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Chemical Structure| 110078-46-1 Chemical Structure| 110078-46-1

Structure of Plerixafor
CAS No.: 110078-46-1

Chemical Structure| 110078-46-1

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CAS No.: 110078-46-1

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Plerixafor is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.

Synonyms: AMD 3100; JM3100; JKL 169

4.5 *For Research Use Only !

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Product Details of Plerixafor

CAS No. :110078-46-1
Formula : C28H54N8
M.W : 502.78
SMILES Code : N1(CC2=CC=C(CN3CCNCCCNCCNCCC3)C=C2)CCNCCCNCCNCCC1
Synonyms :
AMD 3100; JM3100; JKL 169
MDL No. :MFCD05662218
InChI Key :YIQPUIGJQJDJOS-UHFFFAOYSA-N
Pubchem ID :65015

Safety of Plerixafor

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Plerixafor

GPCR

Isoform Comparison

Biological Activity

Target
  • CXCR4

    CXCR4, IC50:44 nM

In Vitro:

Cell Line
Concentration Treated Time Description References
KU812F cells 50 μM 3 h Reduced adhesion of CML cells to BM microenvironment components PMC4124489
KU812F cells 50 μM 3 h Reduced drug resistance of CML cells to nilotinib PMC4124489
EJ cells 50 μM 24 h Inhibited the proliferation and migration capacity of EJ cells by blocking CXCR4 downstream signaling PMC9977173
MDA-MB-231 cells 10 μg/mL 1 h To study the uptake of Plerixafor-modified nanocarriers in CXCR4-expressing MDA-MB-231 cells, results showed that Plerixafor-modified nanocarriers had a higher uptake rate in CXCR4-expressing cells compared to unmodified carriers. PMC5474759

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Mice Radiation-induced wound healing deficit model Subcutaneous injection 5 mg/kg Single injection Plerixafor combined with G-CSF enhanced the efficacy of MSC-FMB in correcting radiation-induced wound healing deficits PMC3519961
Mice Spinal cord injury model Subcutaneous injection 5 mg/kg Once daily for 3 days Plerixafor treatment increased the number of HSPCs released into the blood by more than 6-fold, with a corresponding increase in the number of HSPCs found in the spleen, and reversed the post-SCI leukopenia. PMC7382469
Mice BCR-ABL-positive leukemia mouse model Subcutaneous injection 5 mg/kg Once daily for 10 days Reduced leukemia burden and prolonged survival PMC4124489
Nude mice EJ xenograft model Intravenous injection 100 μM, 100 μl Once every 2 days for a total of five times Plerixafor significantly inhibited tumor growth, with a mean tumor volume of 647±147 mm3, compared to 1086±257 mm3 in the saline group PMC9977173
Rhesus macaque Rhesus gene therapy model Intravenous injection 1 mg/kg Single dose, after 5 days of G-CSF administration Mobilization of CD34+ cells for gene therapy model PMC10570335

