> Leukemia Less << | Phase 1 Phase 2 | Completed | - | United States, Texas ... More >> UT MD Anderson Cancer Center Houston, Texas, United States, 77030 Less << |
NCT00822770 | - | Completed | - | - | |
NCT01220375 | Myeloma | Phase 2 | Completed | - | Switzerland ... More >> Dep. of Medical Oncology, Bern University Hospital Bern, Switzerland, 3010 Less << |
NCT00943943 | Acute Myelogenous Leukemia ... More >> Leukemia Less << | Phase 1 | Completed | - | United States, Texas ... More >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Less << |
NCT00903968 | Multiple Myeloma | Phase 1 Phase 2 | Completed | - | United States, Massachusetts ... More >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Cape Cod Hospital Hyannis, Massachusetts, United States, 02601 Milford Hospital Milford, Massachusetts, United States, 01757 Newton-Wellesley Hospital Newton, Massachusetts, United States, 02462 United States, Pennsylvania Cancer Treatment Centers of America (Eastern Regional Medical Center) Philadelphia, Pennsylvania, United States, 19124 Less << |
NCT01916577 | COPD Cystic F... More >>ibrosis Pulmonary Fibrosis Less << | Phase 1 | Completed | - | United States, Colorado ... More >> University of Colorado Hospital Aurora, Colorado, United States, 80045 Less << |
NCT00903968 | - | Completed | - | - | |
NCT01065129 | Myelodysplastic Syndromes | Phase 1 | Completed | - | United States, Missouri ... More >> Washington University School of Medicine St. Louis, Missouri, United States, 63110 Less << |
NCT01767714 | Non-Hodgkin's Lymphoma | Phase 3 | Completed | - | China ... More >> Investigational Site Number 156017 Beijing, China, 100034 Investigational Site Number 156001 Beijing, China, 100044 Investigational Site Number 156005 Beijing, China, 100071 Investigational Site Number 156002 Beijing, China, 100142 Investigational Site Number 156003 Beijing, China, 100730 Investigational Site Number 156020 Chongqing, China, 400037 Investigational Site Number 156016 Fuzhou, China, 350001 Investigational Site Number 156021 Guangzhou, China, 510060 Investigational Site Number 156011 Hangzhou, China, 310003 Investigational Site Number 156018 Nanjing, China, 210029 Investigational Site Number 156009 Shanghai, China, 200025 Investigational Site Number 156010 Suzhou, China, 215006 Investigational Site Number 156008 Tianjin, China, 300020 Investigational Site Number 156013 Wuhan, China, 430022 Investigational Site Number 156015 Xi'An, China, 710038 Investigational Site Number 156022 Zhengzhou, China, 450008 Less << |
NCT01301963 | Refractory Multiple Myeloma | Phase 3 | Terminated(Slow Accrual) | - | United States, Ohio ... More >> Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center Cleveland, Ohio, United States, 44106 Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center Cleveland, Ohio, United States, 44195 Less << |
NCT01236144 | Acute Myeloid Leukaemia ... More >> High Risk Myelodysplastic Syndrome Less << | Phase 1 Phase 2 | Completed | - | United Kingdom ... More >> Aberdeen Royal Infirmary Aberdeen, United Kingdom Belfast City Hospital Belfast, United Kingdom Birmingham Heartlands Hospital Birmingham, United Kingdom Addenbrooke's Hospital Cambridge, United Kingdom University Hospital of Wales Cardiff, United Kingdom Castle Hill Hospital Hull, United Kingdom St James's University Hospital Leeds, United Kingdom Royal Liverpool University Hospital Liverpool, United Kingdom St Bartholomew's Hospital London, United Kingdom Christie Hospital Manchester, United Kingdom Manchester Royal Infirmary Manchester, United Kingdom Freeman Hospital Newcastle, United Kingdom Nottingham University Hospital Nottingham, United Kingdom Less << |
NCT01301963 | - | Terminated(Slow Accrual) | - | - | |
