[ CAS No. 109384-19-2 ] {[proInfo.proName]}

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Quality Control of [ 109384-19-2 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 109384-19-2 ]

SDS Specification

Alternatived Products of [ 109384-19-2 ]

Product Details of [ 109384-19-2 ]

CAS No. :	109384-19-2	MDL No. :	MFCD01075174
Formula :	C₁₀H₁₉NO₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	PWQLFIKTGRINFF-UHFFFAOYSA-N
M.W :	201.26	Pubchem ID :	643502
Synonyms :	N-Boc-4-hydroxypiperidine	Chemical Name :	tert-Butyl 4-hydroxypiperidine-1-carboxylate

Calculated chemistry of [ 109384-19-2 ] Expand+

Physicochemical Properties

Num. heavy atoms :	14
Num. arom. heavy atoms :	0
Fraction Csp3 :	0.9
Num. rotatable bonds :	3
Num. H-bond acceptors :	3.0
Num. H-bond donors :	1.0
Molar Refractivity :	57.75
TPSA :	49.77 ?2

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.83 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.49
Log Po/w (XLOGP3) :	0.98
Log Po/w (WLOGP) :	1.0
Log Po/w (MLOGP) :	0.86
Log Po/w (SILICOS-IT) :	0.56
Consensus Log Po/w :	1.18

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-1.51
Solubility :	6.26 mg/ml ; 0.0311 mol/l
Class :	Very soluble
Log S (Ali) :	-1.61
Solubility :	4.9 mg/ml ; 0.0244 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-0.7
Solubility :	39.8 mg/ml ; 0.198 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.11

Safety of [ 109384-19-2 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 109384-19-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 109384-19-2 ]
Downstream synthetic route of [ 109384-19-2 ]

[ 109384-19-2 ] Synthesis Path-Upstream 1~1

1
[ 109384-19-2 ]
[ 1201935-36-5 ]

Reference： [1] Patent: WO2013/109388, 2013, A2,
[2] Patent: WO2015/25197, 2015, A1,

[ 109384-19-2 ] Synthesis Path-Downstream 1~15

1
[ 143879-80-5 ]
[ 109384-19-2 ]
4-(4-Cyano-2,3-difluoro-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester [ No CAS ]
4-(6-Cyano-2,3-difluoro-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester [ No CAS ]

Reference： [1]Tetrahedron Letters,1996,vol. 37,p. 6439 - 6442

2
[ 24424-99-5 ]
[ 5382-17-2 ]
[ 109384-19-2 ]

Reference： [1]Bioorganic and medicinal chemistry,2003,vol. 11,p. 2519 - 2527

3
[ 109384-19-2 ]
[ 3202-33-3 ]

Reference： [1]Journal of labelled compounds and radiopharmaceuticals,2004,vol. 47,p. 953 - 969
[2]Molecules,2017,vol. 22

4
[ 109384-19-2 ]
[ 112108-73-3 ]
[ 862874-11-1 ]

Reference： [1]Patent: WO2005/85220,2005,A1 .Location in patent: Page/Page column 72-73

5
[ 24424-99-5 ]
[ 5382-17-2 ]
[ 144-55-8 ]
[ 109384-19-2 ]

Yield	Reaction Conditions	Operation in experiment
100%	In 1,4-dioxane;	(a) 1-(Tert-Butoxycarbonyl)-4-hydroxypiperidine <strong>[5382-17-2]4-Hydroxypiperidine hydrochloride</strong> (3 g) was dissolved in dioxane (30 ml), added with di-tert-butyl dicarbonate (5.2 g) and stirred at room temperature for 10 minutes. The reaction mixture was added with 8percent aqueous sodium hydrogencarbonate (60 ml) and further stirred for 3.5 hours. Dioxane was evaporated under reduced pressure, and the aqueous layer was extracted with ethyl acetate (60 ml). The organic layer was dried over anhydrous magnesium sulfate, and then the solvent was evaporated under reduced pressure. The residue was purified to obtain 4.81 g of the title compound. Yield: 100percent. 1H-NMR (CDCl3) delta (ppm); 1.46 (11H, m), 1.86 (2H, m), 3.04 (2H, m), 3.85 (3H, m)
100%	In 1,4-dioxane;	(a) 1-(tert-Butoxycarbonyl)-4-hydroxypiperidine <strong>[5382-17-2]4-Hydroxypiperidine hydrochloride</strong> (3 g) was dissolved in dioxane (30 ml), added with di-tert-butyl dicarbonate (5.2 g) and stirred at room temperature for 10 minutes. The reaction mixture was added with 8percent aqueous sodium hydrogencarbonate (60 ml) and further stirred for 3.5 hours. Dioxane was evaporated under reduced pressure, and the aqueous layer was extracted with ethyl acetate (60 ml). The organic layer was dried over anhydrous magnesium sulfate, and then the solvent was evaporated under reduced pressure to obtain 4.81 g of the title compound. Yield: 100percent. 1H-NMR (CDCl3); delta (ppm) 1.46 (11H, m), 1.86 (2H, m), 3.04 (2H, m), 3.85 (3H, m)