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01164475 - Completed - -
NCT01711073 End Stage Liver DIsease Phase 1 Unknown September 2013 United States, New Jersey ... More >> University of Medicine and Dentistry of New Jersey Recruiting Newark, New Jersey, United States, 07101 Contact: Baburao Koneru, MD ?? ?? koneruba@umdnj.edu Less <<
NCT01123499 - Recruiting - United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting Bethesda, Maryland, United States, 20892 Contact: Sandra Maxwell, B.S.N. ?? 301-402-1773 ?? maxwells@niaid.nih.gov Less <<
NCT03055247 Chronic Granulomatous Disease ... More >>X-linked (X-CGD) Less << Phase 2 Recruiting August 2018 Italy ... More >> Ospedale Pediatrico Bambino Gesù Recruiting Rome, Lazio, Italy, 00165 Contact: Franco Locatelli, MD, PhD ?? ?? ?? Sub-Investigator: Andrea Finocchi, MD ?? ?? ?? Ospedale San Raffaele Recruiting Milan, Lombardia, Italy, 20132 Contact: Fabio Ciceri, MD, PhD ?? ?? ?? Sub-Investigator: Alessandro Aiuti, MD, PhD ?? ?? ?? Sub-Investigator: Bernhard Gentner, MD, PhD ?? ?? ?? Sub-Investigator: Maddalena Migliavacca, MD ?? ?? ?? Sub-Investigator: Laura Bellio, MD Less <<
NCT01182675 Severe Combined Immunodeficien... More >>cy Less << Phase 2 Terminated(Insufficient eviden... More >>ce of efficacy) Less << - United States, California ... More >> UCSF Benioff Children's Hospital San Francisco, California, United States, 94143 Less <<
NCT01182675 - Terminated(Insufficient eviden... More >>ce of efficacy) Less << - -
NCT00914849 - Completed - -
NCT00291811 - - - -
NCT02231879 Myelokathexis ... More >> WHIMS Neutropenia Warts Less << Phase 3 Active, not recruiting May 31, 2021 United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT00733824 Lymphoma, Non-Hodgkin ... More >> Hodgkin Disease Less << Phase 1 Phase 2 Completed - United States, Missouri ... More >> Washington University School of Medicine St. Louis, Missouri, United States, 63110 Less <<
NCT00733824 - Completed - -
NCT02931071 Fanconi Anemia Phase 2 Unknown September 2018 Spain ... More >> Hospital Universitari Vall d'Hebron Recruiting Barcelona, Spain, 08035 Contact: Cristina Díaz de Heredia, MD, PhD ?? +34934893093 ?? crdiaz@vhebron.net ?? Hospital Infantil Universitario Ni?o Jesus Recruiting Madrid, Spain, 28009 Contact: Julian Sevilla Navarro, MD, PhD ?? 0034 91 5035938 ?? jsevilla.hnjs@salud.madrid.org Less <<
NCT00914849 Hematologic Neoplasms Phase 2 Completed - United States, Missouri ... More >> Washington University School of Medicine St. Louis, Missouri, United States, 63110 Less <<
NCT02098109 - Completed - -
NCT02098109 Multiple Myeloma ... More >> Lymphoma, Non-Hodgkin Less << Phase 2 Completed - United States, Missouri ... More >> Washington University School of Medicine Saint Louis, Missouri, United States, 63110 Less <<
NCT00241358 - Completed - -
NCT01074060 Refractory Multiple Myeloma ... More >> Stage I Multiple Myeloma Stage II Multiple Myeloma Stage III Multiple Myeloma Less << Phase 1 Completed - United States, California ... More >> City of Hope Duarte, California, United States, 91010 Less <<
NCT00241358 Leukemia, Myeloid, Acute ... More >> Leukemia, Myelogenous, Chronic Leukemia, Lymphoblastic, Acute Lymphocytic Leukemia, Chronic Myelodysplastic Syndromes Multiple Myeloma Lymphoma, Non-Hodgkin Hodgkin Disease Less << Phase 1 Phase 2 Completed - United States, Missouri ... More >> Washington University School of Medicine Saint Louis, Missouri, United States, 63110 Less <<
NCT00720603 Non-Hodgkin's Lymphoma|Hodgkin... More >>'s Disease|Multiple Myeloma Less << NO_LONGER_AVAILABLE - -
NCT01288573 Ewing's Sarcoma/Soft Tissue Sa... More >>rcoma Neuroblastoma Brain Tumors Less << Phase 1 Phase 2 Completed - -
NCT01076270 Accelerated Phase Chronic Myel... More >>ogenous Leukemia Adult Acute Lymphoblastic Leukemia in Remission Adult Acute Myeloid Leukemia in Remission Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) Adult Acute Myeloid Leukemia With t(15;17)(q22;q12) Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) Adult Acute Myeloid Leukemia With t(8;21)(q22;q22) Atypical Chronic Myeloid Leukemia, BCR-ABL Negative Blastic Phase Chronic Myelogenous Leukemia Chronic Phase Chronic Myelogenous Leukemia de Novo Myelodysplastic Syndromes Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable Nodal Marginal Zone B-cell Lymphoma Noncontiguous Stage II Adult Burkitt Lymphoma Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma Noncontiguous Stage II Adult Lymphoblastic Lymphoma Noncontiguous Stage II Grade 1 Follicular Lymphoma Noncontiguous Stage II Grade 2 Follicular Lymphoma Noncontiguous Stage II Grade 3 Follicular Lymphoma Noncontiguous Stage II Mantle Cell Lymphoma Noncontiguous Stage II Marginal Zone Lymphoma Noncontiguous Stage II Small Lymphocytic Lymphoma Previously Treated Myelodysplastic Syndromes Recurrent Adult Acute Lymphoblastic Leukemia Recurrent Adult Acute Myeloid Leukemia Recurrent Adult Burkitt Lymphoma Recurrent Adult Diffuse Large Cell Lymphoma Recurrent Adult Diffuse Mixed Cell Lymphoma Recurrent Adult Diffuse Small Cleaved Cell Lymphoma Recurrent Adult Hodgkin Lymphoma Recurrent Adult Immunoblastic Large Cell Lymphoma Recurrent Adult Lymphoblastic Lymphoma Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma Recurrent Grade 1 Follicular Lymphoma Recurrent