NCT01352650 | Acute Myeloid Leukemia | Phase 1 | Completed | - | United States, New York ... More >> Weill Cornell Medical College New York, New York, United States, 10021 Less << |
NCT02006225 | Autologous Stem Cell Transplan... More >>tation Less << | PHASE4 | UNKNOWN | 2025-02-20 | - |
NCT01977677 | Adult Ependymoblastoma ... More >> Adult Giant Cell Glioblastoma Adult Glioblastoma Adult Gliosarcoma Adult Medulloblastoma Adult Mixed Glioma Adult Oligodendroglial Tumors Adult Pineoblastoma Adult Supratentorial Primitive Neuroectodermal Tumor (PNET) Less << | Phase 1 Phase 2 | Completed | - | United States, California ... More >> Stanford University, School of Medicine Stanford, California, United States, 94305 Less << |
NCT00741325 | - | Completed | - | - | |
NCT01160354 | Acute Myelogenous Leukemia | Phase 1 Phase 2 | Terminated(Slow Accrual) | - | United States, Texas ... More >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Less << |
NCT01977677 | - | Completed | - | - | |
NCT01158118 | - | Completed | - | - | |
NCT01164475 | Non-Hodgkin's Lymphoma | Phase 4 | Completed | - | United States, California ... More >> City of Hope National Medical Center Duarte, California, United States, 91010 United States, Colorado University of Colorado Cancer Center Aurora, Colorado, United States, 80045 Canada, Ontario Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Korea, Republic of Samsung Medical Center Seoul, Korea, Republic of, 135-710 St. Mary's Hospital Seoul, Korea, Republic of, 137-701 Taiwan National Taiwan University Hospital Taipei, Taiwan, 10002 Taipei Veterans General Hospital Taipei, Taiwan, 10002 Less << |
NCT01158118 | Leukemia, Myeloid, Acute ... More >> Myelodysplastic Syndromes Lymphoma, Non-Hodgkin Hodgkin Disease Leukemia, Lymphocytic, Chronic, B-Cell Multiple Myeloma Less << | Phase 2 | Completed | - | United States, Missouri ... More >> Washington University School of Medicine Saint Louis, Missouri, United States, 63110 Less << |
NCT00741780 | - | Completed | - | - | |
NCT00512252 | Leukemia, Myeloid, Acute | Phase 1 Phase 2 | Completed | - | United States, Missouri ... More >> Washington University St. Louis, Missouri, United States, 63110 Less << |
NCT01738373 | Bone Marrow / Autologous Trans... More >>plants Less << | COMPLETED | 2025-11-12 | Marseille, France | |
NCT00512252 | - | Completed | - | - | |
NCT01579149 | Healthy Volunteer | Phase 1 | Completed | - | United States, Hawaii ... More >> Honolulu, Hawaii, United States Less << |
NCT01206075 | Beta-Thalassemia | Not Applicable | Completed | - | Greece ... More >> George Papanicolaou Hospital Thessaloniki, Greece Less << |
NCT00396383 | Multiple Myeloma | Phase 2 | Terminated(Insufficient cell m... More >>obilization for tandem transplants) Less << | - | United States, New York ... More >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 United States, Pennsylvania Thomas Jefferson University Philadelphia, Pennsylvania, United States, 19107 Less << |
NCT01339039 | High Grade Glioma: Glioblastom... More >>a (GBM) High Grade Glioma: Gliosarcoma Anaplastic Astrocytoma (AA) Anaplastic Oligodendroglioma (AO) Mixed Anaplastic Oligoastrocytoma (AOA) Less << | Phase 1 | Terminated(Low accrual rate) | - | United States, Massachusetts ... More >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Massachusetts General Hospital Boston, Massachusetts, United States, 02214 Less << |
NCT00396383 | - | Terminated(Insufficient cell m... More >>obilization for tandem transplants) Less << | - | - | |
NCT00396201 | Hodgkin's Disease | Phase 2 | Completed | - | United States, Missouri ... More >> Washington University School of Medicine,Division of Bone Marrow Transplantation & Leukemia St Louis, Missouri, United States, 63110-1093 Less << |
