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Chemical Structure| 107-43-7 Chemical Structure| 107-43-7
Chemical Structure| 107-43-7

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CAS No.: 107-43-7

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βine can enhance the specificity of the polymerase chain reaction by eliminating the base pair composition dependence of DNA melting, which is a natural product isolated and purified from the roots of β vulgaris.

Synonyms: Trimethylglycine; carboxy-N,N,N-trimethylmethanaminium; Abromine

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Hyung Shik Kim ; Elias A. Halabi ; Noah Enbergs ; Rainer H. Kohler ; Fan Fei ; Christopher S. Garris , et al.

Abstract: Rationale: constructs are commonly used for vaccination, immune stimulation, and gene therapy, but their use in cancer still remains limited. One of the reasons is that systemic delivery to tumor-associated antigen-presenting cells (dendritic cells and macrophages) is often inefficient, while off-target nucleic acid-sensing immune pathways can stimulate systemic immune responses. Conversely, certain carbohydrate nanoparticles with small molecule payloads have been shown to target these cells efficiently in the tumor microenvironment. Yet, incorporation into such carbohydrate-based nanoparticles has proven challenging. Methods: We developed a novel approach using cross-linked bis succinyl-cyclodextrin (b-s-CD) nanoparticles to efficiently deliver nucleic acids and small-molecule immune enhancer to phagocytic cells in tumor environments and lymph nodes. Our study involved incorporating these components into the nanoparticles and assessing their efficacy in activating antigen-presenting cells. Results: The multi-modality immune stimulators effectively activated antigen-presenting cells and promoted immunity in vivo. This was evidenced by enhanced delivery to phagocytic cells and subsequent immune response activation in tumor environments and lymph nodes. Conclusion: Here, we describe a new approach to incorporating both nucleic acids and small-molecule immune enhancers into cross-linked bis succinyl-cyclodextrin (b-s-CD) nanoparticles for efficient delivery to phagocytic cells in tumor environments and lymph nodes in vivo. These multi-modality immune stimulators can activate antigen-presenting cells and foster immunity. We argue that this strategy can potentially be used to enhance efficacy.

Keywords: delivery ; nanoparticles ; dendritic cells ; vaccine ; cancer ; lymph node

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Product Details of Betaine

CAS No. :107-43-7
Formula : C5H11NO2
M.W : 117.15
SMILES Code : O=C([O-])C[N+](C)(C)C
Synonyms :
Trimethylglycine; carboxy-N,N,N-trimethylmethanaminium; Abromine
MDL No. :MFCD00012123
InChI Key :KWIUHFFTVRNATP-UHFFFAOYSA-N
Pubchem ID :247

Safety of Betaine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338
 

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