Grade 2 Follicular Lymphoma Recurrent Grade 3 Follicular Lymphoma Recurrent Mantle Cell Lymphoma Recurrent Marginal Zone Lymphoma Recurrent Mycosis Fungoides/Sezary Syndrome Recurrent Small Lymphocytic Lymphoma Refractory Chronic Lymphocytic Leukemia Refractory Hairy Cell Leukemia Refractory Multiple Myeloma Relapsing Chronic Myelogenous Leukemia Secondary Acute Myeloid Leukemia Secondary Myelodysplastic Syndromes Splenic Marginal Zone Lymphoma Stage I Multiple Myeloma Stage II Multiple Myeloma Stage III Adult Burkitt Lymphoma Stage III Adult Diffuse Large Cell Lymphoma Stage III Adult Diffuse Mixed Cell Lymphoma Stage III Adult Diffuse Small Cleaved Cell Lymphoma Stage III Adult Hodgkin Lymphoma Stage III Adult Immunoblastic Large Cell Lymphoma Stage III Adult Lymphoblastic Lymphoma Stage III Chronic Lymphocytic Leukemia Stage III Grade 1 Follicular Lymphoma Stage III Grade 2 Follicular Lymphoma Stage III Grade 3 Follicular Lymphoma Stage III Mantle Cell Lymphoma Stage III Marginal Zone Lymphoma Stage III Multiple Myeloma Stage III Small Lymphocytic Lymphoma Stage IV Adult Burkitt Lymphoma Stage IV Adult Diffuse Large Cell Lymphoma Stage IV Adult Diffuse Mixed Cell Lymphoma Stage IV Adult Diffuse Small Cleaved Cell Lymphoma Stage IV Adult Hodgkin Lymphoma Stage IV Adult Immunoblastic Large Cell Lymphoma Stage IV Adult Lymphoblastic Lymphoma Stage IV Chronic Lymphocytic Leukemia Stage IV Grade 1 Follicular Lymphoma Stage IV Grade 2 Follicular Lymphoma Stage IV Grade 3 Follicular Lymphoma Stage IV Mantle Cell Lymphoma Stage IV Marginal Zone Lymphoma Stage IV Small Lymphocytic Lymphoma Less << Not Applicable Terminated(Funding withdrawal) - United States, Washington ... More >> Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium Seattle, Washington, United States, 98109 Less <<
NCT01076270 - Terminated(Funding withdrawal) - -
NCT01186224 Multiple Myeloma ... More >> Plasma Cell Dyscrasia Lymphoma Lymphoproliferative Disorders Less << Not Applicable Unknown May 2012 United Kingdom ... More >> Dept of Haematology, University of Liverpool Recruiting Liverpool, Merseyside, United Kingdom, L7 8XP Principal Investigator: Richard E Clark, BA, MB, BS Less <<
NCT01027923 Leukemia, Myeloid, Acute Phase 1 Terminated(Withdrawal of suppo... More >>rt from sponsor) Less << - United States, Missouri ... More >> Washington University School of Medicine St. Louis, Missouri, United States, 63110 Less <<
NCT01225419 Children Cancer, Solid Tumor Phase 2 Completed - France ... More >> CHU Clermont-Ferrand Clermont-Ferrand, France, 63003 Less <<
NCT00444912 Non-Hodgkin Lymphoma ... More >> Hodgkin Disease Less << Phase 2 Completed - United States, Georgia ... More >> Winship Cancer Institute Atlanta, Georgia, United States, 30322 Less <<
NCT01610999 Chronic Lymphocytic Leukemia|L... More >>ymphoma|Multiple Myeloma Less << PHASE1 TERMINATED 2025-12-15 Tufts Medical Center, Boston, ... More >>Massachusetts, 02111, United States Less <<
NCT00444912 - Completed - -
NCT00103610 Lymphoma, Non-Hodgkin Phase 3 Completed - -
NCT00103662 Multiple Myeloma Phase 3 Completed - -
NCT00103610 - Completed - -
NCT00103662 - Completed - -
NCT00822770 Stem Cell Transplantation ... More >> Leukemia Less << Phase 1 Phase 2 Completed - United States, Texas ... More >> UT MD Anderson Cancer Center Houston, Texas, United States, 77030 Less <<
NCT00822770 - Completed - -
NCT01220375 Myeloma Phase 2 Completed - Switzerland ... More >> Dep. of Medical Oncology, Bern University Hospital Bern, Switzerland, 3010 Less <<
NCT00943943 Acute Myelogenous Leukemia ... More >> Leukemia Less << Phase 1 Completed - United States, Texas ... More >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Less <<
NCT00903968 Multiple Myeloma Phase 1 Phase 2 Completed - United States, Massachusetts ... More >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Cape Cod Hospital Hyannis, Massachusetts, United States, 02601 Milford Hospital Milford, Massachusetts, United States, 01757 Newton-Wellesley Hospital Newton, Massachusetts, United States, 02462 United States, Pennsylvania Cancer Treatment Centers of America (Eastern Regional Medical Center) Philadelphia, Pennsylvania, United States, 19124 Less <<
NCT01916577 COPD Cystic F... More >>ibrosis Pulmonary Fibrosis Less << Phase 1 Completed - United States, Colorado ... More >> University of Colorado Hospital Aurora, Colorado, United States, 80045 Less <<
NCT00903968 - Completed - -
NCT01065129 Myelodysplastic Syndromes Phase 1 Completed - United States, Missouri ... More >> Washington University School of Medicine St. Louis, Missouri, United States, 63110 Less <<
NCT01767714 Non-Hodgkin's Lymphoma Phase 3 Completed - China ... More >> Investigational Site Number 156017 Beijing, China, 100034 Investigational Site Number 156001 Beijing, China, 100044 Investigational Site Number 156005 Beijing, China, 100071 Investigational Site Number 156002 Beijing, China, 100142 Investigational Site Number 156003 Beijing, China, 100730 Investigational Site Number 156020 Chongqing, China, 400037 Investigational Site Number 156016 Fuzhou, China, 350001 Investigational Site Number 156021 Guangzhou, China, 510060 Investigational Site Number 156011 Hangzhou, China, 310003 Investigational Site Number 156018 Nanjing, China, 210029 Investigational Site Number 156009 Shanghai, China, 200025 Investigational Site Number 156010 Suzhou, China, 215006 Investigational Site Number 156008 Tianjin, China, 300020 Investigational Site Number 156013 Wuhan, China, 430022 Investigational Site Number 156015 Xi'An, China, 710038 Investigational Site Number 156022 Zhengzhou, China, 450008 Less <<