NCT03019809 | Wiskott-Aldrich Syndrome ... More >> Hematopoietic Stem Cell Transplantation Graft Failure Less << | Phase 2 | Recruiting | July 2019 | Russian Federation ... More >> Dmitry Rogachev Federal Research and Clinical Centre of Paediatric Haematology, Oncology and Immunology Recruiting Moscow, Russian Federation, 117997 Contact: Dmitry Balashov, MD, PhD ?? +7(495)287-6570 ext 6534 ?? bala8@yandex.ru ?? Contact: Michael Maschan, Professor ?? +7(926)287-6570 ?? mmaschan@yandex.ru ?? Sub-Investigator: Michael Maschan, Professor ?? ?? ?? Sub-Investigator: Alexandra Laberko, MD ?? ?? ?? Sub-Investigator: Svetlana Kozlovskaya, MD ?? ?? ?? Sub-Investigator: Elena Gutovskaya, MD ?? ?? ?? Sub-Investigator: Anna Shcherbina, Professor Less << |
NCT02212535 | Major Sickle Cell Syndrome of ... More >>Type SS or Sβ Thalassemia Less << | PHASE1|PHASE2 | COMPLETED | 2017-09-27 | H?pital Necker - Enfants Malad... More >>es, Paris, 75015, France Less << |
NCT00396266 | Multiple Myeloma ... More >> Lymphoma, Non-Hodgkin Less << | Phase 2 | Completed | - | Canada, Alberta ... More >> Tom Baker Cancer Center Calgary, Alberta, Canada, T2N 4N2 Canada, British Columbia Vancouver General Hospital, BC Cancer Agency Vancouver, British Columbia, Canada, V5Z 4E3 Less << |
NCT00396201 | - | Completed | - | - | |
NCT00396266 | - | Completed | - | - | |
NCT01753453 | Multiple Myeloma | Phase 2 | Completed | - | Belgium ... More >> Investigational Site Number 056002 Brugge, Belgium, B-8000 Estonia Investigational Site Number 233001 Tallinn, Estonia, 13419 Lithuania Investigational Site Number 440001 Vilnius, Lithuania, LT-08661 Sweden Investigational Site Number 752001 Stockholm, Sweden, 14186 Investigational Site Number 752002 Ume?, Sweden, 901 85 Less << |
NCT00998049 | Multiple Myeloma ... More >> Refractory Multiple Myeloma Stage I Multiple Myeloma Stage II Multiple Myeloma Stage III Multiple Myeloma Less << | Phase 2 | Completed | - | United States, Arizona ... More >> Mayo Clinic in Arizona Scottsdale, Arizona, United States, 85259 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 Less << |
NCT00322842 | Lymphoma, Non-Hodgkin ... More >> Multiple Myeloma Less << | Phase 2 | Completed | - | Germany ... More >> University of Cologne Cologne, Germany Carl Gustav Carus University Hospital Dresden, Germany University of Heidelberg Heidelberg, Germany Less << |
NCT02221492 | Lymphoma | Phase 2 | Completed | - | Japan ... More >> Investigational Site Number 392005 Chiba-Shi, Japan Investigational Site Number 392011 Fukuoka-Shi, Japan Investigational Site Number 392014 Fukuyama-Shi, Japan Investigational Site Number 392010 Hamamatsu-Shi, Japan Investigational Site Number 392006 Kamogawa-Shi, Japan Investigational Site Number 392003 Kobe-Shi, Japan Investigational Site Number 392008 Kurashiki-Shi, Japan Investigational Site Number 392015 Ota-Shi, Japan Investigational Site Number 392004 Sapporo-Shi, Japan Investigational Site Number 392001 Shibuya-Ku, Japan Investigational Site Number 392009 Suwa-Shi, Japan Investigational Site Number 392007 Toyohashi-Shi, Japan Less << |
NCT00322842 | - | Completed | - | - | |
NCT00322491 | Lymphoma, Non-Hodgkin ... More >> Multiple Myeloma Less << | Phase 2 | Completed | - | United States, Arkansas ... More >> University of Arkansas for Medical Sciences Little Rock, Arkansas, United States United States, California UCLA School of Medicine Loa Angeles, California, United States United States, Illinois Loyola University Medical Center Maywood, Illinois, United States United States, Iowa University of Iowa Iowa City, Iowa, United States United States, Minnesota University of Minnesota Minneapolis, Minnesota, United States Mayo Clinic Rochester, Minnesota, United States United States, New York Roswell Park Cancer Institute Buffalo, New York, United States United States, Pennsylvania Thomas Jefferson University Philadelphia, Pennsylvania, United States Less << |