Reference： [1]Patent: US2003/171370,2003,A1
[2]Patent: US2003/176693,2003,A1

6
[ 7651-82-3 ]
[ 109384-19-2 ]
[ 918490-55-8 ]

Yield	Reaction Conditions	Operation in experiment
	With polystyrene-bound triphenylphosphine; triethylamine; In dichloromethane; at 20℃;Product distribution / selectivity;	AAV1 :To 500 mg (1.5 mmol) of triphenylphosphine (bound to polystyrene, 3mmol/g) and 10 ml of dichloromethane 0.195 mL (1.2 mmol) of diethylazodicarboxylate (or alternatively diisopropylazodicarboxylate) were added. The reaction mixture was allowed to shake for 10 min. and then 0.14 mL of triethylamine, 145 mg of <strong>[7651-82-3]6-hydroxyisoquinoline</strong> (7) (or an equivalent amount of a different suitable isoquinol) (reagent 1) and 1 mmol of the desired, boc-protected aminoalcohol (reagent 2) was added. The reaction was shaken at room temperature until no further conversion could be observed by LCMS. For workup, the solution was filtered, the residue was washed with dichloromethane and EPO <DP n="90"/>the organic layer was washed twice with 1 N sodium hydroxide, twice with water and once with brine, dried over magnesium sulfate and evaporated. The crude product was purified by preparative HPLC to yield the boc protected coupled product.

Reference： [1]Patent: WO2007/240,2007,A1 .Location in patent: Page/Page column 88-89; 90

7
[ 5470-65-5 ]
[ 109384-19-2 ]
[ 929281-95-8 ]

Yield	Reaction Conditions	Operation in experiment
75%	With di-isopropyl azodicarboxylate; triphenylphosphine; In diethyl ether; at 25℃; for 18h;	<strong>[5470-65-5]3-Bromo-4-nitrophenol</strong> (11.6 g, 53.2 mmol), 1,1-dimethylethyl 4-hydroxy-1- piperidinecarboxylate (10.7 g, 53.2 mmol) and triphenylphosphine (24 g, 91 mmol) were combined in diethyl ether (400 ml_) at room temperature. Diisopropyl azodicarboxylate (17.2 ml_, 87.8 mmol) was added over 10 min. The solution was stirred at 25 °C for 18 h. The reaction mixture was extracted with 1 N sodium hydroxide (2 x 50 ml_), and brine (100 mL). The organic fractions were combined, dried over magnesium sulfate, filtered, and concentrated onto silica gel. Purification by column chromatography (0 to 40percent ethyl acetate:hexanes) provided 16.0 g (75percent) of the title compound as yellow solid. 1H NMR (300 MHz, DMSO-dfe): delta 8.04 (d, 1 H, J= 9.2 Hz), 7.48 (d, 1 H, J= 2.6 Hz), 7.18 (dd, 1 H1 J= 2.6, 9.2 Hz), 4.79 (m, 1 H)1 3.6 (m, 2H), 3.15 (m, 2H)1 1.89 (m, 2H)1 1.52 (s, 2H), 1.38 (s, 9H).

Reference： [1]Patent: WO2007/30366,2007,A1 .Location in patent: Page/Page column 92

8
[ 2040-90-6 ]
[ 109384-19-2 ]
[ 1058702-84-3 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,p. 4298 - 4302

9
[ 109384-19-2 ]
[ 71902-33-5 ]
[ 1189551-57-2 ]