NCT01301963 Refractory Multiple Myeloma Phase 3 Terminated(Slow Accrual) - United States, Ohio ... More >> Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center Cleveland, Ohio, United States, 44106 Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center Cleveland, Ohio, United States, 44195 Less <<
NCT01236144 Acute Myeloid Leukaemia ... More >> High Risk Myelodysplastic Syndrome Less << Phase 1 Phase 2 Completed - United Kingdom ... More >> Aberdeen Royal Infirmary Aberdeen, United Kingdom Belfast City Hospital Belfast, United Kingdom Birmingham Heartlands Hospital Birmingham, United Kingdom Addenbrooke's Hospital Cambridge, United Kingdom University Hospital of Wales Cardiff, United Kingdom Castle Hill Hospital Hull, United Kingdom St James's University Hospital Leeds, United Kingdom Royal Liverpool University Hospital Liverpool, United Kingdom St Bartholomew's Hospital London, United Kingdom Christie Hospital Manchester, United Kingdom Manchester Royal Infirmary Manchester, United Kingdom Freeman Hospital Newcastle, United Kingdom Nottingham University Hospital Nottingham, United Kingdom Less <<
NCT01301963 - Terminated(Slow Accrual) - -
NCT01352650 Acute Myeloid Leukemia Phase 1 Completed - United States, New York ... More >> Weill Cornell Medical College New York, New York, United States, 10021 Less <<
NCT02006225 Autologous Stem Cell Transplan... More >>tation Less << PHASE4 UNKNOWN 2025-02-20 -
NCT01977677 Adult Ependymoblastoma ... More >> Adult Giant Cell Glioblastoma Adult Glioblastoma Adult Gliosarcoma Adult Medulloblastoma Adult Mixed Glioma Adult Oligodendroglial Tumors Adult Pineoblastoma Adult Supratentorial Primitive Neuroectodermal Tumor (PNET) Less << Phase 1 Phase 2 Completed - United States, California ... More >> Stanford University, School of Medicine Stanford, California, United States, 94305 Less <<
NCT00741325 - Completed - -
NCT01160354 Acute Myelogenous Leukemia Phase 1 Phase 2 Terminated(Slow Accrual) - United States, Texas ... More >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Less <<
NCT01977677 - Completed - -
NCT01158118 - Completed - -
NCT01164475 Non-Hodgkin's Lymphoma Phase 4 Completed - United States, California ... More >> City of Hope National Medical Center Duarte, California, United States, 91010 United States, Colorado University of Colorado Cancer Center Aurora, Colorado, United States, 80045 Canada, Ontario Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Korea, Republic of Samsung Medical Center Seoul, Korea, Republic of, 135-710 St. Mary's Hospital Seoul, Korea, Republic of, 137-701 Taiwan National Taiwan University Hospital Taipei, Taiwan, 10002 Taipei Veterans General Hospital Taipei, Taiwan, 10002 Less <<
NCT01158118 Leukemia, Myeloid, Acute ... More >> Myelodysplastic Syndromes Lymphoma, Non-Hodgkin Hodgkin Disease Leukemia, Lymphocytic, Chronic, B-Cell Multiple Myeloma Less << Phase 2 Completed - United States, Missouri ... More >> Washington University School of Medicine Saint Louis, Missouri, United States, 63110 Less <<
NCT00741780 - Completed - -
NCT00512252 Leukemia, Myeloid, Acute Phase 1 Phase 2 Completed - United States, Missouri ... More >> Washington University St. Louis, Missouri, United States, 63110 Less <<
NCT01738373 Bone Marrow / Autologous Trans... More >>plants Less << COMPLETED 2025-11-12 Marseille, France
NCT00512252 - Completed - -
NCT01579149 Healthy Volunteer Phase 1 Completed - United States, Hawaii ... More >> Honolulu, Hawaii, United States Less <<
NCT01206075 Beta-Thalassemia Not Applicable Completed - Greece ... More >> George Papanicolaou Hospital Thessaloniki, Greece Less <<
NCT00396383 Multiple Myeloma Phase 2 Terminated(Insufficient cell m... More >>obilization for tandem transplants) Less << - United States, New York ... More >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 United States, Pennsylvania Thomas Jefferson University Philadelphia, Pennsylvania, United States, 19107 Less <<
NCT01339039 High Grade Glioma: Glioblastom... More >>a (GBM) High Grade Glioma: Gliosarcoma Anaplastic Astrocytoma (AA) Anaplastic Oligodendroglioma (AO) Mixed Anaplastic Oligoastrocytoma (AOA) Less << Phase 1 Terminated(Low accrual rate) - United States, Massachusetts ... More >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Massachusetts General Hospital Boston, Massachusetts, United States, 02214 Less <<
NCT00396383 - Terminated(Insufficient cell m... More >>obilization for tandem transplants) Less << - -
NCT00396201 Hodgkin's Disease Phase 2 Completed - United States, Missouri ... More >> Washington University School of Medicine,Division of Bone Marrow Transplantation & Leukemia St Louis, Missouri, United States, 63110-1093 Less <<