NCT00322491 | - | Completed | - | - | |
NCT02221479 | Multiple Myeloma | Phase 2 | Completed | - | Japan ... More >> Investigational Site Number 392105 Kamogawa-Shi, Japan Investigational Site Number 392103 Kyoto-Shi, Japan Investigational Site Number 392102 Nagoya-Shi, Japan Investigational Site Number 392104 Okayama-Shi, Japan Investigational Site Number 392101 Shibuya-Ku, Japan Less << |
NCT00322387 | Lymphoma, Non-Hodgkin ... More >> Multiple Myeloma Less << | Phase 2 | Completed | - | United States, California ... More >> City of Hope National Medical Center Duarte, California, United States United States, Indiana Indiana Blood and Marrow Transplantation Beech Grove, Indiana, United States United States, New York University of Rochester Medical Center Rochester, New York, United States United States, Oregon Oregon Health and Science University Portland, Oregon, United States United States, Washington Fred Hutchinson Cancer Research Center Seattle, Washington, United States Less << |
NCT00322387 | - | Completed | - | - | |
NCT00998049 | - | Completed | - | - | |
NCT00075335 | Healthy | Phase 2 | Completed | - | United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less << |
NCT01037517 | Multiple Myeloma ... More >> Lymphoma Less << | Phase 2 | Completed | - | Canada, Manitoba ... More >> CancerCare Manitoba Winnipeg, Manitoba, Canada, R3E 0V9 Less << |
NCT01818284 | Blood And Marrow Transplantati... More >>on Less << | Phase 2 | Completed | - | United States, Texas ... More >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Less << |
NCT00396331 | - | Completed | - | - | |
NCT02678533 | Fanconi Anemia | Phase 1 Phase 2 | Recruiting | March 2021 | France ... More >> H?pital necker-Enfants malades Recruiting Paris, France, 75015 Contact: Francois LEFRERE, MD ?? +33 1 44 49 52 74 ?? francois.lefrere@nck.aphp.fr Less << |
NCT00396331 | Autologous Stem Cell Transplan... More >>tation Less << | Phase 2 | Completed | - | United States, California ... More >> City of Hope National Medical Center` Duarte, California, United States, 91010 United States, Florida H. Lee Moffitt Cancer Center Tampa, Florida, United States, 33612-9497 United States, Georgia Blood & Marrow Transplant Group of Georgia Atlanta, Georgia, United States, 30342 United States, Mississippi University of Mississippi Medical Center, Div of Hematology Jackson, Mississippi, United States, 39216 United States, Missouri Kansas City Cancer Centers Kansas City, Missouri, United States, 64111 United States, New Jersey Hackensack University Medical Center Hackensack, New Jersey, United States, 07601 United States, Virginia Virginia Commonwealth University - Massey Cancer Center Richmond, Virginia, United States, 23298-0037 United States, Wisconsin University of Wisconsin, Blood and Bone Marrow Transplant Madison, Wisconsin, United States, 53792-5156 Less << |
NCT00082329 | Healthy | Phase 2 | Completed | - | United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less << |
