成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 10531-41-6 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 10531-41-6
Chemical Structure| 10531-41-6
Structure of 10531-41-6 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 10531-41-6 ]

Related Doc. of [ 10531-41-6 ]

Alternatived Products of [ 10531-41-6 ]
Product Citations

Product Details of [ 10531-41-6 ]

CAS No. :10531-41-6 MDL No. :MFCD02677721
Formula : C6H5BrOS Boiling Point : -
Linear Structure Formula :- InChI Key :UHWNENCHFSDZQP-UHFFFAOYSA-N
M.W : 205.07 Pubchem ID :2776372
Synonyms :

Calculated chemistry of [ 10531-41-6 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 9
Num. arom. heavy atoms : 5
Fraction Csp3 : 0.17
Num. rotatable bonds : 2
Num. H-bond acceptors : 1.0
Num. H-bond donors : 0.0
Molar Refractivity : 42.38
TPSA : 45.31 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.1 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.65
Log Po/w (XLOGP3) : 2.04
Log Po/w (WLOGP) : 2.33
Log Po/w (MLOGP) : 1.27
Log Po/w (SILICOS-IT) : 3.36
Consensus Log Po/w : 2.13

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -2.68
Solubility : 0.433 mg/ml ; 0.00211 mol/l
Class : Soluble
Log S (Ali) : -2.62
Solubility : 0.492 mg/ml ; 0.0024 mol/l
Class : Soluble
Log S (SILICOS-IT) : -2.88
Solubility : 0.272 mg/ml ; 0.00132 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 2.22

Safety of [ 10531-41-6 ]

Signal Word:Danger Class:8
Precautionary Statements:P260-P264-P270-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P405-P501 UN#:3261
Hazard Statements:H302-H314 Packing Group:Ⅱ
GHS Pictogram:

Application In Synthesis of [ 10531-41-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 10531-41-6 ]

[ 10531-41-6 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 10531-41-6 ]
  • [ 30748-47-1 ]
  • [ 1170673-57-0 ]
YieldReaction ConditionsOperation in experiment
Intermediate 17: (+/-V1-r3-Methyl-6-(2-thienvnimidazor2.1-bi? .3lthiazol-2-yllethanolA solution of 2-bromo-1-(2-thienyl)ethanone (commercially available from Acros Organics) (0.820 g, 4 mmol) in ethanol (12 ml) was added to 1-(2-amino-4-methyl- 1 ,3-thiazol-5-yl)ethanone (commercially available from Aldrich) (0.625 g, 4.00 mmol). The reaction mixture was heated at reflux over night. 1-Butanol (5 ml) was added and the reaction mixture was stirred at reflux for 2 days. The mixture was evaporated under vacuum. Ethanol (25ml) followed by NaBH4 (197 mg, 5.20 mmol) were added and the reaction mixture was stirred at room temperature over night. Water (2ml) was added and the solvent removed under vacuum to obtain a solid which was dissolved <n="41"/>in 50% MeOH/DCM. The MeOH/DCM solution was loaded onto a SCX-2 cartridge. The cartridge was washed with MeOH (40ml) then eluted with a solution of NI-13/MeOH (0.5M) (60ml). The eluant was evaporated to dryness and the residue was purified by MDAP to give the title compound (1 1 mg); MS: ES+ m/z: 265 [MH+] at RT 2.6 min. Ci2H12N2OS2 requires 264 (analysed by LCMS A).
  • 2
  • [ 10531-41-6 ]
  • [ 374750-30-8 ]
  • [ 1188418-39-4 ]
  • 3
  • [ 10531-41-6 ]
  • [ 60827-45-4 ]
  • [ 1207291-32-4 ]
  • [ 1207291-31-3 ]
YieldReaction ConditionsOperation in experiment
With toluene-4-sulfonic acid; In toluene; at 130℃;Product distribution / selectivity; Example 23; Synthesis of (4S)-trans-,cis-2-(4-chlorophenyl)-2-bromomethyl-4-chloromethyl-1,3-dioxolane suppressing halogen exchange between substrates A mixture of 2-bromo-4'-chloroacetophenone (4.94 g, 2-chloro-4'-chloroacetophenone content=0.09%), p-toluenesulfonic acid monohydrate (0.20 g, 0.05 equivalent) and toluene (100 mL) was refluxed at 130C using an azeotropic distillation device with a Dean-Stark tube, and (S)-monochlorohydrin (2.59 g, 1.1 equivalents, >99%ee) was added dropwise under reflux such that the amount of the (S)-monochlorohydrin present in the reaction solution would be not more than 0.1 equivalent (not more than 2.1 mmol) relative to the amount of 2-bromo-4'-chloroacetophenone to be used (21.2 mmol), while analyzing the progress of the reaction by GC. After confirmation of the completion of the azeotropic distillation, the reaction mixture was cooled and washed with 10% aqueous sodium hydrogen carbonate solution and 10% brine. The solvent was evaporated under reduced pressure to give (4S)-trans-,cis-2-(4-chlorophenyl)-2-bromomethyl-4-chloromethyl-1,3-dioxolane (6.56 g, >99%ee). Here, the content percentage of (4S)-trans-,cis-2-(4-chlorophenyl)-2-chloromethyl-4-chloromethyl-1,3-dioxolane halogen-exchanged with a chlorine atom was 0.09%. Examples 30 to 41 Synthesis of (4S)-trans-cis-2-aryl-2-bromomethyl-4-chloromethyl-1,3-dioxolane suppressing halogen exchange In Examples 30 to 41, reactions were performed according to Example 23 and using aryl(bromomethyl)ketones (halogen-exchanged compound content<0.1%) shown in Table 7 and Table 8. The results are shown in Table 9 and Table 10 together with Example 23.
Recommend Products
Same Skeleton Products

Technical Information

Historical Records
; ;