NCT03019809 Wiskott-Aldrich Syndrome ... More >> Hematopoietic Stem Cell Transplantation Graft Failure Less << Phase 2 Recruiting July 2019 Russian Federation ... More >> Dmitry Rogachev Federal Research and Clinical Centre of Paediatric Haematology, Oncology and Immunology Recruiting Moscow, Russian Federation, 117997 Contact: Dmitry Balashov, MD, PhD ?? +7(495)287-6570 ext 6534 ?? bala8@yandex.ru ?? Contact: Michael Maschan, Professor ?? +7(926)287-6570 ?? mmaschan@yandex.ru ?? Sub-Investigator: Michael Maschan, Professor ?? ?? ?? Sub-Investigator: Alexandra Laberko, MD ?? ?? ?? Sub-Investigator: Svetlana Kozlovskaya, MD ?? ?? ?? Sub-Investigator: Elena Gutovskaya, MD ?? ?? ?? Sub-Investigator: Anna Shcherbina, Professor Less <<
NCT02212535 Major Sickle Cell Syndrome of ... More >>Type SS or Sβ Thalassemia Less << PHASE1|PHASE2 COMPLETED 2017-09-27 H?pital Necker - Enfants Malad... More >>es, Paris, 75015, France Less <<
NCT00396266 Multiple Myeloma ... More >> Lymphoma, Non-Hodgkin Less << Phase 2 Completed - Canada, Alberta ... More >> Tom Baker Cancer Center Calgary, Alberta, Canada, T2N 4N2 Canada, British Columbia Vancouver General Hospital, BC Cancer Agency Vancouver, British Columbia, Canada, V5Z 4E3 Less <<
NCT00396201 - Completed - -
NCT00396266 - Completed - -
NCT01753453 Multiple Myeloma Phase 2 Completed - Belgium ... More >> Investigational Site Number 056002 Brugge, Belgium, B-8000 Estonia Investigational Site Number 233001 Tallinn, Estonia, 13419 Lithuania Investigational Site Number 440001 Vilnius, Lithuania, LT-08661 Sweden Investigational Site Number 752001 Stockholm, Sweden, 14186 Investigational Site Number 752002 Ume?, Sweden, 901 85 Less <<
NCT00998049 Multiple Myeloma ... More >> Refractory Multiple Myeloma Stage I Multiple Myeloma Stage II Multiple Myeloma Stage III Multiple Myeloma Less << Phase 2 Completed - United States, Arizona ... More >> Mayo Clinic in Arizona Scottsdale, Arizona, United States, 85259 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 Less <<
NCT00322842 Lymphoma, Non-Hodgkin ... More >> Multiple Myeloma Less << Phase 2 Completed - Germany ... More >> University of Cologne Cologne, Germany Carl Gustav Carus University Hospital Dresden, Germany University of Heidelberg Heidelberg, Germany Less <<
NCT02221492 Lymphoma Phase 2 Completed - Japan ... More >> Investigational Site Number 392005 Chiba-Shi, Japan Investigational Site Number 392011 Fukuoka-Shi, Japan Investigational Site Number 392014 Fukuyama-Shi, Japan Investigational Site Number 392010 Hamamatsu-Shi, Japan Investigational Site Number 392006 Kamogawa-Shi, Japan Investigational Site Number 392003 Kobe-Shi, Japan Investigational Site Number 392008 Kurashiki-Shi, Japan Investigational Site Number 392015 Ota-Shi, Japan Investigational Site Number 392004 Sapporo-Shi, Japan Investigational Site Number 392001 Shibuya-Ku, Japan Investigational Site Number 392009 Suwa-Shi, Japan Investigational Site Number 392007 Toyohashi-Shi, Japan Less <<
NCT00322842 - Completed - -
NCT00322491 Lymphoma, Non-Hodgkin ... More >> Multiple Myeloma Less << Phase 2 Completed - United States, Arkansas ... More >> University of Arkansas for Medical Sciences Little Rock, Arkansas, United States United States, California UCLA School of Medicine Loa Angeles, California, United States United States, Illinois Loyola University Medical Center Maywood, Illinois, United States United States, Iowa University of Iowa Iowa City, Iowa, United States United States, Minnesota University of Minnesota Minneapolis, Minnesota, United States Mayo Clinic Rochester, Minnesota, United States United States, New York Roswell Park Cancer Institute Buffalo, New York, United States United States, Pennsylvania Thomas Jefferson University Philadelphia, Pennsylvania, United States Less <<
NCT00322491 - Completed - -
NCT02221479 Multiple Myeloma Phase 2 Completed - Japan ... More >> Investigational Site Number 392105 Kamogawa-Shi, Japan Investigational Site Number 392103 Kyoto-Shi, Japan Investigational Site Number 392102 Nagoya-Shi, Japan Investigational Site Number 392104 Okayama-Shi, Japan Investigational Site Number 392101 Shibuya-Ku, Japan Less <<
NCT00322387 Lymphoma, Non-Hodgkin ... More >> Multiple Myeloma Less << Phase 2 Completed - United States, California ... More >> City of Hope National Medical Center Duarte, California, United States United States, Indiana Indiana Blood and Marrow Transplantation Beech Grove, Indiana, United States United States, New York University of Rochester Medical Center Rochester, New York, United States United States, Oregon Oregon Health and Science University Portland, Oregon, United States United States, Washington Fred Hutchinson Cancer Research Center Seattle, Washington, United States Less <<
NCT00322387 - Completed - -
NCT00998049 - Completed - -
NCT00075335 Healthy Phase 2 Completed - United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT01037517 Multiple Myeloma ... More >> Lymphoma Less << Phase 2 Completed - Canada, Manitoba ... More >> CancerCare Manitoba Winnipeg, Manitoba, Canada, R3E 0V9 Less <<
NCT01818284 Blood And Marrow Transplantati... More >>on Less << Phase 2 Completed - United States, Texas ... More >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Less <<
NCT00396331 - Completed - -
NCT02678533 Fanconi Anemia Phase 1 Phase 2 Recruiting March 2021 France ... More >> H?pital necker-Enfants malades Recruiting Paris, France, 75015 Contact: Francois LEFRERE, MD ?? +33 1 44 49 52 74 ?? francois.lefrere@nck.aphp.fr Less <<