NCT02200380 | For Donors Re... More >>lated Donors Giving Peripheral Blood Stem Cells (PBSC) to a Sibling For Recipients Acute Myelogenous Leukemia (AML) Acute Lymphoblastic Leukemia (ALL) Myelodysplastic Syndrome (MDS) Chronic Myelogenous Leukemia (CML) Non-Hodgkins Lymphoma (NHL) Hodgkins Disease (HD) Chronic Lymphocytic Leukemia (CLL) Less << | Phase 2 | Terminated | - | United States, California ... More >> UCLA Medical Center Los Angeles, California, United States, 90095 United States, Georgia Emory University-Winship Cancer Institute Atlanta, Georgia, United States, 30322 United States, Indiana Indiana Blood and Marrow Transplant Indianapolis, Indiana, United States, 46237 United States, Iowa University of Iowa Iowa City, Iowa, United States, 52242 United States, North Carolina Wake Forest Baptist Health Winston-Salem, North Carolina, United States, 27157 United States, Ohio Ohio State University Arthur G. James Cancer Hospital and Richard J. Solove Research Institute Columbus, Ohio, United States, 43210 United States, Virginia University of Virginia Medical Center Charlottesville, Virginia, United States, 22908 Virginia Commonwealth University Medical Center Richmond, Virginia, United States, 23298 Less << |
NCT00838357 | Lymphoma (Non-Hodgkin's Lympho... More >>ma) Hodgkin's Disease or Multiple Myeloma Front Line Mobilization Transplantation Less << | Phase 3 | Completed | - | France ... More >> H?pital du Haut Lévêque Bordeaux, France H?pital Lyon Sud Lyon, France Institut Paoli Calmettes Marseille, France CHU Hotel-Dieu Université de Nantes Nantes, France H?pital Saint-Louis Paris, France Institut Gustave Roussy Villejuif, France Germany Charité - Campus Benjamin Franklin Berlin, Germany Klinikum der Universit?t zu K?ln Cologne, Germany Universit?tsklinikum Carl Gustav Carus Dresden, Germany Universit?tsklinikum Heidelberg Heidelberg, Germany Klinikum Nürnberg Nord Nürnberg, Germany Universit?tsklinik Würzburg Würzburg, Germany Italy L. & A. Seragnoli, University of Bologna Bologna, Italy Ospedale Ferrarotto Catania, Italy Azienda Ospedaliera S. Martino Genova, Italy Netherlands VU Medisch Centrum Amsterdam, Netherlands Spain Hospital Santa Creu y Sant Pau Barcelona, Spain Hospital Carlos-Haya Malaga, Spain Hospital Universitario de Salamanca Salamanca, Spain Hospital la Fe Valencia, Spain Sweden Karolinska Universitetssjukhuset Huddinge Stockholm, Sweden Akademiska Sjukhuset Uppsala, Sweden United Kingdom Gartnavel Hospital Glasgow, United Kingdom St James's University Hospital Leeds, United Kingdom King's college Hospital London, United Kingdom Nottingham University NHS Trust Nottingham, United Kingdom Less << |
NCT01058993 | Neutropenia | Phase 1 | Completed | - | United States, Washington ... More >> University of Washington Medical Center Seattle, Washington, United States, 98195 Less << |
NCT00075335 | - | Completed | - | - | |
NCT01058993 | - | Completed | - | - | |
NCT01373229 | - | Completed | - | - | |
NCT01164345 | Non-Hodgkin's Lymphoma|Hodgkin... More >>'s Lymphoma|Stem Cell Mobilization|Autologous Stem Cell Transplantation Less << | PHASE2 | COMPLETED | 2025-05-15 | Chaim Sheba Medical Center, Te... More >>l-Hashomer, Israel Less << |
NCT00082329 | - | Completed | - | - | |
NCT00395967 | Multiple Myeloma ... More >> Lymphoma, Non-Hodgkin's Less << | Phase 2 | Terminated(Enrollment terminat... More >>ed in 2005 to focus on Phase 3 study enrollment.) Less << | - | United States, North Carolina ... More >> Duke University Medical Center - Adult BMT Program Durham, North Carolina, United States, 27705 Less << |
NCT00395967 | - | Terminated(Enrollment terminat... More >>ed in 2005 to focus on Phase 3 study enrollment.) Less << | - | - | |
NCT02069080 | Cancer | Early Phase 1 | Terminated | - | United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less << |
NCT01373229 | Leukemia, Lymphocytic, Chronic... More >>, B-Cell Less << | Phase 1 | Completed | - | United States, North Carolina ... More >> Duke University Medical Center Durham, North Carolina, United States, 27710 Less << |
