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Chemical Structure| 107-97-1 Chemical Structure| 107-97-1
Chemical Structure| 107-97-1

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CAS No.: 107-97-1

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Sarcosine is an NMDAR co-agonist at the glycine binding site. It is an intermediate and byproduct in glycine synthesis and degradation.

Synonyms: N-Methylglycine; Sarcosin; Methylglycine

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Product Details of Sarcosine

CAS No. :107-97-1
Formula : C3H7NO2
M.W : 89.09
SMILES Code : C(C(=O)O)NC
Synonyms :
N-Methylglycine; Sarcosin; Methylglycine
MDL No. :MFCD00004279
InChI Key :FSYKKLYZXJSNPZ-UHFFFAOYSA-N
Pubchem ID :1088

Safety of Sarcosine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Sarcosine

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 107-97-1 ]
  • Downstream synthetic route of [ 107-97-1 ]

[ 107-97-1 ] Synthesis Path-Upstream   1~2

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YieldReaction ConditionsOperation in experiment
80% at 60℃; for 3 h; 196 g (2.2 moles) of N-methylglycine was dissolved in 360 g of water, heated to 80C, and the hot solution was quickly added to the above S-carboxymethylisothiourea aqueous solution to keep the temperature of the reaction system at not lower than 60 ° C. The reaction was stirred for 3 hours. The heating was stopped. The system was cooled to 0-5 ° C in an ice-water bath. The filter cake was washed with a small amount of absolute ethanol and dried to give 238 g of white crystals, melting at 294 ° C. Acid, yield 80percent.The filtrate was extracted four times with 300 ml of chloroform, and the extracts were combined. The chloroform was recovered at normal pressure and the residue was distilled under reduced pressure (vacuum 0.098 MPa). The fractions were collected at 104-106 ° C to give 156 g of thioglycolic acid in a yield of 85percent, and 156 g
References: [1] Patent: CN105777594, 2016, A, . Location in patent: Paragraph 0025; 0026.
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References: [1] Asian Journal of Chemistry, 2014, vol. 26, # 3, p. 926 - 932.
 

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