Yield	Reaction Conditions	Operation in experiment
99%	With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20℃; for 17h;	t-Butyl 4-hydroxypiperidine-1-carboxylate (1.04 g, 5.00 mmol) was added to a N,N-dimethylformamide suspension (5.0 ml) of 60percent sodium hydride (229 mg, 6.00 mmol), at 0°C, and stirring was carried out at room temperature for 30 minutes. Further, at 0°C, <strong>[71902-33-5]3,5-difluoropyridine</strong> (645 mg, 5.50 mmol) was added, and stirring was carried out for 16.5 hours. Water was added to the reaction solution, followed by extraction with ethyl acetate. The extract was washed sequentially with water and saline, and then dried over anhydrous sodium sulfate. The organic layer was concentrated and the resulting residue was purified by silica gel column chromatography to afford t-butyl 4-[(5-fluoropyridin-3-yl)oxy]piperidine-1-carboxylate (1.48 g, yield 99percent) as a colorless oil. 1H-NMR (CDCl3, 400 MHz) delta: 8.16-8.11 (2H, m), 6.96 (1H, dt, J=10.2, 2.3 Hz), 4.52-4.47 (1H, m), 3.73-3.67 (2H, m), 3.39-3.33 (2H, m), 1.99-1.73 (4H, m), 1.47 (9H, s). MS (ESI, m/z): 297 (M+H)+.

Reference： [1]Patent: EP2258697,2010,A1 .Location in patent: Page/Page column 107-108

10
[ 109384-19-2 ]
[ 877399-50-3 ]

Reference： [1]Bioorganic and Medicinal Chemistry,2013,vol. 21,p. 6804 - 6820
[2]Tetrahedron Letters,2014,vol. 55,p. 1528 - 1531
[3]Patent: US2015/11548,2015,A1
[4]Patent: WO2015/81257,2015,A2
[5]Bioorganic Chemistry,2016,vol. 65,p. 146 - 158
[6]Patent: CN106317024,2017,A
[7]Patent: WO2013/53983,2013,A1

11
[ 52427-05-1 ]
[ 109384-19-2 ]
C₁₆H₂₁BrN₂O₅ [ No CAS ]

Reference： [1]ChemBioChem,2014,vol. 15,p. 68 - 79

12
[ 109384-19-2 ]
[ 5382-17-2 ]

Yield	Reaction Conditions	Operation in experiment
99%	With hydrogenchloride; In 1,4-dioxane; at 20℃; for 2.0h;	A mixture of tert-butyl 4-hydroxypiperidine- 1 -carboxylate (5 g, 24.84 mmol, 1.00 equiv) and HC1 (saturated solution in 30 mL of 1 ,4-dioxane) was stirred for 2 h at room temperature. The resulting mixture was concentrated under vacuum to afford the title compound (3.4 g, 99percent) as an off- white solid.
90%	With hydrogenchloride; In diethyl ether; at 20℃; for 2.0h;	A solution of N-Boc-4-hydroxypiperidine (600 mg, 3.0 mmol) in HCl/Et20 (2.0 M, 10 mL) was stirred at room temperature for 2 hours. The reaction mixture was concentrated and the residue obtained washed with Et20 and dried to give the title product (370 mg, 90percent) as white solid which was used without purification.
7.0 g	With hydrogenchloride; In ethyl acetate; at 20℃;	To a solution of ieri-butyl 4-hydroxypiperidine-1-carboxylate (10.9 g, 49.7 mmol, 1 .0 eq) in EtOAc (40 mL) was added a saturated solution of HCI in EtOAc (10 mL), and the resulting mixture was stirred at room temperature overnight. The mixture was concentrated to give the title compound (7.0 g) as a white solid

Reference： [1]Patent: WO2015/52264,2015,A1 .Location in patent: Paragraph 0918; 0919
[2]Patent: WO2017/153520,2017,A1 .Location in patent: Page/Page column 50
[3]Patent: WO2016/34673,2016,A1 .Location in patent: Page/Page column 120