NCT02522572 | Transplants and Implants | Phase 1 Phase 2 | Recruiting | December 2018 | United States, Ohio ... More >> The Christ Hospital Recruiting Cincinnati, Ohio, United States, 45219 Contact: E. Steve Woodle, MD ?? 513-558-6001 ?? Woodlees@uc.edu ?? Sub-Investigator: Adele Rike-Shields, PharmD ?? ?? ?? Sub-Investigator: Michael Cardi, MD ?? ?? ?? Principal Investigator: Ervin S Woodle, MD ?? ?? ?? University of Cincinnati Recruiting Cincinnati, Ohio, United States, 45267 Contact: E. Steve Woodle, MD ?? 513-558-6001 ?? Woodlees@uc.edu ?? Sub-Investigator: Rita R Alloway, PharmD ?? ?? ?? Principal Investigator: Ervin S Woodle, MD ?? ?? ?? Sub-Investigator: Amit Govil, MD Less << |
NCT00990054 | Acute Myeloid Leukemia | PHASE1 | COMPLETED | 2025-03-12 | Duarte, California, United Sta... More >>tes|Boston, Massachusetts, United States|Ann Arbor, Michigan, United States|St. Louis, Missouri, United States|Rochester, New York, United States|Cleveland, Ohio, United States|Houston, Texas, United States|Seattle, Washington, United States Less << |
NCT01403896 | Malignant Lymphoma, Stem Cell ... More >>Type Less << | Phase 2 | Completed | - | Canada, Nova Scotia ... More >> Capital Health District Authority Halifax, Nova Scotia, Canada Less << |
NCT03226691 | Sickle Cell Disease | PHASE1 | COMPLETED | 2019-02-27 | National Institutes of Health ... More >>Clinical Center, Bethesda, Maryland, 20892, United States Less << |
NCT01095757 | Myeloma|Lymphoma | PHASE2 | COMPLETED | 2025-02-14 | Emory University Winship Cance... More >>r Institute, Atlanta, Georgia, 30322, United States Less << |
NCT00445302 | Renal Impairment | Phase 1 | Completed | - | United States, California ... More >> Apex Research of Riverside Santa Ana, California, United States, 92705 United States, Minnesota Prism Research, 1000 Westgate Dr. suite 149 St. Paul, Minnesota, United States, 55114 United States, Nebraska Creighton University Medical Center Omaha, Nebraska, United States, 68131 Less << |
NCT00694590 | Chronic Lymphocytic Leukemia (... More >>CLL) Small Lymphocytic Lymphoma (SLL) Less << | Phase 1 | Completed | - | United States, California ... More >> UCSD Moores Cancer Center La Jolla, California, United States United States, Ohio Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States United States, Texas UTMD Anderson Cancer Center Houston, Texas, United States Less << |
NCT00901225 | Multiple Myeloma ... More >> Non-Hodgkins Lymphoma Hodgkins Disease Less << | Phase 2 | Completed | - | United States, North Carolina ... More >> Duke University Medical Center Durham, North Carolina, United States, 27705 Less << |
NCT01095757 | Myeloma|Lymphoma | PHASE2 | COMPLETED | 2025-02-14 | Emory University Winship Cance... More >>r Institute, Atlanta, Georgia, 30322, United States Less << |
NCT01068301 | Acute Lymphoblastic Leukemia|A... More >>cute Myeloid Leukemia|Chronic Myeloid Leukemia|Myelodysplastic Syndrome|Non-Hodgkin's Lymphoma Less << | PHASE1 | COMPLETED | 2025-10-13 | St. Jude Children's Research H... More >>ospital, Memphis, Tennessee, 38105, United States Less << |
NCT00445302 | - | Completed | - | - | |
NCT01700608 | - | Completed | - | Italy ... More >> Fondazione IRCCS Istituto Nazionale dei Tumori Milan, Italy, 20133 Less << | |
NCT00901225 | - | Completed | - | - | |
NCT03746080 | Glioblastoma ... More >>Glioblastoma With Primitive Neuronal Component Gliosarcoma Malignant Glioma Oligodendroglial Component Present Less << | Phase 2 | Recruiting | January 11, 2027 | United States, California ... More >> Stanford Cancer Institute Palo Alto Recruiting Palo Alto, California, United States, 94304 Contact: Lawrence Recht ?? 650-725-8630 ?? lrecht@stanford.edu ?? Principal Investigator: Lawrence Recht Less << |
NCT01655875 | Pediatric Acute Myeloblastic L... More >>eukemia, Relapsed Pediatric Acute Lymphoblastic Leukemia, Relapsed Less << | Phase 1 | Terminated(lack of patient enr... More >>ollment) Less << | - | United States, Georgia ... More >> Children's Healthcare of Atlanta Atlanta, Georgia, United States, 30322 Less << |