NCT00396331 Autologous Stem Cell Transplan... More >>tation Less << Phase 2 Completed - United States, California ... More >> City of Hope National Medical Center` Duarte, California, United States, 91010 United States, Florida H. Lee Moffitt Cancer Center Tampa, Florida, United States, 33612-9497 United States, Georgia Blood & Marrow Transplant Group of Georgia Atlanta, Georgia, United States, 30342 United States, Mississippi University of Mississippi Medical Center, Div of Hematology Jackson, Mississippi, United States, 39216 United States, Missouri Kansas City Cancer Centers Kansas City, Missouri, United States, 64111 United States, New Jersey Hackensack University Medical Center Hackensack, New Jersey, United States, 07601 United States, Virginia Virginia Commonwealth University - Massey Cancer Center Richmond, Virginia, United States, 23298-0037 United States, Wisconsin University of Wisconsin, Blood and Bone Marrow Transplant Madison, Wisconsin, United States, 53792-5156 Less <<
NCT00082329 Healthy Phase 2 Completed - United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT02200380 For Donors Re... More >>lated Donors Giving Peripheral Blood Stem Cells (PBSC) to a Sibling For Recipients Acute Myelogenous Leukemia (AML) Acute Lymphoblastic Leukemia (ALL) Myelodysplastic Syndrome (MDS) Chronic Myelogenous Leukemia (CML) Non-Hodgkins Lymphoma (NHL) Hodgkins Disease (HD) Chronic Lymphocytic Leukemia (CLL) Less << Phase 2 Terminated - United States, California ... More >> UCLA Medical Center Los Angeles, California, United States, 90095 United States, Georgia Emory University-Winship Cancer Institute Atlanta, Georgia, United States, 30322 United States, Indiana Indiana Blood and Marrow Transplant Indianapolis, Indiana, United States, 46237 United States, Iowa University of Iowa Iowa City, Iowa, United States, 52242 United States, North Carolina Wake Forest Baptist Health Winston-Salem, North Carolina, United States, 27157 United States, Ohio Ohio State University Arthur G. James Cancer Hospital and Richard J. Solove Research Institute Columbus, Ohio, United States, 43210 United States, Virginia University of Virginia Medical Center Charlottesville, Virginia, United States, 22908 Virginia Commonwealth University Medical Center Richmond, Virginia, United States, 23298 Less <<
NCT00838357 Lymphoma (Non-Hodgkin's Lympho... More >>ma) Hodgkin's Disease or Multiple Myeloma Front Line Mobilization Transplantation Less << Phase 3 Completed - France ... More >> H?pital du Haut Lévêque Bordeaux, France H?pital Lyon Sud Lyon, France Institut Paoli Calmettes Marseille, France CHU Hotel-Dieu Université de Nantes Nantes, France H?pital Saint-Louis Paris, France Institut Gustave Roussy Villejuif, France Germany Charité - Campus Benjamin Franklin Berlin, Germany Klinikum der Universit?t zu K?ln Cologne, Germany Universit?tsklinikum Carl Gustav Carus Dresden, Germany Universit?tsklinikum Heidelberg Heidelberg, Germany Klinikum Nürnberg Nord Nürnberg, Germany Universit?tsklinik Würzburg Würzburg, Germany Italy L. & A. Seragnoli, University of Bologna Bologna, Italy Ospedale Ferrarotto Catania, Italy Azienda Ospedaliera S. Martino Genova, Italy Netherlands VU Medisch Centrum Amsterdam, Netherlands Spain Hospital Santa Creu y Sant Pau Barcelona, Spain Hospital Carlos-Haya Malaga, Spain Hospital Universitario de Salamanca Salamanca, Spain Hospital la Fe Valencia, Spain Sweden Karolinska Universitetssjukhuset Huddinge Stockholm, Sweden Akademiska Sjukhuset Uppsala, Sweden United Kingdom Gartnavel Hospital Glasgow, United Kingdom St James's University Hospital Leeds, United Kingdom King's college Hospital London, United Kingdom Nottingham University NHS Trust Nottingham, United Kingdom Less <<
NCT01058993 Neutropenia Phase 1 Completed - United States, Washington ... More >> University of Washington Medical Center Seattle, Washington, United States, 98195 Less <<
NCT00075335 - Completed - -
NCT01058993 - Completed - -
NCT01373229 - Completed - -
NCT01164345 Non-Hodgkin's Lymphoma|Hodgkin... More >>'s Lymphoma|Stem Cell Mobilization|Autologous Stem Cell Transplantation Less << PHASE2 COMPLETED 2025-05-15 Chaim Sheba Medical Center, Te... More >>l-Hashomer, Israel Less <<
NCT00082329 - Completed - -
NCT00395967 Multiple Myeloma ... More >> Lymphoma, Non-Hodgkin's Less << Phase 2 Terminated(Enrollment terminat... More >>ed in 2005 to focus on Phase 3 study enrollment.) Less << - United States, North Carolina ... More >> Duke University Medical Center - Adult BMT Program Durham, North Carolina, United States, 27705 Less <<
NCT00395967 - Terminated(Enrollment terminat... More >>ed in 2005 to focus on Phase 3 study enrollment.) Less << - -
NCT02069080 Cancer Early Phase 1 Terminated - United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT01373229 Leukemia, Lymphocytic, Chronic... More >>, B-Cell Less << Phase 1 Completed - United States, North Carolina ... More >> Duke University Medical Center Durham, North Carolina, United States, 27710 Less <<
NCT02522572 Transplants and Implants Phase 1 Phase 2 Recruiting December 2018 United States, Ohio ... More >> The Christ Hospital Recruiting Cincinnati, Ohio, United States, 45219 Contact: E. Steve Woodle, MD ?? 513-558-6001 ?? Woodlees@uc.edu ?? Sub-Investigator: Adele Rike-Shields, PharmD ?? ?? ?? Sub-Investigator: Michael Cardi, MD ?? ?? ?? Principal Investigator: Ervin S Woodle, MD ?? ?? ?? University of Cincinnati Recruiting Cincinnati, Ohio, United States, 45267 Contact: E. Steve Woodle, MD ?? 513-558-6001 ?? Woodlees@uc.edu ?? Sub-Investigator: Rita R Alloway, PharmD ?? ?? ?? Principal Investigator: Ervin S Woodle, MD ?? ?? ?? Sub-Investigator: Amit Govil, MD Less <<
