100-fold selective for IGF-1R/InsR than Akt1/2, Aurora A/B,B-Raf, CDK2, EGFR etc." />

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Chemical Structure| 1089283-49-7 Chemical Structure| 1089283-49-7
Chemical Structure| 1089283-49-7

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CAS No.: 1089283-49-7

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GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM, being > 100-fold selective for IGF-1R/InsR than Akt1/2, Aurora A/B,B-Raf, CDK2, EGFR etc.

Synonyms: GSK 4529

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Product Details of GSK1904529A

CAS No. :1089283-49-7
Formula : C44H47F2N9O5S
M.W : 851.96
SMILES Code : O=C(C1=CC(C2=C(N3C=CC=CC3=N2)C4=NC(NC5=CC(CC)=C(C=C5OC)N6CCC(CC6)N7CCN(CC7)S(=O)(C)=O)=NC=C4)=CC=C1OC)NC8=C(C=CC=C8F)F
Synonyms :
GSK 4529
MDL No. :MFCD17010271
InChI Key :MOSKATHMXWSZTQ-UHFFFAOYSA-N
Pubchem ID :25124816

Safety of GSK1904529A

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of GSK1904529A

RTK

Isoform Comparison

Biological Activity

Target
  • IGF-1R

    IGF-1R, IC50:27 nM

  • Insulin Receptor

    Insulin Receptor, IC50:25 nM

Protocol

Bio Calculators
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1 mM

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10 mM

1.17mL

0.23mL

0.12mL

5.87mL

1.17mL

0.59mL

11.74mL

2.35mL

1.17mL

 

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