NCT02193191 | Sickle Cell Disease | PHASE1 | ACTIVE_NOT_RECRUITING | 2025-07-25 | Memorial Sloan Kettering Cance... More >>r Center, New York, New York, 10065, United States|Weill Cornell Medical College, New York, New York, 10065, United States Less << |
NCT03277209 | Pancreas Cancer | PHASE1 | TERMINATED | 2019-12-30 | Weill Cornell Medical College,... More >> New York, New York, 10065, United States|Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, United Kingdom Less << |
NCT03244930 | Lymphoma, Non-Hodgkin ... More >> Lymphoma, Hodgkin Myeloma Stem Cell Transplant Complications Less << | Phase 2 | Recruiting | June 10, 2018 | Mexico ... More >> Servicio de Hematología Hospital Universitario "Dr. José Eleuterio Gonzalez", Universidad Autónoma de Nuevo Leon Recruiting Monterrey, Nuevo Leon, Mexico, 64460 Contact: Perla Colunga Pedraza, MD ?? +528110761973 ?? colunga.perla@gmail.com ?? Contact: Guillermo Sotomayor Duque, MD Less << |
NCT02861287 | - | Completed | - | France ... More >> Institut Paoli-Calmettes Marseille, Bouches-du Rh?ne, France, 13009 Less << | |
NCT01280955 | Failure of Bone Marrow Graft | PHASE1|PHASE2 | COMPLETED | 2025-05-15 | Duke University Medical Center... More >>, Durham, North Carolina, 27705, United States|Medical University of South Carolina, Charleston, South Carolina, 29425, United States Less << |
NCT01042717 | Multiple Myeloma|Non-Hodgkins ... More >>Lymphoma Less << | UNKNOWN | 2025-12-11 | Mount Sinai School of Medicine... More >>, New York, New York, 10029, United States Less << | |
NCT01696461 | Related Donors Donating Periph... More >>eral Blood Stem Cells (PBSC) to a Family Member|Acute Myelogenous Leukemia|Acute Lymphoblastic Leukemia|Myelodysplastic Syndrome|Chronic Myelogenous Leukemia|Non-Hodgkin's Lymphoma|Hodgkin's Disease|Chronic Lymphocytic Leukemia Less << | PHASE2 | COMPLETED | 2025-08-16 | H. Lee Moffitt Cancer Center, ... More >>Tampa, Florida, United States|Emory University, Atlanta, Georgia, United States|University of Chicago, Chicago, Illinois, United States|Massachusetts General Hospital, Boston, Massachusetts, United States|University of Minnesota, Minneapolis, Minnesota, United States|Mayo Clinic, Rochester, Minnesota, United States|Washington University, Saint Louis, Missouri, United States|Duke University, Durham, North Carolina, United States|Cleveland Clinic, Cleveland, Ohio, United States|Ohio State University, Columbus, Ohio, United States|West Virginia University, Morgantown, West Virginia, United States|Medical College of Wisconsin, Milwaukee, Wisconsin, United States Less << |
NCT02179970 | Pancreatic Adenocarcinoma Meta... More >>static|Ovarian Serous Adenocarcinoma|Colorectal Cancer Metastatic Less << | PHASE1 | COMPLETED | 2018-12-14 | Addenbrookes Hospital, Cambrid... More >>ge, CB2 0QQ, United Kingdom Less << |
NCT02056210 | Diabetes | PHASE4 | COMPLETED | 2025-10-14 | Policlinico Universitario, Azi... More >>enda Ospedaliera di Padova, Padova, 35128, Italy Less << |
NCT02790957 | Diabetes Woun... More >>ds Critical Limb Ischemia Less << | Phase 2 | Recruiting | February 2020 | Italy ... More >> University Hospital of Padova Recruiting Padova, Italy, 35128 Contact: Gian Paolo Fadini, MD PhD ?? +39-049-8214318 ?? gianpaolo.fadini@unipd.it Less << |
NCT02989701 | Sickle Cell Disease Without Cr... More >>isis Less << | PHASE1 | COMPLETED | 2017-12-11 | Boston Childrens Hospital, Bos... More >>ton, Massachusetts, 02115, United States Less << |