13
[ 109384-19-2 ]
[ 4983-28-2 ]
tert-butyl 4-((2-chloropyrimidin-5-yl)oxy)piperidine-1-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
77%	With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20℃; for 72h;Inert atmosphere;	To a solution of tert-butyl 4-hydroxypiperidine-l-carboxylate (561 mg, 2.79 mmol) in THF (5 mL) was added <strong>[4983-28-2]2-chloropyrimidin-5-ol</strong> (200 mg, 1.532 mmol), triphenylphosphine (548 mg, 2.089 mmol) and DIAD (0.406 mL, 2.089 mmol) and the reaction was stirred at 20 C under an atmosphere of nitrogen for 72 h. The reaction was concentrated, and the residue subjected directly to purification by flash chromatography (60g pre-packed C-18 SNAP cartridge:35% to 90% acetonitrile (0.1% formic acid) in water (0.1% formic acid)). The desired fractions were combined and concentrated to afford the title compound (430 mg, 1.07 mmol, 77 % yield). LCMS T= 1.12 min, ES+ve 258 (M+H-tBu).
77%	With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20℃; for 72h;Inert atmosphere;	(0204) To a solution of tert-butyl 4-hydroxypiperidine-1-carboxylate (561 mg, 2.8 mmol) in THF (5 mL) was added <strong>[4983-28-2]2-chloropyrimidin-5-ol</strong> (200 mg, 1.53 mmol), triphenylphosphine (548 mg, 2.09 mmol) and DIAD (0.406 mL, 2.09 mmol) and the reaction mixture was stirred at 20 C. under nitrogen for 72 h. The reaction mixture was concentrated in vacuo, and the residue was subjected directly to purification by flash chromatography (60 g pre-packed C-18 SNAP cartridge using a gradien elution from 35-90% acetonitrile (0.1% formic acid) in water (0.1% formic acid)). Desired fractions were combined and concentrated to afford the title compound (430 mg, 1.1 mmol, 77% yield). LCMS RT=1.12 min, ES+ve 258 (M+H-tBu).
48%	With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20℃;	To a stirred solution of tert-butyl 4-hydroxypiperidine-1-carboxylate ( 2.5 g, 12.60 mmol) in THF (30 mL), <strong>[4983-28-2]2-chloropyrimidin-5-ol</strong> (1.5 g, 11.4 mmol), TPP (7.4 g, 22.9 mmol) followed by di-tert- butyl azocarboxylate (DTAD, 5.2 g, 22.9 mmol) were added and the reaction mixture was stirred at RT overnight. Completion of the reaction was monitored by TLC. The reaction mixture was diluted with water and the aqueous layer was extracted with EtOAc (2 x 25 mL). The combined organic layer was washed with water (5 mL), brine solution (5 mL), dried over anhydrous sodium sulfate and concentrated under vacuum. The resulting crude material was purified by flash chromatography (Biotage Isolera, eluent: 50percent EtOAc in hexane) to afford the title compound. Yield: 48percent (1.8 g, yellow solid). LCMS: (Method A) 258.2 (M-f-butyl), Rt. 4.5 min, 96.8percent (Max).

Reference： [1]Patent: WO2017/182418,2017,A1 .Location in patent: Page/Page column 66
[2]Patent: US2018/134688,2018,A1 .Location in patent: Paragraph 0203-0204
[3]Patent: WO2019/37860,2019,A1 .Location in patent: Page/Page column 101-102

14
[ 22123-14-4 ]
[ 109384-19-2 ]
C₁₇H₂₃F₃N₂O₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		To a solution of l-Boc-4-hydroxypiperidine (CAS: 109384-19-2; 500 mg, 2.48 mmol) in anhydrous DMF (9 mL) at room temperature was added NaH (60% dispersion in mineral oi, 119 mg, 2.98 mmol) portion wise. The mixture was stirred for 60 min and 2- chloro-6-methyl-4-(trifluoromethyl)pyridine (CAS: 22123-14-4; 534 mg, 2.73 mmol) was added dropwise. The reaction mixture was stirred at 80 C for 18 h. The mixture was cooled down and the volatiles were evaporated in vacuo. The residue was taken up in EtOAc and washed with NaHCCh (sat., aq.). The organic phase was evaporated in vacuo to give intermediate 44 (1.03 g, 77%, 67% purity) as a brown oil.

Reference： [1]Patent: WO2019/243530,2019,A1 .Location in patent: Page/Page column 38-39

15
[ 22123-14-4 ]
[ 109384-19-2 ]
C₁₂H₁₅F₃N₂O [ No CAS ]

Reference： [1]Patent: WO2019/243530,2019,A1

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P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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[ CAS No. 109384-19-2 ] {[proInfo.proName]}

Quality Control of [ 109384-19-2 ]

Related Doc. of [ 109384-19-2 ]

Product Details of [ 109384-19-2 ]

Calculated chemistry of [ 109384-19-2 ] Expand+

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 109384-19-2 ]

Application In Synthesis of [ 109384-19-2 ]

[ 109384-19-2 ] Synthesis Path-Upstream 1~1

[ 109384-19-2 ] Synthesis Path-Downstream 1~15

Technical Information

Related Functional Groups of [ 109384-19-2 ]

Alcohols

Amides

Related Parent Nucleus of [ 109384-19-2 ]

Piperidines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 109384-19-2 ]

Related Parent Nucleus of
[ 109384-19-2 ]