NCT00990054 Acute Myeloid Leukemia PHASE1 COMPLETED 2025-03-12 Duarte, California, United Sta... More >>tes|Boston, Massachusetts, United States|Ann Arbor, Michigan, United States|St. Louis, Missouri, United States|Rochester, New York, United States|Cleveland, Ohio, United States|Houston, Texas, United States|Seattle, Washington, United States Less <<
NCT01403896 Malignant Lymphoma, Stem Cell ... More >>Type Less << Phase 2 Completed - Canada, Nova Scotia ... More >> Capital Health District Authority Halifax, Nova Scotia, Canada Less <<
NCT03226691 Sickle Cell Disease PHASE1 COMPLETED 2019-02-27 National Institutes of Health ... More >>Clinical Center, Bethesda, Maryland, 20892, United States Less <<
NCT01095757 Myeloma|Lymphoma PHASE2 COMPLETED 2025-02-14 Emory University Winship Cance... More >>r Institute, Atlanta, Georgia, 30322, United States Less <<
NCT00445302 Renal Impairment Phase 1 Completed - United States, California ... More >> Apex Research of Riverside Santa Ana, California, United States, 92705 United States, Minnesota Prism Research, 1000 Westgate Dr. suite 149 St. Paul, Minnesota, United States, 55114 United States, Nebraska Creighton University Medical Center Omaha, Nebraska, United States, 68131 Less <<
NCT00694590 Chronic Lymphocytic Leukemia (... More >>CLL) Small Lymphocytic Lymphoma (SLL) Less << Phase 1 Completed - United States, California ... More >> UCSD Moores Cancer Center La Jolla, California, United States United States, Ohio Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States United States, Texas UTMD Anderson Cancer Center Houston, Texas, United States Less <<
NCT00901225 Multiple Myeloma ... More >> Non-Hodgkins Lymphoma Hodgkins Disease Less << Phase 2 Completed - United States, North Carolina ... More >> Duke University Medical Center Durham, North Carolina, United States, 27705 Less <<
NCT01095757 Myeloma|Lymphoma PHASE2 COMPLETED 2025-02-14 Emory University Winship Cance... More >>r Institute, Atlanta, Georgia, 30322, United States Less <<
NCT01068301 Acute Lymphoblastic Leukemia|A... More >>cute Myeloid Leukemia|Chronic Myeloid Leukemia|Myelodysplastic Syndrome|Non-Hodgkin's Lymphoma Less << PHASE1 COMPLETED 2025-10-13 St. Jude Children's Research H... More >>ospital, Memphis, Tennessee, 38105, United States Less <<
NCT00445302 - Completed - -
NCT01700608 - Completed - Italy ... More >> Fondazione IRCCS Istituto Nazionale dei Tumori Milan, Italy, 20133 Less <<
NCT00901225 - Completed - -
NCT03746080 Glioblastoma ... More >>Glioblastoma With Primitive Neuronal Component Gliosarcoma Malignant Glioma Oligodendroglial Component Present Less << Phase 2 Recruiting January 11, 2027 United States, California ... More >> Stanford Cancer Institute Palo Alto Recruiting Palo Alto, California, United States, 94304 Contact: Lawrence Recht ?? 650-725-8630 ?? lrecht@stanford.edu ?? Principal Investigator: Lawrence Recht Less <<
NCT01655875 Pediatric Acute Myeloblastic L... More >>eukemia, Relapsed Pediatric Acute Lymphoblastic Leukemia, Relapsed Less << Phase 1 Terminated(lack of patient enr... More >>ollment) Less << - United States, Georgia ... More >> Children's Healthcare of Atlanta Atlanta, Georgia, United States, 30322 Less <<
NCT02193191 Sickle Cell Disease PHASE1 ACTIVE_NOT_RECRUITING 2025-07-25 Memorial Sloan Kettering Cance... More >>r Center, New York, New York, 10065, United States|Weill Cornell Medical College, New York, New York, 10065, United States Less <<
NCT03277209 Pancreas Cancer PHASE1 TERMINATED 2019-12-30 Weill Cornell Medical College,... More >> New York, New York, 10065, United States|Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, United Kingdom Less <<
NCT03244930 Lymphoma, Non-Hodgkin ... More >> Lymphoma, Hodgkin Myeloma Stem Cell Transplant Complications Less << Phase 2 Recruiting June 10, 2018 Mexico ... More >> Servicio de Hematología Hospital Universitario "Dr. José Eleuterio Gonzalez", Universidad Autónoma de Nuevo Leon Recruiting Monterrey, Nuevo Leon, Mexico, 64460 Contact: Perla Colunga Pedraza, MD ?? +528110761973 ?? colunga.perla@gmail.com ?? Contact: Guillermo Sotomayor Duque, MD Less <<
NCT02861287 - Completed - France ... More >> Institut Paoli-Calmettes Marseille, Bouches-du Rh?ne, France, 13009 Less <<
NCT01280955 Failure of Bone Marrow Graft PHASE1|PHASE2 COMPLETED 2025-05-15 Duke University Medical Center... More >>, Durham, North Carolina, 27705, United States|Medical University of South Carolina, Charleston, South Carolina, 29425, United States Less <<
NCT01042717 Multiple Myeloma|Non-Hodgkins ... More >>Lymphoma Less << UNKNOWN 2025-12-11 Mount Sinai School of Medicine... More >>, New York, New York, 10029, United States Less <<