NCT03547830 | Chronic Granulomatous Disease | Phase 2 | Recruiting | January 1, 2023 | Russian Federation ... More >> Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology Recruiting Moscow, Russian Federation, 117997 Contact: Zhanna Shekhovtsova, MD ?? 4956647078 ext 7538 ?? zhanna.shekhovtsova@fccho-moscow.ru ?? Contact: Eugene Pashanov, PhD ?? +79262205578 ?? e.pashanov@gmail.com ?? Principal Investigator: Dmitry Balashov, MD Less << |
NCT01141543 | - | Completed | - | Canada, Ontario ... More >> Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Less << | |
NCT01149863 | Autologous Transplantation | PHASE2 | COMPLETED | - | Emory University Winship Cance... More >>r Institute, Atlanta, Georgia, 30322, United States Less << |
NCT01149863 | Autologous Transplantation | PHASE2 | COMPLETED | - | Emory University Winship Cance... More >>r Institute, Atlanta, Georgia, 30322, United States Less << |
NCT01280955 | Failure of Bone Marrow Graft | PHASE1|PHASE2 | COMPLETED | 2025-05-15 | Duke University Medical Center... More >>, Durham, North Carolina, 27705, United States|Medical University of South Carolina, Charleston, South Carolina, 29425, United States Less << |
NCT03664830 | Sickle Cell Disease | PHASE1 | ACTIVE_NOT_RECRUITING | 2025-06-06 | City of Hope Medical Center, D... More >>uarte, California, 91010, United States Less << |
NCT01455025 | Acute Myeloid Leukemia | Phase 1 | Terminated(no recruitment on t... More >>ime) Less << | - | France ... More >> Xavier THOMAS Lyon, France, 69437 Less << |
NCT01954914 | Blood Stem Cell Harvest Failur... More >>e Less << | PHASE2 | COMPLETED | 2025-01-16 | Cellex Gesellschaft für Zellge... More >>winnung mbH Dresden, Dresden, 01307, Germany|Universit?tsklinikum Dresden, Medizinische Klinik I, Dresden, 01307, Germany|Cellex Gesellschaft für Zellgewinnung mbH K?ln, K?ln, 50670, Germany Less << |
NCT01319864 | Relapsed/Refractory AML ... More >> Relapsed/Refractory ALL Secondary AML/MDS Acute Leukemia of Ambiguous Lineage AML ALL Less << | Phase 1 | Completed | - | United States, Arizona ... More >> Phoenix Children's Hospital Phoenix, Arizona, United States, 85016 United States, Colorado The Children's Hospital of Denver Denver, Colorado, United States, 80045 United States, Georgia Children's Healthcare of Atlanta/Emory University Atlanta, Georgia, United States, 30322 United States, Maryland Johns Hopkins Medical Center Baltimore, Maryland, United States, 21231 United States, Missouri The Children's Mercy Hospital and Clinics Kansas City, Missouri, United States, 64108 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 United States, Ohio Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229 United States, Pennsylvania Penn State Hershey Children's Hospital Hershey, Pennsylvania, United States, 17033 Canada, Alberta Alberta Children's Hospital Calgary, Alberta, Canada, T3B 6A8 Less << |
NCT01339572 | Non-Hodgkin's Lymphoma ... More >> Multiple Myeloma Less << | Phase 2 | Completed | - | United States, Florida ... More >> Shands Cancer Hospital at the University of Florida Gainesville, Florida, United States, 32608 Less << |
NCT05343572 | Asherman Syndrome|Atrophic End... More >>ometrium|Recurrent Implantation Failure Less << | EARLY_PHASE1 | RECRUITING | 2025-12-26 | Yale Fertility Center, Orange,... More >> Connecticut, 06477, United States Less << |
NCT06141304 | Relapsed Adult ALL|Relapsed Ad... More >>ult AML Less << | PHASE2 | ACTIVE_NOT_RECRUITING | 2025-07-25 | First Hospital of Jilin Univer... More >>sity, Changchun, Jilin, 130021, China Less << |
NCT03406091 | Multiple Myeloma | COMPLETED | 2024-01-17 | A.O.U. Città della Salute e de... More >>lla Scienza di Torino, Torino, 10126, Italy Less << | |
NCT04817345 | Sickle Cell Disease | PHASE2 | WITHDRAWN | 2025-04-23 | - |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
1.99mL 0.40mL 0.20mL |
9.94mL 1.99mL 0.99mL |
19.89mL 3.98mL 1.99mL |