NCT01696461 Related Donors Donating Periph... More >>eral Blood Stem Cells (PBSC) to a Family Member|Acute Myelogenous Leukemia|Acute Lymphoblastic Leukemia|Myelodysplastic Syndrome|Chronic Myelogenous Leukemia|Non-Hodgkin's Lymphoma|Hodgkin's Disease|Chronic Lymphocytic Leukemia Less << PHASE2 COMPLETED 2025-08-16 H. Lee Moffitt Cancer Center, ... More >>Tampa, Florida, United States|Emory University, Atlanta, Georgia, United States|University of Chicago, Chicago, Illinois, United States|Massachusetts General Hospital, Boston, Massachusetts, United States|University of Minnesota, Minneapolis, Minnesota, United States|Mayo Clinic, Rochester, Minnesota, United States|Washington University, Saint Louis, Missouri, United States|Duke University, Durham, North Carolina, United States|Cleveland Clinic, Cleveland, Ohio, United States|Ohio State University, Columbus, Ohio, United States|West Virginia University, Morgantown, West Virginia, United States|Medical College of Wisconsin, Milwaukee, Wisconsin, United States Less <<
NCT02179970 Pancreatic Adenocarcinoma Meta... More >>static|Ovarian Serous Adenocarcinoma|Colorectal Cancer Metastatic Less << PHASE1 COMPLETED 2018-12-14 Addenbrookes Hospital, Cambrid... More >>ge, CB2 0QQ, United Kingdom Less <<
NCT02056210 Diabetes PHASE4 COMPLETED 2025-10-14 Policlinico Universitario, Azi... More >>enda Ospedaliera di Padova, Padova, 35128, Italy Less <<
NCT02790957 Diabetes Woun... More >>ds Critical Limb Ischemia Less << Phase 2 Recruiting February 2020 Italy ... More >> University Hospital of Padova Recruiting Padova, Italy, 35128 Contact: Gian Paolo Fadini, MD PhD ?? +39-049-8214318 ?? gianpaolo.fadini@unipd.it Less <<
NCT02989701 Sickle Cell Disease Without Cr... More >>isis Less << PHASE1 COMPLETED 2017-12-11 Boston Childrens Hospital, Bos... More >>ton, Massachusetts, 02115, United States Less <<
NCT03547830 Chronic Granulomatous Disease Phase 2 Recruiting January 1, 2023 Russian Federation ... More >> Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology Recruiting Moscow, Russian Federation, 117997 Contact: Zhanna Shekhovtsova, MD ?? 4956647078 ext 7538 ?? zhanna.shekhovtsova@fccho-moscow.ru ?? Contact: Eugene Pashanov, PhD ?? +79262205578 ?? e.pashanov@gmail.com ?? Principal Investigator: Dmitry Balashov, MD Less <<
NCT01141543 - Completed - Canada, Ontario ... More >> Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Less <<
NCT01149863 Autologous Transplantation PHASE2 COMPLETED - Emory University Winship Cance... More >>r Institute, Atlanta, Georgia, 30322, United States Less <<
NCT01149863 Autologous Transplantation PHASE2 COMPLETED - Emory University Winship Cance... More >>r Institute, Atlanta, Georgia, 30322, United States Less <<
NCT01280955 Failure of Bone Marrow Graft PHASE1|PHASE2 COMPLETED 2025-05-15 Duke University Medical Center... More >>, Durham, North Carolina, 27705, United States|Medical University of South Carolina, Charleston, South Carolina, 29425, United States Less <<
NCT03664830 Sickle Cell Disease PHASE1 ACTIVE_NOT_RECRUITING 2025-06-06 City of Hope Medical Center, D... More >>uarte, California, 91010, United States Less <<
NCT01455025 Acute Myeloid Leukemia Phase 1 Terminated(no recruitment on t... More >>ime) Less << - France ... More >> Xavier THOMAS Lyon, France, 69437 Less <<
NCT01954914 Blood Stem Cell Harvest Failur... More >>e Less << PHASE2 COMPLETED 2025-01-16 Cellex Gesellschaft für Zellge... More >>winnung mbH Dresden, Dresden, 01307, Germany|Universit?tsklinikum Dresden, Medizinische Klinik I, Dresden, 01307, Germany|Cellex Gesellschaft für Zellgewinnung mbH K?ln, K?ln, 50670, Germany Less <<
NCT01319864 Relapsed/Refractory AML ... More >> Relapsed/Refractory ALL Secondary AML/MDS Acute Leukemia of Ambiguous Lineage AML ALL Less << Phase 1 Completed - United States, Arizona ... More >> Phoenix Children's Hospital Phoenix, Arizona, United States, 85016 United States, Colorado The Children's Hospital of Denver Denver, Colorado, United States, 80045 United States, Georgia Children's Healthcare of Atlanta/Emory University Atlanta, Georgia, United States, 30322 United States, Maryland Johns Hopkins Medical Center Baltimore, Maryland, United States, 21231 United States, Missouri The Children's Mercy Hospital and Clinics Kansas City, Missouri, United States, 64108 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 United States, Ohio Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229 United States, Pennsylvania Penn State Hershey Children's Hospital Hershey, Pennsylvania, United States, 17033 Canada, Alberta Alberta Children's Hospital Calgary, Alberta, Canada, T3B 6A8 Less <<
NCT01339572 Non-Hodgkin's Lymphoma ... More >> Multiple Myeloma Less << Phase 2 Completed - United States, Florida ... More >> Shands Cancer Hospital at the University of Florida Gainesville, Florida, United States, 32608 Less <<
NCT05343572 Asherman Syndrome|Atrophic End... More >>ometrium|Recurrent Implantation Failure Less << EARLY_PHASE1 RECRUITING 2025-12-26 Yale Fertility Center, Orange,... More >> Connecticut, 06477, United States Less <<
NCT06141304 Relapsed Adult ALL|Relapsed Ad... More >>ult AML Less << PHASE2 ACTIVE_NOT_RECRUITING 2025-07-25 First Hospital of Jilin Univer... More >>sity, Changchun, Jilin, 130021, China Less <<
NCT03406091 Multiple Myeloma COMPLETED 2024-01-17 A.O.U. Città della Salute e de... More >>lla Scienza di Torino, Torino, 10126, Italy Less <<
NCT04817345 Sickle Cell Disease PHASE2 WITHDRAWN 2025-04-23 -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.99mL

0.40mL

0.20mL

9.94mL

1.99mL

0.99mL

19.89mL

3.98mL

1.99mL

References

 

Historical Records

Categories